Amino acid dipepetide frequency for Babesia bovis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.512AlaAla: 4.512 ± 0.068	1.086AlaCys: 1.086 ± 0.024	3.119AlaAsp: 3.119 ± 0.054	3.572AlaGlu: 3.572 ± 0.074	2.453AlaPhe: 2.453 ± 0.04	2.987AlaGly: 2.987 ± 0.05	1.381AlaHis: 1.381 ± 0.029	4.155AlaIle: 4.155 ± 0.055	3.876AlaLys: 3.876 ± 0.054	6.663AlaLeu: 6.663 ± 0.08	1.742AlaMet: 1.742 ± 0.034	2.786AlaAsn: 2.786 ± 0.041	2.421AlaPro: 2.421 ± 0.04	2.057AlaGln: 2.057 ± 0.036	2.819AlaArg: 2.819 ± 0.043	4.887AlaSer: 4.887 ± 0.052	3.855AlaThr: 3.855 ± 0.047	4.388AlaVal: 4.388 ± 0.054	0.523AlaTrp: 0.523 ± 0.017	2.09AlaTyr: 2.09 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.353CysAla: 1.353 ± 0.034	0.692CysCys: 0.692 ± 0.023	1.329CysAsp: 1.329 ± 0.026	1.043CysGlu: 1.043 ± 0.026	0.875CysPhe: 0.875 ± 0.022	1.487CysGly: 1.487 ± 0.037	0.648CysHis: 0.648 ± 0.019	1.447CysIle: 1.447 ± 0.031	1.389CysLys: 1.389 ± 0.034	2.084CysLeu: 2.084 ± 0.042	0.53CysMet: 0.53 ± 0.018	1.173CysAsn: 1.173 ± 0.028	0.948CysPro: 0.948 ± 0.032	0.731CysGln: 0.731 ± 0.02	1.223CysArg: 1.223 ± 0.026	1.756CysSer: 1.756 ± 0.039	1.295CysThr: 1.295 ± 0.036	1.337CysVal: 1.337 ± 0.031	0.199CysTrp: 0.199 ± 0.011	0.797CysTyr: 0.797 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.187AspAla: 4.187 ± 0.059	1.139AspCys: 1.139 ± 0.029	4.368AspAsp: 4.368 ± 0.077	4.147AspGlu: 4.147 ± 0.076	2.158AspPhe: 2.158 ± 0.04	3.68AspGly: 3.68 ± 0.056	1.432AspHis: 1.432 ± 0.053	4.597AspIle: 4.597 ± 0.055	3.171AspLys: 3.171 ± 0.045	4.948AspLeu: 4.948 ± 0.057	1.636AspMet: 1.636 ± 0.029	2.85AspAsn: 2.85 ± 0.042	2.575AspPro: 2.575 ± 0.043	1.589AspGln: 1.589 ± 0.03	2.718AspArg: 2.718 ± 0.044	4.87AspSer: 4.87 ± 0.07	3.731AspThr: 3.731 ± 0.061	4.57AspVal: 4.57 ± 0.066	0.573AspTrp: 0.573 ± 0.018	2.112AspTyr: 2.112 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.043GluAla: 4.043 ± 0.08	1.388GluCys: 1.388 ± 0.031	3.655GluAsp: 3.655 ± 0.061	4.413GluGlu: 4.413 ± 0.102	2.231GluPhe: 2.231 ± 0.036	3.017GluGly: 3.017 ± 0.047	1.743GluHis: 1.743 ± 0.03	3.525GluIle: 3.525 ± 0.068	3.484GluLys: 3.484 ± 0.06	5.838GluLeu: 5.838 ± 0.069	1.583GluMet: 1.583 ± 0.032	2.792GluAsn: 2.792 ± 0.051	2.451GluPro: 2.451 ± 0.059	2.127GluGln: 2.127 ± 0.04	3.479GluArg: 3.479 ± 0.062	5.136GluSer: 5.136 ± 0.094	3.184GluThr: 3.184 ± 0.054	3.821GluVal: 3.821 ± 0.057	0.626GluTrp: 0.626 ± 0.018	2.268GluTyr: 2.268 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.206PheAla: 2.206 ± 0.041	0.871PheCys: 0.871 ± 0.024	2.476PheAsp: 2.476 ± 0.035	2.064PheGlu: 2.064 ± 0.039	1.463PhePhe: 1.463 ± 0.028	2.616PheGly: 2.616 ± 0.055	0.974PheHis: 0.974 ± 0.025	2.273PheIle: 2.273 ± 0.04	2.247PheLys: 2.247 ± 0.034	3.366PheLeu: 3.366 ± 0.045	1.015PheMet: 1.015 ± 0.026	1.993PheAsn: 1.993 ± 0.037	1.301PhePro: 1.301 ± 0.029	1.169PheGln: 1.169 ± 0.024	1.94PheArg: 1.94 ± 0.033	2.845PheSer: 2.845 ± 0.038	2.179PheThr: 2.179 ± 0.036	2.69PheVal: 2.69 ± 0.039	0.396PheTrp: 0.396 ± 0.017	1.492PheTyr: 1.492 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	3.248GlyAla: 3.248 ± 0.051	1.328GlyCys: 1.328 ± 0.035	3.519GlyAsp: 3.519 ± 0.049	2.917GlyGlu: 2.917 ± 0.041	2.528GlyPhe: 2.528 ± 0.043	3.759GlyGly: 3.759 ± 0.086	1.486GlyHis: 1.486 ± 0.033	3.968GlyIle: 3.968 ± 0.049	3.67GlyLys: 3.67 ± 0.065	4.687GlyLeu: 4.687 ± 0.062	1.445GlyMet: 1.445 ± 0.029	3.134GlyAsn: 3.134 ± 0.046	1.832GlyPro: 1.832 ± 0.035	1.754GlyGln: 1.754 ± 0.039	2.814GlyArg: 2.814 ± 0.047	5.179GlySer: 5.179 ± 0.078	3.786GlyThr: 3.786 ± 0.059	3.779GlyVal: 3.779 ± 0.051	0.673GlyTrp: 0.673 ± 0.023	2.35GlyTyr: 2.35 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.256HisAla: 1.256 ± 0.028	0.728HisCys: 0.728 ± 0.024	1.434HisAsp: 1.434 ± 0.03	1.485HisGlu: 1.485 ± 0.051	1.101HisPhe: 1.101 ± 0.023	1.69HisGly: 1.69 ± 0.033	0.714HisHis: 0.714 ± 0.021	1.807HisIle: 1.807 ± 0.036	1.409HisLys: 1.409 ± 0.031	2.542HisLeu: 2.542 ± 0.037	0.789HisMet: 0.789 ± 0.021	1.155HisAsn: 1.155 ± 0.024	1.164HisPro: 1.164 ± 0.023	0.925HisGln: 0.925 ± 0.023	1.47HisArg: 1.47 ± 0.033	1.98HisSer: 1.98 ± 0.037	1.295HisThr: 1.295 ± 0.027	1.774HisVal: 1.774 ± 0.036	0.311HisTrp: 0.311 ± 0.013	0.974HisTyr: 0.974 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	3.981IleAla: 3.981 ± 0.063	1.439IleCys: 1.439 ± 0.03	4.018IleAsp: 4.018 ± 0.047	3.752IleGlu: 3.752 ± 0.055	2.325IlePhe: 2.325 ± 0.041	3.245IleGly: 3.245 ± 0.048	1.635IleHis: 1.635 ± 0.031	3.168IleIle: 3.168 ± 0.054	3.653IleLys: 3.653 ± 0.056	5.659IleLeu: 5.659 ± 0.066	1.358IleMet: 1.358 ± 0.03	3.036IleAsn: 3.036 ± 0.044	2.952IlePro: 2.952 ± 0.044	2.157IleGln: 2.157 ± 0.042	3.196IleArg: 3.196 ± 0.048	4.999IleSer: 4.999 ± 0.056	3.478IleThr: 3.478 ± 0.044	3.831IleVal: 3.831 ± 0.052	0.699IleTrp: 0.699 ± 0.021	2.239IleTyr: 2.239 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.562LysAla: 3.562 ± 0.05	1.644LysCys: 1.644 ± 0.053	3.702LysAsp: 3.702 ± 0.056	4.072LysGlu: 4.072 ± 0.061	1.875LysPhe: 1.875 ± 0.039	3.584LysGly: 3.584 ± 0.074	1.747LysHis: 1.747 ± 0.029	3.142LysIle: 3.142 ± 0.05	3.95LysLys: 3.95 ± 0.07	5.563LysLeu: 5.563 ± 0.068	1.441LysMet: 1.441 ± 0.028	2.763LysAsn: 2.763 ± 0.041	2.61LysPro: 2.61 ± 0.046	2.415LysGln: 2.415 ± 0.042	3.822LysArg: 3.822 ± 0.06	4.323LysSer: 4.323 ± 0.059	3.216LysThr: 3.216 ± 0.047	3.883LysVal: 3.883 ± 0.052	0.717LysTrp: 0.717 ± 0.021	2.19LysTyr: 2.19 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	5.239LeuAla: 5.239 ± 0.054	2.269LeuCys: 2.269 ± 0.045	5.639LeuAsp: 5.639 ± 0.067	6.062LeuGlu: 6.062 ± 0.064	3.586LeuPhe: 3.586 ± 0.052	5.266LeuGly: 5.266 ± 0.062	2.523LeuHis: 2.523 ± 0.04	4.872LeuIle: 4.872 ± 0.053	5.84LeuLys: 5.84 ± 0.067	9.613LeuLeu: 9.613 ± 0.11	2.373LeuMet: 2.373 ± 0.039	4.312LeuAsn: 4.312 ± 0.049	4.392LeuPro: 4.392 ± 0.072	3.837LeuGln: 3.837 ± 0.049	5.628LeuArg: 5.628 ± 0.071	8.01LeuSer: 8.01 ± 0.085	4.615LeuThr: 4.615 ± 0.046	5.71LeuVal: 5.71 ± 0.075	1.032LeuTrp: 1.032 ± 0.027	3.823LeuTyr: 3.823 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.961MetAla: 1.961 ± 0.033	0.527MetCys: 0.527 ± 0.016	1.806MetAsp: 1.806 ± 0.037	1.744MetGlu: 1.744 ± 0.034	0.961MetPhe: 0.961 ± 0.025	1.453MetGly: 1.453 ± 0.028	0.626MetHis: 0.626 ± 0.019	1.244MetIle: 1.244 ± 0.028	1.547MetLys: 1.547 ± 0.032	2.798MetLeu: 2.798 ± 0.045	0.76MetMet: 0.76 ± 0.026	1.126MetAsn: 1.126 ± 0.027	1.224MetPro: 1.224 ± 0.03	1.023MetGln: 1.023 ± 0.026	1.388MetArg: 1.388 ± 0.026	1.916MetSer: 1.916 ± 0.032	1.264MetThr: 1.264 ± 0.025	1.638MetVal: 1.638 ± 0.035	0.273MetTrp: 0.273 ± 0.014	0.863MetTyr: 0.863 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.307AsnAla: 3.307 ± 0.044	0.892AsnCys: 0.892 ± 0.024	3.042AsnAsp: 3.042 ± 0.043	2.978AsnGlu: 2.978 ± 0.04	1.57AsnPhe: 1.57 ± 0.028	3.067AsnGly: 3.067 ± 0.049	1.126AsnHis: 1.126 ± 0.023	3.356AsnIle: 3.356 ± 0.045	2.992AsnLys: 2.992 ± 0.048	3.979AsnLeu: 3.979 ± 0.042	1.394AsnMet: 1.394 ± 0.029	2.49AsnAsn: 2.49 ± 0.047	2.195AsnPro: 2.195 ± 0.035	1.504AsnGln: 1.504 ± 0.029	2.578AsnArg: 2.578 ± 0.044	3.39AsnSer: 3.39 ± 0.046	2.978AsnThr: 2.978 ± 0.046	3.595AsnVal: 3.595 ± 0.053	0.418AsnTrp: 0.418 ± 0.016	1.563AsnTyr: 1.563 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	2.272ProAla: 2.272 ± 0.046	0.757ProCys: 0.757 ± 0.025	2.373ProAsp: 2.373 ± 0.048	3.012ProGlu: 3.012 ± 0.065	1.596ProPhe: 1.596 ± 0.031	2.489ProGly: 2.489 ± 0.041	0.922ProHis: 0.922 ± 0.02	2.517ProIle: 2.517 ± 0.042	2.773ProLys: 2.773 ± 0.05	4.079ProLeu: 4.079 ± 0.041	1.173ProMet: 1.173 ± 0.032	2.039ProAsn: 2.039 ± 0.032	2.288ProPro: 2.288 ± 0.047	1.54ProGln: 1.54 ± 0.034	2.185ProArg: 2.185 ± 0.041	3.725ProSer: 3.725 ± 0.059	2.455ProThr: 2.455 ± 0.043	2.868ProVal: 2.868 ± 0.047	0.499ProTrp: 0.499 ± 0.017	1.47ProTyr: 1.47 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	1.936GlnAla: 1.936 ± 0.035	1.044GlnCys: 1.044 ± 0.031	1.608GlnAsp: 1.608 ± 0.031	2.138GlnGlu: 2.138 ± 0.053	1.241GlnPhe: 1.241 ± 0.028	1.787GlnGly: 1.787 ± 0.033	1.079GlnHis: 1.079 ± 0.026	1.861GlnIle: 1.861 ± 0.032	2.102GlnLys: 2.102 ± 0.04	3.874GlnLeu: 3.874 ± 0.055	1.022GlnMet: 1.022 ± 0.027	1.531GlnAsn: 1.531 ± 0.029	1.56GlnPro: 1.56 ± 0.035	1.761GlnGln: 1.761 ± 0.039	2.23GlnArg: 2.23 ± 0.037	2.677GlnSer: 2.677 ± 0.044	1.634GlnThr: 1.634 ± 0.027	2.075GlnVal: 2.075 ± 0.038	0.48GlnTrp: 0.48 ± 0.018	1.359GlnTyr: 1.359 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	2.912ArgAla: 2.912 ± 0.042	1.304ArgCys: 1.304 ± 0.026	3.016ArgAsp: 3.016 ± 0.051	3.045ArgGlu: 3.045 ± 0.044	2.186ArgPhe: 2.186 ± 0.043	2.891ArgGly: 2.891 ± 0.047	1.619ArgHis: 1.619 ± 0.03	3.489ArgIle: 3.489 ± 0.053	3.56ArgLys: 3.56 ± 0.065	5.377ArgLeu: 5.377 ± 0.058	1.522ArgMet: 1.522 ± 0.03	2.77ArgAsn: 2.77 ± 0.045	1.787ArgPro: 1.787 ± 0.036	1.992ArgGln: 1.992 ± 0.056	3.712ArgArg: 3.712 ± 0.062	4.067ArgSer: 4.067 ± 0.05	2.506ArgThr: 2.506 ± 0.036	3.303ArgVal: 3.303 ± 0.044	0.653ArgTrp: 0.653 ± 0.021	2.164ArgTyr: 2.164 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.91SerAla: 4.91 ± 0.061	1.671SerCys: 1.671 ± 0.038	5.254SerAsp: 5.254 ± 0.099	4.403SerGlu: 4.403 ± 0.11	2.951SerPhe: 2.951 ± 0.047	5.293SerGly: 5.293 ± 0.066	2.079SerHis: 2.079 ± 0.04	4.941SerIle: 4.941 ± 0.054	4.518SerLys: 4.518 ± 0.048	7.198SerLeu: 7.198 ± 0.086	2.024SerMet: 2.024 ± 0.032	3.908SerAsn: 3.908 ± 0.046	3.393SerPro: 3.393 ± 0.061	2.887SerGln: 2.887 ± 0.04	4.193SerArg: 4.193 ± 0.057	7.493SerSer: 7.493 ± 0.118	5.277SerThr: 5.277 ± 0.07	5.207SerVal: 5.207 ± 0.072	0.766SerTrp: 0.766 ± 0.02	2.505SerTyr: 2.505 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	3.607ThrAla: 3.607 ± 0.043	1.114ThrCys: 1.114 ± 0.029	3.237ThrAsp: 3.237 ± 0.05	3.268ThrGlu: 3.268 ± 0.051	2.132ThrPhe: 2.132 ± 0.038	3.581ThrGly: 3.581 ± 0.062	1.351ThrHis: 1.351 ± 0.027	3.248ThrIle: 3.248 ± 0.047	3.364ThrLys: 3.364 ± 0.055	5.489ThrLeu: 5.489 ± 0.057	1.421ThrMet: 1.421 ± 0.027	2.791ThrAsn: 2.791 ± 0.043	2.959ThrPro: 2.959 ± 0.045	1.915ThrGln: 1.915 ± 0.036	2.63ThrArg: 2.63 ± 0.043	4.797ThrSer: 4.797 ± 0.054	3.636ThrThr: 3.636 ± 0.061	3.996ThrVal: 3.996 ± 0.049	0.528ThrTrp: 0.528 ± 0.019	1.847ThrTyr: 1.847 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	4.39ValAla: 4.39 ± 0.054	1.401ValCys: 1.401 ± 0.029	4.609ValAsp: 4.609 ± 0.066	4.353ValGlu: 4.353 ± 0.063	2.455ValPhe: 2.455 ± 0.041	3.395ValGly: 3.395 ± 0.046	1.643ValHis: 1.643 ± 0.031	3.942ValIle: 3.942 ± 0.053	3.941ValLys: 3.941 ± 0.049	6.384ValLeu: 6.384 ± 0.074	1.572ValMet: 1.572 ± 0.033	3.174ValAsn: 3.174 ± 0.048	3.151ValPro: 3.151 ± 0.046	2.026ValGln: 2.026 ± 0.035	2.978ValArg: 2.978 ± 0.043	5.269ValSer: 5.269 ± 0.082	3.922ValThr: 3.922 ± 0.046	4.99ValVal: 4.99 ± 0.065	0.512ValTrp: 0.512 ± 0.018	2.316ValTyr: 2.316 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.476TrpAla: 0.476 ± 0.015	0.226TrpCys: 0.226 ± 0.01	0.671TrpAsp: 0.671 ± 0.022	0.543TrpGlu: 0.543 ± 0.016	0.378TrpPhe: 0.378 ± 0.016	0.389TrpGly: 0.389 ± 0.014	0.293TrpHis: 0.293 ± 0.014	0.712TrpIle: 0.712 ± 0.02	0.625TrpLys: 0.625 ± 0.017	1.169TrpLeu: 1.169 ± 0.026	0.303TrpMet: 0.303 ± 0.015	0.592TrpAsn: 0.592 ± 0.02	0.368TrpPro: 0.368 ± 0.013	0.387TrpGln: 0.387 ± 0.016	0.618TrpArg: 0.618 ± 0.016	0.9TrpSer: 0.9 ± 0.024	0.569TrpThr: 0.569 ± 0.019	0.641TrpVal: 0.641 ± 0.02	0.118TrpTrp: 0.118 ± 0.008	0.455TrpTyr: 0.455 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.012TyrAla: 2.012 ± 0.032	0.821TyrCys: 0.821 ± 0.022	2.176TyrAsp: 2.176 ± 0.032	1.794TyrGlu: 1.794 ± 0.037	1.509TyrPhe: 1.509 ± 0.031	2.181TyrGly: 2.181 ± 0.038	0.982TyrHis: 0.982 ± 0.024	2.557TyrIle: 2.557 ± 0.036	2.109TyrLys: 2.109 ± 0.033	3.334TyrLeu: 3.334 ± 0.043	1.036TyrMet: 1.036 ± 0.021	1.997TyrAsn: 1.997 ± 0.035	1.462TyrPro: 1.462 ± 0.029	1.204TyrGln: 1.204 ± 0.024	2.254TyrArg: 2.254 ± 0.038	2.651TyrSer: 2.651 ± 0.043	2.034TyrThr: 2.034 ± 0.033	2.329TyrVal: 2.329 ± 0.04	0.436TyrTrp: 0.436 ± 0.016	1.331TyrTyr: 1.331 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3690 proteins (1851840 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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