Amino acid dipepetide frequency for Streptomyces sp. SID7982

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.034AlaAla: 21.034 ± 0.097	1.041AlaCys: 1.041 ± 0.018	8.494AlaAsp: 8.494 ± 0.054	9.32AlaGlu: 9.32 ± 0.065	3.627AlaPhe: 3.627 ± 0.03	13.27AlaGly: 13.27 ± 0.069	2.857AlaHis: 2.857 ± 0.03	3.209AlaIle: 3.209 ± 0.031	2.848AlaLys: 2.848 ± 0.036	14.873AlaLeu: 14.873 ± 0.078	2.481AlaMet: 2.481 ± 0.024	1.79AlaAsn: 1.79 ± 0.027	7.315AlaPro: 7.315 ± 0.051	3.556AlaGln: 3.556 ± 0.033	10.26AlaArg: 10.26 ± 0.067	5.889AlaSer: 5.889 ± 0.04	7.003AlaThr: 7.003 ± 0.045	12.398AlaVal: 12.398 ± 0.062	1.845AlaTrp: 1.845 ± 0.024	2.865AlaTyr: 2.865 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	1.068CysAla: 1.068 ± 0.018	0.093CysCys: 0.093 ± 0.005	0.451CysAsp: 0.451 ± 0.01	0.401CysGlu: 0.401 ± 0.011	0.216CysPhe: 0.216 ± 0.007	0.94CysGly: 0.94 ± 0.017	0.191CysHis: 0.191 ± 0.008	0.148CysIle: 0.148 ± 0.007	0.11CysLys: 0.11 ± 0.006	0.705CysLeu: 0.705 ± 0.015	0.112CysMet: 0.112 ± 0.005	0.122CysAsn: 0.122 ± 0.006	0.466CysPro: 0.466 ± 0.013	0.162CysGln: 0.162 ± 0.006	0.599CysArg: 0.599 ± 0.012	0.415CysSer: 0.415 ± 0.01	0.487CysThr: 0.487 ± 0.011	0.653CysVal: 0.653 ± 0.013	0.121CysTrp: 0.121 ± 0.005	0.141CysTyr: 0.141 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	7.918AspAla: 7.918 ± 0.052	0.406AspCys: 0.406 ± 0.011	3.569AspAsp: 3.569 ± 0.037	4.043AspGlu: 4.043 ± 0.031	1.612AspPhe: 1.612 ± 0.022	6.505AspGly: 6.505 ± 0.045	1.471AspHis: 1.471 ± 0.019	1.828AspIle: 1.828 ± 0.023	1.186AspLys: 1.186 ± 0.022	6.194AspLeu: 6.194 ± 0.041	0.774AspMet: 0.774 ± 0.014	0.917AspAsn: 0.917 ± 0.016	4.612AspPro: 4.612 ± 0.037	1.593AspGln: 1.593 ± 0.019	5.19AspArg: 5.19 ± 0.041	2.519AspSer: 2.519 ± 0.029	3.288AspThr: 3.288 ± 0.033	4.554AspVal: 4.554 ± 0.037	1.03AspTrp: 1.03 ± 0.018	1.051AspTyr: 1.051 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	8.019GluAla: 8.019 ± 0.053	0.358GluCys: 0.358 ± 0.011	3.101GluAsp: 3.101 ± 0.029	4.122GluGlu: 4.122 ± 0.04	1.472GluPhe: 1.472 ± 0.019	4.796GluGly: 4.796 ± 0.038	1.527GluHis: 1.527 ± 0.019	2.283GluIle: 2.283 ± 0.026	1.643GluLys: 1.643 ± 0.026	6.942GluLeu: 6.942 ± 0.047	0.889GluMet: 0.889 ± 0.014	1.076GluAsn: 1.076 ± 0.018	3.507GluPro: 3.507 ± 0.035	2.338GluGln: 2.338 ± 0.029	5.759GluArg: 5.759 ± 0.046	2.643GluSer: 2.643 ± 0.029	2.982GluThr: 2.982 ± 0.031	4.622GluVal: 4.622 ± 0.037	0.776GluTrp: 0.776 ± 0.014	1.127GluTyr: 1.127 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.778PheAla: 3.778 ± 0.035	0.269PheCys: 0.269 ± 0.009	1.983PheAsp: 1.983 ± 0.023	1.393PheGlu: 1.393 ± 0.018	0.907PhePhe: 0.907 ± 0.019	3.058PheGly: 3.058 ± 0.029	0.639PheHis: 0.639 ± 0.015	0.738PheIle: 0.738 ± 0.014	0.482PheLys: 0.482 ± 0.013	2.681PheLeu: 2.681 ± 0.031	0.388PheMet: 0.388 ± 0.01	0.532PheAsn: 0.532 ± 0.013	1.421PhePro: 1.421 ± 0.02	0.682PheGln: 0.682 ± 0.014	1.834PheArg: 1.834 ± 0.024	1.476PheSer: 1.476 ± 0.018	2.062PheThr: 2.062 ± 0.027	2.185PheVal: 2.185 ± 0.025	0.438PheTrp: 0.438 ± 0.01	0.54PheTyr: 0.54 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	11.265GlyAla: 11.265 ± 0.057	0.813GlyCys: 0.813 ± 0.015	5.3GlyAsp: 5.3 ± 0.036	5.652GlyGlu: 5.652 ± 0.043	2.881GlyPhe: 2.881 ± 0.026	8.989GlyGly: 8.989 ± 0.061	2.331GlyHis: 2.331 ± 0.029	3.335GlyIle: 3.335 ± 0.031	2.445GlyLys: 2.445 ± 0.029	9.667GlyLeu: 9.667 ± 0.054	1.961GlyMet: 1.961 ± 0.024	1.737GlyAsn: 1.737 ± 0.021	5.417GlyPro: 5.417 ± 0.038	2.689GlyGln: 2.689 ± 0.028	7.872GlyArg: 7.872 ± 0.047	5.334GlySer: 5.334 ± 0.044	6.366GlyThr: 6.366 ± 0.042	7.589GlyVal: 7.589 ± 0.049	1.694GlyTrp: 1.694 ± 0.021	2.236GlyTyr: 2.236 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.637HisAla: 2.637 ± 0.028	0.213HisCys: 0.213 ± 0.008	1.307HisAsp: 1.307 ± 0.018	1.21HisGlu: 1.21 ± 0.019	0.647HisPhe: 0.647 ± 0.012	2.372HisGly: 2.372 ± 0.024	0.717HisHis: 0.717 ± 0.016	0.664HisIle: 0.664 ± 0.014	0.325HisLys: 0.325 ± 0.01	2.564HisLeu: 2.564 ± 0.029	0.312HisMet: 0.312 ± 0.009	0.343HisAsn: 0.343 ± 0.01	1.872HisPro: 1.872 ± 0.025	0.679HisGln: 0.679 ± 0.014	2.176HisArg: 2.176 ± 0.026	1.007HisSer: 1.007 ± 0.015	1.379HisThr: 1.379 ± 0.019	1.643HisVal: 1.643 ± 0.022	0.378HisTrp: 0.378 ± 0.011	0.448HisTyr: 0.448 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.655IleAla: 4.655 ± 0.04	0.286IleCys: 0.286 ± 0.009	2.174IleAsp: 2.174 ± 0.027	1.958IleGlu: 1.958 ± 0.026	0.687IlePhe: 0.687 ± 0.013	3.547IleGly: 3.547 ± 0.035	0.582IleHis: 0.582 ± 0.012	0.863IleIle: 0.863 ± 0.016	0.696IleLys: 0.696 ± 0.015	2.388IleLeu: 2.388 ± 0.028	0.444IleMet: 0.444 ± 0.011	0.67IleAsn: 0.67 ± 0.015	1.688IlePro: 1.688 ± 0.022	0.694IleGln: 0.694 ± 0.014	2.12IleArg: 2.12 ± 0.026	1.626IleSer: 1.626 ± 0.02	2.167IleThr: 2.167 ± 0.027	2.658IleVal: 2.658 ± 0.027	0.382IleTrp: 0.382 ± 0.011	0.487IleTyr: 0.487 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	2.937LysAla: 2.937 ± 0.036	0.102LysCys: 0.102 ± 0.005	1.37LysAsp: 1.37 ± 0.023	1.29LysGlu: 1.29 ± 0.021	0.461LysPhe: 0.461 ± 0.012	1.856LysGly: 1.856 ± 0.028	0.435LysHis: 0.435 ± 0.011	0.88LysIle: 0.88 ± 0.016	0.935LysLys: 0.935 ± 0.026	2.034LysLeu: 2.034 ± 0.023	0.358LysMet: 0.358 ± 0.01	0.539LysAsn: 0.539 ± 0.013	1.331LysPro: 1.331 ± 0.023	0.696LysGln: 0.696 ± 0.014	1.45LysArg: 1.45 ± 0.02	1.131LysSer: 1.131 ± 0.019	1.255LysThr: 1.255 ± 0.022	1.869LysVal: 1.869 ± 0.026	0.244LysTrp: 0.244 ± 0.008	0.421LysTyr: 0.421 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	15.357LeuAla: 15.357 ± 0.08	0.844LeuCys: 0.844 ± 0.016	6.934LeuAsp: 6.934 ± 0.046	4.832LeuGlu: 4.832 ± 0.042	2.673LeuPhe: 2.673 ± 0.028	9.392LeuGly: 9.392 ± 0.054	2.391LeuHis: 2.391 ± 0.028	3.324LeuIle: 3.324 ± 0.036	2.059LeuLys: 2.059 ± 0.024	11.725LeuLeu: 11.725 ± 0.078	1.756LeuMet: 1.756 ± 0.023	1.667LeuAsn: 1.667 ± 0.022	6.565LeuPro: 6.565 ± 0.045	2.133LeuGln: 2.133 ± 0.025	8.64LeuArg: 8.64 ± 0.056	5.295LeuSer: 5.295 ± 0.039	7.09LeuThr: 7.09 ± 0.048	9.007LeuVal: 9.007 ± 0.057	1.317LeuTrp: 1.317 ± 0.02	1.84LeuTyr: 1.84 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.243MetAla: 2.243 ± 0.026	0.128MetCys: 0.128 ± 0.006	0.888MetAsp: 0.888 ± 0.015	0.79MetGlu: 0.79 ± 0.016	0.467MetPhe: 0.467 ± 0.011	1.3MetGly: 1.3 ± 0.02	0.325MetHis: 0.325 ± 0.01	0.665MetIle: 0.665 ± 0.015	0.416MetLys: 0.416 ± 0.012	1.66MetLeu: 1.66 ± 0.023	0.301MetMet: 0.301 ± 0.01	0.43MetAsn: 0.43 ± 0.011	1.065MetPro: 1.065 ± 0.017	0.436MetGln: 0.436 ± 0.012	1.369MetArg: 1.369 ± 0.019	1.26MetSer: 1.26 ± 0.017	1.512MetThr: 1.512 ± 0.021	1.304MetVal: 1.304 ± 0.019	0.199MetTrp: 0.199 ± 0.008	0.31MetTyr: 0.31 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.155AsnAla: 2.155 ± 0.026	0.153AsnCys: 0.153 ± 0.007	0.898AsnAsp: 0.898 ± 0.015	0.823AsnGlu: 0.823 ± 0.016	0.466AsnPhe: 0.466 ± 0.01	1.82AsnGly: 1.82 ± 0.022	0.367AsnHis: 0.367 ± 0.011	0.641AsnIle: 0.641 ± 0.013	0.409AsnLys: 0.409 ± 0.011	1.626AsnLeu: 1.626 ± 0.024	0.292AsnMet: 0.292 ± 0.01	0.398AsnAsn: 0.398 ± 0.012	1.274AsnPro: 1.274 ± 0.018	0.504AsnGln: 0.504 ± 0.011	1.251AsnArg: 1.251 ± 0.018	0.858AsnSer: 0.858 ± 0.016	1.082AsnThr: 1.082 ± 0.018	1.297AsnVal: 1.297 ± 0.019	0.268AsnTrp: 0.268 ± 0.01	0.405AsnTyr: 0.405 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	8.836ProAla: 8.836 ± 0.059	0.311ProCys: 0.311 ± 0.011	4.642ProAsp: 4.642 ± 0.034	4.686ProGlu: 4.686 ± 0.036	1.593ProPhe: 1.593 ± 0.02	6.88ProGly: 6.88 ± 0.052	1.4ProHis: 1.4 ± 0.019	1.158ProIle: 1.158 ± 0.019	1.217ProLys: 1.217 ± 0.018	5.538ProLeu: 5.538 ± 0.045	0.982ProMet: 0.982 ± 0.017	0.829ProAsn: 0.829 ± 0.014	3.434ProPro: 3.434 ± 0.043	1.649ProGln: 1.649 ± 0.026	3.906ProArg: 3.906 ± 0.038	3.03ProSer: 3.03 ± 0.028	3.002ProThr: 3.002 ± 0.03	5.561ProVal: 5.561 ± 0.041	0.91ProTrp: 0.91 ± 0.015	1.39ProTyr: 1.39 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.606GlnAla: 3.606 ± 0.034	0.157GlnCys: 0.157 ± 0.007	1.423GlnAsp: 1.423 ± 0.018	1.569GlnGlu: 1.569 ± 0.021	0.66GlnPhe: 0.66 ± 0.011	2.325GlnGly: 2.325 ± 0.03	0.638GlnHis: 0.638 ± 0.013	1.063GlnIle: 1.063 ± 0.018	0.627GlnLys: 0.627 ± 0.016	2.94GlnLeu: 2.94 ± 0.031	0.465GlnMet: 0.465 ± 0.012	0.5GlnAsn: 0.5 ± 0.014	1.582GlnPro: 1.582 ± 0.024	1.225GlnGln: 1.225 ± 0.026	2.344GlnArg: 2.344 ± 0.026	1.194GlnSer: 1.194 ± 0.02	1.265GlnThr: 1.265 ± 0.016	2.342GlnVal: 2.342 ± 0.025	0.429GlnTrp: 0.429 ± 0.009	0.59GlnTyr: 0.59 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	9.937ArgAla: 9.937 ± 0.063	0.584ArgCys: 0.584 ± 0.015	4.375ArgAsp: 4.375 ± 0.037	4.985ArgGlu: 4.985 ± 0.043	2.371ArgPhe: 2.371 ± 0.027	5.825ArgGly: 5.825 ± 0.041	2.072ArgHis: 2.072 ± 0.025	3.198ArgIle: 3.198 ± 0.032	1.661ArgLys: 1.661 ± 0.023	8.841ArgLeu: 8.841 ± 0.059	1.64ArgMet: 1.64 ± 0.022	1.351ArgAsn: 1.351 ± 0.021	5.026ArgPro: 5.026 ± 0.037	2.19ArgGln: 2.19 ± 0.026	7.571ArgArg: 7.571 ± 0.052	4.118ArgSer: 4.118 ± 0.036	5.573ArgThr: 5.573 ± 0.042	5.821ArgVal: 5.821 ± 0.047	1.354ArgTrp: 1.354 ± 0.019	1.782ArgTyr: 1.782 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.654SerAla: 6.654 ± 0.039	0.396SerCys: 0.396 ± 0.01	2.604SerAsp: 2.604 ± 0.027	2.415SerGlu: 2.415 ± 0.026	1.551SerPhe: 1.551 ± 0.023	5.951SerGly: 5.951 ± 0.045	1.033SerHis: 1.033 ± 0.02	1.377SerIle: 1.377 ± 0.02	0.992SerLys: 0.992 ± 0.019	4.96SerLeu: 4.96 ± 0.038	0.985SerMet: 0.985 ± 0.016	0.818SerAsn: 0.818 ± 0.013	3.135SerPro: 3.135 ± 0.027	1.204SerGln: 1.204 ± 0.018	3.606SerArg: 3.606 ± 0.031	2.777SerSer: 2.777 ± 0.036	2.989SerThr: 2.989 ± 0.025	4.242SerVal: 4.242 ± 0.035	0.909SerTrp: 0.909 ± 0.016	1.165SerTyr: 1.165 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.847ThrAla: 8.847 ± 0.045	0.407ThrCys: 0.407 ± 0.013	3.53ThrAsp: 3.53 ± 0.033	3.505ThrGlu: 3.505 ± 0.03	1.625ThrPhe: 1.625 ± 0.024	6.959ThrGly: 6.959 ± 0.046	1.173ThrHis: 1.173 ± 0.022	1.572ThrIle: 1.572 ± 0.023	1.101ThrLys: 1.101 ± 0.02	5.96ThrLeu: 5.96 ± 0.044	0.924ThrMet: 0.924 ± 0.016	0.926ThrAsn: 0.926 ± 0.015	4.144ThrPro: 4.144 ± 0.037	1.282ThrGln: 1.282 ± 0.018	3.934ThrArg: 3.934 ± 0.038	3.011ThrSer: 3.011 ± 0.032	3.83ThrThr: 3.83 ± 0.042	6.199ThrVal: 6.199 ± 0.041	0.895ThrTrp: 0.895 ± 0.017	1.327ThrTyr: 1.327 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	10.599ValAla: 10.599 ± 0.055	0.727ValCys: 0.727 ± 0.016	4.977ValAsp: 4.977 ± 0.035	4.916ValGlu: 4.916 ± 0.039	2.418ValPhe: 2.418 ± 0.028	6.436ValGly: 6.436 ± 0.048	2.009ValHis: 2.009 ± 0.026	2.829ValIle: 2.829 ± 0.031	1.702ValLys: 1.702 ± 0.024	9.741ValLeu: 9.741 ± 0.058	1.47ValMet: 1.47 ± 0.021	1.583ValAsn: 1.583 ± 0.022	5.268ValPro: 5.268 ± 0.043	2.035ValGln: 2.035 ± 0.02	7.255ValArg: 7.255 ± 0.048	4.343ValSer: 4.343 ± 0.038	5.588ValThr: 5.588 ± 0.039	7.901ValVal: 7.901 ± 0.058	1.129ValTrp: 1.129 ± 0.018	1.529ValTyr: 1.529 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.629TrpAla: 1.629 ± 0.022	0.149TrpCys: 0.149 ± 0.006	0.809TrpAsp: 0.809 ± 0.017	0.818TrpGlu: 0.818 ± 0.013	0.534TrpPhe: 0.534 ± 0.013	1.074TrpGly: 1.074 ± 0.016	0.349TrpHis: 0.349 ± 0.01	0.527TrpIle: 0.527 ± 0.011	0.371TrpLys: 0.371 ± 0.01	1.738TrpLeu: 1.738 ± 0.024	0.281TrpMet: 0.281 ± 0.009	0.377TrpAsn: 0.377 ± 0.01	0.783TrpPro: 0.783 ± 0.013	0.612TrpGln: 0.612 ± 0.013	1.323TrpArg: 1.323 ± 0.02	0.933TrpSer: 0.933 ± 0.016	1.029TrpThr: 1.029 ± 0.017	0.985TrpVal: 0.985 ± 0.018	0.33TrpTrp: 0.33 ± 0.009	0.348TrpTyr: 0.348 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.801TyrAla: 2.801 ± 0.027	0.162TyrCys: 0.162 ± 0.007	1.431TyrAsp: 1.431 ± 0.023	1.254TyrGlu: 1.254 ± 0.019	0.619TyrPhe: 0.619 ± 0.013	2.278TyrGly: 2.278 ± 0.025	0.386TyrHis: 0.386 ± 0.011	0.469TyrIle: 0.469 ± 0.012	0.368TyrLys: 0.368 ± 0.01	2.064TyrLeu: 2.064 ± 0.027	0.252TyrMet: 0.252 ± 0.008	0.382TyrAsn: 0.382 ± 0.01	1.053TyrPro: 1.053 ± 0.017	0.585TyrGln: 0.585 ± 0.013	1.817TyrArg: 1.817 ± 0.024	0.904TyrSer: 0.904 ± 0.017	1.204TyrThr: 1.204 ± 0.018	1.624TyrVal: 1.624 ± 0.022	0.351TyrTrp: 0.351 ± 0.011	0.427TyrTyr: 0.427 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 19102 proteins (3686652 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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