Amino acid dipepetide frequency for Sparassis crispa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.83AlaAla: 8.83 ± 0.052	1.103AlaCys: 1.103 ± 0.015	4.527AlaAsp: 4.527 ± 0.033	5.325AlaGlu: 5.325 ± 0.037	3.214AlaPhe: 3.214 ± 0.028	5.291AlaGly: 5.291 ± 0.034	2.355AlaHis: 2.355 ± 0.02	3.926AlaIle: 3.926 ± 0.028	3.971AlaLys: 3.971 ± 0.034	8.529AlaLeu: 8.529 ± 0.046	2.063AlaMet: 2.063 ± 0.02	2.713AlaAsn: 2.713 ± 0.027	5.514AlaPro: 5.514 ± 0.047	3.519AlaGln: 3.519 ± 0.027	5.634AlaArg: 5.634 ± 0.041	7.677AlaSer: 7.677 ± 0.054	5.069AlaThr: 5.069 ± 0.032	5.86AlaVal: 5.86 ± 0.035	1.148AlaTrp: 1.148 ± 0.014	2.228AlaTyr: 2.228 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.092CysAla: 1.092 ± 0.017	0.275CysCys: 0.275 ± 0.007	0.67CysAsp: 0.67 ± 0.01	0.642CysGlu: 0.642 ± 0.01	0.517CysPhe: 0.517 ± 0.01	0.961CysGly: 0.961 ± 0.014	0.364CysHis: 0.364 ± 0.007	0.664CysIle: 0.664 ± 0.012	0.587CysLys: 0.587 ± 0.01	1.237CysLeu: 1.237 ± 0.014	0.318CysMet: 0.318 ± 0.008	0.44CysAsn: 0.44 ± 0.008	0.785CysPro: 0.785 ± 0.014	0.488CysGln: 0.488 ± 0.009	0.805CysArg: 0.805 ± 0.012	0.99CysSer: 0.99 ± 0.014	0.793CysThr: 0.793 ± 0.014	0.847CysVal: 0.847 ± 0.014	0.206CysTrp: 0.206 ± 0.006	0.328CysTyr: 0.328 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.225AspAla: 5.225 ± 0.039	0.686AspCys: 0.686 ± 0.011	4.504AspAsp: 4.504 ± 0.036	4.56AspGlu: 4.56 ± 0.034	2.146AspPhe: 2.146 ± 0.018	3.953AspGly: 3.953 ± 0.028	1.357AspHis: 1.357 ± 0.018	3.047AspIle: 3.047 ± 0.027	2.098AspLys: 2.098 ± 0.019	5.077AspLeu: 5.077 ± 0.029	1.351AspMet: 1.351 ± 0.015	1.79AspAsn: 1.79 ± 0.021	3.427AspPro: 3.427 ± 0.024	1.595AspGln: 1.595 ± 0.016	2.959AspArg: 2.959 ± 0.028	4.073AspSer: 4.073 ± 0.029	2.974AspThr: 2.974 ± 0.022	4.359AspVal: 4.359 ± 0.027	0.884AspTrp: 0.884 ± 0.011	1.443AspTyr: 1.443 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	5.058GluAla: 5.058 ± 0.033	0.705GluCys: 0.705 ± 0.011	4.552GluAsp: 4.552 ± 0.036	5.571GluGlu: 5.571 ± 0.052	1.864GluPhe: 1.864 ± 0.018	3.793GluGly: 3.793 ± 0.029	1.622GluHis: 1.622 ± 0.018	2.733GluIle: 2.733 ± 0.026	3.055GluLys: 3.055 ± 0.028	5.59GluLeu: 5.59 ± 0.035	1.401GluMet: 1.401 ± 0.015	1.911GluAsn: 1.911 ± 0.021	2.912GluPro: 2.912 ± 0.026	2.309GluGln: 2.309 ± 0.019	4.199GluArg: 4.199 ± 0.037	3.956GluSer: 3.956 ± 0.03	3.052GluThr: 3.052 ± 0.025	3.964GluVal: 3.964 ± 0.032	0.98GluTrp: 0.98 ± 0.013	1.625GluTyr: 1.625 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.033PheAla: 3.033 ± 0.026	0.56PheCys: 0.56 ± 0.01	2.244PheAsp: 2.244 ± 0.022	1.98PheGlu: 1.98 ± 0.018	1.426PhePhe: 1.426 ± 0.018	2.493PheGly: 2.493 ± 0.027	0.974PheHis: 0.974 ± 0.015	1.714PheIle: 1.714 ± 0.02	1.406PheLys: 1.406 ± 0.014	3.367PheLeu: 3.367 ± 0.028	0.798PheMet: 0.798 ± 0.012	1.235PheAsn: 1.235 ± 0.014	2.077PhePro: 2.077 ± 0.021	1.225PheGln: 1.225 ± 0.016	1.976PheArg: 1.976 ± 0.019	2.987PheSer: 2.987 ± 0.027	2.108PheThr: 2.108 ± 0.019	2.504PheVal: 2.504 ± 0.02	0.539PheTrp: 0.539 ± 0.011	0.998PheTyr: 0.998 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.124GlyAla: 5.124 ± 0.036	0.83GlyCys: 0.83 ± 0.013	3.384GlyAsp: 3.384 ± 0.026	3.685GlyGlu: 3.685 ± 0.034	2.325GlyPhe: 2.325 ± 0.021	4.855GlyGly: 4.855 ± 0.045	1.68GlyHis: 1.68 ± 0.02	3.013GlyIle: 3.013 ± 0.026	3.182GlyLys: 3.182 ± 0.028	5.331GlyLeu: 5.331 ± 0.035	1.621GlyMet: 1.621 ± 0.021	1.99GlyAsn: 1.99 ± 0.021	3.303GlyPro: 3.303 ± 0.026	2.129GlyGln: 2.129 ± 0.021	4.121GlyArg: 4.121 ± 0.035	5.304GlySer: 5.304 ± 0.04	3.742GlyThr: 3.742 ± 0.027	4.146GlyVal: 4.146 ± 0.033	1.034GlyTrp: 1.034 ± 0.016	1.813GlyTyr: 1.813 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.44HisAla: 2.44 ± 0.022	0.398HisCys: 0.398 ± 0.009	1.447HisAsp: 1.447 ± 0.017	1.409HisGlu: 1.409 ± 0.016	0.964HisPhe: 0.964 ± 0.013	1.674HisGly: 1.674 ± 0.016	0.945HisHis: 0.945 ± 0.018	1.371HisIle: 1.371 ± 0.014	0.953HisLys: 0.953 ± 0.013	2.679HisLeu: 2.679 ± 0.025	0.556HisMet: 0.556 ± 0.011	0.83HisAsn: 0.83 ± 0.014	2.096HisPro: 2.096 ± 0.023	0.905HisGln: 0.905 ± 0.015	1.76HisArg: 1.76 ± 0.019	2.205HisSer: 2.205 ± 0.021	1.542HisThr: 1.542 ± 0.017	1.81HisVal: 1.81 ± 0.017	0.397HisTrp: 0.397 ± 0.008	0.721HisTyr: 0.721 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.131IleAla: 4.131 ± 0.029	0.696IleCys: 0.696 ± 0.011	2.611IleAsp: 2.611 ± 0.024	2.521IleGlu: 2.521 ± 0.025	1.781IlePhe: 1.781 ± 0.019	2.765IleGly: 2.765 ± 0.025	1.23IleHis: 1.23 ± 0.015	2.196IleIle: 2.196 ± 0.021	1.792IleLys: 1.792 ± 0.018	4.36IleLeu: 4.36 ± 0.036	0.953IleMet: 0.953 ± 0.013	1.421IleAsn: 1.421 ± 0.016	3.255IlePro: 3.255 ± 0.023	1.612IleGln: 1.612 ± 0.018	2.75IleArg: 2.75 ± 0.023	3.767IleSer: 3.767 ± 0.025	2.593IleThr: 2.593 ± 0.022	3.221IleVal: 3.221 ± 0.024	0.631IleTrp: 0.631 ± 0.012	1.241IleTyr: 1.241 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.01LysAla: 4.01 ± 0.036	0.532LysCys: 0.532 ± 0.011	2.41LysAsp: 2.41 ± 0.022	3.065LysGlu: 3.065 ± 0.027	1.339LysPhe: 1.339 ± 0.015	2.809LysGly: 2.809 ± 0.025	1.086LysHis: 1.086 ± 0.015	1.891LysIle: 1.891 ± 0.02	2.868LysLys: 2.868 ± 0.031	3.825LysLeu: 3.825 ± 0.03	1.012LysMet: 1.012 ± 0.014	1.327LysAsn: 1.327 ± 0.016	2.466LysPro: 2.466 ± 0.026	1.517LysGln: 1.517 ± 0.018	3.335LysArg: 3.335 ± 0.028	2.983LysSer: 2.983 ± 0.023	2.508LysThr: 2.508 ± 0.023	2.791LysVal: 2.791 ± 0.027	0.692LysTrp: 0.692 ± 0.012	1.174LysTyr: 1.174 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.052LeuAla: 8.052 ± 0.042	1.364LeuCys: 1.364 ± 0.017	5.17LeuAsp: 5.17 ± 0.034	5.503LeuGlu: 5.503 ± 0.035	3.282LeuPhe: 3.282 ± 0.026	5.396LeuGly: 5.396 ± 0.033	2.741LeuHis: 2.741 ± 0.022	3.646LeuIle: 3.646 ± 0.027	3.963LeuLys: 3.963 ± 0.029	8.572LeuLeu: 8.572 ± 0.058	1.78LeuMet: 1.78 ± 0.019	2.947LeuAsn: 2.947 ± 0.025	6.506LeuPro: 6.506 ± 0.04	3.856LeuGln: 3.856 ± 0.033	6.418LeuArg: 6.418 ± 0.041	8.031LeuSer: 8.031 ± 0.039	5.233LeuThr: 5.233 ± 0.032	5.706LeuVal: 5.706 ± 0.037	1.171LeuTrp: 1.171 ± 0.016	2.358LeuTyr: 2.358 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	1.989MetAla: 1.989 ± 0.019	0.272MetCys: 0.272 ± 0.007	1.407MetAsp: 1.407 ± 0.016	1.289MetGlu: 1.289 ± 0.015	0.748MetPhe: 0.748 ± 0.01	1.296MetGly: 1.296 ± 0.018	0.645MetHis: 0.645 ± 0.009	0.899MetIle: 0.899 ± 0.013	0.997MetLys: 0.997 ± 0.013	1.971MetLeu: 1.971 ± 0.019	0.562MetMet: 0.562 ± 0.011	0.791MetAsn: 0.791 ± 0.012	1.442MetPro: 1.442 ± 0.019	0.974MetGln: 0.974 ± 0.014	1.408MetArg: 1.408 ± 0.015	2.084MetSer: 2.084 ± 0.023	1.223MetThr: 1.223 ± 0.014	1.314MetVal: 1.314 ± 0.018	0.298MetTrp: 0.298 ± 0.008	0.553MetTyr: 0.553 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.091AsnAla: 3.091 ± 0.028	0.398AsnCys: 0.398 ± 0.009	1.817AsnAsp: 1.817 ± 0.021	1.703AsnGlu: 1.703 ± 0.018	1.185AsnPhe: 1.185 ± 0.014	2.397AsnGly: 2.397 ± 0.028	0.785AsnHis: 0.785 ± 0.011	1.765AsnIle: 1.765 ± 0.017	1.186AsnLys: 1.186 ± 0.013	2.894AsnLeu: 2.894 ± 0.021	0.732AsnMet: 0.732 ± 0.012	1.065AsnAsn: 1.065 ± 0.014	2.071AsnPro: 2.071 ± 0.022	0.995AsnGln: 0.995 ± 0.014	1.655AsnArg: 1.655 ± 0.017	2.394AsnSer: 2.394 ± 0.027	1.906AsnThr: 1.906 ± 0.019	2.386AsnVal: 2.386 ± 0.025	0.486AsnTrp: 0.486 ± 0.01	0.965AsnTyr: 0.965 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.036ProAla: 6.036 ± 0.045	0.637ProCys: 0.637 ± 0.011	3.44ProAsp: 3.44 ± 0.024	3.73ProGlu: 3.73 ± 0.026	2.258ProPhe: 2.258 ± 0.021	3.714ProGly: 3.714 ± 0.034	1.771ProHis: 1.771 ± 0.02	2.597ProIle: 2.597 ± 0.021	2.372ProLys: 2.372 ± 0.026	5.631ProLeu: 5.631 ± 0.036	1.276ProMet: 1.276 ± 0.016	1.974ProAsn: 1.974 ± 0.019	6.787ProPro: 6.787 ± 0.087	2.433ProGln: 2.433 ± 0.025	3.918ProArg: 3.918 ± 0.037	7.593ProSer: 7.593 ± 0.065	4.354ProThr: 4.354 ± 0.035	4.217ProVal: 4.217 ± 0.031	0.732ProTrp: 0.732 ± 0.012	1.602ProTyr: 1.602 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.298GlnAla: 3.298 ± 0.029	0.506GlnCys: 0.506 ± 0.01	1.931GlnAsp: 1.931 ± 0.017	2.263GlnGlu: 2.263 ± 0.019	1.248GlnPhe: 1.248 ± 0.014	2.102GlnGly: 2.102 ± 0.02	1.097GlnHis: 1.097 ± 0.013	1.611GlnIle: 1.611 ± 0.016	1.636GlnLys: 1.636 ± 0.018	3.431GlnLeu: 3.431 ± 0.025	0.91GlnMet: 0.91 ± 0.014	1.275GlnAsn: 1.275 ± 0.017	2.423GlnPro: 2.423 ± 0.026	1.924GlnGln: 1.924 ± 0.043	2.529GlnArg: 2.529 ± 0.025	2.932GlnSer: 2.932 ± 0.025	2.109GlnThr: 2.109 ± 0.02	2.146GlnVal: 2.146 ± 0.022	0.565GlnTrp: 0.565 ± 0.011	1.103GlnTyr: 1.103 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	5.506ArgAla: 5.506 ± 0.038	0.847ArgCys: 0.847 ± 0.012	3.424ArgAsp: 3.424 ± 0.032	4.072ArgGlu: 4.072 ± 0.037	2.07ArgPhe: 2.07 ± 0.018	3.818ArgGly: 3.818 ± 0.029	1.743ArgHis: 1.743 ± 0.018	2.948ArgIle: 2.948 ± 0.026	3.386ArgLys: 3.386 ± 0.025	5.812ArgLeu: 5.812 ± 0.041	1.488ArgMet: 1.488 ± 0.018	2.071ArgAsn: 2.071 ± 0.02	3.893ArgPro: 3.893 ± 0.032	2.497ArgGln: 2.497 ± 0.021	5.564ArgArg: 5.564 ± 0.043	5.347ArgSer: 5.347 ± 0.041	3.874ArgThr: 3.874 ± 0.027	3.817ArgVal: 3.817 ± 0.027	0.992ArgTrp: 0.992 ± 0.012	1.679ArgTyr: 1.679 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.493SerAla: 7.493 ± 0.048	0.942SerCys: 0.942 ± 0.015	4.543SerAsp: 4.543 ± 0.033	4.098SerGlu: 4.098 ± 0.03	2.956SerPhe: 2.956 ± 0.026	5.344SerGly: 5.344 ± 0.035	2.21SerHis: 2.21 ± 0.019	3.654SerIle: 3.654 ± 0.026	3.257SerLys: 3.257 ± 0.03	7.603SerLeu: 7.603 ± 0.043	1.837SerMet: 1.837 ± 0.022	2.613SerAsn: 2.613 ± 0.027	6.807SerPro: 6.807 ± 0.061	3.144SerGln: 3.144 ± 0.026	5.356SerArg: 5.356 ± 0.039	10.022SerSer: 10.022 ± 0.113	5.868SerThr: 5.868 ± 0.043	5.287SerVal: 5.287 ± 0.039	1.058SerTrp: 1.058 ± 0.013	1.948SerTyr: 1.948 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.332ThrAla: 5.332 ± 0.033	0.746ThrCys: 0.746 ± 0.012	2.85ThrAsp: 2.85 ± 0.023	2.937ThrGlu: 2.937 ± 0.026	2.279ThrPhe: 2.279 ± 0.02	3.563ThrGly: 3.563 ± 0.031	1.534ThrHis: 1.534 ± 0.017	2.777ThrIle: 2.777 ± 0.024	2.253ThrLys: 2.253 ± 0.022	5.651ThrLeu: 5.651 ± 0.034	1.165ThrMet: 1.165 ± 0.016	1.836ThrAsn: 1.836 ± 0.018	4.599ThrPro: 4.599 ± 0.043	1.935ThrGln: 1.935 ± 0.018	3.599ThrArg: 3.599 ± 0.029	5.542ThrSer: 5.542 ± 0.041	3.794ThrThr: 3.794 ± 0.03	3.989ThrVal: 3.989 ± 0.029	0.818ThrTrp: 0.818 ± 0.014	1.509ThrTyr: 1.509 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.447ValAla: 5.447 ± 0.033	0.884ValCys: 0.884 ± 0.012	4.045ValAsp: 4.045 ± 0.024	4.178ValGlu: 4.178 ± 0.028	2.482ValPhe: 2.482 ± 0.024	3.836ValGly: 3.836 ± 0.03	1.89ValHis: 1.89 ± 0.019	3.036ValIle: 3.036 ± 0.026	2.866ValLys: 2.866 ± 0.021	6.247ValLeu: 6.247 ± 0.041	1.376ValMet: 1.376 ± 0.015	2.145ValAsn: 2.145 ± 0.021	4.453ValPro: 4.453 ± 0.028	2.565ValGln: 2.565 ± 0.02	4.143ValArg: 4.143 ± 0.028	5.088ValSer: 5.088 ± 0.035	3.563ValThr: 3.563 ± 0.026	4.7ValVal: 4.7 ± 0.035	0.915ValTrp: 0.915 ± 0.013	1.782ValTyr: 1.782 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.075TrpAla: 1.075 ± 0.015	0.219TrpCys: 0.219 ± 0.006	0.9TrpAsp: 0.9 ± 0.013	0.919TrpGlu: 0.919 ± 0.014	0.51TrpPhe: 0.51 ± 0.009	0.782TrpGly: 0.782 ± 0.012	0.357TrpHis: 0.357 ± 0.008	0.688TrpIle: 0.688 ± 0.012	0.78TrpLys: 0.78 ± 0.012	1.35TrpLeu: 1.35 ± 0.019	0.354TrpMet: 0.354 ± 0.008	0.553TrpAsn: 0.553 ± 0.011	0.672TrpPro: 0.672 ± 0.011	0.505TrpGln: 0.505 ± 0.009	1.091TrpArg: 1.091 ± 0.012	1.064TrpSer: 1.064 ± 0.015	0.86TrpThr: 0.86 ± 0.013	0.834TrpVal: 0.834 ± 0.013	0.29TrpTrp: 0.29 ± 0.007	0.412TrpTyr: 0.412 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.235TyrAla: 2.235 ± 0.02	0.407TyrCys: 0.407 ± 0.009	1.635TyrAsp: 1.635 ± 0.019	1.403TyrGlu: 1.403 ± 0.017	1.051TyrPhe: 1.051 ± 0.015	1.769TyrGly: 1.769 ± 0.017	0.715TyrHis: 0.715 ± 0.012	1.352TyrIle: 1.352 ± 0.018	1.03TyrLys: 1.03 ± 0.014	2.54TyrLeu: 2.54 ± 0.022	0.609TyrMet: 0.609 ± 0.01	0.948TyrAsn: 0.948 ± 0.013	1.583TyrPro: 1.583 ± 0.019	0.912TyrGln: 0.912 ± 0.013	1.628TyrArg: 1.628 ± 0.017	2.002TyrSer: 2.002 ± 0.02	1.542TyrThr: 1.542 ± 0.02	1.744TyrVal: 1.744 ± 0.019	0.376TyrTrp: 0.376 ± 0.008	0.828TyrTyr: 0.828 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13078 proteins (5783113 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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