Amino acid dipepetide frequency for Campylobacter avium LMG 24591

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.965AlaAla: 3.965 ± 0.126
1.176AlaCys: 1.176 ± 0.059
3.034AlaAsp: 3.034 ± 0.086
2.866AlaGlu: 2.866 ± 0.092
4.162AlaPhe: 4.162 ± 0.104
3.429AlaGly: 3.429 ± 0.095
1.138AlaHis: 1.138 ± 0.056
5.231AlaIle: 5.231 ± 0.11
7.877AlaLys: 7.877 ± 0.126
9.304AlaLeu: 9.304 ± 0.154
1.906AlaMet: 1.906 ± 0.069
4.394AlaAsn: 4.394 ± 0.116
1.467AlaPro: 1.467 ± 0.052
2.138AlaGln: 2.138 ± 0.067
3.009AlaArg: 3.009 ± 0.078
4.875AlaSer: 4.875 ± 0.107
2.709AlaThr: 2.709 ± 0.078
3.574AlaVal: 3.574 ± 0.09
0.458AlaTrp: 0.458 ± 0.034
3.004AlaTyr: 3.004 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.008CysAla: 1.008 ± 0.048
0.134CysCys: 0.134 ± 0.015
0.797CysAsp: 0.797 ± 0.04
1.144CysGlu: 1.144 ± 0.054
0.77CysPhe: 0.77 ± 0.04
0.808CysGly: 0.808 ± 0.046
0.155CysHis: 0.155 ± 0.023
0.952CysIle: 0.952 ± 0.045
1.119CysLys: 1.119 ± 0.052
1.251CysLeu: 1.251 ± 0.054
0.282CysMet: 0.282 ± 0.023
0.368CysAsn: 0.368 ± 0.026
0.364CysPro: 0.364 ± 0.032
0.161CysGln: 0.161 ± 0.019
0.197CysArg: 0.197 ± 0.02
0.711CysSer: 0.711 ± 0.04
0.385CysThr: 0.385 ± 0.031
1.032CysVal: 1.032 ± 0.046
0.042CysTrp: 0.042 ± 0.008
0.343CysTyr: 0.343 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.576AspAla: 2.576 ± 0.08
0.598AspCys: 0.598 ± 0.037
3.498AspAsp: 3.498 ± 0.082
6.988AspGlu: 6.988 ± 0.132
4.774AspPhe: 4.774 ± 0.102
2.68AspGly: 2.68 ± 0.08
0.364AspHis: 0.364 ± 0.025
5.517AspIle: 5.517 ± 0.127
5.967AspLys: 5.967 ± 0.103
5.687AspLeu: 5.687 ± 0.122
1.289AspMet: 1.289 ± 0.046
2.709AspAsn: 2.709 ± 0.08
0.964AspPro: 0.964 ± 0.048
0.442AspGln: 0.442 ± 0.03
1.536AspArg: 1.536 ± 0.054
3.381AspSer: 3.381 ± 0.089
2.496AspThr: 2.496 ± 0.08
3.394AspVal: 3.394 ± 0.086
0.201AspTrp: 0.201 ± 0.02
2.26AspTyr: 2.26 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
5.21GluAla: 5.21 ± 0.12
0.693GluCys: 0.693 ± 0.034
3.433GluAsp: 3.433 ± 0.08
4.352GluGlu: 4.352 ± 0.113
4.201GluPhe: 4.201 ± 0.094
2.912GluGly: 2.912 ± 0.078
1.218GluHis: 1.218 ± 0.053
5.741GluIle: 5.741 ± 0.12
7.003GluLys: 7.003 ± 0.148
9.779GluLeu: 9.779 ± 0.174
1.195GluMet: 1.195 ± 0.048
5.44GluAsn: 5.44 ± 0.124
1.454GluPro: 1.454 ± 0.051
2.437GluGln: 2.437 ± 0.073
2.241GluArg: 2.241 ± 0.07
3.82GluSer: 3.82 ± 0.095
1.663GluThr: 1.663 ± 0.064
3.398GluVal: 3.398 ± 0.083
0.412GluTrp: 0.412 ± 0.028
2.456GluTyr: 2.456 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
4.419PheAla: 4.419 ± 0.114
1.017PheCys: 1.017 ± 0.044
3.758PheAsp: 3.758 ± 0.088
3.743PheGlu: 3.743 ± 0.093
3.862PhePhe: 3.862 ± 0.109
2.896PheGly: 2.896 ± 0.091
0.745PheHis: 0.745 ± 0.041
4.944PheIle: 4.944 ± 0.128
5.714PheLys: 5.714 ± 0.123
7.028PheLeu: 7.028 ± 0.146
1.373PheMet: 1.373 ± 0.05
2.914PheAsn: 2.914 ± 0.078
0.998PhePro: 0.998 ± 0.044
0.939PheGln: 0.939 ± 0.041
1.462PheArg: 1.462 ± 0.058
4.841PheSer: 4.841 ± 0.113
2.412PheThr: 2.412 ± 0.068
3.992PheVal: 3.992 ± 0.099
0.42PheTrp: 0.42 ± 0.032
2.749PheTyr: 2.749 ± 0.09
0.0PheXaa: 0.0 ± 0.0
Gly
3.896GlyAla: 3.896 ± 0.101
0.557GlyCys: 0.557 ± 0.04
2.678GlyAsp: 2.678 ± 0.073
3.172GlyGlu: 3.172 ± 0.092
3.823GlyPhe: 3.823 ± 0.089
3.588GlyGly: 3.588 ± 0.111
0.896GlyHis: 0.896 ± 0.045
4.366GlyIle: 4.366 ± 0.109
4.141GlyLys: 4.141 ± 0.094
5.584GlyLeu: 5.584 ± 0.113
1.13GlyMet: 1.13 ± 0.049
1.983GlyAsn: 1.983 ± 0.071
0.736GlyPro: 0.736 ± 0.041
1.259GlyGln: 1.259 ± 0.055
1.542GlyArg: 1.542 ± 0.056
3.352GlySer: 3.352 ± 0.087
2.243GlyThr: 2.243 ± 0.067
4.019GlyVal: 4.019 ± 0.1
0.299GlyTrp: 0.299 ± 0.025
2.138GlyTyr: 2.138 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
0.772HisAla: 0.772 ± 0.038
0.239HisCys: 0.239 ± 0.021
0.575HisAsp: 0.575 ± 0.032
0.753HisGlu: 0.753 ± 0.036
1.149HisPhe: 1.149 ± 0.048
0.826HisGly: 0.826 ± 0.043
0.316HisHis: 0.316 ± 0.024
1.55HisIle: 1.55 ± 0.054
1.557HisLys: 1.557 ± 0.063
1.69HisLeu: 1.69 ± 0.061
0.253HisMet: 0.253 ± 0.024
0.737HisAsn: 0.737 ± 0.034
0.634HisPro: 0.634 ± 0.037
0.406HisGln: 0.406 ± 0.027
0.544HisArg: 0.544 ± 0.031
1.41HisSer: 1.41 ± 0.051
0.764HisThr: 0.764 ± 0.046
0.408HisVal: 0.408 ± 0.028
0.08HisTrp: 0.08 ± 0.017
0.726HisTyr: 0.726 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.911IleAla: 5.911 ± 0.108
1.034IleCys: 1.034 ± 0.051
4.565IleAsp: 4.565 ± 0.099
4.879IleGlu: 4.879 ± 0.119
4.54IlePhe: 4.54 ± 0.115
4.117IleGly: 4.117 ± 0.107
1.147IleHis: 1.147 ± 0.044
5.819IleIle: 5.819 ± 0.13
8.02IleLys: 8.02 ± 0.144
9.085IleLeu: 9.085 ± 0.155
1.473IleMet: 1.473 ± 0.052
4.934IleAsn: 4.934 ± 0.099
2.124IlePro: 2.124 ± 0.061
2.205IleGln: 2.205 ± 0.066
2.536IleArg: 2.536 ± 0.081
6.578IleSer: 6.578 ± 0.129
2.946IleThr: 2.946 ± 0.095
4.147IleVal: 4.147 ± 0.095
0.46IleTrp: 0.46 ± 0.033
3.119IleTyr: 3.119 ± 0.098
0.0IleXaa: 0.0 ± 0.0
Lys
7.21LysAla: 7.21 ± 0.133
0.667LysCys: 0.667 ± 0.037
7.844LysAsp: 7.844 ± 0.14
9.934LysGlu: 9.934 ± 0.159
4.063LysPhe: 4.063 ± 0.093
4.0LysGly: 4.0 ± 0.093
1.672LysHis: 1.672 ± 0.058
8.379LysIle: 8.379 ± 0.124
9.003LysLys: 9.003 ± 0.167
8.712LysLeu: 8.712 ± 0.141
2.05LysMet: 2.05 ± 0.062
7.655LysAsn: 7.655 ± 0.157
2.302LysPro: 2.302 ± 0.065
3.419LysGln: 3.419 ± 0.084
3.287LysArg: 3.287 ± 0.084
5.862LysSer: 5.862 ± 0.101
4.101LysThr: 4.101 ± 0.086
3.938LysVal: 3.938 ± 0.104
0.437LysTrp: 0.437 ± 0.029
2.977LysTyr: 2.977 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
8.471LeuAla: 8.471 ± 0.144
1.849LeuCys: 1.849 ± 0.066
6.944LeuAsp: 6.944 ± 0.116
7.781LeuGlu: 7.781 ± 0.165
5.795LeuPhe: 5.795 ± 0.164
6.055LeuGly: 6.055 ± 0.143
1.718LeuHis: 1.718 ± 0.058
7.451LeuIle: 7.451 ± 0.126
11.576LeuLys: 11.576 ± 0.185
11.269LeuLeu: 11.269 ± 0.203
2.195LeuMet: 2.195 ± 0.067
6.936LeuAsn: 6.936 ± 0.133
3.046LeuPro: 3.046 ± 0.073
3.509LeuGln: 3.509 ± 0.105
3.931LeuArg: 3.931 ± 0.09
10.181LeuSer: 10.181 ± 0.182
3.431LeuThr: 3.431 ± 0.09
5.375LeuVal: 5.375 ± 0.115
0.638LeuTrp: 0.638 ± 0.039
3.942LeuTyr: 3.942 ± 0.093
0.0LeuXaa: 0.0 ± 0.0
Met
1.475MetAla: 1.475 ± 0.057
0.22MetCys: 0.22 ± 0.024
0.996MetAsp: 0.996 ± 0.047
0.743MetGlu: 0.743 ± 0.036
0.973MetPhe: 0.973 ± 0.046
1.264MetGly: 1.264 ± 0.055
0.324MetHis: 0.324 ± 0.026
1.737MetIle: 1.737 ± 0.064
2.048MetLys: 2.048 ± 0.067
2.521MetLeu: 2.521 ± 0.076
0.446MetMet: 0.446 ± 0.03
1.149MetAsn: 1.149 ± 0.049
0.969MetPro: 0.969 ± 0.043
1.523MetGln: 1.523 ± 0.059
0.839MetArg: 0.839 ± 0.038
1.647MetSer: 1.647 ± 0.05
0.588MetThr: 0.588 ± 0.032
0.895MetVal: 0.895 ± 0.039
0.119MetTrp: 0.119 ± 0.016
0.556MetTyr: 0.556 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
4.377AsnAla: 4.377 ± 0.1
0.456AsnCys: 0.456 ± 0.032
3.103AsnAsp: 3.103 ± 0.08
4.915AsnGlu: 4.915 ± 0.116
3.95AsnPhe: 3.95 ± 0.101
2.563AsnGly: 2.563 ± 0.076
0.672AsnHis: 0.672 ± 0.035
5.076AsnIle: 5.076 ± 0.113
4.787AsnLys: 4.787 ± 0.101
7.425AsnLeu: 7.425 ± 0.142
0.994AsnMet: 0.994 ± 0.04
2.647AsnAsn: 2.647 ± 0.098
2.006AsnPro: 2.006 ± 0.062
1.437AsnGln: 1.437 ± 0.054
1.28AsnArg: 1.28 ± 0.054
4.567AsnSer: 4.567 ± 0.126
3.099AsnThr: 3.099 ± 0.096
2.766AsnVal: 2.766 ± 0.073
0.213AsnTrp: 0.213 ± 0.019
2.212AsnTyr: 2.212 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
1.462ProAla: 1.462 ± 0.058
0.329ProCys: 0.329 ± 0.026
1.197ProAsp: 1.197 ± 0.046
1.172ProGlu: 1.172 ± 0.047
1.601ProPhe: 1.601 ± 0.056
1.025ProGly: 1.025 ± 0.049
0.519ProHis: 0.519 ± 0.033
1.866ProIle: 1.866 ± 0.065
2.373ProLys: 2.373 ± 0.068
2.785ProLeu: 2.785 ± 0.077
0.542ProMet: 0.542 ± 0.034
1.5ProAsn: 1.5 ± 0.053
0.67ProPro: 0.67 ± 0.039
0.881ProGln: 0.881 ± 0.045
0.849ProArg: 0.849 ± 0.035
2.013ProSer: 2.013 ± 0.059
1.163ProThr: 1.163 ± 0.048
1.437ProVal: 1.437 ± 0.062
0.232ProTrp: 0.232 ± 0.025
1.222ProTyr: 1.222 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.126GlnAla: 2.126 ± 0.07
0.238GlnCys: 0.238 ± 0.022
1.891GlnAsp: 1.891 ± 0.056
2.358GlnGlu: 2.358 ± 0.071
0.774GlnPhe: 0.774 ± 0.041
1.776GlnGly: 1.776 ± 0.062
0.383GlnHis: 0.383 ± 0.027
2.509GlnIle: 2.509 ± 0.076
3.354GlnLys: 3.354 ± 0.093
1.783GlnLeu: 1.783 ± 0.054
0.646GlnMet: 0.646 ± 0.034
2.59GlnAsn: 2.59 ± 0.082
0.427GlnPro: 0.427 ± 0.029
0.63GlnGln: 0.63 ± 0.041
1.421GlnArg: 1.421 ± 0.044
2.373GlnSer: 2.373 ± 0.076
1.381GlnThr: 1.381 ± 0.053
1.372GlnVal: 1.372 ± 0.048
0.169GlnTrp: 0.169 ± 0.021
0.77GlnTyr: 0.77 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.733ArgAla: 2.733 ± 0.082
0.32ArgCys: 0.32 ± 0.024
1.714ArgAsp: 1.714 ± 0.058
2.019ArgGlu: 2.019 ± 0.077
1.839ArgPhe: 1.839 ± 0.056
1.743ArgGly: 1.743 ± 0.063
0.556ArgHis: 0.556 ± 0.03
2.783ArgIle: 2.783 ± 0.08
2.747ArgLys: 2.747 ± 0.067
3.777ArgLeu: 3.777 ± 0.09
0.808ArgMet: 0.808 ± 0.042
1.467ArgAsn: 1.467 ± 0.049
0.774ArgPro: 0.774 ± 0.039
1.214ArgGln: 1.214 ± 0.047
1.011ArgArg: 1.011 ± 0.048
1.672ArgSer: 1.672 ± 0.065
1.27ArgThr: 1.27 ± 0.052
2.069ArgVal: 2.069 ± 0.067
0.182ArgTrp: 0.182 ± 0.019
1.54ArgTyr: 1.54 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.525SerAla: 4.525 ± 0.114
0.81SerCys: 0.81 ± 0.046
3.538SerAsp: 3.538 ± 0.078
3.655SerGlu: 3.655 ± 0.096
5.593SerPhe: 5.593 ± 0.129
3.917SerGly: 3.917 ± 0.094
1.145SerHis: 1.145 ± 0.046
5.791SerIle: 5.791 ± 0.11
7.632SerLys: 7.632 ± 0.143
9.375SerLeu: 9.375 ± 0.144
1.575SerMet: 1.575 ± 0.059
3.546SerAsn: 3.546 ± 0.097
1.667SerPro: 1.667 ± 0.052
1.849SerGln: 1.849 ± 0.061
1.992SerArg: 1.992 ± 0.062
5.86SerSer: 5.86 ± 0.131
3.048SerThr: 3.048 ± 0.094
3.73SerVal: 3.73 ± 0.092
0.448SerTrp: 0.448 ± 0.029
3.276SerTyr: 3.276 ± 0.084
0.0SerXaa: 0.0 ± 0.0
Thr
2.492ThrAla: 2.492 ± 0.084
0.471ThrCys: 0.471 ± 0.035
1.691ThrAsp: 1.691 ± 0.063
1.632ThrGlu: 1.632 ± 0.066
1.816ThrPhe: 1.816 ± 0.065
2.222ThrGly: 2.222 ± 0.071
0.872ThrHis: 0.872 ± 0.045
2.607ThrIle: 2.607 ± 0.077
3.479ThrLys: 3.479 ± 0.081
4.03ThrLeu: 4.03 ± 0.104
0.851ThrMet: 0.851 ± 0.041
2.458ThrAsn: 2.458 ± 0.08
1.458ThrPro: 1.458 ± 0.053
1.783ThrGln: 1.783 ± 0.065
1.477ThrArg: 1.477 ± 0.059
3.046ThrSer: 3.046 ± 0.083
1.655ThrThr: 1.655 ± 0.069
2.73ThrVal: 2.73 ± 0.067
0.293ThrTrp: 0.293 ± 0.027
1.724ThrTyr: 1.724 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.055ValAla: 4.055 ± 0.105
0.749ValCys: 0.749 ± 0.035
3.255ValAsp: 3.255 ± 0.096
3.105ValGlu: 3.105 ± 0.073
3.714ValPhe: 3.714 ± 0.083
3.186ValGly: 3.186 ± 0.085
0.73ValHis: 0.73 ± 0.036
3.925ValIle: 3.925 ± 0.093
4.729ValLys: 4.729 ± 0.088
6.484ValLeu: 6.484 ± 0.115
1.105ValMet: 1.105 ± 0.054
2.95ValAsn: 2.95 ± 0.08
1.517ValPro: 1.517 ± 0.056
1.306ValGln: 1.306 ± 0.047
1.743ValArg: 1.743 ± 0.061
4.103ValSer: 4.103 ± 0.099
1.477ValThr: 1.477 ± 0.058
3.634ValVal: 3.634 ± 0.099
0.268ValTrp: 0.268 ± 0.023
1.854ValTyr: 1.854 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.408TrpAla: 0.408 ± 0.03
0.075TrpCys: 0.075 ± 0.011
0.324TrpAsp: 0.324 ± 0.025
0.291TrpGlu: 0.291 ± 0.024
0.322TrpPhe: 0.322 ± 0.025
0.408TrpGly: 0.408 ± 0.032
0.176TrpHis: 0.176 ± 0.019
0.442TrpIle: 0.442 ± 0.031
0.287TrpLys: 0.287 ± 0.026
0.774TrpLeu: 0.774 ± 0.043
0.111TrpMet: 0.111 ± 0.015
0.28TrpAsn: 0.28 ± 0.025
0.077TrpPro: 0.077 ± 0.014
0.402TrpGln: 0.402 ± 0.029
0.19TrpArg: 0.19 ± 0.022
0.301TrpSer: 0.301 ± 0.022
0.174TrpThr: 0.174 ± 0.019
0.301TrpVal: 0.301 ± 0.026
0.109TrpTrp: 0.109 ± 0.014
0.232TrpTyr: 0.232 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.624TyrAla: 2.624 ± 0.084
0.389TyrCys: 0.389 ± 0.027
2.486TyrAsp: 2.486 ± 0.076
3.557TyrGlu: 3.557 ± 0.086
2.504TyrPhe: 2.504 ± 0.077
1.988TyrGly: 1.988 ± 0.07
0.642TyrHis: 0.642 ± 0.038
2.954TyrIle: 2.954 ± 0.085
4.097TyrLys: 4.097 ± 0.093
3.749TyrLeu: 3.749 ± 0.079
0.806TyrMet: 0.806 ± 0.042
1.889TyrAsn: 1.889 ± 0.064
1.186TyrPro: 1.186 ± 0.051
1.031TyrGln: 1.031 ± 0.048
1.153TyrArg: 1.153 ± 0.049
2.377TyrSer: 2.377 ± 0.075
1.781TyrThr: 1.781 ± 0.056
1.68TyrVal: 1.68 ± 0.053
0.205TyrTrp: 0.205 ± 0.022
1.567TyrTyr: 1.567 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1636 proteins (522044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski