Amino acid dipepetide frequency for Lachnospiraceae bacterium OF09-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.088AlaAla: 7.088 ± 0.119	1.068AlaCys: 1.068 ± 0.034	4.54AlaAsp: 4.54 ± 0.089	5.84AlaGlu: 5.84 ± 0.099	2.965AlaPhe: 2.965 ± 0.069	6.218AlaGly: 6.218 ± 0.092	1.107AlaHis: 1.107 ± 0.033	5.158AlaIle: 5.158 ± 0.087	4.515AlaLys: 4.515 ± 0.078	6.467AlaLeu: 6.467 ± 0.096	2.541AlaMet: 2.541 ± 0.065	2.417AlaAsn: 2.417 ± 0.055	1.961AlaPro: 1.961 ± 0.06	2.547AlaGln: 2.547 ± 0.054	2.911AlaArg: 2.911 ± 0.059	3.916AlaSer: 3.916 ± 0.082	3.455AlaThr: 3.455 ± 0.093	6.094AlaVal: 6.094 ± 0.081	0.64AlaTrp: 0.64 ± 0.026	2.72AlaTyr: 2.72 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.075CysAla: 1.075 ± 0.043	0.3CysCys: 0.3 ± 0.022	0.892CysAsp: 0.892 ± 0.032	1.004CysGlu: 1.004 ± 0.036	0.652CysPhe: 0.652 ± 0.03	1.553CysGly: 1.553 ± 0.056	0.369CysHis: 0.369 ± 0.021	1.193CysIle: 1.193 ± 0.041	0.865CysLys: 0.865 ± 0.036	1.216CysLeu: 1.216 ± 0.042	0.542CysMet: 0.542 ± 0.026	0.652CysAsn: 0.652 ± 0.029	0.585CysPro: 0.585 ± 0.032	0.564CysGln: 0.564 ± 0.029	0.746CysArg: 0.746 ± 0.031	0.919CysSer: 0.919 ± 0.033	0.809CysThr: 0.809 ± 0.04	1.042CysVal: 1.042 ± 0.035	0.144CysTrp: 0.144 ± 0.014	0.637CysTyr: 0.637 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	4.215AspAla: 4.215 ± 0.083	0.846AspCys: 0.846 ± 0.031	2.714AspAsp: 2.714 ± 0.067	4.345AspGlu: 4.345 ± 0.081	2.344AspPhe: 2.344 ± 0.055	4.577AspGly: 4.577 ± 0.093	0.997AspHis: 0.997 ± 0.037	4.249AspIle: 4.249 ± 0.077	2.981AspLys: 2.981 ± 0.063	4.781AspLeu: 4.781 ± 0.085	1.905AspMet: 1.905 ± 0.049	2.006AspAsn: 2.006 ± 0.046	1.899AspPro: 1.899 ± 0.051	1.882AspGln: 1.882 ± 0.052	2.455AspArg: 2.455 ± 0.054	3.011AspSer: 3.011 ± 0.059	3.317AspThr: 3.317 ± 0.075	3.647AspVal: 3.647 ± 0.077	0.672AspTrp: 0.672 ± 0.024	2.739AspTyr: 2.739 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	5.686GluAla: 5.686 ± 0.087	0.873GluCys: 0.873 ± 0.033	4.3GluAsp: 4.3 ± 0.08	7.789GluGlu: 7.789 ± 0.117	2.491GluPhe: 2.491 ± 0.058	4.161GluGly: 4.161 ± 0.065	1.489GluHis: 1.489 ± 0.046	5.663GluIle: 5.663 ± 0.089	7.339GluLys: 7.339 ± 0.106	6.828GluLeu: 6.828 ± 0.101	2.566GluMet: 2.566 ± 0.057	4.186GluAsn: 4.186 ± 0.075	1.798GluPro: 1.798 ± 0.047	3.39GluGln: 3.39 ± 0.072	3.229GluArg: 3.229 ± 0.072	3.546GluSer: 3.546 ± 0.074	4.195GluThr: 4.195 ± 0.103	4.627GluVal: 4.627 ± 0.076	0.715GluTrp: 0.715 ± 0.032	3.324GluTyr: 3.324 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	2.835PheAla: 2.835 ± 0.066	0.79PheCys: 0.79 ± 0.03	2.276PheAsp: 2.276 ± 0.054	2.421PheGlu: 2.421 ± 0.05	1.754PhePhe: 1.754 ± 0.047	2.875PheGly: 2.875 ± 0.062	0.914PheHis: 0.914 ± 0.032	2.455PheIle: 2.455 ± 0.064	1.672PheLys: 1.672 ± 0.05	3.906PheLeu: 3.906 ± 0.089	1.136PheMet: 1.136 ± 0.038	1.236PheAsn: 1.236 ± 0.035	1.403PhePro: 1.403 ± 0.044	1.548PheGln: 1.548 ± 0.048	1.684PheArg: 1.684 ± 0.05	2.698PheSer: 2.698 ± 0.051	2.306PheThr: 2.306 ± 0.061	2.6PheVal: 2.6 ± 0.061	0.428PheTrp: 0.428 ± 0.023	1.694PheTyr: 1.694 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.768GlyAla: 4.768 ± 0.082	1.27GlyCys: 1.27 ± 0.041	3.4GlyAsp: 3.4 ± 0.074	4.93GlyGlu: 4.93 ± 0.091	2.98GlyPhe: 2.98 ± 0.068	4.593GlyGly: 4.593 ± 0.091	1.328GlyHis: 1.328 ± 0.043	6.195GlyIle: 6.195 ± 0.106	5.596GlyLys: 5.596 ± 0.085	5.64GlyLeu: 5.64 ± 0.085	2.653GlyMet: 2.653 ± 0.056	3.042GlyAsn: 3.042 ± 0.079	1.176GlyPro: 1.176 ± 0.04	2.122GlyGln: 2.122 ± 0.055	2.903GlyArg: 2.903 ± 0.065	4.206GlySer: 4.206 ± 0.07	4.432GlyThr: 4.432 ± 0.087	4.828GlyVal: 4.828 ± 0.088	0.736GlyTrp: 0.736 ± 0.031	3.395GlyTyr: 3.395 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.147HisAla: 1.147 ± 0.038	0.385HisCys: 0.385 ± 0.02	0.914HisAsp: 0.914 ± 0.036	1.127HisGlu: 1.127 ± 0.04	0.85HisPhe: 0.85 ± 0.032	1.369HisGly: 1.369 ± 0.041	0.458HisHis: 0.458 ± 0.036	1.378HisIle: 1.378 ± 0.045	0.933HisLys: 0.933 ± 0.038	1.667HisLeu: 1.667 ± 0.045	0.659HisMet: 0.659 ± 0.027	0.685HisAsn: 0.685 ± 0.03	0.903HisPro: 0.903 ± 0.036	0.719HisGln: 0.719 ± 0.034	0.86HisArg: 0.86 ± 0.031	1.052HisSer: 1.052 ± 0.036	1.037HisThr: 1.037 ± 0.036	1.144HisVal: 1.144 ± 0.037	0.155HisTrp: 0.155 ± 0.011	0.8HisTyr: 0.8 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.595IleAla: 5.595 ± 0.092	1.615IleCys: 1.615 ± 0.049	3.849IleAsp: 3.849 ± 0.068	4.478IleGlu: 4.478 ± 0.081	2.893IlePhe: 2.893 ± 0.068	4.97IleGly: 4.97 ± 0.09	1.356IleHis: 1.356 ± 0.041	4.772IleIle: 4.772 ± 0.097	3.608IleLys: 3.608 ± 0.069	7.385IleLeu: 7.385 ± 0.128	2.153IleMet: 2.153 ± 0.056	2.651IleAsn: 2.651 ± 0.061	3.123IlePro: 3.123 ± 0.065	2.841IleGln: 2.841 ± 0.056	3.9IleArg: 3.9 ± 0.072	4.963IleSer: 4.963 ± 0.077	4.26IleThr: 4.26 ± 0.075	4.808IleVal: 4.808 ± 0.09	0.765IleTrp: 0.765 ± 0.031	2.956IleTyr: 2.956 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.823LysAla: 4.823 ± 0.087	0.768LysCys: 0.768 ± 0.03	3.597LysAsp: 3.597 ± 0.069	6.674LysGlu: 6.674 ± 0.109	1.806LysPhe: 1.806 ± 0.049	4.025LysGly: 4.025 ± 0.075	1.02LysHis: 1.02 ± 0.036	4.901LysIle: 4.901 ± 0.073	6.73LysLys: 6.73 ± 0.107	4.997LysLeu: 4.997 ± 0.07	2.392LysMet: 2.392 ± 0.054	3.685LysAsn: 3.685 ± 0.077	1.861LysPro: 1.861 ± 0.045	2.386LysGln: 2.386 ± 0.057	3.034LysArg: 3.034 ± 0.062	3.261LysSer: 3.261 ± 0.074	3.695LysThr: 3.695 ± 0.064	4.398LysVal: 4.398 ± 0.086	0.642LysTrp: 0.642 ± 0.028	2.785LysTyr: 2.785 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	6.814LeuAla: 6.814 ± 0.101	1.54LeuCys: 1.54 ± 0.049	5.206LeuAsp: 5.206 ± 0.079	6.611LeuGlu: 6.611 ± 0.095	3.447LeuPhe: 3.447 ± 0.087	5.638LeuGly: 5.638 ± 0.086	1.676LeuHis: 1.676 ± 0.053	6.047LeuIle: 6.047 ± 0.1	6.114LeuLys: 6.114 ± 0.078	8.421LeuLeu: 8.421 ± 0.149	2.831LeuMet: 2.831 ± 0.062	3.732LeuAsn: 3.732 ± 0.071	3.323LeuPro: 3.323 ± 0.066	3.206LeuGln: 3.206 ± 0.067	3.434LeuArg: 3.434 ± 0.071	5.818LeuSer: 5.818 ± 0.089	5.323LeuThr: 5.323 ± 0.083	5.483LeuVal: 5.483 ± 0.088	0.745LeuTrp: 0.745 ± 0.028	3.33LeuTyr: 3.33 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.634MetAla: 2.634 ± 0.067	0.383MetCys: 0.383 ± 0.019	1.981MetAsp: 1.981 ± 0.047	2.751MetGlu: 2.751 ± 0.07	1.017MetPhe: 1.017 ± 0.034	2.136MetGly: 2.136 ± 0.054	0.52MetHis: 0.52 ± 0.02	2.508MetIle: 2.508 ± 0.066	2.783MetLys: 2.783 ± 0.056	2.876MetLeu: 2.876 ± 0.058	1.122MetMet: 1.122 ± 0.035	1.711MetAsn: 1.711 ± 0.046	1.14MetPro: 1.14 ± 0.035	1.263MetGln: 1.263 ± 0.041	1.341MetArg: 1.341 ± 0.041	1.849MetSer: 1.849 ± 0.047	1.973MetThr: 1.973 ± 0.05	2.114MetVal: 2.114 ± 0.05	0.22MetTrp: 0.22 ± 0.019	0.925MetTyr: 0.925 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.059AsnAla: 3.059 ± 0.059	0.628AsnCys: 0.628 ± 0.032	2.046AsnAsp: 2.046 ± 0.056	2.753AsnGlu: 2.753 ± 0.062	1.362AsnPhe: 1.362 ± 0.041	3.667AsnGly: 3.667 ± 0.077	0.869AsnHis: 0.869 ± 0.034	3.158AsnIle: 3.158 ± 0.067	2.335AsnLys: 2.335 ± 0.057	3.723AsnLeu: 3.723 ± 0.073	1.371AsnMet: 1.371 ± 0.045	1.605AsnAsn: 1.605 ± 0.055	1.827AsnPro: 1.827 ± 0.051	1.648AsnGln: 1.648 ± 0.044	2.025AsnArg: 2.025 ± 0.051	2.21AsnSer: 2.21 ± 0.048	2.331AsnThr: 2.331 ± 0.055	2.833AsnVal: 2.833 ± 0.058	0.499AsnTrp: 0.499 ± 0.024	1.907AsnTyr: 1.907 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.296ProAla: 2.296 ± 0.059	0.448ProCys: 0.448 ± 0.023	2.448ProAsp: 2.448 ± 0.056	3.326ProGlu: 3.326 ± 0.06	1.489ProPhe: 1.489 ± 0.043	2.212ProGly: 2.212 ± 0.06	0.564ProHis: 0.564 ± 0.025	1.943ProIle: 1.943 ± 0.058	1.751ProLys: 1.751 ± 0.047	2.627ProLeu: 2.627 ± 0.059	0.905ProMet: 0.905 ± 0.034	1.131ProAsn: 1.131 ± 0.036	0.578ProPro: 0.578 ± 0.03	1.124ProGln: 1.124 ± 0.037	0.857ProArg: 0.857 ± 0.033	1.71ProSer: 1.71 ± 0.046	1.547ProThr: 1.547 ± 0.045	2.955ProVal: 2.955 ± 0.062	0.296ProTrp: 0.296 ± 0.021	1.412ProTyr: 1.412 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.643GlnAla: 2.643 ± 0.058	0.411GlnCys: 0.411 ± 0.023	1.73GlnAsp: 1.73 ± 0.046	3.13GlnGlu: 3.13 ± 0.074	1.297GlnPhe: 1.297 ± 0.042	2.054GlnGly: 2.054 ± 0.05	0.571GlnHis: 0.571 ± 0.027	3.17GlnIle: 3.17 ± 0.059	3.251GlnLys: 3.251 ± 0.076	3.001GlnLeu: 3.001 ± 0.06	1.45GlnMet: 1.45 ± 0.041	1.97GlnAsn: 1.97 ± 0.055	1.04GlnPro: 1.04 ± 0.041	1.507GlnGln: 1.507 ± 0.049	1.451GlnArg: 1.451 ± 0.045	1.867GlnSer: 1.867 ± 0.043	2.04GlnThr: 2.04 ± 0.057	2.23GlnVal: 2.23 ± 0.056	0.359GlnTrp: 0.359 ± 0.02	1.51GlnTyr: 1.51 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.57ArgAla: 2.57 ± 0.054	0.641ArgCys: 0.641 ± 0.028	2.114ArgAsp: 2.114 ± 0.054	3.82ArgGlu: 3.82 ± 0.087	1.727ArgPhe: 1.727 ± 0.042	2.314ArgGly: 2.314 ± 0.057	0.821ArgHis: 0.821 ± 0.032	3.492ArgIle: 3.492 ± 0.067	3.73ArgLys: 3.73 ± 0.074	3.729ArgLeu: 3.729 ± 0.077	1.696ArgMet: 1.696 ± 0.037	2.005ArgAsn: 2.005 ± 0.052	1.205ArgPro: 1.205 ± 0.037	1.824ArgGln: 1.824 ± 0.046	2.048ArgArg: 2.048 ± 0.06	2.155ArgSer: 2.155 ± 0.05	2.304ArgThr: 2.304 ± 0.054	2.494ArgVal: 2.494 ± 0.051	0.428ArgTrp: 0.428 ± 0.024	1.92ArgTyr: 1.92 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.27SerAla: 4.27 ± 0.084	0.885SerCys: 0.885 ± 0.03	3.335SerAsp: 3.335 ± 0.078	4.145SerGlu: 4.145 ± 0.077	2.409SerPhe: 2.409 ± 0.047	4.966SerGly: 4.966 ± 0.089	1.035SerHis: 1.035 ± 0.036	3.868SerIle: 3.868 ± 0.066	2.954SerLys: 2.954 ± 0.065	4.954SerLeu: 4.954 ± 0.085	1.947SerMet: 1.947 ± 0.058	2.132SerAsn: 2.132 ± 0.05	1.574SerPro: 1.574 ± 0.044	2.036SerGln: 2.036 ± 0.053	2.751SerArg: 2.751 ± 0.051	3.568SerSer: 3.568 ± 0.073	2.855SerThr: 2.855 ± 0.062	4.369SerVal: 4.369 ± 0.077	0.63SerTrp: 0.63 ± 0.028	2.575SerTyr: 2.575 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	4.618ThrAla: 4.618 ± 0.102	0.799ThrCys: 0.799 ± 0.043	3.472ThrAsp: 3.472 ± 0.084	4.786ThrGlu: 4.786 ± 0.106	2.17ThrPhe: 2.17 ± 0.056	4.956ThrGly: 4.956 ± 0.097	0.908ThrHis: 0.908 ± 0.032	3.991ThrIle: 3.991 ± 0.075	2.82ThrLys: 2.82 ± 0.066	4.947ThrLeu: 4.947 ± 0.084	1.593ThrMet: 1.593 ± 0.045	1.96ThrAsn: 1.96 ± 0.052	2.075ThrPro: 2.075 ± 0.061	1.578ThrGln: 1.578 ± 0.047	2.104ThrArg: 2.104 ± 0.047	3.084ThrSer: 3.084 ± 0.074	3.02ThrThr: 3.02 ± 0.075	4.663ThrVal: 4.663 ± 0.096	0.594ThrTrp: 0.594 ± 0.028	2.279ThrTyr: 2.279 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	4.738ValAla: 4.738 ± 0.088	1.245ValCys: 1.245 ± 0.037	3.618ValAsp: 3.618 ± 0.07	4.521ValGlu: 4.521 ± 0.071	2.789ValPhe: 2.789 ± 0.059	4.203ValGly: 4.203 ± 0.077	1.072ValHis: 1.072 ± 0.036	5.233ValIle: 5.233 ± 0.098	4.428ValLys: 4.428 ± 0.077	6.677ValLeu: 6.677 ± 0.113	2.173ValMet: 2.173 ± 0.058	2.801ValAsn: 2.801 ± 0.057	2.531ValPro: 2.531 ± 0.05	2.208ValGln: 2.208 ± 0.057	2.77ValArg: 2.77 ± 0.067	4.601ValSer: 4.601 ± 0.073	4.53ValThr: 4.53 ± 0.09	4.538ValVal: 4.538 ± 0.083	0.618ValTrp: 0.618 ± 0.028	2.766ValTyr: 2.766 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.508TrpAla: 0.508 ± 0.026	0.182TrpCys: 0.182 ± 0.016	0.525TrpAsp: 0.525 ± 0.024	0.676TrpGlu: 0.676 ± 0.027	0.399TrpPhe: 0.399 ± 0.021	0.633TrpGly: 0.633 ± 0.028	0.193TrpHis: 0.193 ± 0.016	0.783TrpIle: 0.783 ± 0.029	0.952TrpLys: 0.952 ± 0.035	0.868TrpLeu: 0.868 ± 0.028	0.442TrpMet: 0.442 ± 0.023	0.588TrpAsn: 0.588 ± 0.031	0.222TrpPro: 0.222 ± 0.015	0.439TrpGln: 0.439 ± 0.024	0.382TrpArg: 0.382 ± 0.02	0.526TrpSer: 0.526 ± 0.025	0.471TrpThr: 0.471 ± 0.026	0.471TrpVal: 0.471 ± 0.028	0.095TrpTrp: 0.095 ± 0.011	0.423TrpTyr: 0.423 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.788TyrAla: 2.788 ± 0.061	0.683TyrCys: 0.683 ± 0.032	2.626TyrAsp: 2.626 ± 0.067	3.069TyrGlu: 3.069 ± 0.063	1.788TyrPhe: 1.788 ± 0.046	3.074TyrGly: 3.074 ± 0.062	0.975TyrHis: 0.975 ± 0.034	2.783TyrIle: 2.783 ± 0.058	2.126TyrLys: 2.126 ± 0.05	4.031TyrLeu: 4.031 ± 0.08	1.166TyrMet: 1.166 ± 0.035	1.66TyrAsn: 1.66 ± 0.045	1.397TyrPro: 1.397 ± 0.038	1.851TyrGln: 1.851 ± 0.053	2.148TyrArg: 2.148 ± 0.05	2.297TyrSer: 2.297 ± 0.05	2.515TyrThr: 2.515 ± 0.075	2.72TyrVal: 2.72 ± 0.057	0.4TyrTrp: 0.4 ± 0.024	2.021TyrTyr: 2.021 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2857 proteins (872464 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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