Amino acid dipepetide frequency for Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.439AlaAla: 12.439 ± 0.129
0.681AlaCys: 0.681 ± 0.023
9.439AlaAsp: 9.439 ± 0.089
7.921AlaGlu: 7.921 ± 0.098
3.489AlaPhe: 3.489 ± 0.059
8.946AlaGly: 8.946 ± 0.095
1.73AlaHis: 1.73 ± 0.036
4.863AlaIle: 4.863 ± 0.066
1.985AlaLys: 1.985 ± 0.045
9.589AlaLeu: 9.589 ± 0.119
2.18AlaMet: 2.18 ± 0.043
2.494AlaAsn: 2.494 ± 0.052
3.677AlaPro: 3.677 ± 0.058
2.655AlaGln: 2.655 ± 0.049
5.486AlaArg: 5.486 ± 0.077
5.617AlaSer: 5.617 ± 0.077
7.258AlaThr: 7.258 ± 0.09
10.179AlaVal: 10.179 ± 0.122
1.044AlaTrp: 1.044 ± 0.027
2.479AlaTyr: 2.479 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.574CysAla: 0.574 ± 0.024
0.099CysCys: 0.099 ± 0.009
0.558CysAsp: 0.558 ± 0.027
0.596CysGlu: 0.596 ± 0.025
0.188CysPhe: 0.188 ± 0.012
0.867CysGly: 0.867 ± 0.031
0.216CysHis: 0.216 ± 0.013
0.306CysIle: 0.306 ± 0.017
0.132CysLys: 0.132 ± 0.011
0.581CysLeu: 0.581 ± 0.023
0.137CysMet: 0.137 ± 0.01
0.19CysAsn: 0.19 ± 0.013
0.574CysPro: 0.574 ± 0.024
0.232CysGln: 0.232 ± 0.015
0.518CysArg: 0.518 ± 0.022
0.521CysSer: 0.521 ± 0.022
0.441CysThr: 0.441 ± 0.019
0.513CysVal: 0.513 ± 0.022
0.099CysTrp: 0.099 ± 0.008
0.23CysTyr: 0.23 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
9.247AspAla: 9.247 ± 0.108
0.72AspCys: 0.72 ± 0.027
7.552AspAsp: 7.552 ± 0.116
7.463AspGlu: 7.463 ± 0.105
1.987AspPhe: 1.987 ± 0.044
7.914AspGly: 7.914 ± 0.09
1.796AspHis: 1.796 ± 0.039
4.302AspIle: 4.302 ± 0.068
1.214AspLys: 1.214 ± 0.033
6.579AspLeu: 6.579 ± 0.083
1.416AspMet: 1.416 ± 0.037
1.697AspAsn: 1.697 ± 0.044
4.127AspPro: 4.127 ± 0.065
2.087AspGln: 2.087 ± 0.049
5.838AspArg: 5.838 ± 0.066
4.544AspSer: 4.544 ± 0.079
4.98AspThr: 4.98 ± 0.069
6.742AspVal: 6.742 ± 0.078
1.101AspTrp: 1.101 ± 0.034
1.959AspTyr: 1.959 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
7.814GluAla: 7.814 ± 0.1
0.505GluCys: 0.505 ± 0.021
5.354GluAsp: 5.354 ± 0.085
5.88GluGlu: 5.88 ± 0.112
2.869GluPhe: 2.869 ± 0.054
4.715GluGly: 4.715 ± 0.072
1.89GluHis: 1.89 ± 0.037
3.598GluIle: 3.598 ± 0.066
1.862GluLys: 1.862 ± 0.043
6.951GluLeu: 6.951 ± 0.096
2.041GluMet: 2.041 ± 0.044
2.443GluAsn: 2.443 ± 0.048
3.751GluPro: 3.751 ± 0.066
3.599GluGln: 3.599 ± 0.064
6.581GluArg: 6.581 ± 0.09
5.167GluSer: 5.167 ± 0.062
6.873GluThr: 6.873 ± 0.087
5.288GluVal: 5.288 ± 0.069
1.092GluTrp: 1.092 ± 0.031
2.623GluTyr: 2.623 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.354PheAla: 3.354 ± 0.063
0.298PheCys: 0.298 ± 0.015
3.155PheAsp: 3.155 ± 0.052
3.079PheGlu: 3.079 ± 0.058
0.998PhePhe: 0.998 ± 0.033
3.114PheGly: 3.114 ± 0.057
0.63PheHis: 0.63 ± 0.026
1.359PheIle: 1.359 ± 0.038
0.524PheLys: 0.524 ± 0.021
2.798PheLeu: 2.798 ± 0.06
0.511PheMet: 0.511 ± 0.023
0.813PheAsn: 0.813 ± 0.026
1.266PhePro: 1.266 ± 0.034
0.938PheGln: 0.938 ± 0.026
1.717PheArg: 1.717 ± 0.04
1.812PheSer: 1.812 ± 0.039
2.004PheThr: 2.004 ± 0.041
2.888PheVal: 2.888 ± 0.059
0.396PheTrp: 0.396 ± 0.019
0.888PheTyr: 0.888 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
7.314GlyAla: 7.314 ± 0.094
0.736GlyCys: 0.736 ± 0.027
6.479GlyAsp: 6.479 ± 0.088
6.464GlyGlu: 6.464 ± 0.09
3.019GlyPhe: 3.019 ± 0.06
7.288GlyGly: 7.288 ± 0.111
1.672GlyHis: 1.672 ± 0.035
4.22GlyIle: 4.22 ± 0.068
1.933GlyLys: 1.933 ± 0.045
7.391GlyLeu: 7.391 ± 0.114
1.707GlyMet: 1.707 ± 0.044
2.192GlyAsn: 2.192 ± 0.051
3.38GlyPro: 3.38 ± 0.054
2.58GlyGln: 2.58 ± 0.045
4.306GlyArg: 4.306 ± 0.062
5.187GlySer: 5.187 ± 0.071
6.105GlyThr: 6.105 ± 0.079
7.086GlyVal: 7.086 ± 0.085
1.08GlyTrp: 1.08 ± 0.028
2.639GlyTyr: 2.639 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.832HisAla: 1.832 ± 0.04
0.242HisCys: 0.242 ± 0.014
1.837HisAsp: 1.837 ± 0.041
1.69HisGlu: 1.69 ± 0.038
0.541HisPhe: 0.541 ± 0.02
1.916HisGly: 1.916 ± 0.045
0.514HisHis: 0.514 ± 0.024
0.917HisIle: 0.917 ± 0.028
0.381HisLys: 0.381 ± 0.018
1.686HisLeu: 1.686 ± 0.039
0.306HisMet: 0.306 ± 0.018
0.546HisAsn: 0.546 ± 0.022
1.203HisPro: 1.203 ± 0.037
0.521HisGln: 0.521 ± 0.023
1.276HisArg: 1.276 ± 0.04
1.017HisSer: 1.017 ± 0.029
1.121HisThr: 1.121 ± 0.03
1.652HisVal: 1.652 ± 0.042
0.268HisTrp: 0.268 ± 0.014
0.586HisTyr: 0.586 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.035IleAla: 5.035 ± 0.075
0.326IleCys: 0.326 ± 0.016
4.123IleAsp: 4.123 ± 0.066
4.414IleGlu: 4.414 ± 0.062
1.005IlePhe: 1.005 ± 0.03
3.994IleGly: 3.994 ± 0.068
0.936IleHis: 0.936 ± 0.03
1.763IleIle: 1.763 ± 0.047
0.86IleLys: 0.86 ± 0.029
3.188IleLeu: 3.188 ± 0.063
0.549IleMet: 0.549 ± 0.024
1.128IleAsn: 1.128 ± 0.031
2.182IlePro: 2.182 ± 0.043
1.438IleGln: 1.438 ± 0.037
2.612IleArg: 2.612 ± 0.044
2.532IleSer: 2.532 ± 0.053
2.666IleThr: 2.666 ± 0.056
3.783IleVal: 3.783 ± 0.068
0.388IleTrp: 0.388 ± 0.018
0.942IleTyr: 0.942 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
1.921LysAla: 1.921 ± 0.043
0.148LysCys: 0.148 ± 0.012
1.18LysAsp: 1.18 ± 0.032
1.399LysGlu: 1.399 ± 0.04
0.536LysPhe: 0.536 ± 0.022
1.379LysGly: 1.379 ± 0.037
0.561LysHis: 0.561 ± 0.023
0.89LysIle: 0.89 ± 0.028
0.556LysLys: 0.556 ± 0.019
1.848LysLeu: 1.848 ± 0.046
0.417LysMet: 0.417 ± 0.018
0.576LysAsn: 0.576 ± 0.025
0.982LysPro: 0.982 ± 0.028
1.081LysGln: 1.081 ± 0.033
1.643LysArg: 1.643 ± 0.036
1.288LysSer: 1.288 ± 0.029
1.488LysThr: 1.488 ± 0.041
1.257LysVal: 1.257 ± 0.031
0.245LysTrp: 0.245 ± 0.015
0.616LysTyr: 0.616 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
10.187LeuAla: 10.187 ± 0.114
0.666LeuCys: 0.666 ± 0.024
7.446LeuAsp: 7.446 ± 0.095
6.132LeuGlu: 6.132 ± 0.092
3.124LeuPhe: 3.124 ± 0.07
7.291LeuGly: 7.291 ± 0.095
1.501LeuHis: 1.501 ± 0.04
3.27LeuIle: 3.27 ± 0.065
1.715LeuLys: 1.715 ± 0.042
8.757LeuLeu: 8.757 ± 0.132
1.372LeuMet: 1.372 ± 0.037
2.059LeuAsn: 2.059 ± 0.039
4.161LeuPro: 4.161 ± 0.061
2.494LeuGln: 2.494 ± 0.047
5.15LeuArg: 5.15 ± 0.065
6.155LeuSer: 6.155 ± 0.08
5.718LeuThr: 5.718 ± 0.074
7.75LeuVal: 7.75 ± 0.109
0.901LeuTrp: 0.901 ± 0.031
2.252LeuTyr: 2.252 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.016MetAla: 2.016 ± 0.048
0.148MetCys: 0.148 ± 0.012
1.407MetAsp: 1.407 ± 0.034
1.238MetGlu: 1.238 ± 0.036
0.577MetPhe: 0.577 ± 0.021
1.543MetGly: 1.543 ± 0.041
0.361MetHis: 0.361 ± 0.019
0.664MetIle: 0.664 ± 0.023
0.439MetLys: 0.439 ± 0.018
1.669MetLeu: 1.669 ± 0.039
0.333MetMet: 0.333 ± 0.017
0.588MetAsn: 0.588 ± 0.025
0.885MetPro: 0.885 ± 0.026
0.581MetGln: 0.581 ± 0.024
1.164MetArg: 1.164 ± 0.037
1.568MetSer: 1.568 ± 0.035
1.658MetThr: 1.658 ± 0.041
1.342MetVal: 1.342 ± 0.035
0.164MetTrp: 0.164 ± 0.012
0.431MetTyr: 0.431 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.657AsnAla: 2.657 ± 0.047
0.242AsnCys: 0.242 ± 0.014
1.84AsnAsp: 1.84 ± 0.045
1.954AsnGlu: 1.954 ± 0.047
0.684AsnPhe: 0.684 ± 0.026
2.39AsnGly: 2.39 ± 0.056
0.61AsnHis: 0.61 ± 0.023
1.232AsnIle: 1.232 ± 0.035
0.556AsnLys: 0.556 ± 0.023
2.013AsnLeu: 2.013 ± 0.039
0.493AsnMet: 0.493 ± 0.021
0.743AsnAsn: 0.743 ± 0.031
1.636AsnPro: 1.636 ± 0.04
0.803AsnGln: 0.803 ± 0.027
1.717AsnArg: 1.717 ± 0.038
1.316AsnSer: 1.316 ± 0.038
1.627AsnThr: 1.627 ± 0.04
2.239AsnVal: 2.239 ± 0.046
0.366AsnTrp: 0.366 ± 0.018
0.746AsnTyr: 0.746 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
4.649ProAla: 4.649 ± 0.067
0.256ProCys: 0.256 ± 0.015
4.757ProAsp: 4.757 ± 0.066
4.423ProGlu: 4.423 ± 0.069
1.558ProPhe: 1.558 ± 0.04
3.476ProGly: 3.476 ± 0.061
0.858ProHis: 0.858 ± 0.025
1.787ProIle: 1.787 ± 0.04
0.927ProLys: 0.927 ± 0.031
3.727ProLeu: 3.727 ± 0.064
0.914ProMet: 0.914 ± 0.026
1.188ProAsn: 1.188 ± 0.037
2.176ProPro: 2.176 ± 0.046
1.189ProGln: 1.189 ± 0.036
2.142ProArg: 2.142 ± 0.041
2.815ProSer: 2.815 ± 0.054
3.282ProThr: 3.282 ± 0.066
4.21ProVal: 4.21 ± 0.066
0.491ProTrp: 0.491 ± 0.023
1.079ProTyr: 1.079 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.063GlnAla: 3.063 ± 0.058
0.203GlnCys: 0.203 ± 0.013
1.775GlnAsp: 1.775 ± 0.04
2.096GlnGlu: 2.096 ± 0.043
1.283GlnPhe: 1.283 ± 0.038
1.88GlnGly: 1.88 ± 0.044
0.674GlnHis: 0.674 ± 0.021
1.298GlnIle: 1.298 ± 0.04
0.755GlnLys: 0.755 ± 0.026
2.772GlnLeu: 2.772 ± 0.044
0.693GlnMet: 0.693 ± 0.026
0.968GlnAsn: 0.968 ± 0.027
1.381GlnPro: 1.381 ± 0.036
1.594GlnGln: 1.594 ± 0.039
2.475GlnArg: 2.475 ± 0.048
2.306GlnSer: 2.306 ± 0.047
2.368GlnThr: 2.368 ± 0.052
2.162GlnVal: 2.162 ± 0.037
0.423GlnTrp: 0.423 ± 0.02
1.069GlnTyr: 1.069 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.698ArgAla: 5.698 ± 0.072
0.491ArgCys: 0.491 ± 0.021
4.884ArgAsp: 4.884 ± 0.067
5.686ArgGlu: 5.686 ± 0.077
2.103ArgPhe: 2.103 ± 0.044
3.966ArgGly: 3.966 ± 0.058
1.209ArgHis: 1.209 ± 0.032
2.818ArgIle: 2.818 ± 0.053
1.43ArgLys: 1.43 ± 0.038
5.734ArgLeu: 5.734 ± 0.074
1.218ArgMet: 1.218 ± 0.034
1.775ArgAsn: 1.775 ± 0.036
2.476ArgPro: 2.476 ± 0.048
2.287ArgGln: 2.287 ± 0.044
4.368ArgArg: 4.368 ± 0.071
3.555ArgSer: 3.555 ± 0.058
3.952ArgThr: 3.952 ± 0.065
4.858ArgVal: 4.858 ± 0.07
0.779ArgTrp: 0.779 ± 0.027
1.857ArgTyr: 1.857 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.611SerAla: 5.611 ± 0.07
0.371SerCys: 0.371 ± 0.018
5.056SerAsp: 5.056 ± 0.077
4.746SerGlu: 4.746 ± 0.065
1.978SerPhe: 1.978 ± 0.041
5.903SerGly: 5.903 ± 0.081
1.157SerHis: 1.157 ± 0.031
2.509SerIle: 2.509 ± 0.044
1.309SerLys: 1.309 ± 0.035
5.386SerLeu: 5.386 ± 0.076
1.269SerMet: 1.269 ± 0.035
1.556SerAsn: 1.556 ± 0.04
2.795SerPro: 2.795 ± 0.057
1.757SerGln: 1.757 ± 0.041
3.188SerArg: 3.188 ± 0.066
3.414SerSer: 3.414 ± 0.067
3.836SerThr: 3.836 ± 0.06
5.49SerVal: 5.49 ± 0.067
0.642SerTrp: 0.642 ± 0.022
1.577SerTyr: 1.577 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
7.786ThrAla: 7.786 ± 0.091
0.407ThrCys: 0.407 ± 0.02
6.0ThrAsp: 6.0 ± 0.088
5.322ThrGlu: 5.322 ± 0.079
2.207ThrPhe: 2.207 ± 0.046
6.055ThrGly: 6.055 ± 0.073
1.277ThrHis: 1.277 ± 0.031
3.157ThrIle: 3.157 ± 0.054
1.146ThrLys: 1.146 ± 0.03
6.091ThrLeu: 6.091 ± 0.079
1.18ThrMet: 1.18 ± 0.032
1.692ThrAsn: 1.692 ± 0.04
3.447ThrPro: 3.447 ± 0.058
1.858ThrGln: 1.858 ± 0.043
3.264ThrArg: 3.264 ± 0.056
3.261ThrSer: 3.261 ± 0.057
4.761ThrThr: 4.761 ± 0.077
7.792ThrVal: 7.792 ± 0.093
0.609ThrTrp: 0.609 ± 0.023
1.843ThrTyr: 1.843 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
9.292ValAla: 9.292 ± 0.116
0.661ValCys: 0.661 ± 0.026
6.981ValAsp: 6.981 ± 0.079
7.186ValGlu: 7.186 ± 0.082
3.097ValPhe: 3.097 ± 0.058
7.072ValGly: 7.072 ± 0.101
1.568ValHis: 1.568 ± 0.04
3.515ValIle: 3.515 ± 0.061
1.509ValLys: 1.509 ± 0.036
7.691ValLeu: 7.691 ± 0.092
1.423ValMet: 1.423 ± 0.034
2.071ValAsn: 2.071 ± 0.044
4.075ValPro: 4.075 ± 0.066
2.228ValGln: 2.228 ± 0.045
4.944ValArg: 4.944 ± 0.062
5.424ValSer: 5.424 ± 0.069
6.571ValThr: 6.571 ± 0.08
8.221ValVal: 8.221 ± 0.1
0.852ValTrp: 0.852 ± 0.03
2.103ValTyr: 2.103 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.976TrpAla: 0.976 ± 0.029
0.106TrpCys: 0.106 ± 0.01
0.85TrpAsp: 0.85 ± 0.028
0.839TrpGlu: 0.839 ± 0.029
0.44TrpPhe: 0.44 ± 0.023
0.784TrpGly: 0.784 ± 0.025
0.249TrpHis: 0.249 ± 0.016
0.424TrpIle: 0.424 ± 0.018
0.27TrpLys: 0.27 ± 0.015
1.287TrpLeu: 1.287 ± 0.043
0.242TrpMet: 0.242 ± 0.014
0.38TrpAsn: 0.38 ± 0.018
0.465TrpPro: 0.465 ± 0.02
0.434TrpGln: 0.434 ± 0.021
0.807TrpArg: 0.807 ± 0.025
0.624TrpSer: 0.624 ± 0.024
0.805TrpThr: 0.805 ± 0.027
0.91TrpVal: 0.91 ± 0.031
0.207TrpTrp: 0.207 ± 0.013
0.373TrpTyr: 0.373 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.682TyrAla: 2.682 ± 0.055
0.263TyrCys: 0.263 ± 0.015
2.59TyrAsp: 2.59 ± 0.047
2.367TyrGlu: 2.367 ± 0.044
0.858TyrPhe: 0.858 ± 0.03
2.287TyrGly: 2.287 ± 0.044
0.646TyrHis: 0.646 ± 0.026
0.974TyrIle: 0.974 ± 0.027
0.511TyrLys: 0.511 ± 0.02
2.365TyrLeu: 2.365 ± 0.05
0.376TyrMet: 0.376 ± 0.016
0.765TyrAsn: 0.765 ± 0.024
1.267TyrPro: 1.267 ± 0.034
0.882TyrGln: 0.882 ± 0.027
1.945TyrArg: 1.945 ± 0.041
1.426TyrSer: 1.426 ± 0.035
1.642TyrThr: 1.642 ± 0.038
2.123TyrVal: 2.123 ± 0.046
0.323TyrTrp: 0.323 ± 0.017
0.886TyrTyr: 0.886 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4234 proteins (1200597 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski