Amino acid dipepetide frequency for Arenimonas sp. 3729k

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.486AlaAla: 19.486 ± 0.254
1.303AlaCys: 1.303 ± 0.042
7.125AlaAsp: 7.125 ± 0.1
9.246AlaGlu: 9.246 ± 0.134
4.104AlaPhe: 4.104 ± 0.075
13.325AlaGly: 13.325 ± 0.159
2.377AlaHis: 2.377 ± 0.052
4.795AlaIle: 4.795 ± 0.079
2.698AlaLys: 2.698 ± 0.075
16.285AlaLeu: 16.285 ± 0.201
3.383AlaMet: 3.383 ± 0.068
2.346AlaAsn: 2.346 ± 0.054
6.405AlaPro: 6.405 ± 0.11
4.137AlaGln: 4.137 ± 0.085
11.938AlaArg: 11.938 ± 0.129
5.636AlaSer: 5.636 ± 0.087
5.255AlaThr: 5.255 ± 0.085
9.33AlaVal: 9.33 ± 0.125
2.627AlaTrp: 2.627 ± 0.068
2.486AlaTyr: 2.486 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
1.031CysAla: 1.031 ± 0.035
0.113CysCys: 0.113 ± 0.012
0.434CysAsp: 0.434 ± 0.021
0.516CysGlu: 0.516 ± 0.026
0.296CysPhe: 0.296 ± 0.021
0.935CysGly: 0.935 ± 0.048
0.249CysHis: 0.249 ± 0.017
0.283CysIle: 0.283 ± 0.018
0.141CysLys: 0.141 ± 0.013
1.01CysLeu: 1.01 ± 0.035
0.123CysMet: 0.123 ± 0.013
0.188CysAsn: 0.188 ± 0.017
0.496CysPro: 0.496 ± 0.028
0.25CysGln: 0.25 ± 0.016
0.742CysArg: 0.742 ± 0.027
0.417CysSer: 0.417 ± 0.023
0.377CysThr: 0.377 ± 0.022
0.589CysVal: 0.589 ± 0.026
0.125CysTrp: 0.125 ± 0.014
0.204CysTyr: 0.204 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.71AspAla: 6.71 ± 0.1
0.464AspCys: 0.464 ± 0.028
2.763AspAsp: 2.763 ± 0.067
3.518AspGlu: 3.518 ± 0.074
1.988AspPhe: 1.988 ± 0.058
5.64AspGly: 5.64 ± 0.089
1.032AspHis: 1.032 ± 0.037
2.178AspIle: 2.178 ± 0.054
1.229AspLys: 1.229 ± 0.045
6.0AspLeu: 6.0 ± 0.098
1.093AspMet: 1.093 ± 0.039
1.001AspAsn: 1.001 ± 0.046
3.83AspPro: 3.83 ± 0.077
1.567AspGln: 1.567 ± 0.044
4.615AspArg: 4.615 ± 0.074
2.12AspSer: 2.12 ± 0.053
2.439AspThr: 2.439 ± 0.051
3.581AspVal: 3.581 ± 0.075
1.167AspTrp: 1.167 ± 0.038
1.6AspTyr: 1.6 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
9.117GluAla: 9.117 ± 0.135
0.387GluCys: 0.387 ± 0.023
3.02GluAsp: 3.02 ± 0.061
3.092GluGlu: 3.092 ± 0.074
1.885GluPhe: 1.885 ± 0.047
5.044GluGly: 5.044 ± 0.089
1.459GluHis: 1.459 ± 0.042
2.632GluIle: 2.632 ± 0.058
1.567GluLys: 1.567 ± 0.049
7.329GluLeu: 7.329 ± 0.107
1.167GluMet: 1.167 ± 0.045
1.205GluAsn: 1.205 ± 0.04
3.398GluPro: 3.398 ± 0.075
2.689GluGln: 2.689 ± 0.071
6.505GluArg: 6.505 ± 0.096
2.472GluSer: 2.472 ± 0.06
2.543GluThr: 2.543 ± 0.055
4.629GluVal: 4.629 ± 0.063
0.686GluTrp: 0.686 ± 0.031
1.174GluTyr: 1.174 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
4.092PheAla: 4.092 ± 0.073
0.328PheCys: 0.328 ± 0.018
2.351PheAsp: 2.351 ± 0.052
2.158PheGlu: 2.158 ± 0.051
1.119PhePhe: 1.119 ± 0.048
3.321PheGly: 3.321 ± 0.067
0.747PheHis: 0.747 ± 0.034
1.125PheIle: 1.125 ± 0.037
0.657PheLys: 0.657 ± 0.033
3.379PheLeu: 3.379 ± 0.068
0.616PheMet: 0.616 ± 0.024
0.856PheAsn: 0.856 ± 0.035
1.56PhePro: 1.56 ± 0.042
0.922PheGln: 0.922 ± 0.031
2.652PheArg: 2.652 ± 0.06
1.699PheSer: 1.699 ± 0.05
1.517PheThr: 1.517 ± 0.045
2.496PheVal: 2.496 ± 0.059
0.509PheTrp: 0.509 ± 0.031
0.75PheTyr: 0.75 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.196GlyAla: 9.196 ± 0.131
0.854GlyCys: 0.854 ± 0.037
4.831GlyAsp: 4.831 ± 0.09
6.066GlyGlu: 6.066 ± 0.102
3.442GlyPhe: 3.442 ± 0.066
7.499GlyGly: 7.499 ± 0.121
2.205GlyHis: 2.205 ± 0.059
3.762GlyIle: 3.762 ± 0.08
2.844GlyLys: 2.844 ± 0.059
10.878GlyLeu: 10.878 ± 0.131
2.279GlyMet: 2.279 ± 0.053
2.107GlyAsn: 2.107 ± 0.06
3.95GlyPro: 3.95 ± 0.077
3.322GlyGln: 3.322 ± 0.072
8.085GlyArg: 8.085 ± 0.105
4.471GlySer: 4.471 ± 0.095
3.786GlyThr: 3.786 ± 0.064
6.311GlyVal: 6.311 ± 0.095
1.668GlyTrp: 1.668 ± 0.046
2.252GlyTyr: 2.252 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.672HisAla: 2.672 ± 0.065
0.281HisCys: 0.281 ± 0.019
1.177HisAsp: 1.177 ± 0.042
1.211HisGlu: 1.211 ± 0.038
0.763HisPhe: 0.763 ± 0.028
2.264HisGly: 2.264 ± 0.047
0.589HisHis: 0.589 ± 0.029
0.648HisIle: 0.648 ± 0.029
0.426HisLys: 0.426 ± 0.024
2.401HisLeu: 2.401 ± 0.053
0.379HisMet: 0.379 ± 0.021
0.386HisAsn: 0.386 ± 0.02
1.569HisPro: 1.569 ± 0.043
0.574HisGln: 0.574 ± 0.028
1.875HisArg: 1.875 ± 0.053
0.88HisSer: 0.88 ± 0.029
0.77HisThr: 0.77 ± 0.03
1.492HisVal: 1.492 ± 0.041
0.449HisTrp: 0.449 ± 0.022
0.634HisTyr: 0.634 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.458IleAla: 5.458 ± 0.089
0.343IleCys: 0.343 ± 0.02
1.891IleAsp: 1.891 ± 0.045
2.951IleGlu: 2.951 ± 0.069
0.978IlePhe: 0.978 ± 0.039
3.904IleGly: 3.904 ± 0.08
0.759IleHis: 0.759 ± 0.03
1.117IleIle: 1.117 ± 0.04
0.912IleLys: 0.912 ± 0.036
3.084IleLeu: 3.084 ± 0.072
0.507IleMet: 0.507 ± 0.026
1.059IleAsn: 1.059 ± 0.039
1.938IlePro: 1.938 ± 0.052
0.959IleGln: 0.959 ± 0.034
2.973IleArg: 2.973 ± 0.057
1.717IleSer: 1.717 ± 0.045
1.787IleThr: 1.787 ± 0.052
3.024IleVal: 3.024 ± 0.062
0.39IleTrp: 0.39 ± 0.021
0.754IleTyr: 0.754 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.326LysAla: 3.326 ± 0.093
0.13LysCys: 0.13 ± 0.017
1.176LysAsp: 1.176 ± 0.045
1.137LysGlu: 1.137 ± 0.046
0.615LysPhe: 0.615 ± 0.025
1.852LysGly: 1.852 ± 0.057
0.491LysHis: 0.491 ± 0.024
0.88LysIle: 0.88 ± 0.039
0.833LysLys: 0.833 ± 0.06
2.573LysLeu: 2.573 ± 0.059
0.479LysMet: 0.479 ± 0.023
0.476LysAsn: 0.476 ± 0.026
1.617LysPro: 1.617 ± 0.048
0.829LysGln: 0.829 ± 0.036
2.064LysArg: 2.064 ± 0.055
0.954LysSer: 0.954 ± 0.04
1.077LysThr: 1.077 ± 0.036
1.991LysVal: 1.991 ± 0.052
0.207LysTrp: 0.207 ± 0.016
0.542LysTyr: 0.542 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
19.015LeuAla: 19.015 ± 0.218
0.94LeuCys: 0.94 ± 0.033
7.03LeuAsp: 7.03 ± 0.096
6.745LeuGlu: 6.745 ± 0.111
3.468LeuPhe: 3.468 ± 0.082
9.889LeuGly: 9.889 ± 0.145
2.431LeuHis: 2.431 ± 0.052
3.424LeuIle: 3.424 ± 0.073
2.653LeuLys: 2.653 ± 0.062
13.155LeuLeu: 13.155 ± 0.216
2.241LeuMet: 2.241 ± 0.052
2.008LeuAsn: 2.008 ± 0.049
7.386LeuPro: 7.386 ± 0.139
3.535LeuGln: 3.535 ± 0.074
10.654LeuArg: 10.654 ± 0.131
5.978LeuSer: 5.978 ± 0.092
4.16LeuThr: 4.16 ± 0.072
8.892LeuVal: 8.892 ± 0.122
1.498LeuTrp: 1.498 ± 0.049
2.154LeuTyr: 2.154 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.964MetAla: 2.964 ± 0.063
0.119MetCys: 0.119 ± 0.013
1.224MetAsp: 1.224 ± 0.034
0.958MetGlu: 0.958 ± 0.038
0.567MetPhe: 0.567 ± 0.029
1.487MetGly: 1.487 ± 0.041
0.393MetHis: 0.393 ± 0.021
0.789MetIle: 0.789 ± 0.025
0.745MetLys: 0.745 ± 0.029
2.253MetLeu: 2.253 ± 0.06
0.397MetMet: 0.397 ± 0.022
0.635MetAsn: 0.635 ± 0.027
1.357MetPro: 1.357 ± 0.042
0.71MetGln: 0.71 ± 0.031
1.768MetArg: 1.768 ± 0.05
1.497MetSer: 1.497 ± 0.047
1.017MetThr: 1.017 ± 0.035
1.387MetVal: 1.387 ± 0.044
0.178MetTrp: 0.178 ± 0.016
0.332MetTyr: 0.332 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.621AsnAla: 2.621 ± 0.062
0.204AsnCys: 0.204 ± 0.017
1.026AsnAsp: 1.026 ± 0.035
1.063AsnGlu: 1.063 ± 0.039
0.739AsnPhe: 0.739 ± 0.034
1.809AsnGly: 1.809 ± 0.052
0.459AsnHis: 0.459 ± 0.027
0.881AsnIle: 0.881 ± 0.034
0.447AsnLys: 0.447 ± 0.029
2.376AsnLeu: 2.376 ± 0.054
0.328AsnMet: 0.328 ± 0.017
0.448AsnAsn: 0.448 ± 0.027
1.585AsnPro: 1.585 ± 0.044
0.605AsnGln: 0.605 ± 0.023
1.79AsnArg: 1.79 ± 0.05
0.807AsnSer: 0.807 ± 0.042
0.989AsnThr: 0.989 ± 0.041
1.518AsnVal: 1.518 ± 0.042
0.301AsnTrp: 0.301 ± 0.019
0.548AsnTyr: 0.548 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
8.517ProAla: 8.517 ± 0.134
0.361ProCys: 0.361 ± 0.023
3.894ProAsp: 3.894 ± 0.065
4.439ProGlu: 4.439 ± 0.072
1.62ProPhe: 1.62 ± 0.039
6.027ProGly: 6.027 ± 0.104
1.067ProHis: 1.067 ± 0.035
1.674ProIle: 1.674 ± 0.052
1.043ProLys: 1.043 ± 0.038
5.743ProLeu: 5.743 ± 0.097
1.289ProMet: 1.289 ± 0.037
1.016ProAsn: 1.016 ± 0.036
3.504ProPro: 3.504 ± 0.083
1.67ProGln: 1.67 ± 0.042
4.221ProArg: 4.221 ± 0.075
2.422ProSer: 2.422 ± 0.057
2.133ProThr: 2.133 ± 0.05
4.899ProVal: 4.899 ± 0.079
0.961ProTrp: 0.961 ± 0.04
1.126ProTyr: 1.126 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.579GlnAla: 5.579 ± 0.093
0.21GlnCys: 0.21 ± 0.017
1.412GlnAsp: 1.412 ± 0.038
1.56GlnGlu: 1.56 ± 0.052
0.955GlnPhe: 0.955 ± 0.037
2.523GlnGly: 2.523 ± 0.062
0.664GlnHis: 0.664 ± 0.024
1.099GlnIle: 1.099 ± 0.039
0.747GlnLys: 0.747 ± 0.034
3.63GlnLeu: 3.63 ± 0.071
0.652GlnMet: 0.652 ± 0.026
0.541GlnAsn: 0.541 ± 0.031
1.969GlnPro: 1.969 ± 0.053
1.292GlnGln: 1.292 ± 0.046
3.259GlnArg: 3.259 ± 0.06
1.283GlnSer: 1.283 ± 0.037
1.187GlnThr: 1.187 ± 0.039
2.977GlnVal: 2.977 ± 0.06
0.497GlnTrp: 0.497 ± 0.028
0.65GlnTyr: 0.65 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
10.139ArgAla: 10.139 ± 0.132
0.723ArgCys: 0.723 ± 0.029
4.658ArgAsp: 4.658 ± 0.094
6.14ArgGlu: 6.14 ± 0.098
3.368ArgPhe: 3.368 ± 0.067
6.267ArgGly: 6.267 ± 0.108
2.302ArgHis: 2.302 ± 0.053
3.798ArgIle: 3.798 ± 0.069
2.144ArgLys: 2.144 ± 0.056
11.509ArgLeu: 11.509 ± 0.147
2.033ArgMet: 2.033 ± 0.045
1.81ArgAsn: 1.81 ± 0.052
4.919ArgPro: 4.919 ± 0.08
3.477ArgGln: 3.477 ± 0.068
8.485ArgArg: 8.485 ± 0.118
3.623ArgSer: 3.623 ± 0.074
3.185ArgThr: 3.185 ± 0.057
6.152ArgVal: 6.152 ± 0.097
1.687ArgTrp: 1.687 ± 0.051
2.279ArgTyr: 2.279 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.584SerAla: 5.584 ± 0.088
0.343SerCys: 0.343 ± 0.021
2.19SerAsp: 2.19 ± 0.047
2.478SerGlu: 2.478 ± 0.06
1.715SerPhe: 1.715 ± 0.045
4.842SerGly: 4.842 ± 0.093
0.992SerHis: 0.992 ± 0.035
1.615SerIle: 1.615 ± 0.051
0.981SerLys: 0.981 ± 0.035
5.703SerLeu: 5.703 ± 0.088
0.836SerMet: 0.836 ± 0.031
0.991SerAsn: 0.991 ± 0.036
2.862SerPro: 2.862 ± 0.062
1.37SerGln: 1.37 ± 0.047
3.864SerArg: 3.864 ± 0.06
1.998SerSer: 1.998 ± 0.056
1.981SerThr: 1.981 ± 0.054
3.199SerVal: 3.199 ± 0.063
0.73SerTrp: 0.73 ± 0.029
1.078SerTyr: 1.078 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.047ThrAla: 5.047 ± 0.08
0.38ThrCys: 0.38 ± 0.019
2.13ThrAsp: 2.13 ± 0.053
2.087ThrGlu: 2.087 ± 0.054
1.199ThrPhe: 1.199 ± 0.044
4.588ThrGly: 4.588 ± 0.074
0.822ThrHis: 0.822 ± 0.03
1.573ThrIle: 1.573 ± 0.049
0.686ThrLys: 0.686 ± 0.033
5.093ThrLeu: 5.093 ± 0.078
0.71ThrMet: 0.71 ± 0.031
0.76ThrAsn: 0.76 ± 0.036
2.928ThrPro: 2.928 ± 0.066
1.004ThrGln: 1.004 ± 0.04
3.254ThrArg: 3.254 ± 0.063
1.783ThrSer: 1.783 ± 0.053
1.774ThrThr: 1.774 ± 0.051
3.727ThrVal: 3.727 ± 0.07
0.642ThrTrp: 0.642 ± 0.026
0.833ThrTyr: 0.833 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
9.633ValAla: 9.633 ± 0.118
0.673ValCys: 0.673 ± 0.031
4.32ValAsp: 4.32 ± 0.077
4.729ValGlu: 4.729 ± 0.083
2.603ValPhe: 2.603 ± 0.059
5.498ValGly: 5.498 ± 0.102
1.529ValHis: 1.529 ± 0.044
2.966ValIle: 2.966 ± 0.066
1.71ValLys: 1.71 ± 0.053
9.595ValLeu: 9.595 ± 0.127
1.539ValMet: 1.539 ± 0.048
1.842ValAsn: 1.842 ± 0.046
4.27ValPro: 4.27 ± 0.069
2.294ValGln: 2.294 ± 0.058
6.071ValArg: 6.071 ± 0.09
3.673ValSer: 3.673 ± 0.073
3.384ValThr: 3.384 ± 0.06
6.094ValVal: 6.094 ± 0.098
0.905ValTrp: 0.905 ± 0.037
1.588ValTyr: 1.588 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.432TrpAla: 1.432 ± 0.047
0.176TrpCys: 0.176 ± 0.015
0.652TrpAsp: 0.652 ± 0.027
0.653TrpGlu: 0.653 ± 0.027
0.608TrpPhe: 0.608 ± 0.03
0.938TrpGly: 0.938 ± 0.039
0.402TrpHis: 0.402 ± 0.021
0.638TrpIle: 0.638 ± 0.033
0.381TrpLys: 0.381 ± 0.024
2.695TrpLeu: 2.695 ± 0.068
0.354TrpMet: 0.354 ± 0.02
0.381TrpAsn: 0.381 ± 0.023
0.966TrpPro: 0.966 ± 0.038
0.739TrpGln: 0.739 ± 0.028
1.696TrpArg: 1.696 ± 0.049
0.869TrpSer: 0.869 ± 0.036
0.655TrpThr: 0.655 ± 0.027
1.052TrpVal: 1.052 ± 0.039
0.355TrpTrp: 0.355 ± 0.023
0.366TrpTyr: 0.366 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.668TyrAla: 2.668 ± 0.059
0.188TyrCys: 0.188 ± 0.015
1.232TyrAsp: 1.232 ± 0.046
1.251TyrGlu: 1.251 ± 0.037
0.822TyrPhe: 0.822 ± 0.033
2.154TyrGly: 2.154 ± 0.079
0.469TyrHis: 0.469 ± 0.024
0.627TyrIle: 0.627 ± 0.029
0.406TyrLys: 0.406 ± 0.022
2.568TyrLeu: 2.568 ± 0.059
0.371TyrMet: 0.371 ± 0.023
0.485TyrAsn: 0.485 ± 0.025
1.117TyrPro: 1.117 ± 0.039
0.744TyrGln: 0.744 ± 0.034
2.184TyrArg: 2.184 ± 0.054
1.055TyrSer: 1.055 ± 0.038
1.004TyrThr: 1.004 ± 0.04
1.576TyrVal: 1.576 ± 0.048
0.427TyrTrp: 0.427 ± 0.022
0.572TyrTyr: 0.572 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2417 proteins (808156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski