Amino acid dipepetide frequency for Marinicauda sp. WD6-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.633AlaAla: 23.633 ± 0.304
1.31AlaCys: 1.31 ± 0.044
9.378AlaAsp: 9.378 ± 0.127
11.161AlaGlu: 11.161 ± 0.145
5.117AlaPhe: 5.117 ± 0.078
13.567AlaGly: 13.567 ± 0.166
2.321AlaHis: 2.321 ± 0.059
5.712AlaIle: 5.712 ± 0.072
3.25AlaLys: 3.25 ± 0.087
15.097AlaLeu: 15.097 ± 0.179
3.422AlaMet: 3.422 ± 0.08
2.518AlaAsn: 2.518 ± 0.065
7.535AlaPro: 7.535 ± 0.11
3.424AlaGln: 3.424 ± 0.065
11.975AlaArg: 11.975 ± 0.17
6.405AlaSer: 6.405 ± 0.098
5.207AlaThr: 5.207 ± 0.087
9.854AlaVal: 9.854 ± 0.127
2.005AlaTrp: 2.005 ± 0.058
2.647AlaTyr: 2.647 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
1.166CysAla: 1.166 ± 0.041
0.086CysCys: 0.086 ± 0.01
0.523CysAsp: 0.523 ± 0.03
0.519CysGlu: 0.519 ± 0.026
0.254CysPhe: 0.254 ± 0.018
0.881CysGly: 0.881 ± 0.033
0.13CysHis: 0.13 ± 0.013
0.242CysIle: 0.242 ± 0.018
0.122CysLys: 0.122 ± 0.012
0.596CysLeu: 0.596 ± 0.026
0.117CysMet: 0.117 ± 0.012
0.164CysAsn: 0.164 ± 0.014
0.445CysPro: 0.445 ± 0.025
0.15CysGln: 0.15 ± 0.013
0.574CysArg: 0.574 ± 0.026
0.38CysSer: 0.38 ± 0.021
0.31CysThr: 0.31 ± 0.02
0.583CysVal: 0.583 ± 0.027
0.088CysTrp: 0.088 ± 0.01
0.131CysTyr: 0.131 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
10.308AspAla: 10.308 ± 0.125
0.445AspCys: 0.445 ± 0.024
4.401AspAsp: 4.401 ± 0.124
4.699AspGlu: 4.699 ± 0.079
2.434AspPhe: 2.434 ± 0.054
6.617AspGly: 6.617 ± 0.179
1.319AspHis: 1.319 ± 0.041
2.672AspIle: 2.672 ± 0.062
1.337AspLys: 1.337 ± 0.052
6.211AspLeu: 6.211 ± 0.095
1.368AspMet: 1.368 ± 0.042
1.11AspAsn: 1.11 ± 0.046
4.629AspPro: 4.629 ± 0.076
1.668AspGln: 1.668 ± 0.049
5.331AspArg: 5.331 ± 0.086
2.456AspSer: 2.456 ± 0.077
2.272AspThr: 2.272 ± 0.066
4.636AspVal: 4.636 ± 0.098
1.172AspTrp: 1.172 ± 0.039
1.641AspTyr: 1.641 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
11.761GluAla: 11.761 ± 0.16
0.373GluCys: 0.373 ± 0.022
4.284GluAsp: 4.284 ± 0.084
4.513GluGlu: 4.513 ± 0.103
2.014GluPhe: 2.014 ± 0.055
5.633GluGly: 5.633 ± 0.092
1.341GluHis: 1.341 ± 0.045
3.892GluIle: 3.892 ± 0.064
1.848GluLys: 1.848 ± 0.071
5.734GluLeu: 5.734 ± 0.1
1.623GluMet: 1.623 ± 0.048
1.58GluAsn: 1.58 ± 0.044
4.059GluPro: 4.059 ± 0.1
2.044GluGln: 2.044 ± 0.051
6.894GluArg: 6.894 ± 0.106
3.097GluSer: 3.097 ± 0.063
5.362GluThr: 5.362 ± 0.072
4.118GluVal: 4.118 ± 0.084
0.783GluTrp: 0.783 ± 0.033
1.098GluTyr: 1.098 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
5.235PheAla: 5.235 ± 0.092
0.31PheCys: 0.31 ± 0.019
3.041PheAsp: 3.041 ± 0.071
2.724PheGlu: 2.724 ± 0.066
1.453PhePhe: 1.453 ± 0.048
3.408PheGly: 3.408 ± 0.082
0.727PheHis: 0.727 ± 0.034
1.528PheIle: 1.528 ± 0.046
0.759PheLys: 0.759 ± 0.034
3.144PheLeu: 3.144 ± 0.075
0.754PheMet: 0.754 ± 0.027
1.0PheAsn: 1.0 ± 0.045
1.478PhePro: 1.478 ± 0.051
0.824PheGln: 0.824 ± 0.035
2.252PheArg: 2.252 ± 0.055
1.95PheSer: 1.95 ± 0.047
1.952PheThr: 1.952 ± 0.06
2.622PheVal: 2.622 ± 0.064
0.484PheTrp: 0.484 ± 0.025
0.82PheTyr: 0.82 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
12.408GlyAla: 12.408 ± 0.153
0.734GlyCys: 0.734 ± 0.031
5.747GlyAsp: 5.747 ± 0.14
7.246GlyGlu: 7.246 ± 0.116
3.783GlyPhe: 3.783 ± 0.074
8.561GlyGly: 8.561 ± 0.136
1.548GlyHis: 1.548 ± 0.043
2.618GlyIle: 2.618 ± 0.055
2.022GlyLys: 2.022 ± 0.071
9.12GlyLeu: 9.12 ± 0.11
2.097GlyMet: 2.097 ± 0.056
1.379GlyAsn: 1.379 ± 0.054
4.235GlyPro: 4.235 ± 0.07
2.126GlyGln: 2.126 ± 0.051
7.336GlyArg: 7.336 ± 0.108
3.914GlySer: 3.914 ± 0.093
3.166GlyThr: 3.166 ± 0.08
7.518GlyVal: 7.518 ± 0.098
1.536GlyTrp: 1.536 ± 0.039
2.272GlyTyr: 2.272 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
2.525HisAla: 2.525 ± 0.059
0.183HisCys: 0.183 ± 0.013
1.108HisAsp: 1.108 ± 0.041
1.078HisGlu: 1.078 ± 0.034
0.694HisPhe: 0.694 ± 0.03
1.695HisGly: 1.695 ± 0.045
0.479HisHis: 0.479 ± 0.026
0.666HisIle: 0.666 ± 0.028
0.345HisLys: 0.345 ± 0.02
1.743HisLeu: 1.743 ± 0.049
0.382HisMet: 0.382 ± 0.021
0.338HisAsn: 0.338 ± 0.016
1.21HisPro: 1.21 ± 0.043
0.488HisGln: 0.488 ± 0.024
1.353HisArg: 1.353 ± 0.046
0.641HisSer: 0.641 ± 0.03
0.661HisThr: 0.661 ± 0.031
1.481HisVal: 1.481 ± 0.048
0.27HisTrp: 0.27 ± 0.02
0.466HisTyr: 0.466 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.908IleAla: 6.908 ± 0.098
0.366IleCys: 0.366 ± 0.023
3.428IleAsp: 3.428 ± 0.064
3.82IleGlu: 3.82 ± 0.069
1.347IlePhe: 1.347 ± 0.045
4.112IleGly: 4.112 ± 0.081
0.791IleHis: 0.791 ± 0.03
1.519IleIle: 1.519 ± 0.05
0.924IleLys: 0.924 ± 0.034
3.546IleLeu: 3.546 ± 0.075
0.703IleMet: 0.703 ± 0.034
1.065IleAsn: 1.065 ± 0.039
1.797IlePro: 1.797 ± 0.049
0.977IleGln: 0.977 ± 0.036
2.983IleArg: 2.983 ± 0.061
2.133IleSer: 2.133 ± 0.056
2.207IleThr: 2.207 ± 0.061
3.566IleVal: 3.566 ± 0.066
0.501IleTrp: 0.501 ± 0.028
0.923IleTyr: 0.923 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.472LysAla: 3.472 ± 0.091
0.099LysCys: 0.099 ± 0.011
1.286LysAsp: 1.286 ± 0.046
1.197LysGlu: 1.197 ± 0.053
0.633LysPhe: 0.633 ± 0.031
1.828LysGly: 1.828 ± 0.062
0.431LysHis: 0.431 ± 0.026
1.122LysIle: 1.122 ± 0.041
1.089LysLys: 1.089 ± 0.059
2.276LysLeu: 2.276 ± 0.079
0.493LysMet: 0.493 ± 0.026
0.549LysAsn: 0.549 ± 0.028
1.597LysPro: 1.597 ± 0.053
0.678LysGln: 0.678 ± 0.03
2.207LysArg: 2.207 ± 0.067
1.332LysSer: 1.332 ± 0.049
1.625LysThr: 1.625 ± 0.049
1.568LysVal: 1.568 ± 0.061
0.254LysTrp: 0.254 ± 0.017
0.435LysTyr: 0.435 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.639LeuAla: 14.639 ± 0.201
0.638LeuCys: 0.638 ± 0.028
6.881LeuAsp: 6.881 ± 0.107
6.646LeuGlu: 6.646 ± 0.123
3.376LeuPhe: 3.376 ± 0.073
8.045LeuGly: 8.045 ± 0.112
1.726LeuHis: 1.726 ± 0.05
4.601LeuIle: 4.601 ± 0.078
2.813LeuLys: 2.813 ± 0.072
7.718LeuLeu: 7.718 ± 0.135
2.028LeuMet: 2.028 ± 0.058
2.136LeuAsn: 2.136 ± 0.049
4.542LeuPro: 4.542 ± 0.078
2.235LeuGln: 2.235 ± 0.055
6.581LeuArg: 6.581 ± 0.103
5.534LeuSer: 5.534 ± 0.089
4.736LeuThr: 4.736 ± 0.073
7.215LeuVal: 7.215 ± 0.113
1.036LeuTrp: 1.036 ± 0.037
1.84LeuTyr: 1.84 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.915MetAla: 2.915 ± 0.068
0.14MetCys: 0.14 ± 0.011
1.165MetAsp: 1.165 ± 0.038
1.236MetGlu: 1.236 ± 0.045
0.572MetPhe: 0.572 ± 0.024
1.66MetGly: 1.66 ± 0.049
0.37MetHis: 0.37 ± 0.021
1.189MetIle: 1.189 ± 0.041
0.879MetLys: 0.879 ± 0.034
1.98MetLeu: 1.98 ± 0.054
0.537MetMet: 0.537 ± 0.027
0.669MetAsn: 0.669 ± 0.03
1.064MetPro: 1.064 ± 0.035
0.609MetGln: 0.609 ± 0.027
1.844MetArg: 1.844 ± 0.048
1.47MetSer: 1.47 ± 0.043
1.789MetThr: 1.789 ± 0.039
1.338MetVal: 1.338 ± 0.04
0.214MetTrp: 0.214 ± 0.016
0.259MetTyr: 0.259 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.029AsnAla: 3.029 ± 0.061
0.173AsnCys: 0.173 ± 0.014
1.233AsnAsp: 1.233 ± 0.059
1.126AsnGlu: 1.126 ± 0.04
0.832AsnPhe: 0.832 ± 0.035
1.853AsnGly: 1.853 ± 0.069
0.38AsnHis: 0.38 ± 0.022
0.97AsnIle: 0.97 ± 0.042
0.44AsnLys: 0.44 ± 0.027
2.059AsnLeu: 2.059 ± 0.055
0.426AsnMet: 0.426 ± 0.022
0.546AsnAsn: 0.546 ± 0.03
1.478AsnPro: 1.478 ± 0.047
0.599AsnGln: 0.599 ± 0.029
1.479AsnArg: 1.479 ± 0.042
0.887AsnSer: 0.887 ± 0.037
0.949AsnThr: 0.949 ± 0.038
1.647AsnVal: 1.647 ± 0.059
0.291AsnTrp: 0.291 ± 0.02
0.574AsnTyr: 0.574 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
7.209ProAla: 7.209 ± 0.108
0.286ProCys: 0.286 ± 0.018
4.753ProAsp: 4.753 ± 0.084
5.001ProGlu: 5.001 ± 0.097
1.877ProPhe: 1.877 ± 0.041
5.289ProGly: 5.289 ± 0.087
0.947ProHis: 0.947 ± 0.034
1.943ProIle: 1.943 ± 0.048
1.216ProLys: 1.216 ± 0.045
4.256ProLeu: 4.256 ± 0.066
1.009ProMet: 1.009 ± 0.034
1.074ProAsn: 1.074 ± 0.034
2.766ProPro: 2.766 ± 0.073
1.188ProGln: 1.188 ± 0.042
3.326ProArg: 3.326 ± 0.077
2.3ProSer: 2.3 ± 0.058
2.014ProThr: 2.014 ± 0.054
4.386ProVal: 4.386 ± 0.076
0.713ProTrp: 0.713 ± 0.028
1.012ProTyr: 1.012 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.637GlnAla: 3.637 ± 0.07
0.147GlnCys: 0.147 ± 0.013
1.271GlnAsp: 1.271 ± 0.046
1.33GlnGlu: 1.33 ± 0.043
0.805GlnPhe: 0.805 ± 0.038
1.948GlnGly: 1.948 ± 0.05
0.417GlnHis: 0.417 ± 0.023
1.328GlnIle: 1.328 ± 0.042
0.561GlnLys: 0.561 ± 0.031
2.302GlnLeu: 2.302 ± 0.055
0.625GlnMet: 0.625 ± 0.028
0.56GlnAsn: 0.56 ± 0.028
1.449GlnPro: 1.449 ± 0.042
0.718GlnGln: 0.718 ± 0.031
1.928GlnArg: 1.928 ± 0.051
1.286GlnSer: 1.286 ± 0.041
1.412GlnThr: 1.412 ± 0.042
1.801GlnVal: 1.801 ± 0.053
0.277GlnTrp: 0.277 ± 0.019
0.483GlnTyr: 0.483 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
10.705ArgAla: 10.705 ± 0.146
0.553ArgCys: 0.553 ± 0.026
4.972ArgAsp: 4.972 ± 0.084
5.489ArgGlu: 5.489 ± 0.089
3.354ArgPhe: 3.354 ± 0.072
5.558ArgGly: 5.558 ± 0.098
1.387ArgHis: 1.387 ± 0.044
3.936ArgIle: 3.936 ± 0.064
1.903ArgLys: 1.903 ± 0.069
9.168ArgLeu: 9.168 ± 0.149
1.855ArgMet: 1.855 ± 0.047
1.56ArgAsn: 1.56 ± 0.04
4.045ArgPro: 4.045 ± 0.081
1.872ArgGln: 1.872 ± 0.055
7.409ArgArg: 7.409 ± 0.134
3.506ArgSer: 3.506 ± 0.069
3.567ArgThr: 3.567 ± 0.064
5.521ArgVal: 5.521 ± 0.079
1.129ArgTrp: 1.129 ± 0.037
1.881ArgTyr: 1.881 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.25SerAla: 6.25 ± 0.092
0.318SerCys: 0.318 ± 0.017
3.063SerAsp: 3.063 ± 0.069
3.257SerGlu: 3.257 ± 0.07
1.752SerPhe: 1.752 ± 0.049
5.327SerGly: 5.327 ± 0.101
0.744SerHis: 0.744 ± 0.031
2.108SerIle: 2.108 ± 0.055
1.113SerLys: 1.113 ± 0.044
4.471SerLeu: 4.471 ± 0.08
1.117SerMet: 1.117 ± 0.042
1.15SerAsn: 1.15 ± 0.044
2.667SerPro: 2.667 ± 0.056
1.208SerGln: 1.208 ± 0.039
3.492SerArg: 3.492 ± 0.063
2.247SerSer: 2.247 ± 0.065
2.165SerThr: 2.165 ± 0.062
3.382SerVal: 3.382 ± 0.076
0.695SerTrp: 0.695 ± 0.031
1.033SerTyr: 1.033 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.31ThrAla: 6.31 ± 0.1
0.328ThrCys: 0.328 ± 0.023
2.883ThrAsp: 2.883 ± 0.1
2.889ThrGlu: 2.889 ± 0.061
1.585ThrPhe: 1.585 ± 0.046
5.041ThrGly: 5.041 ± 0.086
0.78ThrHis: 0.78 ± 0.029
2.298ThrIle: 2.298 ± 0.065
0.957ThrLys: 0.957 ± 0.04
5.256ThrLeu: 5.256 ± 0.099
0.877ThrMet: 0.877 ± 0.031
1.023ThrAsn: 1.023 ± 0.042
3.16ThrPro: 3.16 ± 0.063
1.06ThrGln: 1.06 ± 0.036
3.356ThrArg: 3.356 ± 0.067
2.092ThrSer: 2.092 ± 0.058
2.279ThrThr: 2.279 ± 0.061
3.824ThrVal: 3.824 ± 0.084
0.521ThrTrp: 0.521 ± 0.023
0.994ThrTyr: 0.994 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
9.018ValAla: 9.018 ± 0.124
0.639ValCys: 0.639 ± 0.026
4.947ValAsp: 4.947 ± 0.084
5.848ValGlu: 5.848 ± 0.091
3.233ValPhe: 3.233 ± 0.055
5.438ValGly: 5.438 ± 0.097
1.334ValHis: 1.334 ± 0.043
3.792ValIle: 3.792 ± 0.067
1.835ValLys: 1.835 ± 0.056
6.762ValLeu: 6.762 ± 0.086
1.782ValMet: 1.782 ± 0.055
1.738ValAsn: 1.738 ± 0.05
2.792ValPro: 2.792 ± 0.056
1.612ValGln: 1.612 ± 0.044
5.787ValArg: 5.787 ± 0.094
4.16ValSer: 4.16 ± 0.093
4.027ValThr: 4.027 ± 0.104
5.691ValVal: 5.691 ± 0.111
1.057ValTrp: 1.057 ± 0.038
1.631ValTyr: 1.631 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.478TrpAla: 1.478 ± 0.049
0.118TrpCys: 0.118 ± 0.013
0.717TrpAsp: 0.717 ± 0.03
0.675TrpGlu: 0.675 ± 0.026
0.53TrpPhe: 0.53 ± 0.022
0.914TrpGly: 0.914 ± 0.039
0.248TrpHis: 0.248 ± 0.017
0.748TrpIle: 0.748 ± 0.034
0.322TrpLys: 0.322 ± 0.025
1.56TrpLeu: 1.56 ± 0.049
0.325TrpMet: 0.325 ± 0.02
0.369TrpAsn: 0.369 ± 0.02
0.692TrpPro: 0.692 ± 0.031
0.231TrpGln: 0.231 ± 0.016
1.648TrpArg: 1.648 ± 0.048
0.852TrpSer: 0.852 ± 0.035
0.925TrpThr: 0.925 ± 0.039
0.755TrpVal: 0.755 ± 0.035
0.223TrpTrp: 0.223 ± 0.016
0.265TrpTyr: 0.265 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.931TyrAla: 2.931 ± 0.06
0.211TyrCys: 0.211 ± 0.016
1.644TyrAsp: 1.644 ± 0.05
1.596TyrGlu: 1.596 ± 0.042
0.818TyrPhe: 0.818 ± 0.028
1.99TyrGly: 1.99 ± 0.052
0.387TyrHis: 0.387 ± 0.021
0.734TyrIle: 0.734 ± 0.035
0.435TyrLys: 0.435 ± 0.027
1.971TyrLeu: 1.971 ± 0.057
0.357TyrMet: 0.357 ± 0.021
0.444TyrAsn: 0.444 ± 0.024
0.926TyrPro: 0.926 ± 0.035
0.572TyrGln: 0.572 ± 0.026
1.615TyrArg: 1.615 ± 0.049
0.918TyrSer: 0.918 ± 0.038
0.89TyrThr: 0.89 ± 0.042
1.618TyrVal: 1.618 ± 0.048
0.348TyrTrp: 0.348 ± 0.02
0.553TyrTyr: 0.553 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2648 proteins (855958 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski