Amino acid dipepetide frequency for Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.409AlaAla: 11.409 ± 0.182	1.03AlaCys: 1.03 ± 0.049	5.712AlaAsp: 5.712 ± 0.102	6.389AlaGlu: 6.389 ± 0.132	3.906AlaPhe: 3.906 ± 0.083	7.633AlaGly: 7.633 ± 0.143	2.171AlaHis: 2.171 ± 0.065	6.747AlaIle: 6.747 ± 0.118	4.692AlaLys: 4.692 ± 0.091	11.432AlaLeu: 11.432 ± 0.179	2.865AlaMet: 2.865 ± 0.067	3.154AlaAsn: 3.154 ± 0.078	4.03AlaPro: 4.03 ± 0.099	3.529AlaGln: 3.529 ± 0.08	5.472AlaArg: 5.472 ± 0.119	6.475AlaSer: 6.475 ± 0.102	4.889AlaThr: 4.889 ± 0.113	6.69AlaVal: 6.69 ± 0.121	1.133AlaTrp: 1.133 ± 0.044	2.473AlaTyr: 2.473 ± 0.073	0.0AlaXaa: 0.0 ± 0.0
Cys	0.676CysAla: 0.676 ± 0.036	0.133CysCys: 0.133 ± 0.017	0.531CysAsp: 0.531 ± 0.035	0.377CysGlu: 0.377 ± 0.025	0.432CysPhe: 0.432 ± 0.033	0.766CysGly: 0.766 ± 0.039	0.28CysHis: 0.28 ± 0.023	0.439CysIle: 0.439 ± 0.029	0.237CysLys: 0.237 ± 0.023	0.973CysLeu: 0.973 ± 0.041	0.145CysMet: 0.145 ± 0.018	0.277CysAsn: 0.277 ± 0.025	0.482CysPro: 0.482 ± 0.034	0.34CysGln: 0.34 ± 0.027	0.514CysArg: 0.514 ± 0.028	0.574CysSer: 0.574 ± 0.033	0.309CysThr: 0.309 ± 0.024	0.479CysVal: 0.479 ± 0.029	0.107CysTrp: 0.107 ± 0.015	0.279CysTyr: 0.279 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.762AspAla: 4.762 ± 0.104	0.466AspCys: 0.466 ± 0.031	2.974AspAsp: 2.974 ± 0.085	3.214AspGlu: 3.214 ± 0.072	2.478AspPhe: 2.478 ± 0.066	4.198AspGly: 4.198 ± 0.106	1.544AspHis: 1.544 ± 0.055	4.477AspIle: 4.477 ± 0.097	2.995AspLys: 2.995 ± 0.072	5.422AspLeu: 5.422 ± 0.093	1.42AspMet: 1.42 ± 0.041	2.446AspAsn: 2.446 ± 0.082	3.015AspPro: 3.015 ± 0.087	2.48AspGln: 2.48 ± 0.063	3.548AspArg: 3.548 ± 0.081	3.436AspSer: 3.436 ± 0.106	2.365AspThr: 2.365 ± 0.085	3.289AspVal: 3.289 ± 0.083	0.871AspTrp: 0.871 ± 0.037	1.821AspTyr: 1.821 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.757GluAla: 6.757 ± 0.137	0.359GluCys: 0.359 ± 0.027	2.909GluAsp: 2.909 ± 0.09	3.84GluGlu: 3.84 ± 0.12	1.44GluPhe: 1.44 ± 0.06	3.761GluGly: 3.761 ± 0.091	1.095GluHis: 1.095 ± 0.042	3.956GluIle: 3.956 ± 0.084	4.759GluLys: 4.759 ± 0.106	4.218GluLeu: 4.218 ± 0.089	1.599GluMet: 1.599 ± 0.06	2.867GluAsn: 2.867 ± 0.077	1.904GluPro: 1.904 ± 0.061	2.333GluGln: 2.333 ± 0.064	3.444GluArg: 3.444 ± 0.082	3.022GluSer: 3.022 ± 0.071	3.197GluThr: 3.197 ± 0.072	3.177GluVal: 3.177 ± 0.079	0.754GluTrp: 0.754 ± 0.037	1.27GluTyr: 1.27 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.499PheAla: 3.499 ± 0.094	0.457PheCys: 0.457 ± 0.029	2.446PheAsp: 2.446 ± 0.067	1.996PheGlu: 1.996 ± 0.052	1.889PhePhe: 1.889 ± 0.07	3.161PheGly: 3.161 ± 0.081	0.938PheHis: 0.938 ± 0.041	2.306PheIle: 2.306 ± 0.073	1.497PheLys: 1.497 ± 0.054	4.038PheLeu: 4.038 ± 0.098	0.893PheMet: 0.893 ± 0.039	1.452PheAsn: 1.452 ± 0.046	1.615PhePro: 1.615 ± 0.061	1.287PheGln: 1.287 ± 0.045	1.947PheArg: 1.947 ± 0.066	3.397PheSer: 3.397 ± 0.074	2.032PheThr: 2.032 ± 0.067	2.273PheVal: 2.273 ± 0.063	0.589PheTrp: 0.589 ± 0.036	1.161PheTyr: 1.161 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	6.298GlyAla: 6.298 ± 0.129	0.869GlyCys: 0.869 ± 0.042	4.07GlyAsp: 4.07 ± 0.107	3.82GlyGlu: 3.82 ± 0.093	3.319GlyPhe: 3.319 ± 0.068	6.189GlyGly: 6.189 ± 0.147	2.163GlyHis: 2.163 ± 0.066	4.893GlyIle: 4.893 ± 0.095	4.057GlyLys: 4.057 ± 0.084	7.484GlyLeu: 7.484 ± 0.129	1.891GlyMet: 1.891 ± 0.063	2.795GlyAsn: 2.795 ± 0.106	1.759GlyPro: 1.759 ± 0.061	3.252GlyGln: 3.252 ± 0.08	4.779GlyArg: 4.779 ± 0.099	4.841GlySer: 4.841 ± 0.12	3.434GlyThr: 3.434 ± 0.161	4.858GlyVal: 4.858 ± 0.095	1.243GlyTrp: 1.243 ± 0.047	2.595GlyTyr: 2.595 ± 0.076	0.0GlyXaa: 0.0 ± 0.0
His	1.997HisAla: 1.997 ± 0.059	0.219HisCys: 0.219 ± 0.019	1.268HisAsp: 1.268 ± 0.056	0.953HisGlu: 0.953 ± 0.04	1.176HisPhe: 1.176 ± 0.047	1.652HisGly: 1.652 ± 0.051	0.849HisHis: 0.849 ± 0.048	1.684HisIle: 1.684 ± 0.048	0.854HisLys: 0.854 ± 0.036	2.526HisLeu: 2.526 ± 0.073	0.541HisMet: 0.541 ± 0.028	0.899HisAsn: 0.899 ± 0.042	1.492HisPro: 1.492 ± 0.053	0.961HisGln: 0.961 ± 0.038	1.343HisArg: 1.343 ± 0.054	1.468HisSer: 1.468 ± 0.052	0.811HisThr: 0.811 ± 0.041	1.403HisVal: 1.403 ± 0.054	0.382HisTrp: 0.382 ± 0.027	0.871HisTyr: 0.871 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	7.509IleAla: 7.509 ± 0.137	0.597IleCys: 0.597 ± 0.035	4.369IleAsp: 4.369 ± 0.088	4.337IleGlu: 4.337 ± 0.091	2.331IlePhe: 2.331 ± 0.074	5.405IleGly: 5.405 ± 0.105	1.328IleHis: 1.328 ± 0.05	3.963IleIle: 3.963 ± 0.088	2.88IleLys: 2.88 ± 0.067	6.071IleLeu: 6.071 ± 0.13	1.283IleMet: 1.283 ± 0.047	2.236IleAsn: 2.236 ± 0.068	3.037IlePro: 3.037 ± 0.067	2.011IleGln: 2.011 ± 0.067	3.811IleArg: 3.811 ± 0.085	4.527IleSer: 4.527 ± 0.098	3.606IleThr: 3.606 ± 0.083	3.903IleVal: 3.903 ± 0.088	0.723IleTrp: 0.723 ± 0.04	1.385IleTyr: 1.385 ± 0.045	0.002IleXaa: 0.002 ± 0.001
Lys	6.201LysAla: 6.201 ± 0.132	0.209LysCys: 0.209 ± 0.021	2.765LysAsp: 2.765 ± 0.069	3.216LysGlu: 3.216 ± 0.08	1.006LysPhe: 1.006 ± 0.041	3.743LysGly: 3.743 ± 0.078	0.804LysHis: 0.804 ± 0.033	3.584LysIle: 3.584 ± 0.084	3.623LysLys: 3.623 ± 0.104	4.424LysLeu: 4.424 ± 0.094	1.392LysMet: 1.392 ± 0.051	2.456LysAsn: 2.456 ± 0.085	2.288LysPro: 2.288 ± 0.063	1.896LysGln: 1.896 ± 0.06	2.782LysArg: 2.782 ± 0.079	3.132LysSer: 3.132 ± 0.077	2.985LysThr: 2.985 ± 0.069	2.675LysVal: 2.675 ± 0.069	0.492LysTrp: 0.492 ± 0.025	0.906LysTyr: 0.906 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	10.556LeuAla: 10.556 ± 0.144	0.834LeuCys: 0.834 ± 0.037	5.634LeuAsp: 5.634 ± 0.115	5.13LeuGlu: 5.13 ± 0.099	4.112LeuPhe: 4.112 ± 0.105	7.314LeuGly: 7.314 ± 0.112	2.019LeuHis: 2.019 ± 0.059	6.086LeuIle: 6.086 ± 0.122	5.145LeuLys: 5.145 ± 0.109	9.782LeuLeu: 9.782 ± 0.199	2.421LeuMet: 2.421 ± 0.07	3.416LeuAsn: 3.416 ± 0.082	5.639LeuPro: 5.639 ± 0.09	3.149LeuGln: 3.149 ± 0.072	5.283LeuArg: 5.283 ± 0.117	7.781LeuSer: 7.781 ± 0.119	5.659LeuThr: 5.659 ± 0.106	6.191LeuVal: 6.191 ± 0.125	1.343LeuTrp: 1.343 ± 0.046	2.423LeuTyr: 2.423 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	3.296MetAla: 3.296 ± 0.082	0.11MetCys: 0.11 ± 0.013	1.09MetAsp: 1.09 ± 0.04	1.121MetGlu: 1.121 ± 0.046	0.574MetPhe: 0.574 ± 0.035	1.742MetGly: 1.742 ± 0.057	0.4MetHis: 0.4 ± 0.026	1.547MetIle: 1.547 ± 0.054	1.255MetLys: 1.255 ± 0.048	2.249MetLeu: 2.249 ± 0.072	0.721MetMet: 0.721 ± 0.043	0.889MetAsn: 0.889 ± 0.046	1.574MetPro: 1.574 ± 0.054	0.824MetGln: 0.824 ± 0.037	1.405MetArg: 1.405 ± 0.056	1.547MetSer: 1.547 ± 0.049	1.737MetThr: 1.737 ± 0.054	1.68MetVal: 1.68 ± 0.058	0.182MetTrp: 0.182 ± 0.02	0.272MetTyr: 0.272 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.556AsnAla: 3.556 ± 0.096	0.299AsnCys: 0.299 ± 0.025	1.969AsnAsp: 1.969 ± 0.06	1.609AsnGlu: 1.609 ± 0.059	1.487AsnPhe: 1.487 ± 0.054	3.062AsnGly: 3.062 ± 0.091	0.981AsnHis: 0.981 ± 0.042	2.698AsnIle: 2.698 ± 0.074	1.742AsnLys: 1.742 ± 0.062	3.71AsnLeu: 3.71 ± 0.085	0.826AsnMet: 0.826 ± 0.036	1.901AsnAsn: 1.901 ± 0.08	2.37AsnPro: 2.37 ± 0.074	1.525AsnGln: 1.525 ± 0.049	2.318AsnArg: 2.318 ± 0.071	2.5AsnSer: 2.5 ± 0.083	1.784AsnThr: 1.784 ± 0.07	1.979AsnVal: 1.979 ± 0.062	0.547AsnTrp: 0.547 ± 0.03	1.008AsnTyr: 1.008 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	4.53ProAla: 4.53 ± 0.092	0.329ProCys: 0.329 ± 0.024	3.471ProAsp: 3.471 ± 0.084	3.713ProGlu: 3.713 ± 0.077	2.034ProPhe: 2.034 ± 0.06	2.443ProGly: 2.443 ± 0.075	1.116ProHis: 1.116 ± 0.048	2.817ProIle: 2.817 ± 0.07	2.353ProLys: 2.353 ± 0.062	4.739ProLeu: 4.739 ± 0.1	0.985ProMet: 0.985 ± 0.045	1.605ProAsn: 1.605 ± 0.048	2.133ProPro: 2.133 ± 0.078	1.715ProGln: 1.715 ± 0.057	2.027ProArg: 2.027 ± 0.064	3.199ProSer: 3.199 ± 0.091	2.373ProThr: 2.373 ± 0.062	3.908ProVal: 3.908 ± 0.088	0.569ProTrp: 0.569 ± 0.03	1.312ProTyr: 1.312 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	4.509GlnAla: 4.509 ± 0.097	0.252GlnCys: 0.252 ± 0.026	1.946GlnAsp: 1.946 ± 0.059	1.952GlnGlu: 1.952 ± 0.056	1.196GlnPhe: 1.196 ± 0.046	2.645GlnGly: 2.645 ± 0.081	0.711GlnHis: 0.711 ± 0.04	2.745GlnIle: 2.745 ± 0.076	2.52GlnLys: 2.52 ± 0.083	3.374GlnLeu: 3.374 ± 0.076	0.944GlnMet: 0.944 ± 0.041	1.702GlnAsn: 1.702 ± 0.061	1.994GlnPro: 1.994 ± 0.061	1.717GlnGln: 1.717 ± 0.063	2.151GlnArg: 2.151 ± 0.066	2.393GlnSer: 2.393 ± 0.071	1.971GlnThr: 1.971 ± 0.064	1.931GlnVal: 1.931 ± 0.056	0.456GlnTrp: 0.456 ± 0.026	0.963GlnTyr: 0.963 ± 0.038	0.002GlnXaa: 0.002 ± 0.002
Arg	4.746ArgAla: 4.746 ± 0.106	0.402ArgCys: 0.402 ± 0.025	3.085ArgAsp: 3.085 ± 0.079	3.047ArgGlu: 3.047 ± 0.084	2.837ArgPhe: 2.837 ± 0.068	3.297ArgGly: 3.297 ± 0.081	1.755ArgHis: 1.755 ± 0.063	3.691ArgIle: 3.691 ± 0.091	2.57ArgLys: 2.57 ± 0.071	7.082ArgLeu: 7.082 ± 0.133	1.428ArgMet: 1.428 ± 0.05	2.019ArgAsn: 2.019 ± 0.064	2.875ArgPro: 2.875 ± 0.072	2.767ArgGln: 2.767 ± 0.072	3.77ArgArg: 3.77 ± 0.107	3.399ArgSer: 3.399 ± 0.074	1.971ArgThr: 1.971 ± 0.057	3.347ArgVal: 3.347 ± 0.085	0.806ArgTrp: 0.806 ± 0.034	2.047ArgTyr: 2.047 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	6.047SerAla: 6.047 ± 0.107	0.584SerCys: 0.584 ± 0.03	4.068SerAsp: 4.068 ± 0.116	3.678SerGlu: 3.678 ± 0.084	3.115SerPhe: 3.115 ± 0.067	5.799SerGly: 5.799 ± 0.14	1.654SerHis: 1.654 ± 0.055	3.803SerIle: 3.803 ± 0.091	2.647SerLys: 2.647 ± 0.081	7.361SerLeu: 7.361 ± 0.116	1.472SerMet: 1.472 ± 0.055	2.261SerAsn: 2.261 ± 0.075	3.107SerPro: 3.107 ± 0.078	2.612SerGln: 2.612 ± 0.073	3.743SerArg: 3.743 ± 0.086	4.701SerSer: 4.701 ± 0.145	2.837SerThr: 2.837 ± 0.098	4.295SerVal: 4.295 ± 0.097	0.939SerTrp: 0.939 ± 0.04	1.961SerTyr: 1.961 ± 0.064	0.002SerXaa: 0.002 ± 0.001
Thr	5.555ThrAla: 5.555 ± 0.111	0.322ThrCys: 0.322 ± 0.024	2.79ThrAsp: 2.79 ± 0.082	2.708ThrGlu: 2.708 ± 0.083	1.53ThrPhe: 1.53 ± 0.05	4.362ThrGly: 4.362 ± 0.108	1.135ThrHis: 1.135 ± 0.043	3.206ThrIle: 3.206 ± 0.085	2.036ThrLys: 2.036 ± 0.062	5.5ThrLeu: 5.5 ± 0.117	1.038ThrMet: 1.038 ± 0.044	1.63ThrAsn: 1.63 ± 0.089	3.239ThrPro: 3.239 ± 0.089	1.69ThrGln: 1.69 ± 0.056	2.612ThrArg: 2.612 ± 0.068	3.247ThrSer: 3.247 ± 0.096	2.72ThrThr: 2.72 ± 0.098	3.748ThrVal: 3.748 ± 0.134	0.474ThrTrp: 0.474 ± 0.028	1.043ThrTyr: 1.043 ± 0.052	0.002ThrXaa: 0.002 ± 0.002
Val	6.583ValAla: 6.583 ± 0.117	0.517ValCys: 0.517 ± 0.034	3.838ValAsp: 3.838 ± 0.08	3.778ValGlu: 3.778 ± 0.089	2.313ValPhe: 2.313 ± 0.066	4.385ValGly: 4.385 ± 0.109	1.26ValHis: 1.26 ± 0.051	4.442ValIle: 4.442 ± 0.099	3.079ValLys: 3.079 ± 0.084	5.39ValLeu: 5.39 ± 0.108	1.562ValMet: 1.562 ± 0.055	2.264ValAsn: 2.264 ± 0.071	2.828ValPro: 2.828 ± 0.074	1.802ValGln: 1.802 ± 0.051	3.212ValArg: 3.212 ± 0.077	4.46ValSer: 4.46 ± 0.09	4.207ValThr: 4.207 ± 0.157	4.277ValVal: 4.277 ± 0.106	0.611ValTrp: 0.611 ± 0.031	1.438ValTyr: 1.438 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.944TrpAla: 0.944 ± 0.039	0.09TrpCys: 0.09 ± 0.011	0.601TrpAsp: 0.601 ± 0.036	0.557TrpGlu: 0.557 ± 0.032	0.534TrpPhe: 0.534 ± 0.032	0.826TrpGly: 0.826 ± 0.041	0.385TrpHis: 0.385 ± 0.026	0.734TrpIle: 0.734 ± 0.043	0.572TrpLys: 0.572 ± 0.028	1.702TrpLeu: 1.702 ± 0.068	0.305TrpMet: 0.305 ± 0.024	0.442TrpAsn: 0.442 ± 0.025	0.684TrpPro: 0.684 ± 0.038	0.819TrpGln: 0.819 ± 0.036	0.906TrpArg: 0.906 ± 0.037	0.818TrpSer: 0.818 ± 0.04	0.561TrpThr: 0.561 ± 0.03	0.776TrpVal: 0.776 ± 0.037	0.175TrpTrp: 0.175 ± 0.018	0.339TrpTyr: 0.339 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.401TyrAla: 2.401 ± 0.073	0.272TyrCys: 0.272 ± 0.021	1.685TyrAsp: 1.685 ± 0.062	1.225TyrGlu: 1.225 ± 0.049	1.163TyrPhe: 1.163 ± 0.048	2.224TyrGly: 2.224 ± 0.073	0.763TyrHis: 0.763 ± 0.035	1.497TyrIle: 1.497 ± 0.051	1.063TyrLys: 1.063 ± 0.047	2.438TyrLeu: 2.438 ± 0.064	0.484TyrMet: 0.484 ± 0.029	1.156TyrAsn: 1.156 ± 0.051	1.307TyrPro: 1.307 ± 0.047	1.363TyrGln: 1.363 ± 0.048	1.872TyrArg: 1.872 ± 0.06	1.767TyrSer: 1.767 ± 0.07	1.14TyrThr: 1.14 ± 0.048	1.368TyrVal: 1.368 ± 0.048	0.375TyrTrp: 0.375 ± 0.027	0.943TyrTyr: 0.943 ± 0.045	0.002TyrXaa: 0.002 ± 0.002
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.003XaaLys: 0.003 ± 0.004	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.022XaaXaa: 0.022 ± 0.013

Statistics based on 1779 proteins (599273 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---