Amino acid dipepetide frequency for Vibrio genomosp. F10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.274AlaAla: 7.274 ± 0.117
0.9AlaCys: 0.9 ± 0.028
4.364AlaAsp: 4.364 ± 0.081
5.252AlaGlu: 5.252 ± 0.079
3.462AlaPhe: 3.462 ± 0.056
5.776AlaGly: 5.776 ± 0.092
1.703AlaHis: 1.703 ± 0.043
6.124AlaIle: 6.124 ± 0.081
4.848AlaLys: 4.848 ± 0.07
9.668AlaLeu: 9.668 ± 0.111
2.778AlaMet: 2.778 ± 0.054
3.466AlaAsn: 3.466 ± 0.063
2.785AlaPro: 2.785 ± 0.059
3.731AlaGln: 3.731 ± 0.072
3.565AlaArg: 3.565 ± 0.067
5.531AlaSer: 5.531 ± 0.077
4.381AlaThr: 4.381 ± 0.064
5.706AlaVal: 5.706 ± 0.089
0.953AlaTrp: 0.953 ± 0.028
2.192AlaTyr: 2.192 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.761CysAla: 0.761 ± 0.029
0.145CysCys: 0.145 ± 0.013
0.622CysAsp: 0.622 ± 0.026
0.614CysGlu: 0.614 ± 0.026
0.46CysPhe: 0.46 ± 0.019
0.882CysGly: 0.882 ± 0.03
0.343CysHis: 0.343 ± 0.018
0.593CysIle: 0.593 ± 0.023
0.393CysLys: 0.393 ± 0.02
0.954CysLeu: 0.954 ± 0.032
0.255CysMet: 0.255 ± 0.017
0.33CysAsn: 0.33 ± 0.019
0.416CysPro: 0.416 ± 0.02
0.474CysGln: 0.474 ± 0.025
0.435CysArg: 0.435 ± 0.023
0.689CysSer: 0.689 ± 0.024
0.495CysThr: 0.495 ± 0.023
0.644CysVal: 0.644 ± 0.026
0.128CysTrp: 0.128 ± 0.012
0.307CysTyr: 0.307 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.434AspAla: 4.434 ± 0.058
0.534AspCys: 0.534 ± 0.024
3.147AspAsp: 3.147 ± 0.054
3.835AspGlu: 3.835 ± 0.079
2.449AspPhe: 2.449 ± 0.047
3.657AspGly: 3.657 ± 0.096
1.205AspHis: 1.205 ± 0.033
4.09AspIle: 4.09 ± 0.067
3.144AspLys: 3.144 ± 0.066
5.448AspLeu: 5.448 ± 0.076
1.423AspMet: 1.423 ± 0.039
2.413AspAsn: 2.413 ± 0.053
2.097AspPro: 2.097 ± 0.069
2.161AspGln: 2.161 ± 0.044
2.416AspArg: 2.416 ± 0.053
3.449AspSer: 3.449 ± 0.06
2.803AspThr: 2.803 ± 0.059
4.208AspVal: 4.208 ± 0.075
0.835AspTrp: 0.835 ± 0.028
1.973AspTyr: 1.973 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.206GluAla: 5.206 ± 0.075
0.548GluCys: 0.548 ± 0.026
2.828GluAsp: 2.828 ± 0.06
4.024GluGlu: 4.024 ± 0.092
2.6GluPhe: 2.6 ± 0.051
3.781GluGly: 3.781 ± 0.063
1.639GluHis: 1.639 ± 0.04
3.807GluIle: 3.807 ± 0.066
3.975GluLys: 3.975 ± 0.069
7.19GluLeu: 7.19 ± 0.082
1.752GluMet: 1.752 ± 0.042
2.616GluAsn: 2.616 ± 0.049
2.027GluPro: 2.027 ± 0.046
3.947GluGln: 3.947 ± 0.068
3.458GluArg: 3.458 ± 0.069
4.076GluSer: 4.076 ± 0.071
3.295GluThr: 3.295 ± 0.06
4.449GluVal: 4.449 ± 0.067
0.805GluTrp: 0.805 ± 0.033
1.739GluTyr: 1.739 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.483PheAla: 3.483 ± 0.064
0.46PheCys: 0.46 ± 0.021
2.737PheAsp: 2.737 ± 0.058
2.574PheGlu: 2.574 ± 0.05
1.689PhePhe: 1.689 ± 0.053
3.216PheGly: 3.216 ± 0.061
0.879PheHis: 0.879 ± 0.03
2.881PheIle: 2.881 ± 0.056
1.848PheLys: 1.848 ± 0.046
3.366PheLeu: 3.366 ± 0.062
1.039PheMet: 1.039 ± 0.034
2.036PheAsn: 2.036 ± 0.045
1.443PhePro: 1.443 ± 0.038
1.342PheGln: 1.342 ± 0.038
1.458PheArg: 1.458 ± 0.039
3.388PheSer: 3.388 ± 0.058
2.359PheThr: 2.359 ± 0.058
2.929PheVal: 2.929 ± 0.058
0.508PheTrp: 0.508 ± 0.024
1.228PheTyr: 1.228 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.312GlyAla: 5.312 ± 0.094
0.868GlyCys: 0.868 ± 0.027
3.798GlyAsp: 3.798 ± 0.074
4.398GlyGlu: 4.398 ± 0.08
3.332GlyPhe: 3.332 ± 0.059
4.801GlyGly: 4.801 ± 0.087
1.609GlyHis: 1.609 ± 0.036
4.828GlyIle: 4.828 ± 0.083
3.917GlyLys: 3.917 ± 0.074
7.123GlyLeu: 7.123 ± 0.096
2.079GlyMet: 2.079 ± 0.053
2.585GlyAsn: 2.585 ± 0.055
1.651GlyPro: 1.651 ± 0.041
2.83GlyGln: 2.83 ± 0.056
3.156GlyArg: 3.156 ± 0.054
4.169GlySer: 4.169 ± 0.065
3.503GlyThr: 3.503 ± 0.07
5.264GlyVal: 5.264 ± 0.08
0.953GlyTrp: 0.953 ± 0.031
2.532GlyTyr: 2.532 ± 0.057
0.001GlyXaa: 0.001 ± 0.001
His
1.653HisAla: 1.653 ± 0.037
0.335HisCys: 0.335 ± 0.017
1.133HisAsp: 1.133 ± 0.035
1.165HisGlu: 1.165 ± 0.033
1.116HisPhe: 1.116 ± 0.038
1.543HisGly: 1.543 ± 0.041
0.769HisHis: 0.769 ± 0.034
1.484HisIle: 1.484 ± 0.041
1.058HisLys: 1.058 ± 0.033
2.262HisLeu: 2.262 ± 0.052
0.486HisMet: 0.486 ± 0.023
0.876HisAsn: 0.876 ± 0.03
1.17HisPro: 1.17 ± 0.033
1.277HisGln: 1.277 ± 0.034
1.091HisArg: 1.091 ± 0.033
1.621HisSer: 1.621 ± 0.037
1.126HisThr: 1.126 ± 0.033
1.381HisVal: 1.381 ± 0.034
0.395HisTrp: 0.395 ± 0.018
0.887HisTyr: 0.887 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.443IleAla: 6.443 ± 0.082
0.646IleCys: 0.646 ± 0.028
4.43IleAsp: 4.43 ± 0.062
5.183IleGlu: 5.183 ± 0.075
2.248IlePhe: 2.248 ± 0.048
4.914IleGly: 4.914 ± 0.077
1.342IleHis: 1.342 ± 0.036
3.765IleIle: 3.765 ± 0.071
3.224IleLys: 3.224 ± 0.052
5.524IleLeu: 5.524 ± 0.084
1.322IleMet: 1.322 ± 0.036
3.038IleAsn: 3.038 ± 0.053
2.802IlePro: 2.802 ± 0.06
2.447IleGln: 2.447 ± 0.049
2.804IleArg: 2.804 ± 0.055
4.727IleSer: 4.727 ± 0.066
3.671IleThr: 3.671 ± 0.066
4.373IleVal: 4.373 ± 0.068
0.617IleTrp: 0.617 ± 0.028
1.616IleTyr: 1.616 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.763LysAla: 4.763 ± 0.07
0.313LysCys: 0.313 ± 0.016
2.734LysAsp: 2.734 ± 0.056
3.636LysGlu: 3.636 ± 0.065
1.437LysPhe: 1.437 ± 0.038
3.585LysGly: 3.585 ± 0.062
1.3LysHis: 1.3 ± 0.038
2.87LysIle: 2.87 ± 0.06
3.062LysLys: 3.062 ± 0.057
5.273LysLeu: 5.273 ± 0.076
1.498LysMet: 1.498 ± 0.034
2.103LysAsn: 2.103 ± 0.041
2.328LysPro: 2.328 ± 0.047
2.938LysGln: 2.938 ± 0.062
2.656LysArg: 2.656 ± 0.053
3.232LysSer: 3.232 ± 0.056
2.857LysThr: 2.857 ± 0.055
3.899LysVal: 3.899 ± 0.063
0.57LysTrp: 0.57 ± 0.021
1.302LysTyr: 1.302 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
9.575LeuAla: 9.575 ± 0.111
0.991LeuCys: 0.991 ± 0.03
5.942LeuAsp: 5.942 ± 0.082
6.42LeuGlu: 6.42 ± 0.093
4.224LeuPhe: 4.224 ± 0.079
7.131LeuGly: 7.131 ± 0.105
2.024LeuHis: 2.024 ± 0.042
6.452LeuIle: 6.452 ± 0.098
5.32LeuLys: 5.32 ± 0.068
10.443LeuLeu: 10.443 ± 0.143
2.731LeuMet: 2.731 ± 0.054
4.674LeuAsn: 4.674 ± 0.07
4.688LeuPro: 4.688 ± 0.069
3.41LeuGln: 3.41 ± 0.062
4.262LeuArg: 4.262 ± 0.078
8.289LeuSer: 8.289 ± 0.107
6.12LeuThr: 6.12 ± 0.076
7.282LeuVal: 7.282 ± 0.093
1.052LeuTrp: 1.052 ± 0.033
2.534LeuTyr: 2.534 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.59MetAla: 2.59 ± 0.054
0.216MetCys: 0.216 ± 0.015
1.391MetAsp: 1.391 ± 0.034
1.348MetGlu: 1.348 ± 0.033
1.008MetPhe: 1.008 ± 0.031
1.847MetGly: 1.847 ± 0.049
0.503MetHis: 0.503 ± 0.022
1.644MetIle: 1.644 ± 0.044
1.55MetLys: 1.55 ± 0.04
2.837MetLeu: 2.837 ± 0.053
0.884MetMet: 0.884 ± 0.03
1.226MetAsn: 1.226 ± 0.036
1.241MetPro: 1.241 ± 0.032
1.032MetGln: 1.032 ± 0.033
1.169MetArg: 1.169 ± 0.031
2.07MetSer: 2.07 ± 0.043
1.79MetThr: 1.79 ± 0.042
1.947MetVal: 1.947 ± 0.047
0.233MetTrp: 0.233 ± 0.016
0.521MetTyr: 0.521 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.415AsnAla: 3.415 ± 0.057
0.355AsnCys: 0.355 ± 0.018
2.404AsnAsp: 2.404 ± 0.053
2.561AsnGlu: 2.561 ± 0.055
1.455AsnPhe: 1.455 ± 0.039
2.962AsnGly: 2.962 ± 0.061
1.017AsnHis: 1.017 ± 0.036
2.875AsnIle: 2.875 ± 0.056
2.234AsnLys: 2.234 ± 0.045
3.881AsnLeu: 3.881 ± 0.066
1.027AsnMet: 1.027 ± 0.03
1.902AsnAsn: 1.902 ± 0.052
2.087AsnPro: 2.087 ± 0.05
2.259AsnGln: 2.259 ± 0.053
2.043AsnArg: 2.043 ± 0.048
2.542AsnSer: 2.542 ± 0.056
2.257AsnThr: 2.257 ± 0.045
2.846AsnVal: 2.846 ± 0.059
0.558AsnTrp: 0.558 ± 0.025
1.276AsnTyr: 1.276 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
2.768ProAla: 2.768 ± 0.057
0.347ProCys: 0.347 ± 0.018
2.297ProAsp: 2.297 ± 0.056
2.976ProGlu: 2.976 ± 0.063
1.762ProPhe: 1.762 ± 0.044
2.125ProGly: 2.125 ± 0.057
0.85ProHis: 0.85 ± 0.029
2.721ProIle: 2.721 ± 0.047
2.022ProLys: 2.022 ± 0.042
4.11ProLeu: 4.11 ± 0.065
1.09ProMet: 1.09 ± 0.036
1.78ProAsn: 1.78 ± 0.052
1.073ProPro: 1.073 ± 0.033
1.627ProGln: 1.627 ± 0.044
1.338ProArg: 1.338 ± 0.038
2.678ProSer: 2.678 ± 0.049
2.281ProThr: 2.281 ± 0.049
2.989ProVal: 2.989 ± 0.054
0.526ProTrp: 0.526 ± 0.023
1.187ProTyr: 1.187 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.114GlnAla: 4.114 ± 0.067
0.409GlnCys: 0.409 ± 0.021
2.126GlnAsp: 2.126 ± 0.054
2.535GlnGlu: 2.535 ± 0.052
1.757GlnPhe: 1.757 ± 0.047
3.05GlnGly: 3.05 ± 0.055
1.138GlnHis: 1.138 ± 0.036
2.59GlnIle: 2.59 ± 0.052
2.157GlnLys: 2.157 ± 0.049
5.104GlnLeu: 5.104 ± 0.08
1.132GlnMet: 1.132 ± 0.035
1.616GlnAsn: 1.616 ± 0.035
1.684GlnPro: 1.684 ± 0.044
2.756GlnGln: 2.756 ± 0.068
2.268GlnArg: 2.268 ± 0.056
3.081GlnSer: 3.081 ± 0.062
2.298GlnThr: 2.298 ± 0.05
3.112GlnVal: 3.112 ± 0.057
0.665GlnTrp: 0.665 ± 0.026
1.486GlnTyr: 1.486 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
3.308ArgAla: 3.308 ± 0.053
0.457ArgCys: 0.457 ± 0.022
2.459ArgAsp: 2.459 ± 0.054
2.934ArgGlu: 2.934 ± 0.058
2.188ArgPhe: 2.188 ± 0.042
2.575ArgGly: 2.575 ± 0.052
1.146ArgHis: 1.146 ± 0.035
3.028ArgIle: 3.028 ± 0.051
2.349ArgLys: 2.349 ± 0.05
4.925ArgLeu: 4.925 ± 0.078
1.237ArgMet: 1.237 ± 0.031
1.874ArgAsn: 1.874 ± 0.046
1.537ArgPro: 1.537 ± 0.039
2.055ArgGln: 2.055 ± 0.052
2.247ArgArg: 2.247 ± 0.065
2.821ArgSer: 2.821 ± 0.053
2.214ArgThr: 2.214 ± 0.048
3.194ArgVal: 3.194 ± 0.066
0.601ArgTrp: 0.601 ± 0.026
1.631ArgTyr: 1.631 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.628SerAla: 5.628 ± 0.07
0.592SerCys: 0.592 ± 0.023
3.912SerAsp: 3.912 ± 0.074
4.255SerGlu: 4.255 ± 0.062
2.839SerPhe: 2.839 ± 0.053
5.12SerGly: 5.12 ± 0.071
1.627SerHis: 1.627 ± 0.044
4.655SerIle: 4.655 ± 0.072
3.353SerLys: 3.353 ± 0.053
7.232SerLeu: 7.232 ± 0.089
1.987SerMet: 1.987 ± 0.05
2.843SerAsn: 2.843 ± 0.068
2.529SerPro: 2.529 ± 0.045
3.18SerGln: 3.18 ± 0.062
2.922SerArg: 2.922 ± 0.05
4.756SerSer: 4.756 ± 0.079
3.613SerThr: 3.613 ± 0.065
4.885SerVal: 4.885 ± 0.067
0.807SerTrp: 0.807 ± 0.029
1.978SerTyr: 1.978 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.378ThrAla: 4.378 ± 0.064
0.491ThrCys: 0.491 ± 0.021
2.926ThrAsp: 2.926 ± 0.048
3.29ThrGlu: 3.29 ± 0.062
2.103ThrPhe: 2.103 ± 0.05
4.016ThrGly: 4.016 ± 0.069
1.349ThrHis: 1.349 ± 0.035
3.482ThrIle: 3.482 ± 0.051
2.405ThrLys: 2.405 ± 0.048
6.468ThrLeu: 6.468 ± 0.087
1.279ThrMet: 1.279 ± 0.036
2.053ThrAsn: 2.053 ± 0.048
2.66ThrPro: 2.66 ± 0.052
2.537ThrGln: 2.537 ± 0.055
2.302ThrArg: 2.302 ± 0.049
3.543ThrSer: 3.543 ± 0.066
2.976ThrThr: 2.976 ± 0.056
3.97ThrVal: 3.97 ± 0.065
0.588ThrTrp: 0.588 ± 0.027
1.404ThrTyr: 1.404 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
6.373ValAla: 6.373 ± 0.081
0.769ValCys: 0.769 ± 0.028
4.29ValAsp: 4.29 ± 0.068
4.812ValGlu: 4.812 ± 0.083
2.848ValPhe: 2.848 ± 0.062
4.953ValGly: 4.953 ± 0.08
1.275ValHis: 1.275 ± 0.036
4.962ValIle: 4.962 ± 0.082
3.654ValLys: 3.654 ± 0.063
6.871ValLeu: 6.871 ± 0.1
2.085ValMet: 2.085 ± 0.046
3.008ValAsn: 3.008 ± 0.059
2.594ValPro: 2.594 ± 0.048
2.311ValGln: 2.311 ± 0.052
2.943ValArg: 2.943 ± 0.05
5.317ValSer: 5.317 ± 0.073
4.228ValThr: 4.228 ± 0.067
5.488ValVal: 5.488 ± 0.082
0.771ValTrp: 0.771 ± 0.03
1.745ValTyr: 1.745 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.833TrpAla: 0.833 ± 0.031
0.171TrpCys: 0.171 ± 0.013
0.577TrpAsp: 0.577 ± 0.025
0.568TrpGlu: 0.568 ± 0.024
0.588TrpPhe: 0.588 ± 0.025
0.78TrpGly: 0.78 ± 0.029
0.324TrpHis: 0.324 ± 0.015
0.694TrpIle: 0.694 ± 0.029
0.562TrpLys: 0.562 ± 0.024
1.696TrpLeu: 1.696 ± 0.042
0.344TrpMet: 0.344 ± 0.017
0.48TrpAsn: 0.48 ± 0.021
0.456TrpPro: 0.456 ± 0.021
0.813TrpGln: 0.813 ± 0.032
0.635TrpArg: 0.635 ± 0.025
0.713TrpSer: 0.713 ± 0.027
0.485TrpThr: 0.485 ± 0.024
0.926TrpVal: 0.926 ± 0.037
0.205TrpTrp: 0.205 ± 0.014
0.365TrpTyr: 0.365 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.149TyrAla: 2.149 ± 0.051
0.393TyrCys: 0.393 ± 0.02
1.605TyrAsp: 1.605 ± 0.043
1.381TyrGlu: 1.381 ± 0.033
1.299TyrPhe: 1.299 ± 0.039
1.995TyrGly: 1.995 ± 0.048
0.787TyrHis: 0.787 ± 0.026
1.591TyrIle: 1.591 ± 0.032
1.284TyrLys: 1.284 ± 0.035
3.19TyrLeu: 3.19 ± 0.059
0.617TyrMet: 0.617 ± 0.027
1.036TyrAsn: 1.036 ± 0.031
1.28TyrPro: 1.28 ± 0.034
1.951TyrGln: 1.951 ± 0.05
1.609TyrArg: 1.609 ± 0.04
2.021TyrSer: 2.021 ± 0.04
1.468TyrThr: 1.468 ± 0.043
1.801TyrVal: 1.801 ± 0.039
0.446TyrTrp: 0.446 ± 0.022
0.907TyrTyr: 0.907 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 3193 proteins (1029883 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski