Amino acid dipepetide frequency for Sulfolobus islandicus filamentous virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.253AlaCys: 0.253 ± 0.151
2.444AlaAsp: 2.444 ± 0.449
3.202AlaGlu: 3.202 ± 0.545
2.697AlaPhe: 2.697 ± 0.621
2.275AlaGly: 2.275 ± 0.558
0.59AlaHis: 0.59 ± 0.204
4.129AlaIle: 4.129 ± 0.711
4.129AlaLys: 4.129 ± 0.631
6.067AlaLeu: 6.067 ± 0.756
1.685AlaMet: 1.685 ± 0.371
2.359AlaAsn: 2.359 ± 0.509
1.348AlaPro: 1.348 ± 0.326
1.095AlaGln: 1.095 ± 0.365
1.601AlaArg: 1.601 ± 0.383
3.539AlaSer: 3.539 ± 0.862
4.129AlaThr: 4.129 ± 0.609
3.202AlaVal: 3.202 ± 0.456
0.59AlaTrp: 0.59 ± 0.229
3.371AlaTyr: 3.371 ± 0.445
0.0AlaXaa: 0.0 ± 0.0
Cys
0.169CysAla: 0.169 ± 0.109
0.0CysCys: 0.0 ± 0.0
0.253CysAsp: 0.253 ± 0.147
1.011CysGlu: 1.011 ± 0.393
0.253CysPhe: 0.253 ± 0.143
0.758CysGly: 0.758 ± 0.227
0.169CysHis: 0.169 ± 0.118
1.264CysIle: 1.264 ± 0.339
0.843CysLys: 0.843 ± 0.339
0.674CysLeu: 0.674 ± 0.286
0.084CysMet: 0.084 ± 0.088
0.843CysAsn: 0.843 ± 0.198
0.506CysPro: 0.506 ± 0.207
0.253CysGln: 0.253 ± 0.133
0.169CysArg: 0.169 ± 0.115
0.758CysSer: 0.758 ± 0.268
1.011CysThr: 1.011 ± 0.288
0.927CysVal: 0.927 ± 0.303
0.084CysTrp: 0.084 ± 0.086
0.674CysTyr: 0.674 ± 0.227
0.0CysXaa: 0.0 ± 0.0
Asp
2.528AspAla: 2.528 ± 0.511
0.674AspCys: 0.674 ± 0.286
2.612AspAsp: 2.612 ± 0.432
4.298AspGlu: 4.298 ± 0.632
2.359AspPhe: 2.359 ± 0.412
2.275AspGly: 2.275 ± 0.428
0.506AspHis: 0.506 ± 0.174
3.792AspIle: 3.792 ± 0.692
4.045AspLys: 4.045 ± 0.682
4.129AspLeu: 4.129 ± 0.503
0.927AspMet: 0.927 ± 0.259
2.107AspAsn: 2.107 ± 0.514
1.685AspPro: 1.685 ± 0.379
0.843AspGln: 0.843 ± 0.255
1.18AspArg: 1.18 ± 0.356
1.938AspSer: 1.938 ± 0.489
1.601AspThr: 1.601 ± 0.419
4.803AspVal: 4.803 ± 0.827
0.506AspTrp: 0.506 ± 0.237
2.107AspTyr: 2.107 ± 0.589
0.0AspXaa: 0.0 ± 0.0
Glu
3.202GluAla: 3.202 ± 0.499
1.011GluCys: 1.011 ± 0.32
4.213GluAsp: 4.213 ± 0.655
5.983GluGlu: 5.983 ± 1.031
2.697GluPhe: 2.697 ± 0.542
2.359GluGly: 2.359 ± 0.45
1.011GluHis: 1.011 ± 0.331
8.09GluIle: 8.09 ± 1.059
6.741GluLys: 6.741 ± 0.939
6.404GluLeu: 6.404 ± 0.637
2.107GluMet: 2.107 ± 0.514
3.961GluAsn: 3.961 ± 0.404
0.927GluPro: 0.927 ± 0.245
2.191GluGln: 2.191 ± 0.468
2.949GluArg: 2.949 ± 0.528
2.359GluSer: 2.359 ± 0.442
3.034GluThr: 3.034 ± 0.531
4.129GluVal: 4.129 ± 0.622
0.59GluTrp: 0.59 ± 0.255
3.455GluTyr: 3.455 ± 0.635
0.0GluXaa: 0.0 ± 0.0
Phe
3.202PheAla: 3.202 ± 0.679
0.337PheCys: 0.337 ± 0.205
2.444PheAsp: 2.444 ± 0.415
2.191PheGlu: 2.191 ± 0.45
2.191PhePhe: 2.191 ± 0.454
2.444PheGly: 2.444 ± 0.459
0.421PheHis: 0.421 ± 0.212
3.876PheIle: 3.876 ± 0.551
3.118PheLys: 3.118 ± 0.573
5.225PheLeu: 5.225 ± 0.656
1.011PheMet: 1.011 ± 0.288
3.371PheAsn: 3.371 ± 0.582
1.18PhePro: 1.18 ± 0.25
1.601PheGln: 1.601 ± 0.371
1.601PheArg: 1.601 ± 0.413
3.202PheSer: 3.202 ± 0.641
3.371PheThr: 3.371 ± 0.602
2.528PheVal: 2.528 ± 0.427
0.253PheTrp: 0.253 ± 0.158
3.034PheTyr: 3.034 ± 0.457
0.0PheXaa: 0.0 ± 0.0
Gly
2.444GlyAla: 2.444 ± 0.452
1.095GlyCys: 1.095 ± 0.295
2.275GlyAsp: 2.275 ± 0.377
2.612GlyGlu: 2.612 ± 0.516
1.854GlyPhe: 1.854 ± 0.452
2.444GlyGly: 2.444 ± 0.715
0.674GlyHis: 0.674 ± 0.267
5.393GlyIle: 5.393 ± 0.57
4.719GlyLys: 4.719 ± 0.612
4.466GlyLeu: 4.466 ± 0.578
1.095GlyMet: 1.095 ± 0.34
3.539GlyAsn: 3.539 ± 0.488
0.084GlyPro: 0.084 ± 0.078
1.264GlyGln: 1.264 ± 0.222
2.107GlyArg: 2.107 ± 0.469
2.275GlySer: 2.275 ± 0.457
3.371GlyThr: 3.371 ± 0.624
4.129GlyVal: 4.129 ± 0.523
0.506GlyTrp: 0.506 ± 0.211
3.371GlyTyr: 3.371 ± 0.583
0.0GlyXaa: 0.0 ± 0.0
His
0.758HisAla: 0.758 ± 0.213
0.253HisCys: 0.253 ± 0.157
1.095HisAsp: 1.095 ± 0.319
1.18HisGlu: 1.18 ± 0.389
0.337HisPhe: 0.337 ± 0.175
0.674HisGly: 0.674 ± 0.25
0.337HisHis: 0.337 ± 0.159
1.601HisIle: 1.601 ± 0.389
0.758HisLys: 0.758 ± 0.308
1.011HisLeu: 1.011 ± 0.307
0.674HisMet: 0.674 ± 0.269
1.011HisAsn: 1.011 ± 0.318
0.59HisPro: 0.59 ± 0.262
0.169HisGln: 0.169 ± 0.123
0.169HisArg: 0.169 ± 0.116
1.011HisSer: 1.011 ± 0.294
0.421HisThr: 0.421 ± 0.184
1.601HisVal: 1.601 ± 0.424
0.084HisTrp: 0.084 ± 0.084
1.095HisTyr: 1.095 ± 0.268
0.0HisXaa: 0.0 ± 0.0
Ile
4.888IleAla: 4.888 ± 0.711
0.59IleCys: 0.59 ± 0.203
3.455IleAsp: 3.455 ± 0.508
6.573IleGlu: 6.573 ± 0.986
3.876IlePhe: 3.876 ± 0.621
3.876IleGly: 3.876 ± 0.616
2.107IleHis: 2.107 ± 0.504
8.848IleIle: 8.848 ± 0.861
8.09IleLys: 8.09 ± 0.983
7.584IleLeu: 7.584 ± 0.915
1.77IleMet: 1.77 ± 0.425
5.899IleAsn: 5.899 ± 0.919
5.309IlePro: 5.309 ± 0.603
3.034IleGln: 3.034 ± 0.534
2.697IleArg: 2.697 ± 0.496
6.067IleSer: 6.067 ± 0.677
5.562IleThr: 5.562 ± 0.613
6.994IleVal: 6.994 ± 0.666
0.253IleTrp: 0.253 ± 0.155
5.73IleTyr: 5.73 ± 0.743
0.0IleXaa: 0.0 ± 0.0
Lys
3.286LysAla: 3.286 ± 0.561
0.337LysCys: 0.337 ± 0.183
2.781LysAsp: 2.781 ± 0.478
7.584LysGlu: 7.584 ± 0.905
2.781LysPhe: 2.781 ± 0.575
3.202LysGly: 3.202 ± 0.581
1.854LysHis: 1.854 ± 0.373
6.657LysIle: 6.657 ± 0.945
7.163LysLys: 7.163 ± 0.922
8.427LysLeu: 8.427 ± 0.835
2.444LysMet: 2.444 ± 0.47
5.562LysAsn: 5.562 ± 0.644
2.275LysPro: 2.275 ± 0.471
2.528LysGln: 2.528 ± 0.552
3.202LysArg: 3.202 ± 0.587
3.708LysSer: 3.708 ± 0.501
4.298LysThr: 4.298 ± 0.682
5.14LysVal: 5.14 ± 0.665
0.421LysTrp: 0.421 ± 0.197
5.309LysTyr: 5.309 ± 0.829
0.0LysXaa: 0.0 ± 0.0
Leu
4.55LeuAla: 4.55 ± 0.557
1.348LeuCys: 1.348 ± 0.396
3.623LeuAsp: 3.623 ± 0.629
5.983LeuGlu: 5.983 ± 0.8
5.562LeuPhe: 5.562 ± 0.719
3.539LeuGly: 3.539 ± 0.602
0.758LeuHis: 0.758 ± 0.24
7.331LeuIle: 7.331 ± 0.941
7.837LeuLys: 7.837 ± 0.91
8.511LeuLeu: 8.511 ± 0.907
2.022LeuMet: 2.022 ± 0.366
5.477LeuAsn: 5.477 ± 0.631
4.045LeuPro: 4.045 ± 0.589
3.961LeuGln: 3.961 ± 0.584
4.55LeuArg: 4.55 ± 0.684
6.067LeuSer: 6.067 ± 0.766
6.404LeuThr: 6.404 ± 0.822
6.32LeuVal: 6.32 ± 0.653
1.264LeuTrp: 1.264 ± 0.267
4.635LeuTyr: 4.635 ± 0.761
0.0LeuXaa: 0.0 ± 0.0
Met
1.601MetAla: 1.601 ± 0.354
0.169MetCys: 0.169 ± 0.135
0.506MetAsp: 0.506 ± 0.217
1.77MetGlu: 1.77 ± 0.278
0.927MetPhe: 0.927 ± 0.197
0.843MetGly: 0.843 ± 0.267
0.337MetHis: 0.337 ± 0.179
2.359MetIle: 2.359 ± 0.496
2.359MetLys: 2.359 ± 0.473
1.77MetLeu: 1.77 ± 0.313
0.169MetMet: 0.169 ± 0.124
1.264MetAsn: 1.264 ± 0.351
0.758MetPro: 0.758 ± 0.299
0.758MetGln: 0.758 ± 0.26
1.517MetArg: 1.517 ± 0.498
2.275MetSer: 2.275 ± 0.431
0.927MetThr: 0.927 ± 0.294
1.854MetVal: 1.854 ± 0.41
0.169MetTrp: 0.169 ± 0.12
0.927MetTyr: 0.927 ± 0.247
0.0MetXaa: 0.0 ± 0.0
Asn
3.623AsnAla: 3.623 ± 0.487
0.758AsnCys: 0.758 ± 0.265
3.034AsnAsp: 3.034 ± 0.505
4.55AsnGlu: 4.55 ± 0.601
3.118AsnPhe: 3.118 ± 0.643
3.961AsnGly: 3.961 ± 0.638
0.674AsnHis: 0.674 ± 0.244
5.225AsnIle: 5.225 ± 0.695
4.045AsnLys: 4.045 ± 0.628
5.056AsnLeu: 5.056 ± 0.625
1.517AsnMet: 1.517 ± 0.375
4.129AsnAsn: 4.129 ± 0.73
1.854AsnPro: 1.854 ± 0.389
1.601AsnGln: 1.601 ± 0.369
1.095AsnArg: 1.095 ± 0.304
3.708AsnSer: 3.708 ± 0.513
3.792AsnThr: 3.792 ± 0.939
5.056AsnVal: 5.056 ± 0.659
0.59AsnTrp: 0.59 ± 0.198
3.034AsnTyr: 3.034 ± 0.392
0.0AsnXaa: 0.0 ± 0.0
Pro
1.601ProAla: 1.601 ± 0.365
0.59ProCys: 0.59 ± 0.187
1.517ProAsp: 1.517 ± 0.453
2.275ProGlu: 2.275 ± 0.455
1.854ProPhe: 1.854 ± 0.358
1.601ProGly: 1.601 ± 0.358
0.421ProHis: 0.421 ± 0.299
3.623ProIle: 3.623 ± 0.499
1.854ProLys: 1.854 ± 0.381
2.865ProLeu: 2.865 ± 0.526
0.421ProMet: 0.421 ± 0.18
2.359ProAsn: 2.359 ± 0.479
2.275ProPro: 2.275 ± 0.503
1.854ProGln: 1.854 ± 0.422
0.927ProArg: 0.927 ± 0.345
4.298ProSer: 4.298 ± 0.78
1.601ProThr: 1.601 ± 0.428
1.854ProVal: 1.854 ± 0.465
0.253ProTrp: 0.253 ± 0.157
1.517ProTyr: 1.517 ± 0.64
0.0ProXaa: 0.0 ± 0.0
Gln
1.517GlnAla: 1.517 ± 0.375
0.421GlnCys: 0.421 ± 0.181
1.18GlnAsp: 1.18 ± 0.371
1.601GlnGlu: 1.601 ± 0.357
1.601GlnPhe: 1.601 ± 0.336
2.444GlnGly: 2.444 ± 0.468
0.421GlnHis: 0.421 ± 0.226
3.202GlnIle: 3.202 ± 0.524
2.528GlnLys: 2.528 ± 0.476
4.382GlnLeu: 4.382 ± 0.71
0.506GlnMet: 0.506 ± 0.226
2.275GlnAsn: 2.275 ± 0.522
1.685GlnPro: 1.685 ± 0.49
2.275GlnGln: 2.275 ± 0.524
0.927GlnArg: 0.927 ± 0.297
1.938GlnSer: 1.938 ± 0.357
1.517GlnThr: 1.517 ± 0.466
1.685GlnVal: 1.685 ± 0.354
0.674GlnTrp: 0.674 ± 0.239
1.685GlnTyr: 1.685 ± 0.461
0.0GlnXaa: 0.0 ± 0.0
Arg
1.685ArgAla: 1.685 ± 0.422
0.337ArgCys: 0.337 ± 0.144
1.601ArgAsp: 1.601 ± 0.368
3.034ArgGlu: 3.034 ± 0.576
1.433ArgPhe: 1.433 ± 0.336
3.118ArgGly: 3.118 ± 0.545
0.927ArgHis: 0.927 ± 0.263
3.455ArgIle: 3.455 ± 0.575
2.612ArgLys: 2.612 ± 0.501
2.949ArgLeu: 2.949 ± 0.526
0.843ArgMet: 0.843 ± 0.267
1.348ArgAsn: 1.348 ± 0.32
0.758ArgPro: 0.758 ± 0.276
1.011ArgGln: 1.011 ± 0.289
1.095ArgArg: 1.095 ± 0.315
1.433ArgSer: 1.433 ± 0.383
1.264ArgThr: 1.264 ± 0.323
2.022ArgVal: 2.022 ± 0.363
0.337ArgTrp: 0.337 ± 0.159
1.517ArgTyr: 1.517 ± 0.361
0.0ArgXaa: 0.0 ± 0.0
Ser
3.539SerAla: 3.539 ± 0.581
0.59SerCys: 0.59 ± 0.228
2.781SerAsp: 2.781 ± 0.583
3.371SerGlu: 3.371 ± 0.541
3.034SerPhe: 3.034 ± 0.469
4.298SerGly: 4.298 ± 0.862
1.011SerHis: 1.011 ± 0.305
4.803SerIle: 4.803 ± 0.659
3.539SerLys: 3.539 ± 0.571
6.152SerLeu: 6.152 ± 0.743
1.77SerMet: 1.77 ± 0.334
3.034SerAsn: 3.034 ± 0.812
2.191SerPro: 2.191 ± 0.483
2.697SerGln: 2.697 ± 0.528
1.77SerArg: 1.77 ± 0.459
5.309SerSer: 5.309 ± 0.967
4.635SerThr: 4.635 ± 0.969
4.803SerVal: 4.803 ± 0.574
0.506SerTrp: 0.506 ± 0.215
4.972SerTyr: 4.972 ± 0.557
0.0SerXaa: 0.0 ± 0.0
Thr
2.949ThrAla: 2.949 ± 0.604
0.337ThrCys: 0.337 ± 0.162
1.938ThrAsp: 1.938 ± 0.508
2.359ThrGlu: 2.359 ± 0.345
3.708ThrPhe: 3.708 ± 0.708
2.865ThrGly: 2.865 ± 0.488
0.843ThrHis: 0.843 ± 0.295
7.078ThrIle: 7.078 ± 0.795
4.129ThrLys: 4.129 ± 0.645
6.826ThrLeu: 6.826 ± 0.895
0.927ThrMet: 0.927 ± 0.271
4.129ThrAsn: 4.129 ± 0.766
2.949ThrPro: 2.949 ± 0.463
3.539ThrGln: 3.539 ± 0.845
1.601ThrArg: 1.601 ± 0.346
4.803ThrSer: 4.803 ± 0.961
4.213ThrThr: 4.213 ± 0.852
4.045ThrVal: 4.045 ± 0.672
0.337ThrTrp: 0.337 ± 0.173
3.202ThrTyr: 3.202 ± 0.547
0.0ThrXaa: 0.0 ± 0.0
Val
3.961ValAla: 3.961 ± 0.682
0.506ValCys: 0.506 ± 0.211
2.949ValAsp: 2.949 ± 0.527
3.876ValGlu: 3.876 ± 0.682
2.865ValPhe: 2.865 ± 0.387
3.623ValGly: 3.623 ± 0.654
0.674ValHis: 0.674 ± 0.298
6.404ValIle: 6.404 ± 0.744
6.573ValLys: 6.573 ± 0.763
5.983ValLeu: 5.983 ± 0.547
1.433ValMet: 1.433 ± 0.32
4.045ValAsn: 4.045 ± 0.555
2.949ValPro: 2.949 ± 0.408
2.022ValGln: 2.022 ± 0.381
2.107ValArg: 2.107 ± 0.466
5.899ValSer: 5.899 ± 0.886
5.814ValThr: 5.814 ± 0.805
4.045ValVal: 4.045 ± 0.695
0.506ValTrp: 0.506 ± 0.217
4.719ValTyr: 4.719 ± 0.654
0.0ValXaa: 0.0 ± 0.0
Trp
0.169TrpAla: 0.169 ± 0.124
0.506TrpCys: 0.506 ± 0.207
0.506TrpAsp: 0.506 ± 0.174
0.758TrpGlu: 0.758 ± 0.189
0.169TrpPhe: 0.169 ± 0.104
0.421TrpGly: 0.421 ± 0.171
0.337TrpHis: 0.337 ± 0.164
1.011TrpIle: 1.011 ± 0.297
0.59TrpLys: 0.59 ± 0.245
0.59TrpLeu: 0.59 ± 0.198
0.253TrpMet: 0.253 ± 0.152
0.59TrpAsn: 0.59 ± 0.2
0.0TrpPro: 0.0 ± 0.0
0.337TrpGln: 0.337 ± 0.155
0.253TrpArg: 0.253 ± 0.153
0.421TrpSer: 0.421 ± 0.217
0.337TrpThr: 0.337 ± 0.133
0.506TrpVal: 0.506 ± 0.203
0.253TrpTrp: 0.253 ± 0.133
0.674TrpTyr: 0.674 ± 0.243
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.034TyrAla: 3.034 ± 0.527
0.59TyrCys: 0.59 ± 0.229
3.708TyrAsp: 3.708 ± 0.753
3.202TyrGlu: 3.202 ± 0.694
3.286TyrPhe: 3.286 ± 0.733
2.697TyrGly: 2.697 ± 0.462
0.843TyrHis: 0.843 ± 0.357
5.056TyrIle: 5.056 ± 0.721
3.286TyrLys: 3.286 ± 0.543
4.719TyrLeu: 4.719 ± 0.805
1.517TyrMet: 1.517 ± 0.246
3.118TyrAsn: 3.118 ± 0.655
2.191TyrPro: 2.191 ± 0.466
1.433TyrGln: 1.433 ± 0.291
1.264TyrArg: 1.264 ± 0.348
3.792TyrSer: 3.792 ± 0.523
5.477TyrThr: 5.477 ± 0.703
5.309TyrVal: 5.309 ± 0.824
0.506TyrTrp: 0.506 ± 0.187
2.444TyrTyr: 2.444 ± 0.462
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 69 proteins (11868 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski