Amino acid dipepetide frequency for Yersinia ruckeri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.341AlaAla: 9.341 ± 0.134	1.046AlaCys: 1.046 ± 0.035	4.789AlaAsp: 4.789 ± 0.078	5.867AlaGlu: 5.867 ± 0.077	3.283AlaPhe: 3.283 ± 0.059	6.903AlaGly: 6.903 ± 0.097	1.657AlaHis: 1.657 ± 0.041	5.96AlaIle: 5.96 ± 0.089	4.174AlaLys: 4.174 ± 0.069	11.037AlaLeu: 11.037 ± 0.125	2.686AlaMet: 2.686 ± 0.049	3.386AlaAsn: 3.386 ± 0.067	3.305AlaPro: 3.305 ± 0.066	4.164AlaGln: 4.164 ± 0.077	4.669AlaArg: 4.669 ± 0.072	5.206AlaSer: 5.206 ± 0.08	4.707AlaThr: 4.707 ± 0.113	6.301AlaVal: 6.301 ± 0.083	1.139AlaTrp: 1.139 ± 0.029	2.262AlaTyr: 2.262 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.886CysAla: 0.886 ± 0.028	0.188CysCys: 0.188 ± 0.013	0.529CysAsp: 0.529 ± 0.023	0.558CysGlu: 0.558 ± 0.024	0.429CysPhe: 0.429 ± 0.017	1.025CysGly: 1.025 ± 0.031	0.373CysHis: 0.373 ± 0.023	0.593CysIle: 0.593 ± 0.022	0.338CysLys: 0.338 ± 0.018	1.042CysLeu: 1.042 ± 0.032	0.246CysMet: 0.246 ± 0.015	0.352CysAsn: 0.352 ± 0.019	0.466CysPro: 0.466 ± 0.025	0.533CysGln: 0.533 ± 0.024	0.607CysArg: 0.607 ± 0.023	0.703CysSer: 0.703 ± 0.026	0.483CysThr: 0.483 ± 0.021	0.705CysVal: 0.705 ± 0.029	0.185CysTrp: 0.185 ± 0.014	0.364CysTyr: 0.364 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.622AspAla: 4.622 ± 0.07	0.531AspCys: 0.531 ± 0.021	2.694AspAsp: 2.694 ± 0.058	3.369AspGlu: 3.369 ± 0.066	2.184AspPhe: 2.184 ± 0.042	3.628AspGly: 3.628 ± 0.065	1.062AspHis: 1.062 ± 0.034	3.808AspIle: 3.808 ± 0.062	2.696AspLys: 2.696 ± 0.068	5.016AspLeu: 5.016 ± 0.078	1.339AspMet: 1.339 ± 0.037	2.383AspAsn: 2.383 ± 0.044	2.038AspPro: 2.038 ± 0.041	1.954AspGln: 1.954 ± 0.045	2.67AspArg: 2.67 ± 0.054	3.063AspSer: 3.063 ± 0.059	2.433AspThr: 2.433 ± 0.049	3.563AspVal: 3.563 ± 0.06	0.804AspTrp: 0.804 ± 0.032	1.912AspTyr: 1.912 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.705GluAla: 4.705 ± 0.07	0.49GluCys: 0.49 ± 0.026	2.358GluAsp: 2.358 ± 0.055	3.109GluGlu: 3.109 ± 0.067	1.909GluPhe: 1.909 ± 0.042	3.187GluGly: 3.187 ± 0.063	1.376GluHis: 1.376 ± 0.035	3.537GluIle: 3.537 ± 0.066	3.273GluLys: 3.273 ± 0.068	6.192GluLeu: 6.192 ± 0.086	1.77GluMet: 1.77 ± 0.041	2.536GluAsn: 2.536 ± 0.049	1.999GluPro: 1.999 ± 0.043	3.605GluGln: 3.605 ± 0.072	3.624GluArg: 3.624 ± 0.074	3.065GluSer: 3.065 ± 0.058	2.841GluThr: 2.841 ± 0.054	3.701GluVal: 3.701 ± 0.073	0.738GluTrp: 0.738 ± 0.029	1.456GluTyr: 1.456 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.356PheAla: 3.356 ± 0.066	0.557PheCys: 0.557 ± 0.02	2.359PheAsp: 2.359 ± 0.049	1.78PheGlu: 1.78 ± 0.04	1.675PhePhe: 1.675 ± 0.047	3.044PheGly: 3.044 ± 0.058	0.785PheHis: 0.785 ± 0.03	2.787PheIle: 2.787 ± 0.065	1.435PheLys: 1.435 ± 0.037	3.301PheLeu: 3.301 ± 0.065	0.977PheMet: 0.977 ± 0.028	1.891PheAsn: 1.891 ± 0.046	1.506PhePro: 1.506 ± 0.036	1.17PheGln: 1.17 ± 0.035	1.831PheArg: 1.831 ± 0.039	3.283PheSer: 3.283 ± 0.056	2.292PheThr: 2.292 ± 0.054	2.36PheVal: 2.36 ± 0.054	0.534PheTrp: 0.534 ± 0.022	1.341PheTyr: 1.341 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.644GlyAla: 5.644 ± 0.092	0.911GlyCys: 0.911 ± 0.029	3.535GlyAsp: 3.535 ± 0.068	4.243GlyGlu: 4.243 ± 0.065	3.108GlyPhe: 3.108 ± 0.061	5.071GlyGly: 5.071 ± 0.096	1.654GlyHis: 1.654 ± 0.046	5.121GlyIle: 5.121 ± 0.076	3.947GlyLys: 3.947 ± 0.069	7.301GlyLeu: 7.301 ± 0.093	2.238GlyMet: 2.238 ± 0.048	2.724GlyAsn: 2.724 ± 0.058	1.819GlyPro: 1.819 ± 0.041	3.007GlyGln: 3.007 ± 0.057	3.644GlyArg: 3.644 ± 0.066	4.333GlySer: 4.333 ± 0.08	3.608GlyThr: 3.608 ± 0.065	5.469GlyVal: 5.469 ± 0.088	1.142GlyTrp: 1.142 ± 0.04	2.504GlyTyr: 2.504 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.761HisAla: 1.761 ± 0.035	0.352HisCys: 0.352 ± 0.018	1.09HisAsp: 1.09 ± 0.035	1.066HisGlu: 1.066 ± 0.032	1.072HisPhe: 1.072 ± 0.031	1.642HisGly: 1.642 ± 0.043	0.77HisHis: 0.77 ± 0.028	1.416HisIle: 1.416 ± 0.036	0.841HisLys: 0.841 ± 0.029	2.399HisLeu: 2.399 ± 0.053	0.547HisMet: 0.547 ± 0.022	0.882HisAsn: 0.882 ± 0.028	1.275HisPro: 1.275 ± 0.035	1.4HisGln: 1.4 ± 0.044	1.295HisArg: 1.295 ± 0.036	1.368HisSer: 1.368 ± 0.047	1.062HisThr: 1.062 ± 0.031	1.157HisVal: 1.157 ± 0.038	0.439HisTrp: 0.439 ± 0.022	0.864HisTyr: 0.864 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.329IleAla: 6.329 ± 0.079	0.673IleCys: 0.673 ± 0.024	3.841IleAsp: 3.841 ± 0.061	3.713IleGlu: 3.713 ± 0.067	2.26IlePhe: 2.26 ± 0.056	4.782IleGly: 4.782 ± 0.076	1.264IleHis: 1.264 ± 0.039	3.839IleIle: 3.839 ± 0.079	2.878IleLys: 2.878 ± 0.052	5.737IleLeu: 5.737 ± 0.083	1.401IleMet: 1.401 ± 0.039	3.054IleAsn: 3.054 ± 0.059	2.967IlePro: 2.967 ± 0.052	2.244IleGln: 2.244 ± 0.056	3.222IleArg: 3.222 ± 0.063	4.512IleSer: 4.512 ± 0.074	3.767IleThr: 3.767 ± 0.062	3.799IleVal: 3.799 ± 0.064	0.707IleTrp: 0.707 ± 0.028	1.753IleTyr: 1.753 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.015LysAla: 4.015 ± 0.069	0.25LysCys: 0.25 ± 0.018	2.242LysAsp: 2.242 ± 0.052	2.508LysGlu: 2.508 ± 0.057	1.219LysPhe: 1.219 ± 0.032	2.908LysGly: 2.908 ± 0.06	0.928LysHis: 0.928 ± 0.033	2.814LysIle: 2.814 ± 0.056	2.619LysLys: 2.619 ± 0.06	4.763LysLeu: 4.763 ± 0.072	1.35LysMet: 1.35 ± 0.034	2.198LysAsn: 2.198 ± 0.053	2.194LysPro: 2.194 ± 0.043	2.31LysGln: 2.31 ± 0.049	2.56LysArg: 2.56 ± 0.052	2.636LysSer: 2.636 ± 0.048	2.626LysThr: 2.626 ± 0.053	3.152LysVal: 3.152 ± 0.059	0.462LysTrp: 0.462 ± 0.02	1.21LysTyr: 1.21 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.373LeuAla: 11.373 ± 0.131	1.259LeuCys: 1.259 ± 0.038	5.749LeuAsp: 5.749 ± 0.082	5.356LeuGlu: 5.356 ± 0.082	4.221LeuPhe: 4.221 ± 0.075	7.371LeuGly: 7.371 ± 0.094	2.279LeuHis: 2.279 ± 0.047	6.364LeuIle: 6.364 ± 0.085	4.75LeuLys: 4.75 ± 0.081	12.419LeuLeu: 12.419 ± 0.16	2.967LeuMet: 2.967 ± 0.059	4.505LeuAsn: 4.505 ± 0.073	5.821LeuPro: 5.821 ± 0.077	4.624LeuGln: 4.624 ± 0.082	5.914LeuArg: 5.914 ± 0.089	7.939LeuSer: 7.939 ± 0.088	6.377LeuThr: 6.377 ± 0.098	7.232LeuVal: 7.232 ± 0.1	1.324LeuTrp: 1.324 ± 0.039	2.708LeuTyr: 2.708 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.842MetAla: 2.842 ± 0.053	0.2MetCys: 0.2 ± 0.013	1.199MetAsp: 1.199 ± 0.031	1.249MetGlu: 1.249 ± 0.033	0.866MetPhe: 0.866 ± 0.032	1.857MetGly: 1.857 ± 0.042	0.515MetHis: 0.515 ± 0.025	1.602MetIle: 1.602 ± 0.037	1.316MetLys: 1.316 ± 0.031	3.179MetLeu: 3.179 ± 0.058	0.852MetMet: 0.852 ± 0.028	1.102MetAsn: 1.102 ± 0.036	1.283MetPro: 1.283 ± 0.032	1.182MetGln: 1.182 ± 0.03	1.449MetArg: 1.449 ± 0.038	1.815MetSer: 1.815 ± 0.037	1.775MetThr: 1.775 ± 0.035	1.946MetVal: 1.946 ± 0.041	0.209MetTrp: 0.209 ± 0.014	0.526MetTyr: 0.526 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.457AsnAla: 3.457 ± 0.058	0.339AsnCys: 0.339 ± 0.016	2.168AsnAsp: 2.168 ± 0.049	2.056AsnGlu: 2.056 ± 0.043	1.371AsnPhe: 1.371 ± 0.035	3.11AsnGly: 3.11 ± 0.08	0.968AsnHis: 0.968 ± 0.028	2.702AsnIle: 2.702 ± 0.054	1.973AsnLys: 1.973 ± 0.049	3.946AsnLeu: 3.946 ± 0.068	1.024AsnMet: 1.024 ± 0.031	1.987AsnAsn: 1.987 ± 0.051	2.169AsnPro: 2.169 ± 0.046	1.959AsnGln: 1.959 ± 0.046	2.217AsnArg: 2.217 ± 0.052	2.446AsnSer: 2.446 ± 0.052	2.269AsnThr: 2.269 ± 0.05	2.444AsnVal: 2.444 ± 0.044	0.575AsnTrp: 0.575 ± 0.026	1.285AsnTyr: 1.285 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	4.124ProAla: 4.124 ± 0.075	0.37ProCys: 0.37 ± 0.019	2.572ProAsp: 2.572 ± 0.054	3.252ProGlu: 3.252 ± 0.055	1.749ProPhe: 1.749 ± 0.038	2.926ProGly: 2.926 ± 0.055	0.972ProHis: 0.972 ± 0.032	2.411ProIle: 2.411 ± 0.051	1.668ProLys: 1.668 ± 0.042	5.106ProLeu: 5.106 ± 0.082	1.105ProMet: 1.105 ± 0.033	1.483ProAsn: 1.483 ± 0.035	1.643ProPro: 1.643 ± 0.041	2.188ProGln: 2.188 ± 0.048	1.839ProArg: 1.839 ± 0.041	2.326ProSer: 2.326 ± 0.05	2.381ProThr: 2.381 ± 0.046	3.536ProVal: 3.536 ± 0.071	0.58ProTrp: 0.58 ± 0.024	1.309ProTyr: 1.309 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.627GlnAla: 4.627 ± 0.072	0.43GlnCys: 0.43 ± 0.019	2.109GlnAsp: 2.109 ± 0.049	2.224GlnGlu: 2.224 ± 0.052	1.598GlnPhe: 1.598 ± 0.044	3.281GlnGly: 3.281 ± 0.059	1.338GlnHis: 1.338 ± 0.044	2.574GlnIle: 2.574 ± 0.048	1.885GlnLys: 1.885 ± 0.046	5.64GlnLeu: 5.64 ± 0.079	1.212GlnMet: 1.212 ± 0.03	1.544GlnAsn: 1.544 ± 0.042	2.367GlnPro: 2.367 ± 0.059	4.039GlnGln: 4.039 ± 0.106	3.284GlnArg: 3.284 ± 0.065	2.634GlnSer: 2.634 ± 0.049	2.187GlnThr: 2.187 ± 0.051	3.362GlnVal: 3.362 ± 0.053	0.694GlnTrp: 0.694 ± 0.028	1.202GlnTyr: 1.202 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	4.289ArgAla: 4.289 ± 0.059	0.579ArgCys: 0.579 ± 0.022	2.865ArgAsp: 2.865 ± 0.051	3.35ArgGlu: 3.35 ± 0.058	2.447ArgPhe: 2.447 ± 0.051	3.179ArgGly: 3.179 ± 0.065	1.532ArgHis: 1.532 ± 0.042	3.49ArgIle: 3.49 ± 0.056	2.354ArgLys: 2.354 ± 0.045	6.402ArgLeu: 6.402 ± 0.101	1.516ArgMet: 1.516 ± 0.032	2.058ArgAsn: 2.058 ± 0.049	2.133ArgPro: 2.133 ± 0.05	3.25ArgGln: 3.25 ± 0.058	3.349ArgArg: 3.349 ± 0.068	2.797ArgSer: 2.797 ± 0.047	2.46ArgThr: 2.46 ± 0.047	3.606ArgVal: 3.606 ± 0.058	0.876ArgTrp: 0.876 ± 0.031	2.106ArgTyr: 2.106 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.658SerAla: 5.658 ± 0.08	0.625SerCys: 0.625 ± 0.024	3.284SerAsp: 3.284 ± 0.059	3.338SerGlu: 3.338 ± 0.057	2.473SerPhe: 2.473 ± 0.054	5.328SerGly: 5.328 ± 0.086	1.605SerHis: 1.605 ± 0.035	3.582SerIle: 3.582 ± 0.066	2.391SerLys: 2.391 ± 0.055	7.204SerLeu: 7.204 ± 0.087	1.593SerMet: 1.593 ± 0.042	2.174SerAsn: 2.174 ± 0.048	2.646SerPro: 2.646 ± 0.053	2.856SerGln: 2.856 ± 0.055	3.408SerArg: 3.408 ± 0.053	3.942SerSer: 3.942 ± 0.069	3.162SerThr: 3.162 ± 0.06	4.304SerVal: 4.304 ± 0.062	0.943SerTrp: 0.943 ± 0.029	1.839SerTyr: 1.839 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	5.101ThrAla: 5.101 ± 0.122	0.48ThrCys: 0.48 ± 0.022	2.73ThrAsp: 2.73 ± 0.05	2.928ThrGlu: 2.928 ± 0.057	1.984ThrPhe: 1.984 ± 0.041	4.12ThrGly: 4.12 ± 0.075	1.228ThrHis: 1.228 ± 0.033	3.012ThrIle: 3.012 ± 0.061	1.778ThrLys: 1.778 ± 0.043	7.271ThrLeu: 7.271 ± 0.096	1.054ThrMet: 1.054 ± 0.032	1.756ThrAsn: 1.756 ± 0.056	3.034ThrPro: 3.034 ± 0.052	2.367ThrGln: 2.367 ± 0.048	2.727ThrArg: 2.727 ± 0.054	3.035ThrSer: 3.035 ± 0.065	2.881ThrThr: 2.881 ± 0.072	3.754ThrVal: 3.754 ± 0.101	0.614ThrTrp: 0.614 ± 0.025	1.353ThrTyr: 1.353 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.474ValAla: 6.474 ± 0.091	0.761ValCys: 0.761 ± 0.027	3.639ValAsp: 3.639 ± 0.054	3.822ValGlu: 3.822 ± 0.066	2.505ValPhe: 2.505 ± 0.05	4.677ValGly: 4.677 ± 0.079	1.22ValHis: 1.22 ± 0.031	4.815ValIle: 4.815 ± 0.066	3.154ValLys: 3.154 ± 0.047	7.037ValLeu: 7.037 ± 0.082	2.061ValMet: 2.061 ± 0.044	2.901ValAsn: 2.901 ± 0.055	2.84ValPro: 2.84 ± 0.046	2.309ValGln: 2.309 ± 0.053	3.451ValArg: 3.451 ± 0.066	4.652ValSer: 4.652 ± 0.071	4.03ValThr: 4.03 ± 0.088	5.274ValVal: 5.274 ± 0.09	0.788ValTrp: 0.788 ± 0.027	1.743ValTyr: 1.743 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.906TrpAla: 0.906 ± 0.033	0.167TrpCys: 0.167 ± 0.012	0.549TrpAsp: 0.549 ± 0.021	0.516TrpGlu: 0.516 ± 0.02	0.61TrpPhe: 0.61 ± 0.024	0.824TrpGly: 0.824 ± 0.03	0.397TrpHis: 0.397 ± 0.017	0.725TrpIle: 0.725 ± 0.025	0.489TrpLys: 0.489 ± 0.023	2.148TrpLeu: 2.148 ± 0.053	0.364TrpMet: 0.364 ± 0.02	0.446TrpAsn: 0.446 ± 0.022	0.609TrpPro: 0.609 ± 0.025	1.155TrpGln: 1.155 ± 0.037	0.906TrpArg: 0.906 ± 0.03	0.745TrpSer: 0.745 ± 0.027	0.434TrpThr: 0.434 ± 0.023	0.906TrpVal: 0.906 ± 0.032	0.226TrpTrp: 0.226 ± 0.014	0.349TrpTyr: 0.349 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.372TyrAla: 2.372 ± 0.052	0.399TyrCys: 0.399 ± 0.021	1.47TyrAsp: 1.47 ± 0.04	1.165TyrGlu: 1.165 ± 0.034	1.299TyrPhe: 1.299 ± 0.038	2.161TyrGly: 2.161 ± 0.049	0.776TyrHis: 0.776 ± 0.031	1.592TyrIle: 1.592 ± 0.042	1.005TyrLys: 1.005 ± 0.033	3.416TyrLeu: 3.416 ± 0.061	0.657TyrMet: 0.657 ± 0.023	1.104TyrAsn: 1.104 ± 0.035	1.427TyrPro: 1.427 ± 0.035	1.912TyrGln: 1.912 ± 0.045	1.975TyrArg: 1.975 ± 0.041	1.857TyrSer: 1.857 ± 0.04	1.427TyrThr: 1.427 ± 0.035	1.581TyrVal: 1.581 ± 0.047	0.491TyrTrp: 0.491 ± 0.023	0.915TyrTyr: 0.915 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3467 proteins (1084460 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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