Amino acid dipepetide frequency for archaeon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.073AlaAla: 6.073 ± 0.058	1.224AlaCys: 1.224 ± 0.024	3.537AlaAsp: 3.537 ± 0.038	4.173AlaGlu: 4.173 ± 0.043	2.809AlaPhe: 2.809 ± 0.033	3.915AlaGly: 3.915 ± 0.043	1.848AlaHis: 1.848 ± 0.031	3.862AlaIle: 3.862 ± 0.042	3.835AlaLys: 3.835 ± 0.044	7.406AlaLeu: 7.406 ± 0.054	2.002AlaMet: 2.002 ± 0.027	2.802AlaAsn: 2.802 ± 0.031	2.771AlaPro: 2.771 ± 0.042	2.877AlaGln: 2.877 ± 0.033	3.286AlaArg: 3.286 ± 0.036	6.085AlaSer: 6.085 ± 0.053	3.785AlaThr: 3.785 ± 0.042	5.009AlaVal: 5.009 ± 0.045	0.724AlaTrp: 0.724 ± 0.014	2.347AlaTyr: 2.347 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.167CysAla: 1.167 ± 0.024	0.506CysCys: 0.506 ± 0.015	0.821CysAsp: 0.821 ± 0.018	0.778CysGlu: 0.778 ± 0.02	0.899CysPhe: 0.899 ± 0.018	1.08CysGly: 1.08 ± 0.024	0.472CysHis: 0.472 ± 0.014	1.289CysIle: 1.289 ± 0.022	0.907CysLys: 0.907 ± 0.02	1.958CysLeu: 1.958 ± 0.028	0.743CysMet: 0.743 ± 0.017	0.74CysAsn: 0.74 ± 0.017	0.792CysPro: 0.792 ± 0.023	0.657CysGln: 0.657 ± 0.02	0.932CysArg: 0.932 ± 0.019	1.534CysSer: 1.534 ± 0.024	1.054CysThr: 1.054 ± 0.019	1.484CysVal: 1.484 ± 0.024	0.196CysTrp: 0.196 ± 0.008	0.66CysTyr: 0.66 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.469AspAla: 3.469 ± 0.039	0.873AspCys: 0.873 ± 0.018	3.428AspAsp: 3.428 ± 0.042	3.853AspGlu: 3.853 ± 0.044	2.256AspPhe: 2.256 ± 0.029	3.098AspGly: 3.098 ± 0.039	1.196AspHis: 1.196 ± 0.022	3.448AspIle: 3.448 ± 0.038	2.935AspLys: 2.935 ± 0.038	5.072AspLeu: 5.072 ± 0.045	1.575AspMet: 1.575 ± 0.021	2.266AspAsn: 2.266 ± 0.035	2.047AspPro: 2.047 ± 0.028	1.791AspGln: 1.791 ± 0.024	2.506AspArg: 2.506 ± 0.032	4.175AspSer: 4.175 ± 0.044	2.606AspThr: 2.606 ± 0.032	3.734AspVal: 3.734 ± 0.045	0.698AspTrp: 0.698 ± 0.016	1.861AspTyr: 1.861 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	4.147GluAla: 4.147 ± 0.042	0.801GluCys: 0.801 ± 0.017	3.868GluAsp: 3.868 ± 0.045	5.524GluGlu: 5.524 ± 0.074	1.977GluPhe: 1.977 ± 0.025	3.46GluGly: 3.46 ± 0.041	1.537GluHis: 1.537 ± 0.028	3.039GluIle: 3.039 ± 0.036	3.761GluLys: 3.761 ± 0.047	5.648GluLeu: 5.648 ± 0.055	1.594GluMet: 1.594 ± 0.024	2.372GluAsn: 2.372 ± 0.032	1.552GluPro: 1.552 ± 0.026	2.653GluGln: 2.653 ± 0.037	3.118GluArg: 3.118 ± 0.038	3.999GluSer: 3.999 ± 0.041	2.618GluThr: 2.618 ± 0.03	4.318GluVal: 4.318 ± 0.046	0.563GluTrp: 0.563 ± 0.016	1.856GluTyr: 1.856 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	2.779PheAla: 2.779 ± 0.032	0.863PheCys: 0.863 ± 0.02	2.296PheAsp: 2.296 ± 0.029	2.03PheGlu: 2.03 ± 0.027	1.98PhePhe: 1.98 ± 0.033	2.282PheGly: 2.282 ± 0.033	1.132PheHis: 1.132 ± 0.019	2.468PheIle: 2.468 ± 0.033	1.709PheLys: 1.709 ± 0.026	4.154PheLeu: 4.154 ± 0.042	1.087PheMet: 1.087 ± 0.022	1.801PheAsn: 1.801 ± 0.03	1.721PhePro: 1.721 ± 0.026	1.49PheGln: 1.49 ± 0.024	1.849PheArg: 1.849 ± 0.023	3.609PheSer: 3.609 ± 0.042	2.269PheThr: 2.269 ± 0.032	3.024PheVal: 3.024 ± 0.034	0.454PheTrp: 0.454 ± 0.012	1.518PheTyr: 1.518 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	3.526GlyAla: 3.526 ± 0.045	1.016GlyCys: 1.016 ± 0.02	3.137GlyAsp: 3.137 ± 0.041	3.334GlyGlu: 3.334 ± 0.04	2.188GlyPhe: 2.188 ± 0.031	4.61GlyGly: 4.61 ± 0.064	1.327GlyHis: 1.327 ± 0.024	2.984GlyIle: 2.984 ± 0.035	3.533GlyLys: 3.533 ± 0.043	4.921GlyLeu: 4.921 ± 0.042	1.737GlyMet: 1.737 ± 0.03	2.422GlyAsn: 2.422 ± 0.037	1.532GlyPro: 1.532 ± 0.027	2.191GlyGln: 2.191 ± 0.049	2.805GlyArg: 2.805 ± 0.038	4.722GlySer: 4.722 ± 0.057	2.776GlyThr: 2.776 ± 0.037	4.023GlyVal: 4.023 ± 0.045	0.642GlyTrp: 0.642 ± 0.018	1.945GlyTyr: 1.945 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.848HisAla: 1.848 ± 0.03	0.523HisCys: 0.523 ± 0.013	1.331HisAsp: 1.331 ± 0.025	1.328HisGlu: 1.328 ± 0.024	1.089HisPhe: 1.089 ± 0.02	1.402HisGly: 1.402 ± 0.025	1.08HisHis: 1.08 ± 0.026	1.902HisIle: 1.902 ± 0.027	1.35HisLys: 1.35 ± 0.025	2.609HisLeu: 2.609 ± 0.034	0.81HisMet: 0.81 ± 0.017	1.198HisAsn: 1.198 ± 0.021	1.418HisPro: 1.418 ± 0.025	0.926HisGln: 0.926 ± 0.021	1.425HisArg: 1.425 ± 0.027	2.263HisSer: 2.263 ± 0.035	2.032HisThr: 2.032 ± 0.032	1.882HisVal: 1.882 ± 0.028	0.296HisTrp: 0.296 ± 0.011	1.024HisTyr: 1.024 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.094IleAla: 4.094 ± 0.04	1.194IleCys: 1.194 ± 0.02	3.089IleAsp: 3.089 ± 0.035	3.265IleGlu: 3.265 ± 0.034	2.4IlePhe: 2.4 ± 0.031	2.911IleGly: 2.911 ± 0.036	1.584IleHis: 1.584 ± 0.025	3.022IleIle: 3.022 ± 0.034	2.808IleLys: 2.808 ± 0.035	5.517IleLeu: 5.517 ± 0.045	1.485IleMet: 1.485 ± 0.028	2.378IleAsn: 2.378 ± 0.028	2.58IlePro: 2.58 ± 0.033	2.268IleGln: 2.268 ± 0.033	2.659IleArg: 2.659 ± 0.038	4.609IleSer: 4.609 ± 0.042	3.054IleThr: 3.054 ± 0.035	3.982IleVal: 3.982 ± 0.038	0.591IleTrp: 0.591 ± 0.015	1.967IleTyr: 1.967 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.047LysAla: 4.047 ± 0.044	0.773LysCys: 0.773 ± 0.018	2.918LysAsp: 2.918 ± 0.039	3.873LysGlu: 3.873 ± 0.05	1.838LysPhe: 1.838 ± 0.027	2.884LysGly: 2.884 ± 0.03	1.499LysHis: 1.499 ± 0.025	2.652LysIle: 2.652 ± 0.031	4.171LysLys: 4.171 ± 0.062	5.436LysLeu: 5.436 ± 0.051	1.602LysMet: 1.602 ± 0.026	2.03LysAsn: 2.03 ± 0.027	2.145LysPro: 2.145 ± 0.032	2.588LysGln: 2.588 ± 0.033	3.167LysArg: 3.167 ± 0.04	4.021LysSer: 4.021 ± 0.042	2.821LysThr: 2.821 ± 0.038	4.031LysVal: 4.031 ± 0.039	0.579LysTrp: 0.579 ± 0.015	1.886LysTyr: 1.886 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	7.107LeuAla: 7.107 ± 0.055	2.164LeuCys: 2.164 ± 0.031	5.28LeuAsp: 5.28 ± 0.041	5.532LeuGlu: 5.532 ± 0.051	4.263LeuPhe: 4.263 ± 0.043	5.012LeuGly: 5.012 ± 0.045	3.085LeuHis: 3.085 ± 0.038	4.814LeuIle: 4.814 ± 0.049	5.054LeuLys: 5.054 ± 0.053	11.353LeuLeu: 11.353 ± 0.099	2.426LeuMet: 2.426 ± 0.035	3.934LeuAsn: 3.934 ± 0.033	5.236LeuPro: 5.236 ± 0.042	5.179LeuGln: 5.179 ± 0.051	5.257LeuArg: 5.257 ± 0.047	9.103LeuSer: 9.103 ± 0.076	5.56LeuThr: 5.56 ± 0.044	6.593LeuVal: 6.593 ± 0.055	1.06LeuTrp: 1.06 ± 0.019	3.455LeuTyr: 3.455 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.793MetAla: 1.793 ± 0.025	0.585MetCys: 0.585 ± 0.014	1.43MetAsp: 1.43 ± 0.024	1.606MetGlu: 1.606 ± 0.024	1.124MetPhe: 1.124 ± 0.022	1.433MetGly: 1.433 ± 0.023	0.895MetHis: 0.895 ± 0.019	1.388MetIle: 1.388 ± 0.023	1.633MetLys: 1.633 ± 0.024	3.0MetLeu: 3.0 ± 0.031	0.903MetMet: 0.903 ± 0.018	1.105MetAsn: 1.105 ± 0.023	1.121MetPro: 1.121 ± 0.02	1.469MetGln: 1.469 ± 0.028	1.569MetArg: 1.569 ± 0.026	2.417MetSer: 2.417 ± 0.03	1.477MetThr: 1.477 ± 0.024	1.82MetVal: 1.82 ± 0.025	0.309MetTrp: 0.309 ± 0.011	0.999MetTyr: 0.999 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.092AsnAla: 3.092 ± 0.042	0.674AsnCys: 0.674 ± 0.015	2.094AsnAsp: 2.094 ± 0.025	2.287AsnGlu: 2.287 ± 0.03	1.642AsnPhe: 1.642 ± 0.025	2.077AsnGly: 2.077 ± 0.033	0.968AsnHis: 0.968 ± 0.017	2.732AsnIle: 2.732 ± 0.033	2.48AsnLys: 2.48 ± 0.029	3.938AsnLeu: 3.938 ± 0.04	1.285AsnMet: 1.285 ± 0.024	2.178AsnAsn: 2.178 ± 0.036	2.091AsnPro: 2.091 ± 0.028	1.584AsnGln: 1.584 ± 0.025	2.021AsnArg: 2.021 ± 0.028	3.504AsnSer: 3.504 ± 0.047	2.602AsnThr: 2.602 ± 0.034	2.901AsnVal: 2.901 ± 0.033	0.422AsnTrp: 0.422 ± 0.011	1.353AsnTyr: 1.353 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	3.123ProAla: 3.123 ± 0.037	0.642ProCys: 0.642 ± 0.017	2.013ProAsp: 2.013 ± 0.027	2.176ProGlu: 2.176 ± 0.029	1.704ProPhe: 1.704 ± 0.028	2.031ProGly: 2.031 ± 0.031	1.186ProHis: 1.186 ± 0.025	2.328ProIle: 2.328 ± 0.028	1.967ProLys: 1.967 ± 0.027	4.234ProLeu: 4.234 ± 0.042	0.976ProMet: 0.976 ± 0.018	1.821ProAsn: 1.821 ± 0.028	2.871ProPro: 2.871 ± 0.045	1.457ProGln: 1.457 ± 0.024	1.802ProArg: 1.802 ± 0.027	5.163ProSer: 5.163 ± 0.123	3.302ProThr: 3.302 ± 0.086	2.868ProVal: 2.868 ± 0.037	0.425ProTrp: 0.425 ± 0.012	1.513ProTyr: 1.513 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.151GlnAla: 3.151 ± 0.033	0.717GlnCys: 0.717 ± 0.019	2.117GlnAsp: 2.117 ± 0.03	2.64GlnGlu: 2.64 ± 0.036	1.461GlnPhe: 1.461 ± 0.021	2.183GlnGly: 2.183 ± 0.029	1.394GlnHis: 1.394 ± 0.024	1.975GlnIle: 1.975 ± 0.028	2.147GlnLys: 2.147 ± 0.035	4.295GlnLeu: 4.295 ± 0.048	1.001GlnMet: 1.001 ± 0.019	1.544GlnAsn: 1.544 ± 0.021	2.353GlnPro: 2.353 ± 0.145	2.537GlnGln: 2.537 ± 0.049	2.337GlnArg: 2.337 ± 0.03	3.362GlnSer: 3.362 ± 0.041	2.096GlnThr: 2.096 ± 0.026	2.846GlnVal: 2.846 ± 0.033	0.474GlnTrp: 0.474 ± 0.016	1.491GlnTyr: 1.491 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	3.276ArgAla: 3.276 ± 0.037	0.853ArgCys: 0.853 ± 0.018	2.563ArgAsp: 2.563 ± 0.037	3.095ArgGlu: 3.095 ± 0.037	1.871ArgPhe: 1.871 ± 0.027	2.79ArgGly: 2.79 ± 0.036	1.387ArgHis: 1.387 ± 0.023	2.828ArgIle: 2.828 ± 0.033	3.235ArgLys: 3.235 ± 0.038	5.09ArgLeu: 5.09 ± 0.045	1.569ArgMet: 1.569 ± 0.024	2.142ArgAsn: 2.142 ± 0.024	1.963ArgPro: 1.963 ± 0.027	2.282ArgGln: 2.282 ± 0.027	3.25ArgArg: 3.25 ± 0.049	4.006ArgSer: 4.006 ± 0.04	2.448ArgThr: 2.448 ± 0.029	3.224ArgVal: 3.224 ± 0.031	0.575ArgTrp: 0.575 ± 0.015	1.795ArgTyr: 1.795 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.087SerAla: 6.087 ± 0.056	1.477SerCys: 1.477 ± 0.025	3.918SerAsp: 3.918 ± 0.039	3.938SerGlu: 3.938 ± 0.04	3.692SerPhe: 3.692 ± 0.047	4.565SerGly: 4.565 ± 0.056	2.186SerHis: 2.186 ± 0.032	5.069SerIle: 5.069 ± 0.048	4.767SerLys: 4.767 ± 0.047	9.05SerLeu: 9.05 ± 0.067	2.482SerMet: 2.482 ± 0.032	3.924SerAsn: 3.924 ± 0.049	4.063SerPro: 4.063 ± 0.054	3.317SerGln: 3.317 ± 0.061	4.009SerArg: 4.009 ± 0.039	9.848SerSer: 9.848 ± 0.116	5.407SerThr: 5.407 ± 0.056	5.768SerVal: 5.768 ± 0.058	0.876SerTrp: 0.876 ± 0.021	2.807SerTyr: 2.807 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	3.936ThrAla: 3.936 ± 0.039	1.067ThrCys: 1.067 ± 0.022	2.567ThrAsp: 2.567 ± 0.033	2.689ThrGlu: 2.689 ± 0.032	2.267ThrPhe: 2.267 ± 0.036	3.171ThrGly: 3.171 ± 0.04	1.77ThrHis: 1.77 ± 0.028	3.258ThrIle: 3.258 ± 0.037	2.792ThrLys: 2.792 ± 0.032	5.766ThrLeu: 5.766 ± 0.051	1.495ThrMet: 1.495 ± 0.023	2.379ThrAsn: 2.379 ± 0.034	2.835ThrPro: 2.835 ± 0.038	2.118ThrGln: 2.118 ± 0.032	2.312ThrArg: 2.312 ± 0.031	5.258ThrSer: 5.258 ± 0.056	3.289ThrThr: 3.289 ± 0.046	3.88ThrVal: 3.88 ± 0.048	0.627ThrTrp: 0.627 ± 0.015	1.98ThrTyr: 1.98 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	4.82ValAla: 4.82 ± 0.041	1.662ValCys: 1.662 ± 0.029	4.002ValAsp: 4.002 ± 0.035	3.945ValGlu: 3.945 ± 0.043	2.98ValPhe: 2.98 ± 0.036	3.844ValGly: 3.844 ± 0.04	1.9ValHis: 1.9 ± 0.027	3.631ValIle: 3.631 ± 0.035	3.578ValLys: 3.578 ± 0.037	7.293ValLeu: 7.293 ± 0.05	1.868ValMet: 1.868 ± 0.021	2.762ValAsn: 2.762 ± 0.037	2.79ValPro: 2.79 ± 0.032	2.978ValGln: 2.978 ± 0.037	3.472ValArg: 3.472 ± 0.034	5.979ValSer: 5.979 ± 0.063	3.527ValThr: 3.527 ± 0.051	5.101ValVal: 5.101 ± 0.059	0.854ValTrp: 0.854 ± 0.017	2.657ValTyr: 2.657 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.584TrpAla: 0.584 ± 0.015	0.255TrpCys: 0.255 ± 0.009	0.6TrpAsp: 0.6 ± 0.018	0.544TrpGlu: 0.544 ± 0.015	0.438TrpPhe: 0.438 ± 0.013	0.603TrpGly: 0.603 ± 0.014	0.309TrpHis: 0.309 ± 0.01	0.614TrpIle: 0.614 ± 0.017	0.703TrpLys: 0.703 ± 0.018	1.142TrpLeu: 1.142 ± 0.021	0.362TrpMet: 0.362 ± 0.01	0.502TrpAsn: 0.502 ± 0.012	0.381TrpPro: 0.381 ± 0.012	0.521TrpGln: 0.521 ± 0.014	0.656TrpArg: 0.656 ± 0.018	0.853TrpSer: 0.853 ± 0.016	0.666TrpThr: 0.666 ± 0.018	0.654TrpVal: 0.654 ± 0.015	0.16TrpTrp: 0.16 ± 0.008	0.389TrpTyr: 0.389 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.254TyrAla: 2.254 ± 0.026	0.799TyrCys: 0.799 ± 0.017	1.879TyrAsp: 1.879 ± 0.029	1.793TyrGlu: 1.793 ± 0.027	1.639TyrPhe: 1.639 ± 0.026	2.02TyrGly: 2.02 ± 0.034	0.979TyrHis: 0.979 ± 0.018	2.154TyrIle: 2.154 ± 0.033	1.598TyrLys: 1.598 ± 0.028	3.585TyrLeu: 3.585 ± 0.04	1.076TyrMet: 1.076 ± 0.017	1.623TyrAsn: 1.623 ± 0.028	1.34TyrPro: 1.34 ± 0.026	1.236TyrGln: 1.236 ± 0.018	1.809TyrArg: 1.809 ± 0.026	2.742TyrSer: 2.742 ± 0.041	2.067TyrThr: 2.067 ± 0.033	2.502TyrVal: 2.502 ± 0.032	0.411TyrTrp: 0.411 ± 0.012	1.409TyrTyr: 1.409 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11629 proteins (2917676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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