Amino acid dipepetide frequency for endosymbiont of Tevnia jerichonana (vent Tica)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.885AlaAla: 10.885 ± 0.16	1.109AlaCys: 1.109 ± 0.037	5.586AlaAsp: 5.586 ± 0.083	7.37AlaGlu: 7.37 ± 0.11	3.314AlaPhe: 3.314 ± 0.064	8.064AlaGly: 8.064 ± 0.109	1.97AlaHis: 1.97 ± 0.052	5.356AlaIle: 5.356 ± 0.071	3.458AlaLys: 3.458 ± 0.074	11.196AlaLeu: 11.196 ± 0.133	2.601AlaMet: 2.601 ± 0.062	2.855AlaAsn: 2.855 ± 0.061	3.639AlaPro: 3.639 ± 0.065	4.103AlaGln: 4.103 ± 0.079	6.0AlaArg: 6.0 ± 0.087	5.578AlaSer: 5.578 ± 0.088	4.315AlaThr: 4.315 ± 0.074	6.517AlaVal: 6.517 ± 0.093	1.323AlaTrp: 1.323 ± 0.045	2.251AlaTyr: 2.251 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.8CysAla: 0.8 ± 0.032	0.154CysCys: 0.154 ± 0.014	0.566CysAsp: 0.566 ± 0.029	0.596CysGlu: 0.596 ± 0.027	0.357CysPhe: 0.357 ± 0.021	1.002CysGly: 1.002 ± 0.038	0.543CysHis: 0.543 ± 0.063	0.461CysIle: 0.461 ± 0.024	0.274CysLys: 0.274 ± 0.014	0.934CysLeu: 0.934 ± 0.031	0.201CysMet: 0.201 ± 0.015	0.302CysAsn: 0.302 ± 0.018	0.637CysPro: 0.637 ± 0.034	0.361CysGln: 0.361 ± 0.021	0.779CysArg: 0.779 ± 0.029	0.691CysSer: 0.691 ± 0.032	0.442CysThr: 0.442 ± 0.023	0.584CysVal: 0.584 ± 0.025	0.109CysTrp: 0.109 ± 0.011	0.247CysTyr: 0.247 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.399AspAla: 5.399 ± 0.085	0.546AspCys: 0.546 ± 0.026	3.064AspAsp: 3.064 ± 0.076	4.024AspGlu: 4.024 ± 0.067	2.101AspPhe: 2.101 ± 0.045	4.501AspGly: 4.501 ± 0.104	1.213AspHis: 1.213 ± 0.042	2.839AspIle: 2.839 ± 0.056	1.933AspLys: 1.933 ± 0.047	6.182AspLeu: 6.182 ± 0.091	1.233AspMet: 1.233 ± 0.034	1.678AspAsn: 1.678 ± 0.049	3.119AspPro: 3.119 ± 0.059	2.53AspGln: 2.53 ± 0.057	3.32AspArg: 3.32 ± 0.062	3.235AspSer: 3.235 ± 0.068	2.389AspThr: 2.389 ± 0.061	3.053AspVal: 3.053 ± 0.061	0.855AspTrp: 0.855 ± 0.032	1.853AspTyr: 1.853 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.13GluAla: 7.13 ± 0.11	0.518GluCys: 0.518 ± 0.026	2.643GluAsp: 2.643 ± 0.054	4.164GluGlu: 4.164 ± 0.079	2.163GluPhe: 2.163 ± 0.05	4.419GluGly: 4.419 ± 0.078	1.464GluHis: 1.464 ± 0.038	4.082GluIle: 4.082 ± 0.066	2.637GluLys: 2.637 ± 0.058	7.659GluLeu: 7.659 ± 0.101	1.989GluMet: 1.989 ± 0.044	1.804GluAsn: 1.804 ± 0.048	2.821GluPro: 2.821 ± 0.063	4.497GluGln: 4.497 ± 0.081	5.243GluArg: 5.243 ± 0.082	3.882GluSer: 3.882 ± 0.063	3.237GluThr: 3.237 ± 0.06	4.556GluVal: 4.556 ± 0.072	0.908GluTrp: 0.908 ± 0.03	1.429GluTyr: 1.429 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.193PheAla: 3.193 ± 0.069	0.42PheCys: 0.42 ± 0.022	2.617PheAsp: 2.617 ± 0.061	2.328PheGlu: 2.328 ± 0.053	1.449PhePhe: 1.449 ± 0.046	2.983PheGly: 2.983 ± 0.064	0.908PheHis: 0.908 ± 0.032	1.958PheIle: 1.958 ± 0.049	1.237PheLys: 1.237 ± 0.033	3.524PheLeu: 3.524 ± 0.076	0.78PheMet: 0.78 ± 0.031	1.306PheAsn: 1.306 ± 0.041	1.536PhePro: 1.536 ± 0.042	1.22PheGln: 1.22 ± 0.033	2.083PheArg: 2.083 ± 0.047	2.764PheSer: 2.764 ± 0.059	1.926PheThr: 1.926 ± 0.042	2.253PheVal: 2.253 ± 0.048	0.538PheTrp: 0.538 ± 0.023	1.047PheTyr: 1.047 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.37GlyAla: 6.37 ± 0.104	1.043GlyCys: 1.043 ± 0.04	4.283GlyAsp: 4.283 ± 0.078	5.487GlyGlu: 5.487 ± 0.082	3.281GlyPhe: 3.281 ± 0.053	6.197GlyGly: 6.197 ± 0.112	1.73GlyHis: 1.73 ± 0.046	4.652GlyIle: 4.652 ± 0.075	3.36GlyLys: 3.36 ± 0.068	8.392GlyLeu: 8.392 ± 0.115	2.465GlyMet: 2.465 ± 0.058	2.433GlyAsn: 2.433 ± 0.063	2.4GlyPro: 2.4 ± 0.055	2.958GlyGln: 2.958 ± 0.049	5.143GlyArg: 5.143 ± 0.08	4.764GlySer: 4.764 ± 0.079	3.48GlyThr: 3.48 ± 0.065	5.612GlyVal: 5.612 ± 0.086	1.2GlyTrp: 1.2 ± 0.039	2.43GlyTyr: 2.43 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.971HisAla: 1.971 ± 0.047	0.317HisCys: 0.317 ± 0.017	1.16HisAsp: 1.16 ± 0.038	1.213HisGlu: 1.213 ± 0.033	1.036HisPhe: 1.036 ± 0.029	1.763HisGly: 1.763 ± 0.043	0.794HisHis: 0.794 ± 0.031	1.167HisIle: 1.167 ± 0.037	0.78HisLys: 0.78 ± 0.027	2.636HisLeu: 2.636 ± 0.056	0.478HisMet: 0.478 ± 0.024	0.862HisAsn: 0.862 ± 0.038	1.516HisPro: 1.516 ± 0.04	1.188HisGln: 1.188 ± 0.039	1.567HisArg: 1.567 ± 0.043	1.347HisSer: 1.347 ± 0.04	1.059HisThr: 1.059 ± 0.033	1.086HisVal: 1.086 ± 0.038	0.408HisTrp: 0.408 ± 0.021	0.877HisTyr: 0.877 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.657IleAla: 5.657 ± 0.077	0.574IleCys: 0.574 ± 0.025	3.907IleAsp: 3.907 ± 0.057	4.277IleGlu: 4.277 ± 0.064	1.78IlePhe: 1.78 ± 0.045	4.636IleGly: 4.636 ± 0.062	1.308IleHis: 1.308 ± 0.039	2.865IleIle: 2.865 ± 0.06	2.262IleLys: 2.262 ± 0.052	4.944IleLeu: 4.944 ± 0.088	1.027IleMet: 1.027 ± 0.032	2.193IleAsn: 2.193 ± 0.045	2.786IlePro: 2.786 ± 0.057	1.975IleGln: 1.975 ± 0.041	3.52IleArg: 3.52 ± 0.058	3.712IleSer: 3.712 ± 0.071	3.004IleThr: 3.004 ± 0.056	3.056IleVal: 3.056 ± 0.067	0.59IleTrp: 0.59 ± 0.022	1.426IleTyr: 1.426 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.694LysAla: 3.694 ± 0.07	0.247LysCys: 0.247 ± 0.015	1.655LysAsp: 1.655 ± 0.047	2.164LysGlu: 2.164 ± 0.048	0.911LysPhe: 0.911 ± 0.034	2.805LysGly: 2.805 ± 0.06	0.848LysHis: 0.848 ± 0.032	2.111LysIle: 2.111 ± 0.052	1.863LysLys: 1.863 ± 0.057	3.753LysLeu: 3.753 ± 0.066	0.939LysMet: 0.939 ± 0.033	1.165LysAsn: 1.165 ± 0.044	2.006LysPro: 2.006 ± 0.055	2.133LysGln: 2.133 ± 0.053	2.873LysArg: 2.873 ± 0.061	2.141LysSer: 2.141 ± 0.046	1.807LysThr: 1.807 ± 0.053	2.474LysVal: 2.474 ± 0.057	0.355LysTrp: 0.355 ± 0.018	0.824LysTyr: 0.824 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.645LeuAla: 11.645 ± 0.142	0.971LeuCys: 0.971 ± 0.03	6.342LeuAsp: 6.342 ± 0.09	7.558LeuGlu: 7.558 ± 0.108	4.385LeuPhe: 4.385 ± 0.073	7.944LeuGly: 7.944 ± 0.101	2.46LeuHis: 2.46 ± 0.05	6.121LeuIle: 6.121 ± 0.085	4.402LeuLys: 4.402 ± 0.074	14.031LeuLeu: 14.031 ± 0.185	2.697LeuMet: 2.697 ± 0.057	3.473LeuAsn: 3.473 ± 0.057	5.788LeuPro: 5.788 ± 0.091	5.545LeuGln: 5.545 ± 0.091	7.08LeuArg: 7.08 ± 0.109	7.349LeuSer: 7.349 ± 0.084	5.191LeuThr: 5.191 ± 0.082	7.12LeuVal: 7.12 ± 0.101	1.208LeuTrp: 1.208 ± 0.036	2.484LeuTyr: 2.484 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.653MetAla: 2.653 ± 0.062	0.159MetCys: 0.159 ± 0.014	1.405MetAsp: 1.405 ± 0.037	1.575MetGlu: 1.575 ± 0.041	0.651MetPhe: 0.651 ± 0.028	1.899MetGly: 1.899 ± 0.044	0.492MetHis: 0.492 ± 0.025	1.271MetIle: 1.271 ± 0.036	1.106MetLys: 1.106 ± 0.03	2.889MetLeu: 2.889 ± 0.055	0.711MetMet: 0.711 ± 0.029	0.807MetAsn: 0.807 ± 0.032	1.334MetPro: 1.334 ± 0.037	1.294MetGln: 1.294 ± 0.034	1.642MetArg: 1.642 ± 0.045	1.604MetSer: 1.604 ± 0.042	1.187MetThr: 1.187 ± 0.036	1.779MetVal: 1.779 ± 0.043	0.162MetTrp: 0.162 ± 0.013	0.371MetTyr: 0.371 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.784AsnAla: 2.784 ± 0.057	0.368AsnCys: 0.368 ± 0.019	1.617AsnAsp: 1.617 ± 0.046	1.589AsnGlu: 1.589 ± 0.043	1.021AsnPhe: 1.021 ± 0.03	2.51AsnGly: 2.51 ± 0.058	0.779AsnHis: 0.779 ± 0.027	1.765AsnIle: 1.765 ± 0.048	1.112AsnLys: 1.112 ± 0.033	3.49AsnLeu: 3.49 ± 0.062	0.712AsnMet: 0.712 ± 0.028	1.127AsnAsn: 1.127 ± 0.046	2.089AsnPro: 2.089 ± 0.051	1.461AsnGln: 1.461 ± 0.046	2.374AsnArg: 2.374 ± 0.043	1.836AsnSer: 1.836 ± 0.049	1.452AsnThr: 1.452 ± 0.045	1.651AsnVal: 1.651 ± 0.042	0.414AsnTrp: 0.414 ± 0.021	0.858AsnTyr: 0.858 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.656ProAla: 4.656 ± 0.078	0.371ProCys: 0.371 ± 0.019	3.13ProAsp: 3.13 ± 0.057	3.93ProGlu: 3.93 ± 0.062	1.757ProPhe: 1.757 ± 0.039	3.908ProGly: 3.908 ± 0.063	1.025ProHis: 1.025 ± 0.031	2.303ProIle: 2.303 ± 0.043	1.558ProLys: 1.558 ± 0.046	5.368ProLeu: 5.368 ± 0.095	1.152ProMet: 1.152 ± 0.035	1.386ProAsn: 1.386 ± 0.04	2.217ProPro: 2.217 ± 0.06	2.107ProGln: 2.107 ± 0.057	2.32ProArg: 2.32 ± 0.051	2.409ProSer: 2.409 ± 0.047	2.05ProThr: 2.05 ± 0.044	3.606ProVal: 3.606 ± 0.065	0.613ProTrp: 0.613 ± 0.029	1.195ProTyr: 1.195 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.464GlnAla: 5.464 ± 0.094	0.347GlnCys: 0.347 ± 0.022	1.702GlnAsp: 1.702 ± 0.04	2.704GlnGlu: 2.704 ± 0.064	1.363GlnPhe: 1.363 ± 0.033	3.52GlnGly: 3.52 ± 0.063	1.133GlnHis: 1.133 ± 0.034	2.778GlnIle: 2.778 ± 0.051	1.432GlnLys: 1.432 ± 0.041	5.759GlnLeu: 5.759 ± 0.094	1.185GlnMet: 1.185 ± 0.039	1.093GlnAsn: 1.093 ± 0.034	2.354GlnPro: 2.354 ± 0.051	3.622GlnGln: 3.622 ± 0.084	3.842GlnArg: 3.842 ± 0.078	2.425GlnSer: 2.425 ± 0.056	2.04GlnThr: 2.04 ± 0.044	3.297GlnVal: 3.297 ± 0.065	0.542GlnTrp: 0.542 ± 0.024	0.737GlnTyr: 0.737 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.145ArgAla: 5.145 ± 0.069	0.686ArgCys: 0.686 ± 0.03	3.315ArgAsp: 3.315 ± 0.053	4.596ArgGlu: 4.596 ± 0.079	3.096ArgPhe: 3.096 ± 0.061	3.983ArgGly: 3.983 ± 0.071	1.803ArgHis: 1.803 ± 0.046	4.062ArgIle: 4.062 ± 0.058	2.363ArgLys: 2.363 ± 0.051	8.577ArgLeu: 8.577 ± 0.1	1.784ArgMet: 1.784 ± 0.043	2.055ArgAsn: 2.055 ± 0.044	2.843ArgPro: 2.843 ± 0.06	3.641ArgGln: 3.641 ± 0.072	4.816ArgArg: 4.816 ± 0.076	3.746ArgSer: 3.746 ± 0.057	2.555ArgThr: 2.555 ± 0.059	4.42ArgVal: 4.42 ± 0.073	0.991ArgTrp: 0.991 ± 0.032	2.079ArgTyr: 2.079 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.818SerAla: 5.818 ± 0.1	0.7SerCys: 0.7 ± 0.05	3.509SerAsp: 3.509 ± 0.063	3.731SerGlu: 3.731 ± 0.067	2.208SerPhe: 2.208 ± 0.055	5.84SerGly: 5.84 ± 0.087	1.452SerHis: 1.452 ± 0.04	3.247SerIle: 3.247 ± 0.056	1.967SerLys: 1.967 ± 0.043	6.806SerLeu: 6.806 ± 0.096	1.481SerMet: 1.481 ± 0.039	1.883SerAsn: 1.883 ± 0.047	2.585SerPro: 2.585 ± 0.054	2.539SerGln: 2.539 ± 0.048	4.08SerArg: 4.08 ± 0.064	3.888SerSer: 3.888 ± 0.092	2.626SerThr: 2.626 ± 0.061	3.76SerVal: 3.76 ± 0.065	0.831SerTrp: 0.831 ± 0.03	1.589SerTyr: 1.589 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.478ThrAla: 4.478 ± 0.076	0.387ThrCys: 0.387 ± 0.023	2.556ThrAsp: 2.556 ± 0.057	2.809ThrGlu: 2.809 ± 0.063	1.431ThrPhe: 1.431 ± 0.04	4.116ThrGly: 4.116 ± 0.076	1.082ThrHis: 1.082 ± 0.033	2.632ThrIle: 2.632 ± 0.053	1.366ThrLys: 1.366 ± 0.038	6.063ThrLeu: 6.063 ± 0.094	0.892ThrMet: 0.892 ± 0.034	1.294ThrAsn: 1.294 ± 0.037	2.922ThrPro: 2.922 ± 0.056	1.761ThrGln: 1.761 ± 0.044	2.783ThrArg: 2.783 ± 0.059	2.706ThrSer: 2.706 ± 0.051	2.465ThrThr: 2.465 ± 0.056	3.002ThrVal: 3.002 ± 0.066	0.453ThrTrp: 0.453 ± 0.019	1.011ThrTyr: 1.011 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.65ValAla: 6.65 ± 0.093	0.677ValCys: 0.677 ± 0.029	4.038ValAsp: 4.038 ± 0.073	5.104ValGlu: 5.104 ± 0.078	2.231ValPhe: 2.231 ± 0.057	4.797ValGly: 4.797 ± 0.081	1.251ValHis: 1.251 ± 0.035	4.001ValIle: 4.001 ± 0.073	2.379ValLys: 2.379 ± 0.059	6.556ValLeu: 6.556 ± 0.096	1.842ValMet: 1.842 ± 0.041	2.071ValAsn: 2.071 ± 0.05	2.642ValPro: 2.642 ± 0.058	2.159ValGln: 2.159 ± 0.049	3.945ValArg: 3.945 ± 0.076	4.085ValSer: 4.085 ± 0.072	3.42ValThr: 3.42 ± 0.068	5.288ValVal: 5.288 ± 0.091	0.738ValTrp: 0.738 ± 0.028	1.479ValTyr: 1.479 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.846TrpAla: 0.846 ± 0.028	0.163TrpCys: 0.163 ± 0.014	0.635TrpAsp: 0.635 ± 0.03	0.696TrpGlu: 0.696 ± 0.026	0.52TrpPhe: 0.52 ± 0.027	0.875TrpGly: 0.875 ± 0.035	0.346TrpHis: 0.346 ± 0.018	0.704TrpIle: 0.704 ± 0.027	0.445TrpLys: 0.445 ± 0.02	1.89TrpLeu: 1.89 ± 0.044	0.348TrpMet: 0.348 ± 0.02	0.424TrpAsn: 0.424 ± 0.022	0.525TrpPro: 0.525 ± 0.023	0.857TrpGln: 0.857 ± 0.034	1.024TrpArg: 1.024 ± 0.034	0.768TrpSer: 0.768 ± 0.031	0.374TrpThr: 0.374 ± 0.02	0.84TrpVal: 0.84 ± 0.03	0.21TrpTrp: 0.21 ± 0.015	0.336TrpTyr: 0.336 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.251TyrAla: 2.251 ± 0.05	0.281TyrCys: 0.281 ± 0.015	1.336TyrAsp: 1.336 ± 0.036	1.33TyrGlu: 1.33 ± 0.044	1.015TyrPhe: 1.015 ± 0.036	1.92TyrGly: 1.92 ± 0.046	0.625TyrHis: 0.625 ± 0.024	1.125TyrIle: 1.125 ± 0.039	0.829TyrLys: 0.829 ± 0.034	3.146TyrLeu: 3.146 ± 0.056	0.472TyrMet: 0.472 ± 0.022	0.801TyrAsn: 0.801 ± 0.032	1.304TyrPro: 1.304 ± 0.043	1.391TyrGln: 1.391 ± 0.039	2.12TyrArg: 2.12 ± 0.052	1.608TyrSer: 1.608 ± 0.042	1.189TyrThr: 1.189 ± 0.043	1.401TyrVal: 1.401 ± 0.04	0.381TyrTrp: 0.381 ± 0.018	0.705TyrTyr: 0.705 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3230 proteins (1002472 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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