Amino acid dipepetide frequency for Fusarium sp. AF-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.738AlaAla: 8.738 ± 0.071	1.157AlaCys: 1.157 ± 0.013	4.217AlaAsp: 4.217 ± 0.027	5.2AlaGlu: 5.2 ± 0.048	3.185AlaPhe: 3.185 ± 0.026	5.582AlaGly: 5.582 ± 0.034	1.705AlaHis: 1.705 ± 0.015	4.422AlaIle: 4.422 ± 0.025	4.115AlaLys: 4.115 ± 0.029	7.699AlaLeu: 7.699 ± 0.036	2.045AlaMet: 2.045 ± 0.019	2.815AlaAsn: 2.815 ± 0.02	4.787AlaPro: 4.787 ± 0.049	3.278AlaGln: 3.278 ± 0.023	4.704AlaArg: 4.704 ± 0.03	7.013AlaSer: 7.013 ± 0.036	5.126AlaThr: 5.126 ± 0.031	5.346AlaVal: 5.346 ± 0.031	1.296AlaTrp: 1.296 ± 0.013	2.125AlaTyr: 2.125 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.955CysAla: 0.955 ± 0.012	0.266CysCys: 0.266 ± 0.008	0.724CysAsp: 0.724 ± 0.011	0.67CysGlu: 0.67 ± 0.009	0.59CysPhe: 0.59 ± 0.01	0.983CysGly: 0.983 ± 0.014	0.374CysHis: 0.374 ± 0.008	0.774CysIle: 0.774 ± 0.011	0.565CysLys: 0.565 ± 0.01	1.346CysLeu: 1.346 ± 0.015	0.287CysMet: 0.287 ± 0.006	0.454CysAsn: 0.454 ± 0.008	0.728CysPro: 0.728 ± 0.012	0.502CysGln: 0.502 ± 0.009	0.817CysArg: 0.817 ± 0.011	0.942CysSer: 0.942 ± 0.014	0.735CysThr: 0.735 ± 0.013	0.858CysVal: 0.858 ± 0.012	0.243CysTrp: 0.243 ± 0.006	0.375CysTyr: 0.375 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.769AspAla: 4.769 ± 0.026	0.696AspCys: 0.696 ± 0.011	4.696AspAsp: 4.696 ± 0.045	4.729AspGlu: 4.729 ± 0.033	2.314AspPhe: 2.314 ± 0.019	4.274AspGly: 4.274 ± 0.028	1.283AspHis: 1.283 ± 0.014	3.104AspIle: 3.104 ± 0.024	2.658AspLys: 2.658 ± 0.023	5.219AspLeu: 5.219 ± 0.027	1.383AspMet: 1.383 ± 0.015	1.96AspAsn: 1.96 ± 0.019	3.414AspPro: 3.414 ± 0.023	1.978AspGln: 1.978 ± 0.019	3.064AspArg: 3.064 ± 0.028	4.157AspSer: 4.157 ± 0.03	3.031AspThr: 3.031 ± 0.024	3.74AspVal: 3.74 ± 0.025	1.003AspTrp: 1.003 ± 0.012	1.597AspTyr: 1.597 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.753GluAla: 5.753 ± 0.055	0.699GluCys: 0.699 ± 0.01	4.319GluAsp: 4.319 ± 0.03	5.551GluGlu: 5.551 ± 0.06	2.042GluPhe: 2.042 ± 0.019	3.828GluGly: 3.828 ± 0.026	1.405GluHis: 1.405 ± 0.014	3.001GluIle: 3.001 ± 0.022	3.675GluLys: 3.675 ± 0.034	5.269GluLeu: 5.269 ± 0.029	1.531GluMet: 1.531 ± 0.015	2.26GluAsn: 2.26 ± 0.017	3.17GluPro: 3.17 ± 0.042	2.404GluGln: 2.404 ± 0.023	3.822GluArg: 3.822 ± 0.029	4.314GluSer: 4.314 ± 0.031	3.773GluThr: 3.773 ± 0.025	3.691GluVal: 3.691 ± 0.027	0.965GluTrp: 0.965 ± 0.013	1.685GluTyr: 1.685 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.04PheAla: 3.04 ± 0.024	0.612PheCys: 0.612 ± 0.009	2.387PheAsp: 2.387 ± 0.019	2.209PheGlu: 2.209 ± 0.016	1.718PhePhe: 1.718 ± 0.017	2.943PheGly: 2.943 ± 0.024	0.938PheHis: 0.938 ± 0.011	1.938PheIle: 1.938 ± 0.021	1.619PheLys: 1.619 ± 0.017	3.574PheLeu: 3.574 ± 0.028	0.841PheMet: 0.841 ± 0.013	1.496PheAsn: 1.496 ± 0.016	1.97PhePro: 1.97 ± 0.017	1.444PheGln: 1.444 ± 0.015	1.989PheArg: 1.989 ± 0.017	2.955PheSer: 2.955 ± 0.022	2.17PheThr: 2.17 ± 0.018	2.447PheVal: 2.447 ± 0.021	0.719PheTrp: 0.719 ± 0.01	1.139PheTyr: 1.139 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.177GlyAla: 5.177 ± 0.029	0.96GlyCys: 0.96 ± 0.014	3.806GlyAsp: 3.806 ± 0.03	3.708GlyGlu: 3.708 ± 0.026	2.959GlyPhe: 2.959 ± 0.024	5.501GlyGly: 5.501 ± 0.044	1.743GlyHis: 1.743 ± 0.015	3.65GlyIle: 3.65 ± 0.025	3.419GlyLys: 3.419 ± 0.025	6.21GlyLeu: 6.21 ± 0.035	1.615GlyMet: 1.615 ± 0.016	2.545GlyAsn: 2.545 ± 0.024	3.395GlyPro: 3.395 ± 0.027	2.649GlyGln: 2.649 ± 0.022	4.082GlyArg: 4.082 ± 0.027	5.686GlySer: 5.686 ± 0.05	4.005GlyThr: 4.005 ± 0.03	4.335GlyVal: 4.335 ± 0.03	1.272GlyTrp: 1.272 ± 0.015	2.146GlyTyr: 2.146 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.747HisAla: 1.747 ± 0.017	0.347HisCys: 0.347 ± 0.007	1.392HisAsp: 1.392 ± 0.014	1.365HisGlu: 1.365 ± 0.013	0.96HisPhe: 0.96 ± 0.011	1.766HisGly: 1.766 ± 0.014	0.875HisHis: 0.875 ± 0.016	1.231HisIle: 1.231 ± 0.012	0.937HisLys: 0.937 ± 0.012	2.302HisLeu: 2.302 ± 0.019	0.51HisMet: 0.51 ± 0.009	0.795HisAsn: 0.795 ± 0.012	1.589HisPro: 1.589 ± 0.017	1.016HisGln: 1.016 ± 0.013	1.524HisArg: 1.524 ± 0.015	1.684HisSer: 1.684 ± 0.02	1.179HisThr: 1.179 ± 0.017	1.485HisVal: 1.485 ± 0.014	0.373HisTrp: 0.373 ± 0.008	0.691HisTyr: 0.691 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	4.123IleAla: 4.123 ± 0.029	0.797IleCys: 0.797 ± 0.011	2.944IleAsp: 2.944 ± 0.022	2.952IleGlu: 2.952 ± 0.025	2.049IlePhe: 2.049 ± 0.02	3.281IleGly: 3.281 ± 0.025	1.189IleHis: 1.189 ± 0.015	2.644IleIle: 2.644 ± 0.028	2.268IleLys: 2.268 ± 0.019	4.613IleLeu: 4.613 ± 0.03	1.089IleMet: 1.089 ± 0.012	1.833IleAsn: 1.833 ± 0.016	3.011IlePro: 3.011 ± 0.021	1.947IleGln: 1.947 ± 0.017	2.824IleArg: 2.824 ± 0.017	3.722IleSer: 3.722 ± 0.025	2.905IleThr: 2.905 ± 0.028	3.206IleVal: 3.206 ± 0.024	0.827IleTrp: 0.827 ± 0.009	1.398IleTyr: 1.398 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.36LysAla: 4.36 ± 0.031	0.55LysCys: 0.55 ± 0.009	2.974LysAsp: 2.974 ± 0.025	3.411LysGlu: 3.411 ± 0.031	1.528LysPhe: 1.528 ± 0.014	3.042LysGly: 3.042 ± 0.025	1.155LysHis: 1.155 ± 0.013	2.235LysIle: 2.235 ± 0.019	3.254LysLys: 3.254 ± 0.037	4.12LysLeu: 4.12 ± 0.025	1.057LysMet: 1.057 ± 0.012	1.731LysAsn: 1.731 ± 0.016	2.874LysPro: 2.874 ± 0.026	1.768LysGln: 1.768 ± 0.02	3.209LysArg: 3.209 ± 0.028	3.356LysSer: 3.356 ± 0.025	2.992LysThr: 2.992 ± 0.021	2.891LysVal: 2.891 ± 0.022	0.727LysTrp: 0.727 ± 0.012	1.345LysTyr: 1.345 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.909LeuAla: 7.909 ± 0.041	1.304LeuCys: 1.304 ± 0.014	5.406LeuAsp: 5.406 ± 0.029	5.655LeuGlu: 5.655 ± 0.032	3.421LeuPhe: 3.421 ± 0.026	6.161LeuGly: 6.161 ± 0.034	2.183LeuHis: 2.183 ± 0.019	4.026LeuIle: 4.026 ± 0.031	4.191LeuLys: 4.191 ± 0.032	8.302LeuLeu: 8.302 ± 0.05	1.849LeuMet: 1.849 ± 0.016	3.116LeuAsn: 3.116 ± 0.02	5.345LeuPro: 5.345 ± 0.033	3.67LeuGln: 3.67 ± 0.028	5.649LeuArg: 5.649 ± 0.033	7.084LeuSer: 7.084 ± 0.031	4.812LeuThr: 4.812 ± 0.029	5.653LeuVal: 5.653 ± 0.03	1.317LeuTrp: 1.317 ± 0.016	2.351LeuTyr: 2.351 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.405MetAla: 2.405 ± 0.018	0.268MetCys: 0.268 ± 0.006	1.326MetAsp: 1.326 ± 0.013	1.319MetGlu: 1.319 ± 0.013	0.788MetPhe: 0.788 ± 0.013	1.526MetGly: 1.526 ± 0.013	0.48MetHis: 0.48 ± 0.009	1.052MetIle: 1.052 ± 0.012	1.017MetLys: 1.017 ± 0.012	1.868MetLeu: 1.868 ± 0.018	0.635MetMet: 0.635 ± 0.011	0.788MetAsn: 0.788 ± 0.014	1.34MetPro: 1.34 ± 0.016	0.799MetGln: 0.799 ± 0.01	1.276MetArg: 1.276 ± 0.015	1.93MetSer: 1.93 ± 0.017	1.384MetThr: 1.384 ± 0.013	1.375MetVal: 1.375 ± 0.013	0.293MetTrp: 0.293 ± 0.006	0.519MetTyr: 0.519 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.913AsnAla: 2.913 ± 0.019	0.472AsnCys: 0.472 ± 0.008	2.008AsnAsp: 2.008 ± 0.017	2.007AsnGlu: 2.007 ± 0.018	1.364AsnPhe: 1.364 ± 0.015	2.902AsnGly: 2.902 ± 0.025	0.853AsnHis: 0.853 ± 0.01	1.949AsnIle: 1.949 ± 0.018	1.634AsnLys: 1.634 ± 0.015	3.289AsnLeu: 3.289 ± 0.025	0.87AsnMet: 0.87 ± 0.012	1.47AsnAsn: 1.47 ± 0.019	2.427AsnPro: 2.427 ± 0.02	1.329AsnGln: 1.329 ± 0.014	1.868AsnArg: 1.868 ± 0.018	2.604AsnSer: 2.604 ± 0.02	2.091AsnThr: 2.091 ± 0.019	2.248AsnVal: 2.248 ± 0.018	0.589AsnTrp: 0.589 ± 0.007	1.034AsnTyr: 1.034 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.026ProAla: 5.026 ± 0.043	0.57ProCys: 0.57 ± 0.009	3.44ProAsp: 3.44 ± 0.022	4.216ProGlu: 4.216 ± 0.037	2.097ProPhe: 2.097 ± 0.018	4.069ProGly: 4.069 ± 0.046	1.267ProHis: 1.267 ± 0.015	2.561ProIle: 2.561 ± 0.021	2.776ProLys: 2.776 ± 0.026	4.647ProLeu: 4.647 ± 0.029	1.103ProMet: 1.103 ± 0.014	2.175ProAsn: 2.175 ± 0.018	4.823ProPro: 4.823 ± 0.054	2.437ProGln: 2.437 ± 0.028	3.443ProArg: 3.443 ± 0.03	5.657ProSer: 5.657 ± 0.041	3.886ProThr: 3.886 ± 0.035	3.618ProVal: 3.618 ± 0.029	0.847ProTrp: 0.847 ± 0.012	1.467ProTyr: 1.467 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.441GlnAla: 3.441 ± 0.025	0.451GlnCys: 0.451 ± 0.008	2.257GlnAsp: 2.257 ± 0.018	2.446GlnGlu: 2.446 ± 0.022	1.268GlnPhe: 1.268 ± 0.013	2.523GlnGly: 2.523 ± 0.023	1.063GlnHis: 1.063 ± 0.013	1.773GlnIle: 1.773 ± 0.015	1.86GlnLys: 1.86 ± 0.019	3.424GlnLeu: 3.424 ± 0.021	0.874GlnMet: 0.874 ± 0.013	1.429GlnAsn: 1.429 ± 0.016	2.585GlnPro: 2.585 ± 0.029	2.298GlnGln: 2.298 ± 0.036	2.514GlnArg: 2.514 ± 0.021	2.897GlnSer: 2.897 ± 0.023	2.251GlnThr: 2.251 ± 0.02	2.307GlnVal: 2.307 ± 0.017	0.591GlnTrp: 0.591 ± 0.008	1.093GlnTyr: 1.093 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.498ArgAla: 4.498 ± 0.028	0.759ArgCys: 0.759 ± 0.011	3.549ArgAsp: 3.549 ± 0.031	3.701ArgGlu: 3.701 ± 0.03	2.185ArgPhe: 2.185 ± 0.017	3.693ArgGly: 3.693 ± 0.029	1.607ArgHis: 1.607 ± 0.017	2.867ArgIle: 2.867 ± 0.02	3.222ArgLys: 3.222 ± 0.026	5.498ArgLeu: 5.498 ± 0.031	1.296ArgMet: 1.296 ± 0.015	2.168ArgAsn: 2.168 ± 0.019	3.504ArgPro: 3.504 ± 0.026	2.559ArgGln: 2.559 ± 0.02	5.032ArgArg: 5.032 ± 0.04	4.469ArgSer: 4.469 ± 0.03	3.1ArgThr: 3.1 ± 0.024	3.426ArgVal: 3.426 ± 0.02	1.014ArgTrp: 1.014 ± 0.011	1.662ArgTyr: 1.662 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	6.096SerAla: 6.096 ± 0.034	0.931SerCys: 0.931 ± 0.013	4.259SerAsp: 4.259 ± 0.031	4.178SerGlu: 4.178 ± 0.026	3.025SerPhe: 3.025 ± 0.021	5.431SerGly: 5.431 ± 0.053	1.861SerHis: 1.861 ± 0.015	3.944SerIle: 3.944 ± 0.027	3.628SerLys: 3.628 ± 0.028	7.067SerLeu: 7.067 ± 0.033	1.75SerMet: 1.75 ± 0.018	2.848SerAsn: 2.848 ± 0.022	5.188SerPro: 5.188 ± 0.041	3.155SerGln: 3.155 ± 0.022	4.866SerArg: 4.866 ± 0.032	8.016SerSer: 8.016 ± 0.054	5.344SerThr: 5.344 ± 0.038	4.472SerVal: 4.472 ± 0.022	1.25SerTrp: 1.25 ± 0.013	2.018SerTyr: 2.018 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	5.003ThrAla: 5.003 ± 0.031	0.807ThrCys: 0.807 ± 0.011	2.9ThrAsp: 2.9 ± 0.021	3.325ThrGlu: 3.325 ± 0.031	2.284ThrPhe: 2.284 ± 0.022	4.175ThrGly: 4.175 ± 0.028	1.242ThrHis: 1.242 ± 0.015	3.157ThrIle: 3.157 ± 0.032	2.74ThrLys: 2.74 ± 0.026	5.243ThrLeu: 5.243 ± 0.028	1.251ThrMet: 1.251 ± 0.013	2.079ThrAsn: 2.079 ± 0.018	4.229ThrPro: 4.229 ± 0.035	2.055ThrGln: 2.055 ± 0.021	3.149ThrArg: 3.149 ± 0.022	5.093ThrSer: 5.093 ± 0.037	4.333ThrThr: 4.333 ± 0.053	3.755ThrVal: 3.755 ± 0.035	0.964ThrTrp: 0.964 ± 0.012	1.61ThrTyr: 1.61 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.258ValAla: 5.258 ± 0.028	0.866ValCys: 0.866 ± 0.012	3.812ValAsp: 3.812 ± 0.025	4.022ValGlu: 4.022 ± 0.026	2.552ValPhe: 2.552 ± 0.026	4.04ValGly: 4.04 ± 0.029	1.387ValHis: 1.387 ± 0.013	3.069ValIle: 3.069 ± 0.022	2.993ValLys: 2.993 ± 0.023	5.589ValLeu: 5.589 ± 0.037	1.366ValMet: 1.366 ± 0.013	2.204ValAsn: 2.204 ± 0.019	3.628ValPro: 3.628 ± 0.029	2.342ValGln: 2.342 ± 0.023	3.35ValArg: 3.35 ± 0.023	4.652ValSer: 4.652 ± 0.027	3.675ValThr: 3.675 ± 0.036	4.44ValVal: 4.44 ± 0.029	0.924ValTrp: 0.924 ± 0.013	1.759ValTyr: 1.759 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.258TrpAla: 1.258 ± 0.013	0.225TrpCys: 0.225 ± 0.005	0.972TrpAsp: 0.972 ± 0.012	0.941TrpGlu: 0.941 ± 0.013	0.618TrpPhe: 0.618 ± 0.009	1.055TrpGly: 1.055 ± 0.012	0.398TrpHis: 0.398 ± 0.007	0.858TrpIle: 0.858 ± 0.013	0.89TrpLys: 0.89 ± 0.012	1.493TrpLeu: 1.493 ± 0.017	0.411TrpMet: 0.411 ± 0.007	0.664TrpAsn: 0.664 ± 0.011	0.676TrpPro: 0.676 ± 0.009	0.609TrpGln: 0.609 ± 0.01	1.005TrpArg: 1.005 ± 0.013	1.143TrpSer: 1.143 ± 0.014	1.033TrpThr: 1.033 ± 0.013	0.992TrpVal: 0.992 ± 0.012	0.313TrpTrp: 0.313 ± 0.006	0.463TrpTyr: 0.463 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.084TyrAla: 2.084 ± 0.02	0.452TyrCys: 0.452 ± 0.008	1.677TyrAsp: 1.677 ± 0.015	1.553TyrGlu: 1.553 ± 0.016	1.201TyrPhe: 1.201 ± 0.015	2.09TyrGly: 2.09 ± 0.018	0.755TyrHis: 0.755 ± 0.009	1.367TyrIle: 1.367 ± 0.015	1.12TyrLys: 1.12 ± 0.014	2.631TyrLeu: 2.631 ± 0.02	0.627TyrMet: 0.627 ± 0.009	1.09TyrAsn: 1.09 ± 0.013	1.443TyrPro: 1.443 ± 0.015	1.106TyrGln: 1.106 ± 0.015	1.624TyrArg: 1.624 ± 0.017	1.95TyrSer: 1.95 ± 0.017	1.57TyrThr: 1.57 ± 0.018	1.644TyrVal: 1.644 ± 0.017	0.492TyrTrp: 0.492 ± 0.009	0.908TyrTyr: 0.908 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 16262 proteins (7482626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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