Amino acid dipepetide frequency for Neosynechococcus sphagnicola sy1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.961AlaAla: 9.961 ± 0.146	1.026AlaCys: 1.026 ± 0.038	4.553AlaAsp: 4.553 ± 0.093	5.293AlaGlu: 5.293 ± 0.105	3.084AlaPhe: 3.084 ± 0.075	6.041AlaGly: 6.041 ± 0.098	1.725AlaHis: 1.725 ± 0.053	7.11AlaIle: 7.11 ± 0.109	3.147AlaLys: 3.147 ± 0.069	9.978AlaLeu: 9.978 ± 0.137	2.065AlaMet: 2.065 ± 0.062	2.986AlaAsn: 2.986 ± 0.108	3.636AlaPro: 3.636 ± 0.078	4.982AlaGln: 4.982 ± 0.092	4.253AlaArg: 4.253 ± 0.083	4.889AlaSer: 4.889 ± 0.095	5.422AlaThr: 5.422 ± 0.087	6.641AlaVal: 6.641 ± 0.108	1.144AlaTrp: 1.144 ± 0.044	2.484AlaTyr: 2.484 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.71CysAla: 0.71 ± 0.033	0.215CysCys: 0.215 ± 0.02	0.639CysAsp: 0.639 ± 0.031	0.545CysGlu: 0.545 ± 0.027	0.468CysPhe: 0.468 ± 0.028	0.969CysGly: 0.969 ± 0.034	0.341CysHis: 0.341 ± 0.025	0.538CysIle: 0.538 ± 0.031	0.296CysLys: 0.296 ± 0.022	1.383CysLeu: 1.383 ± 0.054	0.212CysMet: 0.212 ± 0.019	0.379CysAsn: 0.379 ± 0.024	0.717CysPro: 0.717 ± 0.036	0.759CysGln: 0.759 ± 0.031	0.709CysArg: 0.709 ± 0.034	0.657CysSer: 0.657 ± 0.033	0.54CysThr: 0.54 ± 0.029	0.643CysVal: 0.643 ± 0.034	0.199CysTrp: 0.199 ± 0.016	0.408CysTyr: 0.408 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.922AspAla: 3.922 ± 0.071	0.58AspCys: 0.58 ± 0.03	1.94AspAsp: 1.94 ± 0.054	2.428AspGlu: 2.428 ± 0.067	2.095AspPhe: 2.095 ± 0.051	3.183AspGly: 3.183 ± 0.071	1.096AspHis: 1.096 ± 0.045	2.59AspIle: 2.59 ± 0.065	1.297AspLys: 1.297 ± 0.045	6.732AspLeu: 6.732 ± 0.103	0.898AspMet: 0.898 ± 0.038	1.281AspAsn: 1.281 ± 0.045	3.108AspPro: 3.108 ± 0.072	2.634AspGln: 2.634 ± 0.065	3.669AspArg: 3.669 ± 0.072	2.482AspSer: 2.482 ± 0.058	2.32AspThr: 2.32 ± 0.065	2.85AspVal: 2.85 ± 0.06	0.967AspTrp: 0.967 ± 0.036	1.756AspTyr: 1.756 ± 0.053	0.001AspXaa: 0.001 ± 0.001
Glu	5.729GluAla: 5.729 ± 0.09	0.429GluCys: 0.429 ± 0.025	2.426GluAsp: 2.426 ± 0.06	3.15GluGlu: 3.15 ± 0.093	2.231GluPhe: 2.231 ± 0.06	3.273GluGly: 3.273 ± 0.077	1.132GluHis: 1.132 ± 0.041	4.032GluIle: 4.032 ± 0.072	2.201GluLys: 2.201 ± 0.064	6.369GluLeu: 6.369 ± 0.101	1.313GluMet: 1.313 ± 0.045	1.779GluAsn: 1.779 ± 0.047	2.512GluPro: 2.512 ± 0.058	3.471GluGln: 3.471 ± 0.08	3.435GluArg: 3.435 ± 0.073	3.095GluSer: 3.095 ± 0.067	3.342GluThr: 3.342 ± 0.088	4.177GluVal: 4.177 ± 0.075	0.756GluTrp: 0.756 ± 0.036	1.399GluTyr: 1.399 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.115PheAla: 3.115 ± 0.071	0.535PheCys: 0.535 ± 0.029	2.06PheAsp: 2.06 ± 0.06	2.085PheGlu: 2.085 ± 0.058	1.455PhePhe: 1.455 ± 0.049	2.698PheGly: 2.698 ± 0.071	0.814PheHis: 0.814 ± 0.036	1.883PheIle: 1.883 ± 0.055	1.212PheLys: 1.212 ± 0.045	4.208PheLeu: 4.208 ± 0.084	0.7PheMet: 0.7 ± 0.031	1.3PheAsn: 1.3 ± 0.047	1.972PhePro: 1.972 ± 0.06	2.027PheGln: 2.027 ± 0.057	1.964PheArg: 1.964 ± 0.052	2.568PheSer: 2.568 ± 0.065	2.138PheThr: 2.138 ± 0.063	2.467PheVal: 2.467 ± 0.063	0.756PheTrp: 0.756 ± 0.041	1.256PheTyr: 1.256 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.745GlyAla: 5.745 ± 0.132	0.996GlyCys: 0.996 ± 0.046	3.553GlyAsp: 3.553 ± 0.084	3.718GlyGlu: 3.718 ± 0.071	3.063GlyPhe: 3.063 ± 0.069	4.942GlyGly: 4.942 ± 0.113	1.461GlyHis: 1.461 ± 0.05	4.751GlyIle: 4.751 ± 0.076	3.112GlyLys: 3.112 ± 0.068	8.176GlyLeu: 8.176 ± 0.151	1.835GlyMet: 1.835 ± 0.053	2.584GlyAsn: 2.584 ± 0.09	1.6GlyPro: 1.6 ± 0.053	3.523GlyGln: 3.523 ± 0.086	3.807GlyArg: 3.807 ± 0.074	4.442GlySer: 4.442 ± 0.091	4.147GlyThr: 4.147 ± 0.099	5.178GlyVal: 5.178 ± 0.093	1.291GlyTrp: 1.291 ± 0.048	2.329GlyTyr: 2.329 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.355HisAla: 1.355 ± 0.048	0.393HisCys: 0.393 ± 0.025	0.887HisAsp: 0.887 ± 0.037	0.91HisGlu: 0.91 ± 0.039	0.953HisPhe: 0.953 ± 0.038	1.405HisGly: 1.405 ± 0.051	0.895HisHis: 0.895 ± 0.044	0.983HisIle: 0.983 ± 0.041	0.511HisLys: 0.511 ± 0.028	3.033HisLeu: 3.033 ± 0.076	0.296HisMet: 0.296 ± 0.02	0.618HisAsn: 0.618 ± 0.029	1.96HisPro: 1.96 ± 0.056	1.567HisGln: 1.567 ± 0.05	1.594HisArg: 1.594 ± 0.045	1.253HisSer: 1.253 ± 0.044	1.128HisThr: 1.128 ± 0.042	0.957HisVal: 0.957 ± 0.04	0.511HisTrp: 0.511 ± 0.028	0.808HisTyr: 0.808 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	7.002IleAla: 7.002 ± 0.103	0.709IleCys: 0.709 ± 0.034	3.164IleAsp: 3.164 ± 0.072	3.437IleGlu: 3.437 ± 0.08	2.233IlePhe: 2.233 ± 0.07	4.259IleGly: 4.259 ± 0.094	1.376IleHis: 1.376 ± 0.045	2.451IleIle: 2.451 ± 0.063	1.799IleLys: 1.799 ± 0.056	6.467IleLeu: 6.467 ± 0.109	0.819IleMet: 0.819 ± 0.035	1.98IleAsn: 1.98 ± 0.062	3.566IlePro: 3.566 ± 0.066	3.17IleGln: 3.17 ± 0.074	3.257IleArg: 3.257 ± 0.073	3.698IleSer: 3.698 ± 0.089	3.211IleThr: 3.211 ± 0.071	3.81IleVal: 3.81 ± 0.078	0.829IleTrp: 0.829 ± 0.033	1.73IleTyr: 1.73 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	3.25LysAla: 3.25 ± 0.08	0.238LysCys: 0.238 ± 0.019	1.54LysAsp: 1.54 ± 0.045	1.732LysGlu: 1.732 ± 0.064	1.271LysPhe: 1.271 ± 0.05	2.088LysGly: 2.088 ± 0.058	0.636LysHis: 0.636 ± 0.035	2.247LysIle: 2.247 ± 0.061	1.352LysLys: 1.352 ± 0.055	4.102LysLeu: 4.102 ± 0.082	0.694LysMet: 0.694 ± 0.033	1.197LysAsn: 1.197 ± 0.043	1.941LysPro: 1.941 ± 0.054	1.999LysGln: 1.999 ± 0.058	2.019LysArg: 2.019 ± 0.056	2.035LysSer: 2.035 ± 0.06	2.277LysThr: 2.277 ± 0.062	2.382LysVal: 2.382 ± 0.061	0.356LysTrp: 0.356 ± 0.023	0.835LysTyr: 0.835 ± 0.038	0.001LysXaa: 0.001 ± 0.001
Leu	10.919LeuAla: 10.919 ± 0.137	1.301LeuCys: 1.301 ± 0.046	5.547LeuAsp: 5.547 ± 0.088	7.5LeuGlu: 7.5 ± 0.123	3.693LeuPhe: 3.693 ± 0.081	8.665LeuGly: 8.665 ± 0.144	2.389LeuHis: 2.389 ± 0.062	6.613LeuIle: 6.613 ± 0.113	4.594LeuLys: 4.594 ± 0.069	12.628LeuLeu: 12.628 ± 0.186	2.6LeuMet: 2.6 ± 0.06	3.989LeuAsn: 3.989 ± 0.085	6.553LeuPro: 6.553 ± 0.107	6.807LeuGln: 6.807 ± 0.118	6.619LeuArg: 6.619 ± 0.111	7.844LeuSer: 7.844 ± 0.105	7.101LeuThr: 7.101 ± 0.108	8.071LeuVal: 8.071 ± 0.123	1.762LeuTrp: 1.762 ± 0.057	2.706LeuTyr: 2.706 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.181MetAla: 2.181 ± 0.059	0.116MetCys: 0.116 ± 0.013	0.958MetAsp: 0.958 ± 0.036	1.108MetGlu: 1.108 ± 0.037	0.522MetPhe: 0.522 ± 0.024	1.713MetGly: 1.713 ± 0.05	0.397MetHis: 0.397 ± 0.027	1.169MetIle: 1.169 ± 0.046	0.849MetLys: 0.849 ± 0.039	2.159MetLeu: 2.159 ± 0.058	0.488MetMet: 0.488 ± 0.028	0.793MetAsn: 0.793 ± 0.037	1.25MetPro: 1.25 ± 0.042	1.126MetGln: 1.126 ± 0.04	1.096MetArg: 1.096 ± 0.038	1.306MetSer: 1.306 ± 0.042	1.527MetThr: 1.527 ± 0.047	1.64MetVal: 1.64 ± 0.052	0.168MetTrp: 0.168 ± 0.014	0.392MetTyr: 0.392 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.581AsnAla: 2.581 ± 0.064	0.438AsnCys: 0.438 ± 0.026	1.34AsnAsp: 1.34 ± 0.074	1.128AsnGlu: 1.128 ± 0.05	1.4AsnPhe: 1.4 ± 0.048	2.164AsnGly: 2.164 ± 0.068	0.837AsnHis: 0.837 ± 0.033	1.72AsnIle: 1.72 ± 0.049	0.802AsnLys: 0.802 ± 0.036	4.758AsnLeu: 4.758 ± 0.124	0.538AsnMet: 0.538 ± 0.029	1.003AsnAsn: 1.003 ± 0.038	2.478AsnPro: 2.478 ± 0.055	2.015AsnGln: 2.015 ± 0.055	2.089AsnArg: 2.089 ± 0.055	1.924AsnSer: 1.924 ± 0.054	1.649AsnThr: 1.649 ± 0.057	1.868AsnVal: 1.868 ± 0.06	0.644AsnTrp: 0.644 ± 0.029	1.004AsnTyr: 1.004 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	4.295ProAla: 4.295 ± 0.077	0.468ProCys: 0.468 ± 0.023	3.399ProAsp: 3.399 ± 0.073	3.877ProGlu: 3.877 ± 0.088	1.739ProPhe: 1.739 ± 0.052	3.759ProGly: 3.759 ± 0.071	1.146ProHis: 1.146 ± 0.044	2.96ProIle: 2.96 ± 0.066	1.755ProLys: 1.755 ± 0.051	5.948ProLeu: 5.948 ± 0.108	1.205ProMet: 1.205 ± 0.041	1.679ProAsn: 1.679 ± 0.054	3.049ProPro: 3.049 ± 0.079	3.117ProGln: 3.117 ± 0.071	2.471ProArg: 2.471 ± 0.058	3.363ProSer: 3.363 ± 0.079	3.35ProThr: 3.35 ± 0.082	3.63ProVal: 3.63 ± 0.071	0.897ProTrp: 0.897 ± 0.035	1.476ProTyr: 1.476 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	5.887GlnAla: 5.887 ± 0.11	0.488GlnCys: 0.488 ± 0.031	2.204GlnAsp: 2.204 ± 0.049	3.274GlnGlu: 3.274 ± 0.084	2.003GlnPhe: 2.003 ± 0.053	4.041GlnGly: 4.041 ± 0.082	1.184GlnHis: 1.184 ± 0.04	3.599GlnIle: 3.599 ± 0.077	1.928GlnLys: 1.928 ± 0.054	6.681GlnLeu: 6.681 ± 0.116	1.19GlnMet: 1.19 ± 0.047	1.505GlnAsn: 1.505 ± 0.05	3.282GlnPro: 3.282 ± 0.077	4.491GlnGln: 4.491 ± 0.133	3.84GlnArg: 3.84 ± 0.086	3.371GlnSer: 3.371 ± 0.072	3.297GlnThr: 3.297 ± 0.089	4.669GlnVal: 4.669 ± 0.1	0.842GlnTrp: 0.842 ± 0.037	1.261GlnTyr: 1.261 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.942ArgAla: 3.942 ± 0.071	0.686ArgCys: 0.686 ± 0.03	2.688ArgAsp: 2.688 ± 0.057	3.276ArgGlu: 3.276 ± 0.069	2.386ArgPhe: 2.386 ± 0.058	3.445ArgGly: 3.445 ± 0.072	1.375ArgHis: 1.375 ± 0.044	3.22ArgIle: 3.22 ± 0.067	2.002ArgLys: 2.002 ± 0.068	7.008ArgLeu: 7.008 ± 0.1	1.337ArgMet: 1.337 ± 0.046	1.815ArgAsn: 1.815 ± 0.051	2.759ArgPro: 2.759 ± 0.076	4.019ArgGln: 4.019 ± 0.08	3.647ArgArg: 3.647 ± 0.077	3.787ArgSer: 3.787 ± 0.081	2.656ArgThr: 2.656 ± 0.057	3.988ArgVal: 3.988 ± 0.076	1.083ArgTrp: 1.083 ± 0.042	1.954ArgTyr: 1.954 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.653SerAla: 4.653 ± 0.086	0.627SerCys: 0.627 ± 0.032	2.907SerAsp: 2.907 ± 0.069	3.254SerGlu: 3.254 ± 0.085	2.25SerPhe: 2.25 ± 0.055	4.903SerGly: 4.903 ± 0.107	1.53SerHis: 1.53 ± 0.053	3.221SerIle: 3.221 ± 0.075	1.913SerLys: 1.913 ± 0.06	7.413SerLeu: 7.413 ± 0.113	1.294SerMet: 1.294 ± 0.045	2.013SerAsn: 2.013 ± 0.057	3.877SerPro: 3.877 ± 0.067	3.66SerGln: 3.66 ± 0.088	3.383SerArg: 3.383 ± 0.078	3.92SerSer: 3.92 ± 0.092	3.287SerThr: 3.287 ± 0.078	3.789SerVal: 3.789 ± 0.064	0.895SerTrp: 0.895 ± 0.033	1.623SerTyr: 1.623 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.539ThrAla: 5.539 ± 0.099	0.651ThrCys: 0.651 ± 0.036	2.643ThrAsp: 2.643 ± 0.064	2.986ThrGlu: 2.986 ± 0.067	1.951ThrPhe: 1.951 ± 0.057	4.267ThrGly: 4.267 ± 0.1	1.405ThrHis: 1.405 ± 0.041	3.342ThrIle: 3.342 ± 0.069	1.517ThrLys: 1.517 ± 0.05	7.338ThrLeu: 7.338 ± 0.107	0.963ThrMet: 0.963 ± 0.039	1.634ThrAsn: 1.634 ± 0.047	3.758ThrPro: 3.758 ± 0.087	3.072ThrGln: 3.072 ± 0.08	2.548ThrArg: 2.548 ± 0.065	3.131ThrSer: 3.131 ± 0.075	3.579ThrThr: 3.579 ± 0.083	4.292ThrVal: 4.292 ± 0.08	0.865ThrTrp: 0.865 ± 0.037	1.669ThrTyr: 1.669 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	6.455ValAla: 6.455 ± 0.091	0.824ValCys: 0.824 ± 0.036	3.339ValAsp: 3.339 ± 0.059	4.241ValGlu: 4.241 ± 0.084	2.597ValPhe: 2.597 ± 0.065	5.127ValGly: 5.127 ± 0.098	1.187ValHis: 1.187 ± 0.04	4.363ValIle: 4.363 ± 0.086	2.591ValLys: 2.591 ± 0.069	7.649ValLeu: 7.649 ± 0.124	1.652ValMet: 1.652 ± 0.054	2.457ValAsn: 2.457 ± 0.065	3.359ValPro: 3.359 ± 0.066	3.3ValGln: 3.3 ± 0.07	3.645ValArg: 3.645 ± 0.073	4.223ValSer: 4.223 ± 0.089	4.109ValThr: 4.109 ± 0.072	5.356ValVal: 5.356 ± 0.088	0.93ValTrp: 0.93 ± 0.035	1.756ValTyr: 1.756 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.03TrpAla: 1.03 ± 0.042	0.187TrpCys: 0.187 ± 0.018	0.661TrpAsp: 0.661 ± 0.035	0.874TrpGlu: 0.874 ± 0.039	0.613TrpPhe: 0.613 ± 0.031	1.124TrpGly: 1.124 ± 0.041	0.38TrpHis: 0.38 ± 0.026	0.848TrpIle: 0.848 ± 0.039	0.537TrpLys: 0.537 ± 0.033	2.267TrpLeu: 2.267 ± 0.072	0.413TrpMet: 0.413 ± 0.025	0.518TrpAsn: 0.518 ± 0.028	0.486TrpPro: 0.486 ± 0.027	1.41TrpGln: 1.41 ± 0.048	0.931TrpArg: 0.931 ± 0.039	0.895TrpSer: 0.895 ± 0.039	0.637TrpThr: 0.637 ± 0.03	1.178TrpVal: 1.178 ± 0.052	0.28TrpTrp: 0.28 ± 0.026	0.4TrpTyr: 0.4 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.145TyrAla: 2.145 ± 0.061	0.42TyrCys: 0.42 ± 0.025	1.382TyrAsp: 1.382 ± 0.045	1.438TyrGlu: 1.438 ± 0.047	1.205TyrPhe: 1.205 ± 0.04	2.19TyrGly: 2.19 ± 0.05	0.71TyrHis: 0.71 ± 0.039	1.326TyrIle: 1.326 ± 0.043	0.776TyrLys: 0.776 ± 0.037	3.606TyrLeu: 3.606 ± 0.072	0.446TyrMet: 0.446 ± 0.024	0.87TyrAsn: 0.87 ± 0.037	1.719TyrPro: 1.719 ± 0.047	1.887TyrGln: 1.887 ± 0.052	2.095TyrArg: 2.095 ± 0.057	1.531TyrSer: 1.531 ± 0.053	1.432TyrThr: 1.432 ± 0.046	1.575TyrVal: 1.575 ± 0.054	0.494TyrTrp: 0.494 ± 0.025	0.951TyrTyr: 0.951 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2723 proteins (696927 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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