Amino acid dipepetide frequency for Tateyamaria sp. ANG-S1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.808AlaAla: 15.808 ± 0.173
1.133AlaCys: 1.133 ± 0.039
7.474AlaAsp: 7.474 ± 0.079
7.722AlaGlu: 7.722 ± 0.089
4.413AlaPhe: 4.413 ± 0.064
9.904AlaGly: 9.904 ± 0.091
2.453AlaHis: 2.453 ± 0.042
5.932AlaIle: 5.932 ± 0.069
3.922AlaLys: 3.922 ± 0.068
13.403AlaLeu: 13.403 ± 0.133
3.879AlaMet: 3.879 ± 0.061
2.78AlaAsn: 2.78 ± 0.052
5.702AlaPro: 5.702 ± 0.088
4.802AlaGln: 4.802 ± 0.065
7.98AlaArg: 7.98 ± 0.098
5.553AlaSer: 5.553 ± 0.063
6.188AlaThr: 6.188 ± 0.084
8.328AlaVal: 8.328 ± 0.094
1.594AlaTrp: 1.594 ± 0.038
2.595AlaTyr: 2.595 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.093CysAla: 1.093 ± 0.03
0.103CysCys: 0.103 ± 0.008
0.625CysAsp: 0.625 ± 0.029
0.422CysGlu: 0.422 ± 0.018
0.338CysPhe: 0.338 ± 0.017
0.896CysGly: 0.896 ± 0.028
0.269CysHis: 0.269 ± 0.014
0.434CysIle: 0.434 ± 0.022
0.233CysLys: 0.233 ± 0.016
0.79CysLeu: 0.79 ± 0.027
0.162CysMet: 0.162 ± 0.013
0.2CysAsn: 0.2 ± 0.014
0.492CysPro: 0.492 ± 0.022
0.243CysGln: 0.243 ± 0.014
0.472CysArg: 0.472 ± 0.021
0.467CysSer: 0.467 ± 0.022
0.494CysThr: 0.494 ± 0.022
0.664CysVal: 0.664 ± 0.026
0.1CysTrp: 0.1 ± 0.008
0.212CysTyr: 0.212 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
8.25AspAla: 8.25 ± 0.094
0.488AspCys: 0.488 ± 0.022
3.963AspAsp: 3.963 ± 0.083
3.486AspGlu: 3.486 ± 0.062
2.333AspPhe: 2.333 ± 0.045
6.009AspGly: 6.009 ± 0.09
1.508AspHis: 1.508 ± 0.042
3.475AspIle: 3.475 ± 0.055
1.78AspLys: 1.78 ± 0.039
6.507AspLeu: 6.507 ± 0.093
1.964AspMet: 1.964 ± 0.041
1.47AspAsn: 1.47 ± 0.034
3.629AspPro: 3.629 ± 0.057
2.183AspGln: 2.183 ± 0.044
4.213AspArg: 4.213 ± 0.061
2.135AspSer: 2.135 ± 0.044
3.744AspThr: 3.744 ± 0.077
5.092AspVal: 5.092 ± 0.067
1.177AspTrp: 1.177 ± 0.035
1.575AspTyr: 1.575 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.77GluAla: 7.77 ± 0.09
0.337GluCys: 0.337 ± 0.017
3.53GluAsp: 3.53 ± 0.055
3.414GluGlu: 3.414 ± 0.066
1.793GluPhe: 1.793 ± 0.042
4.575GluGly: 4.575 ± 0.068
1.164GluHis: 1.164 ± 0.035
3.249GluIle: 3.249 ± 0.065
1.977GluLys: 1.977 ± 0.051
4.896GluLeu: 4.896 ± 0.068
1.924GluMet: 1.924 ± 0.042
1.814GluAsn: 1.814 ± 0.041
2.495GluPro: 2.495 ± 0.054
1.978GluGln: 1.978 ± 0.047
3.921GluArg: 3.921 ± 0.062
1.873GluSer: 1.873 ± 0.042
3.703GluThr: 3.703 ± 0.056
4.402GluVal: 4.402 ± 0.064
0.715GluTrp: 0.715 ± 0.024
1.07GluTyr: 1.07 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.528PheAla: 4.528 ± 0.067
0.435PheCys: 0.435 ± 0.022
3.118PheAsp: 3.118 ± 0.057
2.382PheGlu: 2.382 ± 0.043
1.515PhePhe: 1.515 ± 0.04
3.832PheGly: 3.832 ± 0.061
0.75PheHis: 0.75 ± 0.028
1.722PheIle: 1.722 ± 0.043
1.028PheLys: 1.028 ± 0.026
3.374PheLeu: 3.374 ± 0.066
0.961PheMet: 0.961 ± 0.03
1.096PheAsn: 1.096 ± 0.031
1.507PhePro: 1.507 ± 0.031
1.178PheGln: 1.178 ± 0.032
1.994PheArg: 1.994 ± 0.044
2.184PheSer: 2.184 ± 0.046
2.088PheThr: 2.088 ± 0.04
2.772PheVal: 2.772 ± 0.053
0.613PheTrp: 0.613 ± 0.024
0.959PheTyr: 0.959 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
9.785GlyAla: 9.785 ± 0.098
0.832GlyCys: 0.832 ± 0.031
5.086GlyAsp: 5.086 ± 0.09
4.39GlyGlu: 4.39 ± 0.069
3.751GlyPhe: 3.751 ± 0.058
7.349GlyGly: 7.349 ± 0.109
2.038GlyHis: 2.038 ± 0.043
4.505GlyIle: 4.505 ± 0.067
3.041GlyLys: 3.041 ± 0.064
8.785GlyLeu: 8.785 ± 0.093
2.634GlyMet: 2.634 ± 0.053
2.252GlyAsn: 2.252 ± 0.065
3.734GlyPro: 3.734 ± 0.06
3.325GlyGln: 3.325 ± 0.047
5.18GlyArg: 5.18 ± 0.059
4.124GlySer: 4.124 ± 0.072
5.149GlyThr: 5.149 ± 0.083
6.435GlyVal: 6.435 ± 0.084
1.48GlyTrp: 1.48 ± 0.033
2.268GlyTyr: 2.268 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.425HisAla: 2.425 ± 0.052
0.227HisCys: 0.227 ± 0.014
1.368HisAsp: 1.368 ± 0.037
1.0HisGlu: 1.0 ± 0.031
0.878HisPhe: 0.878 ± 0.025
2.02HisGly: 2.02 ± 0.05
0.577HisHis: 0.577 ± 0.024
1.152HisIle: 1.152 ± 0.031
0.576HisLys: 0.576 ± 0.023
2.199HisLeu: 2.199 ± 0.048
0.599HisMet: 0.599 ± 0.025
0.508HisAsn: 0.508 ± 0.021
1.349HisPro: 1.349 ± 0.037
0.593HisGln: 0.593 ± 0.025
1.275HisArg: 1.275 ± 0.033
0.911HisSer: 0.911 ± 0.03
0.999HisThr: 0.999 ± 0.032
1.689HisVal: 1.689 ± 0.038
0.37HisTrp: 0.37 ± 0.017
0.564HisTyr: 0.564 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.98IleAla: 6.98 ± 0.076
0.584IleCys: 0.584 ± 0.025
3.736IleAsp: 3.736 ± 0.055
3.567IleGlu: 3.567 ± 0.058
1.782IlePhe: 1.782 ± 0.054
4.892IleGly: 4.892 ± 0.06
0.896IleHis: 0.896 ± 0.025
2.38IleIle: 2.38 ± 0.052
1.546IleLys: 1.546 ± 0.038
4.7IleLeu: 4.7 ± 0.077
1.162IleMet: 1.162 ± 0.033
1.54IleAsn: 1.54 ± 0.044
2.384IlePro: 2.384 ± 0.045
1.316IleGln: 1.316 ± 0.035
2.904IleArg: 2.904 ± 0.049
2.864IleSer: 2.864 ± 0.047
3.052IleThr: 3.052 ± 0.054
3.885IleVal: 3.885 ± 0.057
0.772IleTrp: 0.772 ± 0.025
1.218IleTyr: 1.218 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.978LysAla: 3.978 ± 0.066
0.193LysCys: 0.193 ± 0.013
1.897LysAsp: 1.897 ± 0.042
1.547LysGlu: 1.547 ± 0.042
0.944LysPhe: 0.944 ± 0.03
2.692LysGly: 2.692 ± 0.048
0.693LysHis: 0.693 ± 0.025
1.514LysIle: 1.514 ± 0.04
1.192LysLys: 1.192 ± 0.041
2.929LysLeu: 2.929 ± 0.051
0.912LysMet: 0.912 ± 0.026
0.794LysAsn: 0.794 ± 0.03
1.813LysPro: 1.813 ± 0.045
0.945LysGln: 0.945 ± 0.026
2.307LysArg: 2.307 ± 0.05
1.777LysSer: 1.777 ± 0.044
2.01LysThr: 2.01 ± 0.042
2.354LysVal: 2.354 ± 0.048
0.385LysTrp: 0.385 ± 0.015
0.65LysTyr: 0.65 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
12.01LeuAla: 12.01 ± 0.119
0.936LeuCys: 0.936 ± 0.03
6.192LeuAsp: 6.192 ± 0.082
5.065LeuGlu: 5.065 ± 0.075
3.581LeuPhe: 3.581 ± 0.068
8.207LeuGly: 8.207 ± 0.092
1.909LeuHis: 1.909 ± 0.044
5.247LeuIle: 5.247 ± 0.085
3.207LeuLys: 3.207 ± 0.056
8.486LeuLeu: 8.486 ± 0.114
2.775LeuMet: 2.775 ± 0.057
2.951LeuAsn: 2.951 ± 0.056
5.272LeuPro: 5.272 ± 0.08
2.887LeuGln: 2.887 ± 0.051
6.486LeuArg: 6.486 ± 0.074
6.379LeuSer: 6.379 ± 0.085
6.216LeuThr: 6.216 ± 0.065
6.606LeuVal: 6.606 ± 0.094
1.305LeuTrp: 1.305 ± 0.039
1.918LeuTyr: 1.918 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.572MetAla: 3.572 ± 0.054
0.229MetCys: 0.229 ± 0.014
1.65MetAsp: 1.65 ± 0.036
1.442MetGlu: 1.442 ± 0.035
0.911MetPhe: 0.911 ± 0.026
2.4MetGly: 2.4 ± 0.043
0.473MetHis: 0.473 ± 0.019
1.606MetIle: 1.606 ± 0.034
1.041MetLys: 1.041 ± 0.028
2.726MetLeu: 2.726 ± 0.046
0.841MetMet: 0.841 ± 0.027
0.877MetAsn: 0.877 ± 0.025
1.535MetPro: 1.535 ± 0.038
1.155MetGln: 1.155 ± 0.034
2.026MetArg: 2.026 ± 0.043
1.792MetSer: 1.792 ± 0.044
2.183MetThr: 2.183 ± 0.04
1.918MetVal: 1.918 ± 0.039
0.292MetTrp: 0.292 ± 0.016
0.38MetTyr: 0.38 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.435AsnAla: 3.435 ± 0.055
0.267AsnCys: 0.267 ± 0.018
1.707AsnAsp: 1.707 ± 0.057
1.298AsnGlu: 1.298 ± 0.033
1.006AsnPhe: 1.006 ± 0.027
2.57AsnGly: 2.57 ± 0.059
0.571AsnHis: 0.571 ± 0.02
1.445AsnIle: 1.445 ± 0.038
0.692AsnLys: 0.692 ± 0.023
2.524AsnLeu: 2.524 ± 0.053
0.767AsnMet: 0.767 ± 0.027
0.743AsnAsn: 0.743 ± 0.028
1.84AsnPro: 1.84 ± 0.049
0.755AsnGln: 0.755 ± 0.027
1.75AsnArg: 1.75 ± 0.041
1.155AsnSer: 1.155 ± 0.035
1.484AsnThr: 1.484 ± 0.038
1.96AsnVal: 1.96 ± 0.036
0.45AsnTrp: 0.45 ± 0.02
0.68AsnTyr: 0.68 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
5.242ProAla: 5.242 ± 0.079
0.34ProCys: 0.34 ± 0.018
4.167ProAsp: 4.167 ± 0.067
3.857ProGlu: 3.857 ± 0.068
2.016ProPhe: 2.016 ± 0.042
4.178ProGly: 4.178 ± 0.06
1.133ProHis: 1.133 ± 0.034
2.402ProIle: 2.402 ± 0.046
1.748ProLys: 1.748 ± 0.043
4.506ProLeu: 4.506 ± 0.065
1.383ProMet: 1.383 ± 0.035
1.461ProAsn: 1.461 ± 0.04
2.075ProPro: 2.075 ± 0.052
1.668ProGln: 1.668 ± 0.044
2.589ProArg: 2.589 ± 0.05
2.505ProSer: 2.505 ± 0.05
2.66ProThr: 2.66 ± 0.045
4.053ProVal: 4.053 ± 0.066
0.697ProTrp: 0.697 ± 0.024
1.121ProTyr: 1.121 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.06GlnAla: 4.06 ± 0.068
0.216GlnCys: 0.216 ± 0.014
1.929GlnAsp: 1.929 ± 0.046
1.588GlnGlu: 1.588 ± 0.041
1.197GlnPhe: 1.197 ± 0.036
2.701GlnGly: 2.701 ± 0.045
0.684GlnHis: 0.684 ± 0.024
2.095GlnIle: 2.095 ± 0.04
1.083GlnLys: 1.083 ± 0.034
2.898GlnLeu: 2.898 ± 0.055
1.186GlnMet: 1.186 ± 0.032
1.035GlnAsn: 1.035 ± 0.029
1.647GlnPro: 1.647 ± 0.04
1.179GlnGln: 1.179 ± 0.034
2.314GlnArg: 2.314 ± 0.05
1.923GlnSer: 1.923 ± 0.036
2.065GlnThr: 2.065 ± 0.05
2.562GlnVal: 2.562 ± 0.053
0.437GlnTrp: 0.437 ± 0.017
0.66GlnTyr: 0.66 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
7.644ArgAla: 7.644 ± 0.092
0.453ArgCys: 0.453 ± 0.019
4.329ArgAsp: 4.329 ± 0.064
3.245ArgGlu: 3.245 ± 0.054
2.631ArgPhe: 2.631 ± 0.05
4.339ArgGly: 4.339 ± 0.064
1.436ArgHis: 1.436 ± 0.033
3.605ArgIle: 3.605 ± 0.058
2.154ArgLys: 2.154 ± 0.046
6.453ArgLeu: 6.453 ± 0.083
1.932ArgMet: 1.932 ± 0.04
1.731ArgAsn: 1.731 ± 0.04
2.99ArgPro: 2.99 ± 0.053
2.183ArgGln: 2.183 ± 0.045
4.242ArgArg: 4.242 ± 0.062
3.123ArgSer: 3.123 ± 0.053
3.271ArgThr: 3.271 ± 0.052
4.579ArgVal: 4.579 ± 0.076
0.891ArgTrp: 0.891 ± 0.03
1.472ArgTyr: 1.472 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
5.646SerAla: 5.646 ± 0.068
0.385SerCys: 0.385 ± 0.02
3.528SerAsp: 3.528 ± 0.058
2.722SerGlu: 2.722 ± 0.053
2.235SerPhe: 2.235 ± 0.046
5.253SerGly: 5.253 ± 0.086
1.056SerHis: 1.056 ± 0.029
2.552SerIle: 2.552 ± 0.053
1.61SerLys: 1.61 ± 0.037
4.776SerLeu: 4.776 ± 0.067
1.411SerMet: 1.411 ± 0.038
1.391SerAsn: 1.391 ± 0.037
2.389SerPro: 2.389 ± 0.042
1.544SerGln: 1.544 ± 0.036
2.86SerArg: 2.86 ± 0.049
2.41SerSer: 2.41 ± 0.046
2.645SerThr: 2.645 ± 0.044
3.943SerVal: 3.943 ± 0.054
0.652SerTrp: 0.652 ± 0.022
1.278SerTyr: 1.278 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.443ThrAla: 6.443 ± 0.076
0.526ThrCys: 0.526 ± 0.02
3.682ThrAsp: 3.682 ± 0.06
3.078ThrGlu: 3.078 ± 0.042
2.235ThrPhe: 2.235 ± 0.051
5.53ThrGly: 5.53 ± 0.085
1.336ThrHis: 1.336 ± 0.034
2.865ThrIle: 2.865 ± 0.05
1.524ThrLys: 1.524 ± 0.042
6.441ThrLeu: 6.441 ± 0.074
1.415ThrMet: 1.415 ± 0.038
1.421ThrAsn: 1.421 ± 0.04
3.486ThrPro: 3.486 ± 0.063
1.864ThrGln: 1.864 ± 0.04
3.451ThrArg: 3.451 ± 0.054
2.841ThrSer: 2.841 ± 0.047
3.148ThrThr: 3.148 ± 0.07
4.515ThrVal: 4.515 ± 0.072
0.813ThrTrp: 0.813 ± 0.026
1.466ThrTyr: 1.466 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
8.873ValAla: 8.873 ± 0.096
0.652ValCys: 0.652 ± 0.025
4.45ValAsp: 4.45 ± 0.064
4.477ValGlu: 4.477 ± 0.069
2.948ValPhe: 2.948 ± 0.064
5.654ValGly: 5.654 ± 0.073
1.463ValHis: 1.463 ± 0.032
4.241ValIle: 4.241 ± 0.065
2.117ValLys: 2.117 ± 0.048
7.467ValLeu: 7.467 ± 0.085
2.197ValMet: 2.197 ± 0.048
1.988ValAsn: 1.988 ± 0.042
3.701ValPro: 3.701 ± 0.058
2.345ValGln: 2.345 ± 0.045
4.191ValArg: 4.191 ± 0.07
4.309ValSer: 4.309 ± 0.059
4.858ValThr: 4.858 ± 0.067
5.74ValVal: 5.74 ± 0.093
0.99ValTrp: 0.99 ± 0.03
1.466ValTyr: 1.466 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.449TrpAla: 1.449 ± 0.033
0.139TrpCys: 0.139 ± 0.01
0.86TrpAsp: 0.86 ± 0.028
0.627TrpGlu: 0.627 ± 0.024
0.591TrpPhe: 0.591 ± 0.022
1.053TrpGly: 1.053 ± 0.033
0.351TrpHis: 0.351 ± 0.017
0.757TrpIle: 0.757 ± 0.029
0.431TrpLys: 0.431 ± 0.019
1.603TrpLeu: 1.603 ± 0.039
0.442TrpMet: 0.442 ± 0.02
0.442TrpAsn: 0.442 ± 0.021
0.688TrpPro: 0.688 ± 0.024
0.611TrpGln: 0.611 ± 0.023
1.072TrpArg: 1.072 ± 0.033
0.833TrpSer: 0.833 ± 0.027
0.883TrpThr: 0.883 ± 0.028
0.968TrpVal: 0.968 ± 0.03
0.251TrpTrp: 0.251 ± 0.015
0.286TrpTyr: 0.286 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.575TyrAla: 2.575 ± 0.047
0.233TyrCys: 0.233 ± 0.014
1.688TyrAsp: 1.688 ± 0.04
1.272TyrGlu: 1.272 ± 0.038
0.94TyrPhe: 0.94 ± 0.033
2.09TyrGly: 2.09 ± 0.043
0.517TyrHis: 0.517 ± 0.019
0.982TyrIle: 0.982 ± 0.028
0.623TyrLys: 0.623 ± 0.024
2.17TyrLeu: 2.17 ± 0.048
0.503TyrMet: 0.503 ± 0.019
0.605TyrAsn: 0.605 ± 0.022
1.074TyrPro: 1.074 ± 0.029
0.707TyrGln: 0.707 ± 0.024
1.477TyrArg: 1.477 ± 0.032
1.126TyrSer: 1.126 ± 0.034
1.241TyrThr: 1.241 ± 0.034
1.662TyrVal: 1.662 ± 0.034
0.352TyrTrp: 0.352 ± 0.017
0.593TyrTyr: 0.593 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3983 proteins (1214556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski