Amino acid dipepetide frequency for Candidatus Termititenax spirochaetophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.341AlaAla: 9.341 ± 0.684
0.593AlaCys: 0.593 ± 0.147
5.93AlaAsp: 5.93 ± 0.446
7.621AlaGlu: 7.621 ± 0.562
3.143AlaPhe: 3.143 ± 0.349
6.375AlaGly: 6.375 ± 0.341
1.483AlaHis: 1.483 ± 0.244
4.062AlaIle: 4.062 ± 0.387
6.583AlaLys: 6.583 ± 0.379
8.184AlaLeu: 8.184 ± 0.518
1.631AlaMet: 1.631 ± 0.186
2.876AlaAsn: 2.876 ± 0.278
2.58AlaPro: 2.58 ± 0.281
3.41AlaGln: 3.41 ± 0.327
4.181AlaArg: 4.181 ± 0.358
4.27AlaSer: 4.27 ± 0.406
2.461AlaThr: 2.461 ± 0.28
7.235AlaVal: 7.235 ± 0.444
0.445AlaTrp: 0.445 ± 0.126
2.432AlaTyr: 2.432 ± 0.291
0.0AlaXaa: 0.0 ± 0.0
Cys
1.216CysAla: 1.216 ± 0.216
0.119CysCys: 0.119 ± 0.068
0.237CysAsp: 0.237 ± 0.075
0.385CysGlu: 0.385 ± 0.102
0.237CysPhe: 0.237 ± 0.075
0.949CysGly: 0.949 ± 0.19
0.267CysHis: 0.267 ± 0.082
0.563CysIle: 0.563 ± 0.108
0.534CysLys: 0.534 ± 0.136
0.771CysLeu: 0.771 ± 0.165
0.237CysMet: 0.237 ± 0.088
0.237CysAsn: 0.237 ± 0.092
0.919CysPro: 0.919 ± 0.199
0.385CysGln: 0.385 ± 0.117
0.801CysArg: 0.801 ± 0.172
0.534CysSer: 0.534 ± 0.126
0.534CysThr: 0.534 ± 0.125
0.504CysVal: 0.504 ± 0.112
0.089CysTrp: 0.089 ± 0.047
0.356CysTyr: 0.356 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
3.944AspAla: 3.944 ± 0.364
0.474AspCys: 0.474 ± 0.127
2.461AspAsp: 2.461 ± 0.327
2.55AspGlu: 2.55 ± 0.305
3.054AspPhe: 3.054 ± 0.349
3.321AspGly: 3.321 ± 0.302
1.186AspHis: 1.186 ± 0.173
3.736AspIle: 3.736 ± 0.303
3.944AspLys: 3.944 ± 0.36
5.842AspLeu: 5.842 ± 0.482
1.275AspMet: 1.275 ± 0.191
2.698AspAsn: 2.698 ± 0.283
1.957AspPro: 1.957 ± 0.22
1.69AspGln: 1.69 ± 0.238
2.698AspArg: 2.698 ± 0.276
3.647AspSer: 3.647 ± 0.373
2.728AspThr: 2.728 ± 0.301
3.262AspVal: 3.262 ± 0.343
0.682AspTrp: 0.682 ± 0.125
2.669AspTyr: 2.669 ± 0.388
0.0AspXaa: 0.0 ± 0.0
Glu
5.367GluAla: 5.367 ± 0.447
0.445GluCys: 0.445 ± 0.134
2.906GluAsp: 2.906 ± 0.252
3.796GluGlu: 3.796 ± 0.372
2.965GluPhe: 2.965 ± 0.295
3.114GluGly: 3.114 ± 0.291
1.216GluHis: 1.216 ± 0.175
5.248GluIle: 5.248 ± 0.533
5.901GluLys: 5.901 ± 0.587
7.057GluLeu: 7.057 ± 0.535
1.216GluMet: 1.216 ± 0.201
3.291GluAsn: 3.291 ± 0.417
1.364GluPro: 1.364 ± 0.22
3.321GluGln: 3.321 ± 0.391
2.461GluArg: 2.461 ± 0.381
2.847GluSer: 2.847 ± 0.292
2.936GluThr: 2.936 ± 0.31
4.715GluVal: 4.715 ± 0.427
0.771GluTrp: 0.771 ± 0.155
2.847GluTyr: 2.847 ± 0.322
0.0GluXaa: 0.0 ± 0.0
Phe
3.884PheAla: 3.884 ± 0.414
0.86PheCys: 0.86 ± 0.142
2.046PheAsp: 2.046 ± 0.259
1.957PheGlu: 1.957 ± 0.23
2.55PhePhe: 2.55 ± 0.493
2.491PheGly: 2.491 ± 0.281
0.83PheHis: 0.83 ± 0.223
2.194PheIle: 2.194 ± 0.279
2.313PheLys: 2.313 ± 0.284
4.566PheLeu: 4.566 ± 0.418
1.127PheMet: 1.127 ± 0.164
1.838PheAsn: 1.838 ± 0.227
1.809PhePro: 1.809 ± 0.217
1.542PheGln: 1.542 ± 0.251
2.254PheArg: 2.254 ± 0.286
2.965PheSer: 2.965 ± 0.321
2.313PheThr: 2.313 ± 0.235
2.669PheVal: 2.669 ± 0.289
0.534PheTrp: 0.534 ± 0.12
1.542PheTyr: 1.542 ± 0.209
0.0PheXaa: 0.0 ± 0.0
Gly
5.071GlyAla: 5.071 ± 0.445
0.83GlyCys: 0.83 ± 0.136
3.647GlyAsp: 3.647 ± 0.397
3.143GlyGlu: 3.143 ± 0.309
3.084GlyPhe: 3.084 ± 0.352
4.566GlyGly: 4.566 ± 0.49
1.69GlyHis: 1.69 ± 0.221
4.211GlyIle: 4.211 ± 0.414
5.842GlyLys: 5.842 ± 0.473
6.108GlyLeu: 6.108 ± 0.396
1.69GlyMet: 1.69 ± 0.26
2.758GlyAsn: 2.758 ± 0.259
1.245GlyPro: 1.245 ± 0.195
2.906GlyGln: 2.906 ± 0.282
3.618GlyArg: 3.618 ± 0.33
3.796GlySer: 3.796 ± 0.35
3.647GlyThr: 3.647 ± 0.352
4.774GlyVal: 4.774 ± 0.345
0.652GlyTrp: 0.652 ± 0.224
2.965GlyTyr: 2.965 ± 0.3
0.0GlyXaa: 0.0 ± 0.0
His
1.69HisAla: 1.69 ± 0.252
0.237HisCys: 0.237 ± 0.086
0.949HisAsp: 0.949 ± 0.157
0.949HisGlu: 0.949 ± 0.181
0.682HisPhe: 0.682 ± 0.124
1.72HisGly: 1.72 ± 0.201
0.356HisHis: 0.356 ± 0.104
1.394HisIle: 1.394 ± 0.193
1.364HisLys: 1.364 ± 0.21
1.216HisLeu: 1.216 ± 0.197
0.385HisMet: 0.385 ± 0.11
1.097HisAsn: 1.097 ± 0.152
0.949HisPro: 0.949 ± 0.236
0.741HisGln: 0.741 ± 0.16
0.771HisArg: 0.771 ± 0.181
1.245HisSer: 1.245 ± 0.171
1.275HisThr: 1.275 ± 0.207
0.741HisVal: 0.741 ± 0.149
0.267HisTrp: 0.267 ± 0.087
0.741HisTyr: 0.741 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
6.049IleAla: 6.049 ± 0.486
0.623IleCys: 0.623 ± 0.155
4.596IleAsp: 4.596 ± 0.38
4.448IleGlu: 4.448 ± 0.426
3.588IlePhe: 3.588 ± 0.309
4.24IleGly: 4.24 ± 0.38
1.097IleHis: 1.097 ± 0.183
5.753IleIle: 5.753 ± 0.39
5.189IleLys: 5.189 ± 0.388
5.753IleLeu: 5.753 ± 0.496
1.275IleMet: 1.275 ± 0.209
3.41IleAsn: 3.41 ± 0.316
2.847IlePro: 2.847 ± 0.323
1.779IleGln: 1.779 ± 0.246
3.114IleArg: 3.114 ± 0.321
4.3IleSer: 4.3 ± 0.362
3.469IleThr: 3.469 ± 0.28
4.448IleVal: 4.448 ± 0.462
0.504IleTrp: 0.504 ± 0.104
2.995IleTyr: 2.995 ± 0.347
0.0IleXaa: 0.0 ± 0.0
Lys
5.189LysAla: 5.189 ± 0.433
0.415LysCys: 0.415 ± 0.125
4.448LysAsp: 4.448 ± 0.362
5.545LysGlu: 5.545 ± 0.51
2.283LysPhe: 2.283 ± 0.263
4.033LysGly: 4.033 ± 0.379
1.186LysHis: 1.186 ± 0.226
7.146LysIle: 7.146 ± 0.528
6.286LysLys: 6.286 ± 0.674
6.879LysLeu: 6.879 ± 0.507
1.957LysMet: 1.957 ± 0.241
4.566LysAsn: 4.566 ± 0.346
2.995LysPro: 2.995 ± 0.273
3.232LysGln: 3.232 ± 0.33
3.173LysArg: 3.173 ± 0.284
3.914LysSer: 3.914 ± 0.302
4.626LysThr: 4.626 ± 0.398
4.418LysVal: 4.418 ± 0.431
0.297LysTrp: 0.297 ± 0.114
3.469LysTyr: 3.469 ± 0.4
0.0LysXaa: 0.0 ± 0.0
Leu
8.57LeuAla: 8.57 ± 0.558
0.919LeuCys: 0.919 ± 0.18
4.982LeuAsp: 4.982 ± 0.444
6.435LeuGlu: 6.435 ± 0.513
3.707LeuPhe: 3.707 ± 0.306
6.286LeuGly: 6.286 ± 0.447
1.661LeuHis: 1.661 ± 0.24
6.168LeuIle: 6.168 ± 0.464
7.472LeuLys: 7.472 ± 0.513
10.497LeuLeu: 10.497 ± 0.693
2.194LeuMet: 2.194 ± 0.26
4.655LeuAsn: 4.655 ± 0.431
4.952LeuPro: 4.952 ± 0.397
3.825LeuGln: 3.825 ± 0.372
5.426LeuArg: 5.426 ± 0.458
6.257LeuSer: 6.257 ± 0.534
5.337LeuThr: 5.337 ± 0.414
5.664LeuVal: 5.664 ± 0.558
0.801LeuTrp: 0.801 ± 0.138
2.876LeuTyr: 2.876 ± 0.259
0.0LeuXaa: 0.0 ± 0.0
Met
1.453MetAla: 1.453 ± 0.254
0.148MetCys: 0.148 ± 0.068
0.86MetAsp: 0.86 ± 0.132
0.801MetGlu: 0.801 ± 0.146
0.86MetPhe: 0.86 ± 0.148
1.216MetGly: 1.216 ± 0.195
0.534MetHis: 0.534 ± 0.131
1.305MetIle: 1.305 ± 0.195
1.156MetLys: 1.156 ± 0.156
2.224MetLeu: 2.224 ± 0.278
0.356MetMet: 0.356 ± 0.097
0.801MetAsn: 0.801 ± 0.134
1.779MetPro: 1.779 ± 0.25
1.186MetGln: 1.186 ± 0.222
0.712MetArg: 0.712 ± 0.173
1.512MetSer: 1.512 ± 0.207
1.127MetThr: 1.127 ± 0.166
1.483MetVal: 1.483 ± 0.225
0.148MetTrp: 0.148 ± 0.054
0.712MetTyr: 0.712 ± 0.148
0.0MetXaa: 0.0 ± 0.0
Asn
3.202AsnAla: 3.202 ± 0.281
0.593AsnCys: 0.593 ± 0.127
2.105AsnAsp: 2.105 ± 0.269
2.491AsnGlu: 2.491 ± 0.244
2.313AsnPhe: 2.313 ± 0.25
2.787AsnGly: 2.787 ± 0.245
0.563AsnHis: 0.563 ± 0.12
4.626AsnIle: 4.626 ± 0.313
3.766AsnLys: 3.766 ± 0.367
4.566AsnLeu: 4.566 ± 0.375
1.156AsnMet: 1.156 ± 0.187
2.847AsnAsn: 2.847 ± 0.354
2.046AsnPro: 2.046 ± 0.245
1.305AsnGln: 1.305 ± 0.201
1.72AsnArg: 1.72 ± 0.243
2.787AsnSer: 2.787 ± 0.287
2.787AsnThr: 2.787 ± 0.274
2.787AsnVal: 2.787 ± 0.328
0.474AsnTrp: 0.474 ± 0.124
2.105AsnTyr: 2.105 ± 0.315
0.0AsnXaa: 0.0 ± 0.0
Pro
3.558ProAla: 3.558 ± 0.433
0.356ProCys: 0.356 ± 0.112
2.076ProAsp: 2.076 ± 0.239
3.588ProGlu: 3.588 ± 0.343
1.067ProPhe: 1.067 ± 0.199
2.876ProGly: 2.876 ± 0.325
0.89ProHis: 0.89 ± 0.147
2.165ProIle: 2.165 ± 0.277
2.817ProLys: 2.817 ± 0.296
3.647ProLeu: 3.647 ± 0.353
0.474ProMet: 0.474 ± 0.112
1.453ProAsn: 1.453 ± 0.197
1.245ProPro: 1.245 ± 0.227
1.868ProGln: 1.868 ± 0.219
2.105ProArg: 2.105 ± 0.276
1.987ProSer: 1.987 ± 0.228
1.394ProThr: 1.394 ± 0.225
2.965ProVal: 2.965 ± 0.289
0.593ProTrp: 0.593 ± 0.131
1.453ProTyr: 1.453 ± 0.188
0.0ProXaa: 0.0 ± 0.0
Gln
3.351GlnAla: 3.351 ± 0.326
0.237GlnCys: 0.237 ± 0.076
1.69GlnAsp: 1.69 ± 0.193
3.588GlnGlu: 3.588 ± 0.354
1.067GlnPhe: 1.067 ± 0.197
1.749GlnGly: 1.749 ± 0.246
0.771GlnHis: 0.771 ± 0.166
2.639GlnIle: 2.639 ± 0.252
4.151GlnLys: 4.151 ± 0.426
3.499GlnLeu: 3.499 ± 0.316
0.89GlnMet: 0.89 ± 0.173
2.817GlnAsn: 2.817 ± 0.289
1.423GlnPro: 1.423 ± 0.202
1.334GlnGln: 1.334 ± 0.253
1.987GlnArg: 1.987 ± 0.251
1.72GlnSer: 1.72 ± 0.251
2.313GlnThr: 2.313 ± 0.266
2.135GlnVal: 2.135 ± 0.254
0.297GlnTrp: 0.297 ± 0.101
1.423GlnTyr: 1.423 ± 0.219
0.0GlnXaa: 0.0 ± 0.0
Arg
3.321ArgAla: 3.321 ± 0.354
0.474ArgCys: 0.474 ± 0.138
2.58ArgAsp: 2.58 ± 0.266
3.499ArgGlu: 3.499 ± 0.305
1.779ArgPhe: 1.779 ± 0.272
3.025ArgGly: 3.025 ± 0.334
0.919ArgHis: 0.919 ± 0.201
3.202ArgIle: 3.202 ± 0.245
3.855ArgLys: 3.855 ± 0.316
5.664ArgLeu: 5.664 ± 0.492
1.097ArgMet: 1.097 ± 0.167
2.402ArgAsn: 2.402 ± 0.278
1.394ArgPro: 1.394 ± 0.188
2.165ArgGln: 2.165 ± 0.279
2.965ArgArg: 2.965 ± 0.326
2.372ArgSer: 2.372 ± 0.264
2.698ArgThr: 2.698 ± 0.253
3.202ArgVal: 3.202 ± 0.268
0.534ArgTrp: 0.534 ± 0.122
2.194ArgTyr: 2.194 ± 0.252
0.0ArgXaa: 0.0 ± 0.0
Ser
6.138SerAla: 6.138 ± 0.384
0.86SerCys: 0.86 ± 0.144
2.372SerAsp: 2.372 ± 0.218
2.995SerGlu: 2.995 ± 0.323
2.461SerPhe: 2.461 ± 0.299
6.197SerGly: 6.197 ± 0.43
0.801SerHis: 0.801 ± 0.167
3.588SerIle: 3.588 ± 0.336
3.796SerLys: 3.796 ± 0.323
4.863SerLeu: 4.863 ± 0.437
0.919SerMet: 0.919 ± 0.139
1.927SerAsn: 1.927 ± 0.234
2.105SerPro: 2.105 ± 0.289
1.661SerGln: 1.661 ± 0.208
3.499SerArg: 3.499 ± 0.341
2.847SerSer: 2.847 ± 0.282
2.906SerThr: 2.906 ± 0.332
3.469SerVal: 3.469 ± 0.307
0.623SerTrp: 0.623 ± 0.14
2.313SerTyr: 2.313 ± 0.3
0.0SerXaa: 0.0 ± 0.0
Thr
5.545ThrAla: 5.545 ± 0.438
0.385ThrCys: 0.385 ± 0.119
3.114ThrAsp: 3.114 ± 0.261
3.588ThrGlu: 3.588 ± 0.373
2.105ThrPhe: 2.105 ± 0.276
4.359ThrGly: 4.359 ± 0.355
1.008ThrHis: 1.008 ± 0.161
3.351ThrIle: 3.351 ± 0.303
3.084ThrLys: 3.084 ± 0.292
4.804ThrLeu: 4.804 ± 0.356
0.83ThrMet: 0.83 ± 0.152
1.779ThrAsn: 1.779 ± 0.228
2.432ThrPro: 2.432 ± 0.249
1.542ThrGln: 1.542 ± 0.198
1.987ThrArg: 1.987 ± 0.232
2.461ThrSer: 2.461 ± 0.262
2.847ThrThr: 2.847 ± 0.525
3.677ThrVal: 3.677 ± 0.386
0.267ThrTrp: 0.267 ± 0.092
1.927ThrTyr: 1.927 ± 0.214
0.0ThrXaa: 0.0 ± 0.0
Val
4.27ValAla: 4.27 ± 0.355
0.741ValCys: 0.741 ± 0.15
3.529ValAsp: 3.529 ± 0.344
3.855ValGlu: 3.855 ± 0.369
2.876ValPhe: 2.876 ± 0.324
4.033ValGly: 4.033 ± 0.401
1.245ValHis: 1.245 ± 0.188
5.041ValIle: 5.041 ± 0.398
4.715ValLys: 4.715 ± 0.423
7.443ValLeu: 7.443 ± 0.501
0.979ValMet: 0.979 ± 0.162
3.202ValAsn: 3.202 ± 0.345
2.432ValPro: 2.432 ± 0.267
2.609ValGln: 2.609 ± 0.242
3.262ValArg: 3.262 ± 0.341
4.181ValSer: 4.181 ± 0.327
3.202ValThr: 3.202 ± 0.35
4.804ValVal: 4.804 ± 0.508
0.623ValTrp: 0.623 ± 0.159
2.254ValTyr: 2.254 ± 0.297
0.0ValXaa: 0.0 ± 0.0
Trp
0.534TrpAla: 0.534 ± 0.109
0.059TrpCys: 0.059 ± 0.041
0.563TrpAsp: 0.563 ± 0.162
0.445TrpGlu: 0.445 ± 0.105
0.385TrpPhe: 0.385 ± 0.125
0.445TrpGly: 0.445 ± 0.095
0.326TrpHis: 0.326 ± 0.089
0.385TrpIle: 0.385 ± 0.125
0.445TrpLys: 0.445 ± 0.107
1.156TrpLeu: 1.156 ± 0.267
0.059TrpMet: 0.059 ± 0.041
0.474TrpAsn: 0.474 ± 0.132
0.267TrpPro: 0.267 ± 0.092
0.89TrpGln: 0.89 ± 0.167
0.652TrpArg: 0.652 ± 0.149
0.652TrpSer: 0.652 ± 0.137
0.445TrpThr: 0.445 ± 0.111
0.445TrpVal: 0.445 ± 0.118
0.148TrpTrp: 0.148 ± 0.07
0.534TrpTyr: 0.534 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.143TyrAla: 3.143 ± 0.283
0.504TyrCys: 0.504 ± 0.118
2.728TyrAsp: 2.728 ± 0.348
2.135TyrGlu: 2.135 ± 0.26
2.076TyrPhe: 2.076 ± 0.286
2.461TyrGly: 2.461 ± 0.3
0.741TyrHis: 0.741 ± 0.162
2.698TyrIle: 2.698 ± 0.289
2.847TyrLys: 2.847 ± 0.296
3.944TyrLeu: 3.944 ± 0.358
0.593TyrMet: 0.593 ± 0.188
1.898TyrAsn: 1.898 ± 0.232
1.838TyrPro: 1.838 ± 0.251
1.69TyrGln: 1.69 ± 0.199
1.957TyrArg: 1.957 ± 0.28
2.046TyrSer: 2.046 ± 0.302
2.046TyrThr: 2.046 ± 0.237
1.898TyrVal: 1.898 ± 0.302
0.563TyrTrp: 0.563 ± 0.186
1.927TyrTyr: 1.927 ± 0.283
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 135 proteins (33725 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski