Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA385M11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.21AlaAla: 5.21 ± 0.412
1.365AlaCys: 1.365 ± 0.186
3.253AlaAsp: 3.253 ± 0.263
4.755AlaGlu: 4.755 ± 0.328
2.616AlaPhe: 2.616 ± 0.229
5.551AlaGly: 5.551 ± 0.393
1.479AlaHis: 1.479 ± 0.234
4.118AlaIle: 4.118 ± 0.268
4.095AlaLys: 4.095 ± 0.321
6.962AlaLeu: 6.962 ± 0.475
1.888AlaMet: 1.888 ± 0.22
2.07AlaAsn: 2.07 ± 0.228
1.979AlaPro: 1.979 ± 0.238
2.889AlaGln: 2.889 ± 0.271
4.254AlaArg: 4.254 ± 0.304
4.232AlaSer: 4.232 ± 0.337
1.957AlaThr: 1.957 ± 0.215
4.459AlaVal: 4.459 ± 0.351
0.978AlaTrp: 0.978 ± 0.131
1.729AlaTyr: 1.729 ± 0.205
0.0AlaXaa: 0.0 ± 0.0
Cys
0.933CysAla: 0.933 ± 0.135
0.228CysCys: 0.228 ± 0.08
0.364CysAsp: 0.364 ± 0.113
0.546CysGlu: 0.546 ± 0.122
0.91CysPhe: 0.91 ± 0.137
1.024CysGly: 1.024 ± 0.151
0.341CysHis: 0.341 ± 0.084
0.774CysIle: 0.774 ± 0.129
0.592CysLys: 0.592 ± 0.114
1.706CysLeu: 1.706 ± 0.175
0.341CysMet: 0.341 ± 0.082
0.364CysAsn: 0.364 ± 0.084
0.592CysPro: 0.592 ± 0.118
0.478CysGln: 0.478 ± 0.122
0.819CysArg: 0.819 ± 0.135
0.728CysSer: 0.728 ± 0.122
0.432CysThr: 0.432 ± 0.109
0.637CysVal: 0.637 ± 0.121
0.159CysTrp: 0.159 ± 0.062
0.569CysTyr: 0.569 ± 0.138
0.0CysXaa: 0.0 ± 0.0
Asp
2.525AspAla: 2.525 ± 0.221
0.751AspCys: 0.751 ± 0.134
2.434AspAsp: 2.434 ± 0.296
3.549AspGlu: 3.549 ± 0.337
3.003AspPhe: 3.003 ± 0.291
2.343AspGly: 2.343 ± 0.213
1.115AspHis: 1.115 ± 0.163
3.663AspIle: 3.663 ± 0.388
3.777AspLys: 3.777 ± 0.336
6.325AspLeu: 6.325 ± 0.382
1.365AspMet: 1.365 ± 0.167
2.116AspAsn: 2.116 ± 0.236
2.412AspPro: 2.412 ± 0.258
2.571AspGln: 2.571 ± 0.247
3.617AspArg: 3.617 ± 0.325
2.821AspSer: 2.821 ± 0.233
1.957AspThr: 1.957 ± 0.21
2.958AspVal: 2.958 ± 0.231
1.024AspTrp: 1.024 ± 0.138
2.434AspTyr: 2.434 ± 0.235
0.0AspXaa: 0.0 ± 0.0
Glu
4.982GluAla: 4.982 ± 0.324
0.683GluCys: 0.683 ± 0.126
4.163GluAsp: 4.163 ± 0.352
6.279GluGlu: 6.279 ± 0.484
3.117GluPhe: 3.117 ± 0.31
3.799GluGly: 3.799 ± 0.319
1.593GluHis: 1.593 ± 0.216
5.597GluIle: 5.597 ± 0.4
5.847GluLys: 5.847 ± 0.401
7.963GluLeu: 7.963 ± 0.484
2.025GluMet: 2.025 ± 0.2
3.117GluAsn: 3.117 ± 0.315
2.07GluPro: 2.07 ± 0.196
3.14GluGln: 3.14 ± 0.282
4.095GluArg: 4.095 ± 0.347
3.959GluSer: 3.959 ± 0.299
3.367GluThr: 3.367 ± 0.284
4.664GluVal: 4.664 ± 0.348
0.978GluTrp: 0.978 ± 0.151
2.776GluTyr: 2.776 ± 0.276
0.0GluXaa: 0.0 ± 0.0
Phe
2.616PheAla: 2.616 ± 0.277
0.614PheCys: 0.614 ± 0.133
2.798PheAsp: 2.798 ± 0.249
3.094PheGlu: 3.094 ± 0.272
2.753PhePhe: 2.753 ± 0.289
2.639PheGly: 2.639 ± 0.233
1.229PheHis: 1.229 ± 0.182
3.071PheIle: 3.071 ± 0.267
2.776PheLys: 2.776 ± 0.278
4.527PheLeu: 4.527 ± 0.319
1.001PheMet: 1.001 ± 0.166
1.979PheAsn: 1.979 ± 0.25
1.797PhePro: 1.797 ± 0.222
1.661PheGln: 1.661 ± 0.205
2.639PheArg: 2.639 ± 0.249
3.231PheSer: 3.231 ± 0.31
2.207PheThr: 2.207 ± 0.238
3.344PheVal: 3.344 ± 0.272
0.842PheTrp: 0.842 ± 0.134
1.729PheTyr: 1.729 ± 0.213
0.0PheXaa: 0.0 ± 0.0
Gly
3.686GlyAla: 3.686 ± 0.267
0.865GlyCys: 0.865 ± 0.142
2.844GlyAsp: 2.844 ± 0.285
4.141GlyGlu: 4.141 ± 0.366
3.549GlyPhe: 3.549 ± 0.251
4.596GlyGly: 4.596 ± 0.429
1.547GlyHis: 1.547 ± 0.18
4.3GlyIle: 4.3 ± 0.298
4.414GlyLys: 4.414 ± 0.299
6.575GlyLeu: 6.575 ± 0.477
1.684GlyMet: 1.684 ± 0.197
2.503GlyAsn: 2.503 ± 0.234
2.275GlyPro: 2.275 ± 0.206
2.912GlyGln: 2.912 ± 0.305
4.072GlyArg: 4.072 ± 0.284
3.913GlySer: 3.913 ± 0.313
3.117GlyThr: 3.117 ± 0.22
3.526GlyVal: 3.526 ± 0.319
1.024GlyTrp: 1.024 ± 0.157
2.525GlyTyr: 2.525 ± 0.267
0.0GlyXaa: 0.0 ± 0.0
His
1.297HisAla: 1.297 ± 0.204
0.364HisCys: 0.364 ± 0.088
1.001HisAsp: 1.001 ± 0.127
1.706HisGlu: 1.706 ± 0.19
1.251HisPhe: 1.251 ± 0.186
1.342HisGly: 1.342 ± 0.169
0.501HisHis: 0.501 ± 0.104
1.752HisIle: 1.752 ± 0.233
1.32HisLys: 1.32 ± 0.161
2.412HisLeu: 2.412 ± 0.225
0.41HisMet: 0.41 ± 0.085
0.956HisAsn: 0.956 ± 0.155
1.251HisPro: 1.251 ± 0.191
0.523HisGln: 0.523 ± 0.11
1.593HisArg: 1.593 ± 0.198
1.684HisSer: 1.684 ± 0.187
0.66HisThr: 0.66 ± 0.102
1.229HisVal: 1.229 ± 0.168
0.296HisTrp: 0.296 ± 0.09
0.933HisTyr: 0.933 ± 0.18
0.0HisXaa: 0.0 ± 0.0
Ile
4.573IleAla: 4.573 ± 0.334
0.887IleCys: 0.887 ± 0.127
3.253IleAsp: 3.253 ± 0.272
4.436IleGlu: 4.436 ± 0.311
2.844IlePhe: 2.844 ± 0.224
4.05IleGly: 4.05 ± 0.314
1.843IleHis: 1.843 ± 0.217
4.027IleIle: 4.027 ± 0.284
4.436IleLys: 4.436 ± 0.3
5.847IleLeu: 5.847 ± 0.347
1.661IleMet: 1.661 ± 0.191
2.889IleAsn: 2.889 ± 0.292
3.299IlePro: 3.299 ± 0.26
2.753IleGln: 2.753 ± 0.224
3.504IleArg: 3.504 ± 0.27
4.186IleSer: 4.186 ± 0.325
2.889IleThr: 2.889 ± 0.317
3.367IleVal: 3.367 ± 0.236
1.206IleTrp: 1.206 ± 0.211
2.298IleTyr: 2.298 ± 0.211
0.0IleXaa: 0.0 ± 0.0
Lys
4.664LysAla: 4.664 ± 0.303
0.614LysCys: 0.614 ± 0.115
3.913LysAsp: 3.913 ± 0.349
5.915LysGlu: 5.915 ± 0.431
1.957LysPhe: 1.957 ± 0.219
4.368LysGly: 4.368 ± 0.343
1.547LysHis: 1.547 ± 0.208
4.436LysIle: 4.436 ± 0.33
5.324LysLys: 5.324 ± 0.451
5.437LysLeu: 5.437 ± 0.376
1.911LysMet: 1.911 ± 0.19
3.231LysAsn: 3.231 ± 0.28
2.457LysPro: 2.457 ± 0.186
2.798LysGln: 2.798 ± 0.26
4.254LysArg: 4.254 ± 0.327
3.822LysSer: 3.822 ± 0.281
3.367LysThr: 3.367 ± 0.297
3.822LysVal: 3.822 ± 0.275
1.433LysTrp: 1.433 ± 0.201
2.685LysTyr: 2.685 ± 0.25
0.0LysXaa: 0.0 ± 0.0
Leu
7.667LeuAla: 7.667 ± 0.481
1.342LeuCys: 1.342 ± 0.16
5.528LeuAsp: 5.528 ± 0.328
7.621LeuGlu: 7.621 ± 0.349
4.209LeuPhe: 4.209 ± 0.358
6.302LeuGly: 6.302 ± 0.462
2.002LeuHis: 2.002 ± 0.221
5.87LeuIle: 5.87 ± 0.381
6.78LeuLys: 6.78 ± 0.374
9.441LeuLeu: 9.441 ± 0.577
2.207LeuMet: 2.207 ± 0.219
3.936LeuAsn: 3.936 ± 0.286
5.073LeuPro: 5.073 ± 0.346
4.436LeuGln: 4.436 ± 0.321
5.847LeuArg: 5.847 ± 0.373
7.462LeuSer: 7.462 ± 0.541
4.414LeuThr: 4.414 ± 0.305
5.642LeuVal: 5.642 ± 0.376
1.183LeuTrp: 1.183 ± 0.192
3.094LeuTyr: 3.094 ± 0.264
0.0LeuXaa: 0.0 ± 0.0
Met
2.434MetAla: 2.434 ± 0.232
0.159MetCys: 0.159 ± 0.059
1.752MetAsp: 1.752 ± 0.194
1.752MetGlu: 1.752 ± 0.194
0.751MetPhe: 0.751 ± 0.117
1.593MetGly: 1.593 ± 0.21
0.455MetHis: 0.455 ± 0.094
1.524MetIle: 1.524 ± 0.187
1.547MetLys: 1.547 ± 0.187
2.002MetLeu: 2.002 ± 0.245
0.501MetMet: 0.501 ± 0.112
1.274MetAsn: 1.274 ± 0.19
1.092MetPro: 1.092 ± 0.135
1.024MetGln: 1.024 ± 0.146
1.433MetArg: 1.433 ± 0.198
1.775MetSer: 1.775 ± 0.183
1.32MetThr: 1.32 ± 0.206
1.206MetVal: 1.206 ± 0.17
0.182MetTrp: 0.182 ± 0.073
0.728MetTyr: 0.728 ± 0.13
0.0MetXaa: 0.0 ± 0.0
Asn
2.252AsnAla: 2.252 ± 0.257
0.546AsnCys: 0.546 ± 0.113
1.456AsnAsp: 1.456 ± 0.213
2.366AsnGlu: 2.366 ± 0.22
2.116AsnPhe: 2.116 ± 0.22
2.252AsnGly: 2.252 ± 0.249
1.183AsnHis: 1.183 ± 0.156
3.003AsnIle: 3.003 ± 0.263
2.844AsnLys: 2.844 ± 0.274
4.209AsnLeu: 4.209 ± 0.328
1.115AsnMet: 1.115 ± 0.163
2.002AsnAsn: 2.002 ± 0.293
2.662AsnPro: 2.662 ± 0.234
1.752AsnGln: 1.752 ± 0.209
2.457AsnArg: 2.457 ± 0.265
2.07AsnSer: 2.07 ± 0.232
2.093AsnThr: 2.093 ± 0.239
2.139AsnVal: 2.139 ± 0.206
0.751AsnTrp: 0.751 ± 0.144
1.57AsnTyr: 1.57 ± 0.225
0.0AsnXaa: 0.0 ± 0.0
Pro
2.525ProAla: 2.525 ± 0.269
0.637ProCys: 0.637 ± 0.121
2.616ProAsp: 2.616 ± 0.235
4.755ProGlu: 4.755 ± 0.324
1.843ProPhe: 1.843 ± 0.231
2.821ProGly: 2.821 ± 0.282
0.933ProHis: 0.933 ± 0.14
2.252ProIle: 2.252 ± 0.25
2.093ProLys: 2.093 ± 0.186
3.959ProLeu: 3.959 ± 0.335
0.842ProMet: 0.842 ± 0.114
1.297ProAsn: 1.297 ± 0.169
1.661ProPro: 1.661 ± 0.211
1.661ProGln: 1.661 ± 0.202
2.48ProArg: 2.48 ± 0.262
2.548ProSer: 2.548 ± 0.271
1.547ProThr: 1.547 ± 0.19
3.162ProVal: 3.162 ± 0.292
0.819ProTrp: 0.819 ± 0.136
1.32ProTyr: 1.32 ± 0.203
0.0ProXaa: 0.0 ± 0.0
Gln
3.981GlnAla: 3.981 ± 0.283
0.364GlnCys: 0.364 ± 0.091
2.23GlnAsp: 2.23 ± 0.227
3.936GlnGlu: 3.936 ± 0.316
1.342GlnPhe: 1.342 ± 0.19
3.344GlnGly: 3.344 ± 0.279
0.842GlnHis: 0.842 ± 0.124
2.321GlnIle: 2.321 ± 0.24
3.231GlnLys: 3.231 ± 0.292
3.094GlnLeu: 3.094 ± 0.219
1.115GlnMet: 1.115 ± 0.154
1.888GlnAsn: 1.888 ± 0.242
1.411GlnPro: 1.411 ± 0.173
1.706GlnGln: 1.706 ± 0.206
2.73GlnArg: 2.73 ± 0.299
2.23GlnSer: 2.23 ± 0.23
2.048GlnThr: 2.048 ± 0.179
2.798GlnVal: 2.798 ± 0.258
0.705GlnTrp: 0.705 ± 0.16
1.274GlnTyr: 1.274 ± 0.148
0.0GlnXaa: 0.0 ± 0.0
Arg
3.435ArgAla: 3.435 ± 0.295
0.796ArgCys: 0.796 ± 0.143
3.572ArgAsp: 3.572 ± 0.298
4.709ArgGlu: 4.709 ± 0.398
3.14ArgPhe: 3.14 ± 0.299
3.39ArgGly: 3.39 ± 0.3
1.365ArgHis: 1.365 ± 0.184
3.845ArgIle: 3.845 ± 0.281
4.527ArgLys: 4.527 ± 0.367
6.643ArgLeu: 6.643 ± 0.359
1.547ArgMet: 1.547 ± 0.185
2.23ArgAsn: 2.23 ± 0.258
2.503ArgPro: 2.503 ± 0.255
3.185ArgGln: 3.185 ± 0.31
4.163ArgArg: 4.163 ± 0.302
3.549ArgSer: 3.549 ± 0.278
3.208ArgThr: 3.208 ± 0.352
3.322ArgVal: 3.322 ± 0.299
0.978ArgTrp: 0.978 ± 0.154
2.321ArgTyr: 2.321 ± 0.266
0.0ArgXaa: 0.0 ± 0.0
Ser
3.435SerAla: 3.435 ± 0.309
0.842SerCys: 0.842 ± 0.117
2.889SerAsp: 2.889 ± 0.273
3.959SerGlu: 3.959 ± 0.334
3.435SerPhe: 3.435 ± 0.355
4.254SerGly: 4.254 ± 0.288
1.047SerHis: 1.047 ± 0.18
4.072SerIle: 4.072 ± 0.31
4.277SerLys: 4.277 ± 0.303
6.643SerLeu: 6.643 ± 0.447
1.342SerMet: 1.342 ± 0.198
2.321SerAsn: 2.321 ± 0.239
2.457SerPro: 2.457 ± 0.271
2.776SerGln: 2.776 ± 0.321
4.05SerArg: 4.05 ± 0.295
4.05SerSer: 4.05 ± 0.336
2.457SerThr: 2.457 ± 0.242
3.367SerVal: 3.367 ± 0.256
1.274SerTrp: 1.274 ± 0.176
2.457SerTyr: 2.457 ± 0.236
0.0SerXaa: 0.0 ± 0.0
Thr
3.071ThrAla: 3.071 ± 0.337
0.273ThrCys: 0.273 ± 0.09
2.798ThrAsp: 2.798 ± 0.238
3.367ThrGlu: 3.367 ± 0.29
1.866ThrPhe: 1.866 ± 0.187
3.549ThrGly: 3.549 ± 0.297
0.865ThrHis: 0.865 ± 0.139
2.958ThrIle: 2.958 ± 0.316
2.707ThrLys: 2.707 ± 0.247
4.209ThrLeu: 4.209 ± 0.34
0.819ThrMet: 0.819 ± 0.14
1.524ThrAsn: 1.524 ± 0.191
2.275ThrPro: 2.275 ± 0.249
1.479ThrGln: 1.479 ± 0.196
2.389ThrArg: 2.389 ± 0.233
2.844ThrSer: 2.844 ± 0.239
2.298ThrThr: 2.298 ± 0.23
2.685ThrVal: 2.685 ± 0.229
0.842ThrTrp: 0.842 ± 0.124
1.297ThrTyr: 1.297 ± 0.157
0.0ThrXaa: 0.0 ± 0.0
Val
3.39ValAla: 3.39 ± 0.269
0.592ValCys: 0.592 ± 0.099
3.367ValAsp: 3.367 ± 0.282
3.845ValGlu: 3.845 ± 0.272
3.231ValPhe: 3.231 ± 0.292
3.185ValGly: 3.185 ± 0.275
1.206ValHis: 1.206 ± 0.158
3.595ValIle: 3.595 ± 0.234
4.118ValLys: 4.118 ± 0.35
6.097ValLeu: 6.097 ± 0.377
1.593ValMet: 1.593 ± 0.16
2.685ValAsn: 2.685 ± 0.253
2.161ValPro: 2.161 ± 0.229
2.616ValGln: 2.616 ± 0.235
4.55ValArg: 4.55 ± 0.305
3.299ValSer: 3.299 ± 0.329
2.412ValThr: 2.412 ± 0.183
3.595ValVal: 3.595 ± 0.331
0.887ValTrp: 0.887 ± 0.109
2.503ValTyr: 2.503 ± 0.208
0.0ValXaa: 0.0 ± 0.0
Trp
0.91TrpAla: 0.91 ± 0.147
0.159TrpCys: 0.159 ± 0.065
0.819TrpAsp: 0.819 ± 0.141
1.206TrpGlu: 1.206 ± 0.161
0.842TrpPhe: 0.842 ± 0.16
1.115TrpGly: 1.115 ± 0.17
0.273TrpHis: 0.273 ± 0.068
0.978TrpIle: 0.978 ± 0.158
1.274TrpLys: 1.274 ± 0.192
1.524TrpLeu: 1.524 ± 0.179
0.41TrpMet: 0.41 ± 0.095
0.819TrpAsn: 0.819 ± 0.155
0.683TrpPro: 0.683 ± 0.132
0.592TrpGln: 0.592 ± 0.128
0.774TrpArg: 0.774 ± 0.152
1.229TrpSer: 1.229 ± 0.169
0.91TrpThr: 0.91 ± 0.149
1.115TrpVal: 1.115 ± 0.2
0.25TrpTrp: 0.25 ± 0.115
0.501TrpTyr: 0.501 ± 0.106
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.252TyrAla: 2.252 ± 0.186
0.455TyrCys: 0.455 ± 0.104
1.706TyrAsp: 1.706 ± 0.207
2.275TyrGlu: 2.275 ± 0.223
1.775TyrPhe: 1.775 ± 0.192
2.548TyrGly: 2.548 ± 0.316
1.115TyrHis: 1.115 ± 0.161
2.093TyrIle: 2.093 ± 0.271
1.979TyrLys: 1.979 ± 0.234
4.482TyrLeu: 4.482 ± 0.353
0.705TyrMet: 0.705 ± 0.133
1.638TyrAsn: 1.638 ± 0.197
1.661TyrPro: 1.661 ± 0.169
1.638TyrGln: 1.638 ± 0.181
2.707TyrArg: 2.707 ± 0.218
1.797TyrSer: 1.797 ± 0.23
1.456TyrThr: 1.456 ± 0.196
1.888TyrVal: 1.888 ± 0.208
0.569TyrTrp: 0.569 ± 0.132
1.638TyrTyr: 1.638 ± 0.187
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 228 proteins (43957 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski