Amino acid dipepetide frequency for Kribbella sp. 16K104

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.735AlaAla: 18.735 ± 0.129	0.911AlaCys: 0.911 ± 0.019	8.243AlaAsp: 8.243 ± 0.066	7.961AlaGlu: 7.961 ± 0.081	3.623AlaPhe: 3.623 ± 0.04	12.61AlaGly: 12.61 ± 0.09	2.232AlaHis: 2.232 ± 0.032	4.838AlaIle: 4.838 ± 0.056	3.047AlaLys: 3.047 ± 0.052	12.442AlaLeu: 12.442 ± 0.09	2.446AlaMet: 2.446 ± 0.038	2.391AlaAsn: 2.391 ± 0.037	5.466AlaPro: 5.466 ± 0.061	3.515AlaGln: 3.515 ± 0.043	8.523AlaArg: 8.523 ± 0.069	5.773AlaSer: 5.773 ± 0.055	7.244AlaThr: 7.244 ± 0.065	11.589AlaVal: 11.589 ± 0.087	1.886AlaTrp: 1.886 ± 0.035	2.63AlaTyr: 2.63 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.844CysAla: 0.844 ± 0.021	0.099CysCys: 0.099 ± 0.007	0.454CysAsp: 0.454 ± 0.014	0.39CysGlu: 0.39 ± 0.015	0.232CysPhe: 0.232 ± 0.011	0.858CysGly: 0.858 ± 0.023	0.182CysHis: 0.182 ± 0.009	0.195CysIle: 0.195 ± 0.009	0.108CysLys: 0.108 ± 0.007	0.675CysLeu: 0.675 ± 0.019	0.104CysMet: 0.104 ± 0.007	0.154CysAsn: 0.154 ± 0.008	0.446CysPro: 0.446 ± 0.015	0.176CysGln: 0.176 ± 0.01	0.568CysArg: 0.568 ± 0.017	0.429CysSer: 0.429 ± 0.015	0.499CysThr: 0.499 ± 0.016	0.568CysVal: 0.568 ± 0.014	0.12CysTrp: 0.12 ± 0.008	0.16CysTyr: 0.16 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.234AspAla: 7.234 ± 0.067	0.41AspCys: 0.41 ± 0.011	4.132AspAsp: 4.132 ± 0.046	4.138AspGlu: 4.138 ± 0.047	1.703AspPhe: 1.703 ± 0.029	6.305AspGly: 6.305 ± 0.067	1.499AspHis: 1.499 ± 0.028	1.976AspIle: 1.976 ± 0.032	1.327AspLys: 1.327 ± 0.025	6.895AspLeu: 6.895 ± 0.067	0.723AspMet: 0.723 ± 0.02	1.18AspAsn: 1.18 ± 0.029	4.526AspPro: 4.526 ± 0.049	1.941AspGln: 1.941 ± 0.034	4.883AspArg: 4.883 ± 0.048	2.637AspSer: 2.637 ± 0.038	2.793AspThr: 2.793 ± 0.04	5.531AspVal: 5.531 ± 0.053	1.083AspTrp: 1.083 ± 0.024	1.292AspTyr: 1.292 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.438GluAla: 6.438 ± 0.061	0.304GluCys: 0.304 ± 0.014	2.588GluAsp: 2.588 ± 0.04	2.704GluGlu: 2.704 ± 0.039	1.637GluPhe: 1.637 ± 0.027	3.482GluGly: 3.482 ± 0.046	1.528GluHis: 1.528 ± 0.027	2.435GluIle: 2.435 ± 0.041	1.323GluLys: 1.323 ± 0.034	7.154GluLeu: 7.154 ± 0.07	0.874GluMet: 0.874 ± 0.02	1.11GluAsn: 1.11 ± 0.021	3.281GluPro: 3.281 ± 0.044	2.341GluGln: 2.341 ± 0.035	4.692GluArg: 4.692 ± 0.061	2.754GluSer: 2.754 ± 0.037	2.882GluThr: 2.882 ± 0.036	4.683GluVal: 4.683 ± 0.055	0.848GluTrp: 0.848 ± 0.017	1.282GluTyr: 1.282 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.791PheAla: 3.791 ± 0.044	0.277PheCys: 0.277 ± 0.011	2.192PheAsp: 2.192 ± 0.033	1.622PheGlu: 1.622 ± 0.026	0.955PhePhe: 0.955 ± 0.024	3.209PheGly: 3.209 ± 0.04	0.637PheHis: 0.637 ± 0.018	0.808PheIle: 0.808 ± 0.021	0.565PheLys: 0.565 ± 0.017	2.701PheLeu: 2.701 ± 0.038	0.377PheMet: 0.377 ± 0.013	0.662PheAsn: 0.662 ± 0.018	1.381PhePro: 1.381 ± 0.025	0.758PheGln: 0.758 ± 0.019	1.994PheArg: 1.994 ± 0.028	1.607PheSer: 1.607 ± 0.031	2.075PheThr: 2.075 ± 0.032	2.747PheVal: 2.747 ± 0.037	0.491PheTrp: 0.491 ± 0.014	0.712PheTyr: 0.712 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	9.462GlyAla: 9.462 ± 0.075	0.816GlyCys: 0.816 ± 0.021	5.171GlyAsp: 5.171 ± 0.059	4.579GlyGlu: 4.579 ± 0.05	3.027GlyPhe: 3.027 ± 0.04	7.752GlyGly: 7.752 ± 0.078	1.988GlyHis: 1.988 ± 0.03	3.867GlyIle: 3.867 ± 0.046	2.491GlyLys: 2.491 ± 0.042	9.577GlyLeu: 9.577 ± 0.084	1.863GlyMet: 1.863 ± 0.031	2.076GlyAsn: 2.076 ± 0.04	4.655GlyPro: 4.655 ± 0.059	2.794GlyGln: 2.794 ± 0.047	6.965GlyArg: 6.965 ± 0.056	5.346GlySer: 5.346 ± 0.055	5.824GlyThr: 5.824 ± 0.062	7.838GlyVal: 7.838 ± 0.061	1.824GlyTrp: 1.824 ± 0.031	2.441GlyTyr: 2.441 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.275HisAla: 2.275 ± 0.036	0.188HisCys: 0.188 ± 0.01	1.327HisAsp: 1.327 ± 0.028	1.185HisGlu: 1.185 ± 0.025	0.606HisPhe: 0.606 ± 0.019	2.098HisGly: 2.098 ± 0.034	0.666HisHis: 0.666 ± 0.018	0.588HisIle: 0.588 ± 0.016	0.389HisLys: 0.389 ± 0.015	2.415HisLeu: 2.415 ± 0.033	0.266HisMet: 0.266 ± 0.012	0.436HisAsn: 0.436 ± 0.014	1.564HisPro: 1.564 ± 0.029	0.689HisGln: 0.689 ± 0.018	1.892HisArg: 1.892 ± 0.034	0.992HisSer: 0.992 ± 0.023	1.116HisThr: 1.116 ± 0.025	1.732HisVal: 1.732 ± 0.032	0.379HisTrp: 0.379 ± 0.011	0.478HisTyr: 0.478 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.49IleAla: 5.49 ± 0.054	0.323IleCys: 0.323 ± 0.013	2.825IleAsp: 2.825 ± 0.04	2.352IleGlu: 2.352 ± 0.036	0.98IlePhe: 0.98 ± 0.022	4.158IleGly: 4.158 ± 0.047	0.678IleHis: 0.678 ± 0.02	1.079IleIle: 1.079 ± 0.025	0.776IleLys: 0.776 ± 0.022	2.992IleLeu: 2.992 ± 0.039	0.479IleMet: 0.479 ± 0.014	0.796IleAsn: 0.796 ± 0.019	2.028IlePro: 2.028 ± 0.03	0.912IleGln: 0.912 ± 0.022	2.654IleArg: 2.654 ± 0.038	2.058IleSer: 2.058 ± 0.031	2.62IleThr: 2.62 ± 0.034	3.472IleVal: 3.472 ± 0.039	0.493IleTrp: 0.493 ± 0.015	0.768IleTyr: 0.768 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.05LysAla: 3.05 ± 0.048	0.112LysCys: 0.112 ± 0.008	1.274LysAsp: 1.274 ± 0.029	1.032LysGlu: 1.032 ± 0.024	0.575LysPhe: 0.575 ± 0.018	1.672LysGly: 1.672 ± 0.034	0.507LysHis: 0.507 ± 0.016	0.885LysIle: 0.885 ± 0.023	0.761LysLys: 0.761 ± 0.029	2.437LysLeu: 2.437 ± 0.038	0.388LysMet: 0.388 ± 0.014	0.561LysAsn: 0.561 ± 0.016	1.548LysPro: 1.548 ± 0.035	0.785LysGln: 0.785 ± 0.022	1.417LysArg: 1.417 ± 0.028	1.274LysSer: 1.274 ± 0.032	1.365LysThr: 1.365 ± 0.03	2.198LysVal: 2.198 ± 0.034	0.31LysTrp: 0.31 ± 0.014	0.587LysTyr: 0.587 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.314LeuAla: 14.314 ± 0.092	0.714LeuCys: 0.714 ± 0.018	6.842LeuAsp: 6.842 ± 0.063	5.049LeuGlu: 5.049 ± 0.06	2.701LeuPhe: 2.701 ± 0.041	9.199LeuGly: 9.199 ± 0.081	2.178LeuHis: 2.178 ± 0.032	3.982LeuIle: 3.982 ± 0.052	2.09LeuLys: 2.09 ± 0.03	10.578LeuLeu: 10.578 ± 0.1	1.681LeuMet: 1.681 ± 0.03	1.985LeuAsn: 1.985 ± 0.027	6.029LeuPro: 6.029 ± 0.057	2.673LeuGln: 2.673 ± 0.035	8.012LeuArg: 8.012 ± 0.076	5.565LeuSer: 5.565 ± 0.056	7.104LeuThr: 7.104 ± 0.06	9.381LeuVal: 9.381 ± 0.077	1.371LeuTrp: 1.371 ± 0.026	1.93LeuTyr: 1.93 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.133MetAla: 2.133 ± 0.035	0.102MetCys: 0.102 ± 0.008	0.847MetAsp: 0.847 ± 0.022	0.696MetGlu: 0.696 ± 0.019	0.537MetPhe: 0.537 ± 0.018	1.153MetGly: 1.153 ± 0.026	0.349MetHis: 0.349 ± 0.011	0.765MetIle: 0.765 ± 0.019	0.465MetLys: 0.465 ± 0.015	1.824MetLeu: 1.824 ± 0.029	0.322MetMet: 0.322 ± 0.014	0.464MetAsn: 0.464 ± 0.015	1.073MetPro: 1.073 ± 0.023	0.458MetGln: 0.458 ± 0.015	1.359MetArg: 1.359 ± 0.024	1.33MetSer: 1.33 ± 0.026	1.591MetThr: 1.591 ± 0.025	1.444MetVal: 1.444 ± 0.025	0.193MetTrp: 0.193 ± 0.009	0.336MetTyr: 0.336 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.457AsnAla: 2.457 ± 0.033	0.18AsnCys: 0.18 ± 0.01	1.243AsnAsp: 1.243 ± 0.027	0.991AsnGlu: 0.991 ± 0.024	0.611AsnPhe: 0.611 ± 0.018	2.182AsnGly: 2.182 ± 0.038	0.488AsnHis: 0.488 ± 0.015	0.714AsnIle: 0.714 ± 0.021	0.444AsnLys: 0.444 ± 0.016	2.125AsnLeu: 2.125 ± 0.03	0.301AsnMet: 0.301 ± 0.011	0.534AsnAsn: 0.534 ± 0.02	1.617AsnPro: 1.617 ± 0.029	0.736AsnGln: 0.736 ± 0.019	1.508AsnArg: 1.508 ± 0.026	1.102AsnSer: 1.102 ± 0.026	1.192AsnThr: 1.192 ± 0.029	1.693AsnVal: 1.693 ± 0.027	0.402AsnTrp: 0.402 ± 0.013	0.526AsnTyr: 0.526 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.779ProAla: 7.779 ± 0.061	0.303ProCys: 0.303 ± 0.013	4.483ProAsp: 4.483 ± 0.044	3.799ProGlu: 3.799 ± 0.042	1.546ProPhe: 1.546 ± 0.029	5.862ProGly: 5.862 ± 0.056	1.124ProHis: 1.124 ± 0.026	1.851ProIle: 1.851 ± 0.029	1.277ProLys: 1.277 ± 0.028	4.86ProLeu: 4.86 ± 0.059	1.0ProMet: 1.0 ± 0.023	1.203ProAsn: 1.203 ± 0.027	3.131ProPro: 3.131 ± 0.047	1.594ProGln: 1.594 ± 0.027	3.492ProArg: 3.492 ± 0.042	3.201ProSer: 3.201 ± 0.048	3.412ProThr: 3.412 ± 0.046	5.128ProVal: 5.128 ± 0.048	0.959ProTrp: 0.959 ± 0.02	1.379ProTyr: 1.379 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.839GlnAla: 3.839 ± 0.041	0.162GlnCys: 0.162 ± 0.009	1.381GlnAsp: 1.381 ± 0.025	1.313GlnGlu: 1.313 ± 0.025	0.85GlnPhe: 0.85 ± 0.021	2.069GlnGly: 2.069 ± 0.04	0.685GlnHis: 0.685 ± 0.019	1.238GlnIle: 1.238 ± 0.025	0.67GlnLys: 0.67 ± 0.021	3.526GlnLeu: 3.526 ± 0.039	0.486GlnMet: 0.486 ± 0.018	0.63GlnAsn: 0.63 ± 0.017	1.905GlnPro: 1.905 ± 0.04	1.346GlnGln: 1.346 ± 0.033	2.467GlnArg: 2.467 ± 0.035	1.442GlnSer: 1.442 ± 0.025	1.568GlnThr: 1.568 ± 0.031	2.85GlnVal: 2.85 ± 0.033	0.525GlnTrp: 0.525 ± 0.017	0.785GlnTyr: 0.785 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.115ArgAla: 8.115 ± 0.069	0.524ArgCys: 0.524 ± 0.016	4.162ArgAsp: 4.162 ± 0.051	3.989ArgGlu: 3.989 ± 0.046	2.383ArgPhe: 2.383 ± 0.032	5.216ArgGly: 5.216 ± 0.05	1.724ArgHis: 1.724 ± 0.03	3.487ArgIle: 3.487 ± 0.038	1.696ArgLys: 1.696 ± 0.035	8.258ArgLeu: 8.258 ± 0.08	1.704ArgMet: 1.704 ± 0.03	1.591ArgAsn: 1.591 ± 0.026	4.362ArgPro: 4.362 ± 0.054	2.402ArgGln: 2.402 ± 0.03	7.33ArgArg: 7.33 ± 0.087	4.297ArgSer: 4.297 ± 0.042	4.991ArgThr: 4.991 ± 0.05	5.585ArgVal: 5.585 ± 0.054	1.438ArgTrp: 1.438 ± 0.029	1.87ArgTyr: 1.87 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.471SerAla: 6.471 ± 0.056	0.39SerCys: 0.39 ± 0.014	2.792SerAsp: 2.792 ± 0.038	2.509SerGlu: 2.509 ± 0.037	1.715SerPhe: 1.715 ± 0.029	5.757SerGly: 5.757 ± 0.052	0.999SerHis: 0.999 ± 0.024	2.035SerIle: 2.035 ± 0.029	1.182SerLys: 1.182 ± 0.023	5.074SerLeu: 5.074 ± 0.049	1.239SerMet: 1.239 ± 0.023	1.133SerAsn: 1.133 ± 0.027	3.098SerPro: 3.098 ± 0.04	1.407SerGln: 1.407 ± 0.025	3.8SerArg: 3.8 ± 0.044	3.109SerSer: 3.109 ± 0.04	3.609SerThr: 3.609 ± 0.049	4.489SerVal: 4.489 ± 0.045	1.03SerTrp: 1.03 ± 0.026	1.447SerTyr: 1.447 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.142ThrAla: 8.142 ± 0.072	0.431ThrCys: 0.431 ± 0.013	3.613ThrAsp: 3.613 ± 0.041	3.211ThrGlu: 3.211 ± 0.042	1.972ThrPhe: 1.972 ± 0.032	6.309ThrGly: 6.309 ± 0.058	1.117ThrHis: 1.117 ± 0.022	2.423ThrIle: 2.423 ± 0.04	1.387ThrLys: 1.387 ± 0.033	5.65ThrLeu: 5.65 ± 0.049	1.088ThrMet: 1.088 ± 0.021	1.266ThrAsn: 1.266 ± 0.03	4.022ThrPro: 4.022 ± 0.055	1.483ThrGln: 1.483 ± 0.03	3.807ThrArg: 3.807 ± 0.041	3.453ThrSer: 3.453 ± 0.043	4.315ThrThr: 4.315 ± 0.066	6.072ThrVal: 6.072 ± 0.055	1.044ThrTrp: 1.044 ± 0.024	1.523ThrTyr: 1.523 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.24ValAla: 11.24 ± 0.089	0.656ValCys: 0.656 ± 0.017	5.864ValAsp: 5.864 ± 0.055	4.984ValGlu: 4.984 ± 0.059	2.548ValPhe: 2.548 ± 0.034	7.054ValGly: 7.054 ± 0.067	1.835ValHis: 1.835 ± 0.035	3.515ValIle: 3.515 ± 0.041	1.889ValLys: 1.889 ± 0.033	9.813ValLeu: 9.813 ± 0.082	1.503ValMet: 1.503 ± 0.031	1.92ValAsn: 1.92 ± 0.029	5.163ValPro: 5.163 ± 0.053	2.348ValGln: 2.348 ± 0.035	6.642ValArg: 6.642 ± 0.059	4.608ValSer: 4.608 ± 0.041	5.753ValThr: 5.753 ± 0.062	9.177ValVal: 9.177 ± 0.078	1.137ValTrp: 1.137 ± 0.025	1.709ValTyr: 1.709 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.611TrpAla: 1.611 ± 0.028	0.151TrpCys: 0.151 ± 0.008	0.879TrpAsp: 0.879 ± 0.022	0.663TrpGlu: 0.663 ± 0.018	0.615TrpPhe: 0.615 ± 0.016	1.057TrpGly: 1.057 ± 0.023	0.406TrpHis: 0.406 ± 0.014	0.711TrpIle: 0.711 ± 0.019	0.406TrpLys: 0.406 ± 0.013	1.953TrpLeu: 1.953 ± 0.033	0.344TrpMet: 0.344 ± 0.011	0.476TrpAsn: 0.476 ± 0.017	0.904TrpPro: 0.904 ± 0.02	0.65TrpGln: 0.65 ± 0.019	1.287TrpArg: 1.287 ± 0.024	1.156TrpSer: 1.156 ± 0.025	1.134TrpThr: 1.134 ± 0.024	1.167TrpVal: 1.167 ± 0.022	0.391TrpTrp: 0.391 ± 0.013	0.369TrpTyr: 0.369 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.683TyrAla: 2.683 ± 0.033	0.206TyrCys: 0.206 ± 0.01	1.897TyrAsp: 1.897 ± 0.033	1.172TyrGlu: 1.172 ± 0.023	0.746TyrPhe: 0.746 ± 0.017	2.355TyrGly: 2.355 ± 0.036	0.461TyrHis: 0.461 ± 0.016	0.543TyrIle: 0.543 ± 0.015	0.447TyrLys: 0.447 ± 0.017	2.429TyrLeu: 2.429 ± 0.04	0.253TyrMet: 0.253 ± 0.01	0.476TyrAsn: 0.476 ± 0.017	1.183TyrPro: 1.183 ± 0.026	0.73TyrGln: 0.73 ± 0.021	1.835TyrArg: 1.835 ± 0.032	1.15TyrSer: 1.15 ± 0.025	1.243TyrThr: 1.243 ± 0.024	2.013TyrVal: 2.013 ± 0.029	0.402TyrTrp: 0.402 ± 0.016	0.578TyrTyr: 0.578 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6875 proteins (2191178 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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