Amino acid dipepetide frequency for Penicillium patulum (Penicillium griseofulvum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.376AlaAla: 8.376 ± 0.06	1.019AlaCys: 1.019 ± 0.014	4.247AlaAsp: 4.247 ± 0.033	5.098AlaGlu: 5.098 ± 0.043	3.169AlaPhe: 3.169 ± 0.029	5.64AlaGly: 5.64 ± 0.045	1.795AlaHis: 1.795 ± 0.019	4.441AlaIle: 4.441 ± 0.035	3.96AlaLys: 3.96 ± 0.034	7.672AlaLeu: 7.672 ± 0.05	2.028AlaMet: 2.028 ± 0.021	2.973AlaAsn: 2.973 ± 0.026	4.7AlaPro: 4.7 ± 0.048	3.365AlaGln: 3.365 ± 0.029	4.723AlaArg: 4.723 ± 0.034	7.001AlaSer: 7.001 ± 0.039	5.153AlaThr: 5.153 ± 0.037	5.294AlaVal: 5.294 ± 0.036	1.132AlaTrp: 1.132 ± 0.018	2.135AlaTyr: 2.135 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.915CysAla: 0.915 ± 0.014	0.22CysCys: 0.22 ± 0.007	0.643CysAsp: 0.643 ± 0.013	0.583CysGlu: 0.583 ± 0.011	0.541CysPhe: 0.541 ± 0.012	0.903CysGly: 0.903 ± 0.013	0.315CysHis: 0.315 ± 0.01	0.688CysIle: 0.688 ± 0.011	0.468CysLys: 0.468 ± 0.011	1.245CysLeu: 1.245 ± 0.016	0.269CysMet: 0.269 ± 0.007	0.406CysAsn: 0.406 ± 0.01	0.618CysPro: 0.618 ± 0.013	0.433CysGln: 0.433 ± 0.01	0.677CysArg: 0.677 ± 0.014	0.847CysSer: 0.847 ± 0.014	0.653CysThr: 0.653 ± 0.013	0.796CysVal: 0.796 ± 0.014	0.188CysTrp: 0.188 ± 0.006	0.342CysTyr: 0.342 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.513AspAla: 4.513 ± 0.036	0.604AspCys: 0.604 ± 0.012	3.969AspAsp: 3.969 ± 0.038	4.375AspGlu: 4.375 ± 0.037	2.216AspPhe: 2.216 ± 0.025	3.888AspGly: 3.888 ± 0.03	1.337AspHis: 1.337 ± 0.017	3.337AspIle: 3.337 ± 0.025	2.327AspLys: 2.327 ± 0.025	5.252AspLeu: 5.252 ± 0.042	1.367AspMet: 1.367 ± 0.018	1.957AspAsn: 1.957 ± 0.021	3.48AspPro: 3.48 ± 0.031	2.036AspGln: 2.036 ± 0.021	3.102AspArg: 3.102 ± 0.033	4.338AspSer: 4.338 ± 0.038	3.114AspThr: 3.114 ± 0.024	3.62AspVal: 3.62 ± 0.032	0.887AspTrp: 0.887 ± 0.016	1.631AspTyr: 1.631 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.187GluAla: 5.187 ± 0.042	0.625GluCys: 0.625 ± 0.012	4.227GluAsp: 4.227 ± 0.035	5.304GluGlu: 5.304 ± 0.056	2.035GluPhe: 2.035 ± 0.023	3.612GluGly: 3.612 ± 0.032	1.423GluHis: 1.423 ± 0.017	3.303GluIle: 3.303 ± 0.03	3.678GluLys: 3.678 ± 0.033	5.255GluLeu: 5.255 ± 0.034	1.537GluMet: 1.537 ± 0.021	2.424GluAsn: 2.424 ± 0.026	2.886GluPro: 2.886 ± 0.045	2.505GluGln: 2.505 ± 0.022	3.751GluArg: 3.751 ± 0.033	4.525GluSer: 4.525 ± 0.036	3.702GluThr: 3.702 ± 0.032	3.534GluVal: 3.534 ± 0.029	0.891GluTrp: 0.891 ± 0.014	1.713GluTyr: 1.713 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.1PheAla: 3.1 ± 0.03	0.544PheCys: 0.544 ± 0.011	2.394PheAsp: 2.394 ± 0.023	2.201PheGlu: 2.201 ± 0.019	1.709PhePhe: 1.709 ± 0.022	2.896PheGly: 2.896 ± 0.031	0.943PheHis: 0.943 ± 0.014	1.954PheIle: 1.954 ± 0.024	1.522PheLys: 1.522 ± 0.02	3.525PheLeu: 3.525 ± 0.031	0.856PheMet: 0.856 ± 0.013	1.533PheAsn: 1.533 ± 0.017	1.997PhePro: 1.997 ± 0.019	1.469PheGln: 1.469 ± 0.017	1.946PheArg: 1.946 ± 0.021	3.02PheSer: 3.02 ± 0.025	2.183PheThr: 2.183 ± 0.02	2.418PheVal: 2.418 ± 0.025	0.658PheTrp: 0.658 ± 0.012	1.148PheTyr: 1.148 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.208GlyAla: 5.208 ± 0.042	0.856GlyCys: 0.856 ± 0.015	3.598GlyAsp: 3.598 ± 0.033	3.533GlyGlu: 3.533 ± 0.028	2.867GlyPhe: 2.867 ± 0.031	5.321GlyGly: 5.321 ± 0.056	1.693GlyHis: 1.693 ± 0.023	3.697GlyIle: 3.697 ± 0.032	3.344GlyLys: 3.344 ± 0.031	6.143GlyLeu: 6.143 ± 0.038	1.636GlyMet: 1.636 ± 0.019	2.57GlyAsn: 2.57 ± 0.027	3.378GlyPro: 3.378 ± 0.031	2.543GlyGln: 2.543 ± 0.026	3.87GlyArg: 3.87 ± 0.036	5.674GlySer: 5.674 ± 0.042	3.938GlyThr: 3.938 ± 0.031	4.356GlyVal: 4.356 ± 0.032	1.161GlyTrp: 1.161 ± 0.019	2.173GlyTyr: 2.173 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.823HisAla: 1.823 ± 0.021	0.319HisCys: 0.319 ± 0.009	1.353HisAsp: 1.353 ± 0.017	1.374HisGlu: 1.374 ± 0.017	0.946HisPhe: 0.946 ± 0.015	1.723HisGly: 1.723 ± 0.02	0.797HisHis: 0.797 ± 0.017	1.276HisIle: 1.276 ± 0.015	0.882HisLys: 0.882 ± 0.015	2.267HisLeu: 2.267 ± 0.022	0.531HisMet: 0.531 ± 0.011	0.892HisAsn: 0.892 ± 0.013	1.686HisPro: 1.686 ± 0.022	0.971HisGln: 0.971 ± 0.015	1.531HisArg: 1.531 ± 0.019	1.903HisSer: 1.903 ± 0.02	1.344HisThr: 1.344 ± 0.018	1.44HisVal: 1.44 ± 0.016	0.358HisTrp: 0.358 ± 0.01	0.701HisTyr: 0.701 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.378IleAla: 4.378 ± 0.031	0.779IleCys: 0.779 ± 0.013	3.077IleAsp: 3.077 ± 0.027	3.054IleGlu: 3.054 ± 0.025	2.161IlePhe: 2.161 ± 0.025	3.407IleGly: 3.407 ± 0.032	1.277IleHis: 1.277 ± 0.017	2.707IleIle: 2.707 ± 0.024	2.232IleLys: 2.232 ± 0.023	4.758IleLeu: 4.758 ± 0.041	1.121IleMet: 1.121 ± 0.014	1.892IleAsn: 1.892 ± 0.021	3.347IlePro: 3.347 ± 0.026	2.073IleGln: 2.073 ± 0.023	2.833IleArg: 2.833 ± 0.027	4.134IleSer: 4.134 ± 0.033	2.941IleThr: 2.941 ± 0.028	3.286IleVal: 3.286 ± 0.027	0.76IleTrp: 0.76 ± 0.012	1.477IleTyr: 1.477 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.067LysAla: 4.067 ± 0.042	0.473LysCys: 0.473 ± 0.011	2.769LysAsp: 2.769 ± 0.026	3.3LysGlu: 3.3 ± 0.031	1.503LysPhe: 1.503 ± 0.017	2.882LysGly: 2.882 ± 0.024	1.087LysHis: 1.087 ± 0.016	2.33LysIle: 2.33 ± 0.024	3.121LysLys: 3.121 ± 0.043	3.988LysLeu: 3.988 ± 0.032	1.021LysMet: 1.021 ± 0.015	1.775LysAsn: 1.775 ± 0.021	2.706LysPro: 2.706 ± 0.03	1.878LysGln: 1.878 ± 0.024	3.207LysArg: 3.207 ± 0.032	3.595LysSer: 3.595 ± 0.033	2.827LysThr: 2.827 ± 0.028	2.806LysVal: 2.806 ± 0.027	0.684LysTrp: 0.684 ± 0.012	1.383LysTyr: 1.383 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.798LeuAla: 7.798 ± 0.044	1.182LeuCys: 1.182 ± 0.015	5.305LeuAsp: 5.305 ± 0.045	5.582LeuGlu: 5.582 ± 0.038	3.38LeuPhe: 3.38 ± 0.033	6.036LeuGly: 6.036 ± 0.043	2.237LeuHis: 2.237 ± 0.023	4.179LeuIle: 4.179 ± 0.034	4.136LeuLys: 4.136 ± 0.033	8.318LeuLeu: 8.318 ± 0.063	1.874LeuMet: 1.874 ± 0.018	3.308LeuAsn: 3.308 ± 0.027	5.437LeuPro: 5.437 ± 0.042	3.851LeuGln: 3.851 ± 0.031	5.602LeuArg: 5.602 ± 0.036	7.405LeuSer: 7.405 ± 0.04	4.798LeuThr: 4.798 ± 0.032	5.492LeuVal: 5.492 ± 0.041	1.185LeuTrp: 1.185 ± 0.016	2.394LeuTyr: 2.394 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.24MetAla: 2.24 ± 0.024	0.249MetCys: 0.249 ± 0.007	1.364MetAsp: 1.364 ± 0.017	1.375MetGlu: 1.375 ± 0.019	0.805MetPhe: 0.805 ± 0.013	1.577MetGly: 1.577 ± 0.02	0.511MetHis: 0.511 ± 0.012	1.119MetIle: 1.119 ± 0.017	1.038MetLys: 1.038 ± 0.015	1.886MetLeu: 1.886 ± 0.02	0.626MetMet: 0.626 ± 0.012	0.874MetAsn: 0.874 ± 0.013	1.287MetPro: 1.287 ± 0.016	0.914MetGln: 0.914 ± 0.014	1.277MetArg: 1.277 ± 0.017	1.953MetSer: 1.953 ± 0.021	1.383MetThr: 1.383 ± 0.016	1.38MetVal: 1.38 ± 0.018	0.28MetTrp: 0.28 ± 0.007	0.536MetTyr: 0.536 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.152AsnAla: 3.152 ± 0.027	0.431AsnCys: 0.431 ± 0.009	2.01AsnAsp: 2.01 ± 0.02	2.15AsnGlu: 2.15 ± 0.022	1.434AsnPhe: 1.434 ± 0.018	2.931AsnGly: 2.931 ± 0.027	0.869AsnHis: 0.869 ± 0.014	2.187AsnIle: 2.187 ± 0.022	1.578AsnLys: 1.578 ± 0.02	3.349AsnLeu: 3.349 ± 0.026	0.918AsnMet: 0.918 ± 0.014	1.475AsnAsn: 1.475 ± 0.018	2.659AsnPro: 2.659 ± 0.028	1.402AsnGln: 1.402 ± 0.016	1.975AsnArg: 1.975 ± 0.024	2.821AsnSer: 2.821 ± 0.029	2.263AsnThr: 2.263 ± 0.024	2.375AsnVal: 2.375 ± 0.022	0.579AsnTrp: 0.579 ± 0.012	1.089AsnTyr: 1.089 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.157ProAla: 5.157 ± 0.051	0.489ProCys: 0.489 ± 0.01	3.259ProAsp: 3.259 ± 0.032	3.987ProGlu: 3.987 ± 0.04	2.13ProPhe: 2.13 ± 0.022	3.88ProGly: 3.88 ± 0.037	1.358ProHis: 1.358 ± 0.02	2.732ProIle: 2.732 ± 0.023	2.688ProLys: 2.688 ± 0.028	4.711ProLeu: 4.711 ± 0.033	1.154ProMet: 1.154 ± 0.019	2.306ProAsn: 2.306 ± 0.024	4.629ProPro: 4.629 ± 0.063	2.429ProGln: 2.429 ± 0.027	3.353ProArg: 3.353 ± 0.031	6.023ProSer: 6.023 ± 0.051	4.118ProThr: 4.118 ± 0.038	3.74ProVal: 3.74 ± 0.036	0.773ProTrp: 0.773 ± 0.013	1.515ProTyr: 1.515 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.382GlnAla: 3.382 ± 0.03	0.425GlnCys: 0.425 ± 0.009	2.065GlnAsp: 2.065 ± 0.023	2.42GlnGlu: 2.42 ± 0.026	1.404GlnPhe: 1.404 ± 0.017	2.415GlnGly: 2.415 ± 0.025	1.034GlnHis: 1.034 ± 0.016	2.022GlnIle: 2.022 ± 0.021	2.022GlnLys: 2.022 ± 0.022	3.501GlnLeu: 3.501 ± 0.028	0.935GlnMet: 0.935 ± 0.015	1.621GlnAsn: 1.621 ± 0.018	2.544GlnPro: 2.544 ± 0.03	2.128GlnGln: 2.128 ± 0.039	2.545GlnArg: 2.545 ± 0.024	3.293GlnSer: 3.293 ± 0.027	2.437GlnThr: 2.437 ± 0.023	2.233GlnVal: 2.233 ± 0.023	0.595GlnTrp: 0.595 ± 0.012	1.21GlnTyr: 1.21 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.502ArgAla: 4.502 ± 0.029	0.632ArgCys: 0.632 ± 0.012	3.324ArgAsp: 3.324 ± 0.031	3.73ArgGlu: 3.73 ± 0.035	2.162ArgPhe: 2.162 ± 0.021	3.645ArgGly: 3.645 ± 0.037	1.491ArgHis: 1.491 ± 0.016	2.915ArgIle: 2.915 ± 0.025	3.294ArgLys: 3.294 ± 0.034	5.371ArgLeu: 5.371 ± 0.04	1.307ArgMet: 1.307 ± 0.016	2.217ArgAsn: 2.217 ± 0.025	3.353ArgPro: 3.353 ± 0.035	2.488ArgGln: 2.488 ± 0.024	4.661ArgArg: 4.661 ± 0.047	4.644ArgSer: 4.644 ± 0.041	3.207ArgThr: 3.207 ± 0.029	3.375ArgVal: 3.375 ± 0.026	0.908ArgTrp: 0.908 ± 0.012	1.617ArgTyr: 1.617 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.547SerAla: 6.547 ± 0.037	0.817SerCys: 0.817 ± 0.013	4.408SerAsp: 4.408 ± 0.036	4.406SerGlu: 4.406 ± 0.033	3.086SerPhe: 3.086 ± 0.028	5.519SerGly: 5.519 ± 0.041	2.051SerHis: 2.051 ± 0.022	4.166SerIle: 4.166 ± 0.033	3.738SerLys: 3.738 ± 0.036	7.381SerLeu: 7.381 ± 0.047	1.828SerMet: 1.828 ± 0.022	3.125SerAsn: 3.125 ± 0.026	5.513SerPro: 5.513 ± 0.051	3.406SerGln: 3.406 ± 0.033	4.824SerArg: 4.824 ± 0.043	8.418SerSer: 8.418 ± 0.074	5.575SerThr: 5.575 ± 0.043	4.764SerVal: 4.764 ± 0.033	1.155SerTrp: 1.155 ± 0.017	2.117SerTyr: 2.117 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.089ThrAla: 5.089 ± 0.035	0.696ThrCys: 0.696 ± 0.013	2.993ThrAsp: 2.993 ± 0.021	3.382ThrGlu: 3.382 ± 0.029	2.217ThrPhe: 2.217 ± 0.021	4.255ThrGly: 4.255 ± 0.033	1.335ThrHis: 1.335 ± 0.017	3.187ThrIle: 3.187 ± 0.031	2.655ThrLys: 2.655 ± 0.026	5.268ThrLeu: 5.268 ± 0.036	1.25ThrMet: 1.25 ± 0.016	2.18ThrAsn: 2.18 ± 0.021	4.429ThrPro: 4.429 ± 0.037	2.207ThrGln: 2.207 ± 0.024	3.108ThrArg: 3.108 ± 0.027	5.242ThrSer: 5.242 ± 0.043	4.121ThrThr: 4.121 ± 0.043	3.797ThrVal: 3.797 ± 0.033	0.858ThrTrp: 0.858 ± 0.014	1.615ThrTyr: 1.615 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.171ValAla: 5.171 ± 0.04	0.816ValCys: 0.816 ± 0.012	3.766ValAsp: 3.766 ± 0.028	3.824ValGlu: 3.824 ± 0.036	2.518ValPhe: 2.518 ± 0.027	4.006ValGly: 4.006 ± 0.037	1.448ValHis: 1.448 ± 0.017	3.197ValIle: 3.197 ± 0.029	2.8ValLys: 2.8 ± 0.025	5.566ValLeu: 5.566 ± 0.042	1.373ValMet: 1.373 ± 0.018	2.319ValAsn: 2.319 ± 0.024	3.648ValPro: 3.648 ± 0.036	2.439ValGln: 2.439 ± 0.024	3.316ValArg: 3.316 ± 0.023	4.83ValSer: 4.83 ± 0.033	3.563ValThr: 3.563 ± 0.029	4.224ValVal: 4.224 ± 0.036	0.849ValTrp: 0.849 ± 0.014	1.761ValTyr: 1.761 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.166TrpAla: 1.166 ± 0.018	0.188TrpCys: 0.188 ± 0.006	0.922TrpAsp: 0.922 ± 0.016	0.871TrpGlu: 0.871 ± 0.015	0.533TrpPhe: 0.533 ± 0.01	0.935TrpGly: 0.935 ± 0.015	0.358TrpHis: 0.358 ± 0.009	0.793TrpIle: 0.793 ± 0.012	0.81TrpLys: 0.81 ± 0.016	1.346TrpLeu: 1.346 ± 0.017	0.381TrpMet: 0.381 ± 0.009	0.651TrpAsn: 0.651 ± 0.013	0.587TrpPro: 0.587 ± 0.01	0.556TrpGln: 0.556 ± 0.011	0.93TrpArg: 0.93 ± 0.014	1.074TrpSer: 1.074 ± 0.015	0.913TrpThr: 0.913 ± 0.015	0.89TrpVal: 0.89 ± 0.015	0.283TrpTrp: 0.283 ± 0.008	0.441TrpTyr: 0.441 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.149TyrAla: 2.149 ± 0.023	0.384TyrCys: 0.384 ± 0.009	1.661TyrAsp: 1.661 ± 0.02	1.566TyrGlu: 1.566 ± 0.018	1.199TyrPhe: 1.199 ± 0.016	2.091TyrGly: 2.091 ± 0.025	0.761TyrHis: 0.761 ± 0.013	1.463TyrIle: 1.463 ± 0.018	1.11TyrLys: 1.11 ± 0.016	2.696TyrLeu: 2.696 ± 0.027	0.661TyrMet: 0.661 ± 0.012	1.149TyrAsn: 1.149 ± 0.016	1.546TyrPro: 1.546 ± 0.022	1.138TyrGln: 1.138 ± 0.016	1.61TyrArg: 1.61 ± 0.019	2.105TyrSer: 2.105 ± 0.024	1.648TyrThr: 1.648 ± 0.021	1.616TyrVal: 1.616 ± 0.019	0.444TyrTrp: 0.444 ± 0.009	0.968TyrTyr: 0.968 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9628 proteins (5009552 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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