Amino acid dipepetide frequency for [Candida] inconspicua

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.776AlaAla: 3.776 ± 0.054	0.661AlaCys: 0.661 ± 0.019	2.768AlaAsp: 2.768 ± 0.036	3.279AlaGlu: 3.279 ± 0.045	2.304AlaPhe: 2.304 ± 0.035	2.739AlaGly: 2.739 ± 0.048	0.958AlaHis: 0.958 ± 0.019	3.787AlaIle: 3.787 ± 0.039	3.894AlaLys: 3.894 ± 0.053	5.078AlaLeu: 5.078 ± 0.056	1.133AlaMet: 1.133 ± 0.021	2.89AlaAsn: 2.89 ± 0.032	2.015AlaPro: 2.015 ± 0.041	1.812AlaGln: 1.812 ± 0.034	2.128AlaArg: 2.128 ± 0.036	4.32AlaSer: 4.32 ± 0.047	3.425AlaThr: 3.425 ± 0.045	3.179AlaVal: 3.179 ± 0.043	0.461AlaTrp: 0.461 ± 0.014	1.736AlaTyr: 1.736 ± 0.026	0.001AlaXaa: 0.001 ± 0.001
Cys	0.654CysAla: 0.654 ± 0.019	0.259CysCys: 0.259 ± 0.011	0.729CysAsp: 0.729 ± 0.018	0.71CysGlu: 0.71 ± 0.016	0.644CysPhe: 0.644 ± 0.017	0.797CysGly: 0.797 ± 0.02	0.276CysHis: 0.276 ± 0.011	0.949CysIle: 0.949 ± 0.021	0.769CysLys: 0.769 ± 0.017	1.212CysLeu: 1.212 ± 0.022	0.255CysMet: 0.255 ± 0.011	0.59CysAsn: 0.59 ± 0.017	0.447CysPro: 0.447 ± 0.014	0.396CysGln: 0.396 ± 0.015	0.462CysArg: 0.462 ± 0.013	0.976CysSer: 0.976 ± 0.021	0.65CysThr: 0.65 ± 0.02	0.76CysVal: 0.76 ± 0.019	0.148CysTrp: 0.148 ± 0.008	0.472CysTyr: 0.472 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.182AspAla: 3.182 ± 0.042	0.682AspCys: 0.682 ± 0.017	5.474AspAsp: 5.474 ± 0.07	5.453AspGlu: 5.453 ± 0.064	2.855AspPhe: 2.855 ± 0.033	2.903AspGly: 2.903 ± 0.035	1.129AspHis: 1.129 ± 0.019	4.548AspIle: 4.548 ± 0.048	3.801AspLys: 3.801 ± 0.043	5.842AspLeu: 5.842 ± 0.049	1.167AspMet: 1.167 ± 0.021	3.557AspAsn: 3.557 ± 0.04	2.464AspPro: 2.464 ± 0.03	1.816AspGln: 1.816 ± 0.03	1.939AspArg: 1.939 ± 0.036	5.185AspSer: 5.185 ± 0.048	3.188AspThr: 3.188 ± 0.035	3.81AspVal: 3.81 ± 0.046	0.64AspTrp: 0.64 ± 0.014	2.373AspTyr: 2.373 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	3.261GluAla: 3.261 ± 0.043	0.682GluCys: 0.682 ± 0.017	4.305GluAsp: 4.305 ± 0.055	6.184GluGlu: 6.184 ± 0.094	3.042GluPhe: 3.042 ± 0.036	2.708GluGly: 2.708 ± 0.037	1.232GluHis: 1.232 ± 0.021	5.152GluIle: 5.152 ± 0.053	5.869GluLys: 5.869 ± 0.067	6.687GluLeu: 6.687 ± 0.071	1.494GluMet: 1.494 ± 0.026	4.725GluAsn: 4.725 ± 0.051	1.88GluPro: 1.88 ± 0.029	2.335GluGln: 2.335 ± 0.033	3.001GluArg: 3.001 ± 0.036	5.252GluSer: 5.252 ± 0.05	3.928GluThr: 3.928 ± 0.051	3.617GluVal: 3.617 ± 0.037	0.672GluTrp: 0.672 ± 0.016	2.305GluTyr: 2.305 ± 0.031	0.002GluXaa: 0.002 ± 0.001
Phe	2.413PheAla: 2.413 ± 0.037	0.567PheCys: 0.567 ± 0.016	3.151PheAsp: 3.151 ± 0.038	3.162PheGlu: 3.162 ± 0.04	1.94PhePhe: 1.94 ± 0.035	2.643PheGly: 2.643 ± 0.041	0.907PheHis: 0.907 ± 0.018	3.027PheIle: 3.027 ± 0.036	3.448PheLys: 3.448 ± 0.041	3.83PheLeu: 3.83 ± 0.046	0.924PheMet: 0.924 ± 0.02	2.959PheAsn: 2.959 ± 0.042	1.64PhePro: 1.64 ± 0.025	1.674PheGln: 1.674 ± 0.027	1.564PheArg: 1.564 ± 0.031	3.584PheSer: 3.584 ± 0.039	2.687PheThr: 2.687 ± 0.038	2.693PheVal: 2.693 ± 0.035	0.514PheTrp: 0.514 ± 0.016	1.566PheTyr: 1.566 ± 0.03	0.002PheXaa: 0.002 ± 0.001
Gly	2.579GlyAla: 2.579 ± 0.042	0.688GlyCys: 0.688 ± 0.017	2.876GlyAsp: 2.876 ± 0.035	2.989GlyGlu: 2.989 ± 0.039	2.445GlyPhe: 2.445 ± 0.035	3.049GlyGly: 3.049 ± 0.055	0.993GlyHis: 0.993 ± 0.02	3.589GlyIle: 3.589 ± 0.043	3.594GlyLys: 3.594 ± 0.038	4.507GlyLeu: 4.507 ± 0.051	1.001GlyMet: 1.001 ± 0.023	2.662GlyAsn: 2.662 ± 0.038	1.47GlyPro: 1.47 ± 0.029	1.288GlyGln: 1.288 ± 0.026	1.986GlyArg: 1.986 ± 0.035	4.189GlySer: 4.189 ± 0.075	2.762GlyThr: 2.762 ± 0.04	3.091GlyVal: 3.091 ± 0.045	0.578GlyTrp: 0.578 ± 0.016	1.92GlyTyr: 1.92 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	0.998HisAla: 0.998 ± 0.02	0.284HisCys: 0.284 ± 0.011	1.169HisAsp: 1.169 ± 0.024	1.25HisGlu: 1.25 ± 0.025	0.924HisPhe: 0.924 ± 0.018	1.022HisGly: 1.022 ± 0.023	0.638HisHis: 0.638 ± 0.019	1.402HisIle: 1.402 ± 0.026	1.281HisLys: 1.281 ± 0.023	2.072HisLeu: 2.072 ± 0.03	0.416HisMet: 0.416 ± 0.013	1.194HisAsn: 1.194 ± 0.023	1.052HisPro: 1.052 ± 0.023	0.884HisGln: 0.884 ± 0.028	0.907HisArg: 0.907 ± 0.018	1.83HisSer: 1.83 ± 0.032	1.087HisThr: 1.087 ± 0.024	1.161HisVal: 1.161 ± 0.023	0.195HisTrp: 0.195 ± 0.009	0.771HisTyr: 0.771 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.88IleAla: 3.88 ± 0.039	0.948IleCys: 0.948 ± 0.02	5.15IleAsp: 5.15 ± 0.054	4.974IleGlu: 4.974 ± 0.053	2.913IlePhe: 2.913 ± 0.04	3.373IleGly: 3.373 ± 0.039	1.483IleHis: 1.483 ± 0.025	4.6IleIle: 4.6 ± 0.057	5.042IleLys: 5.042 ± 0.058	6.394IleLeu: 6.394 ± 0.06	1.344IleMet: 1.344 ± 0.025	4.489IleAsn: 4.489 ± 0.047	3.445IlePro: 3.445 ± 0.032	2.589IleGln: 2.589 ± 0.037	2.675IleArg: 2.675 ± 0.034	5.905IleSer: 5.905 ± 0.052	3.988IleThr: 3.988 ± 0.05	4.248IleVal: 4.248 ± 0.045	0.677IleTrp: 0.677 ± 0.017	2.327IleTyr: 2.327 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.569LysAla: 3.569 ± 0.045	0.833LysCys: 0.833 ± 0.02	4.182LysAsp: 4.182 ± 0.049	5.327LysGlu: 5.327 ± 0.06	3.376LysPhe: 3.376 ± 0.041	2.965LysGly: 2.965 ± 0.04	1.53LysHis: 1.53 ± 0.023	5.211LysIle: 5.211 ± 0.049	6.293LysLys: 6.293 ± 0.08	7.938LysLeu: 7.938 ± 0.07	1.562LysMet: 1.562 ± 0.022	4.474LysAsn: 4.474 ± 0.043	2.851LysPro: 2.851 ± 0.04	2.817LysGln: 2.817 ± 0.038	3.8LysArg: 3.8 ± 0.049	6.174LysSer: 6.174 ± 0.061	4.039LysThr: 4.039 ± 0.044	4.398LysVal: 4.398 ± 0.048	0.738LysTrp: 0.738 ± 0.019	2.77LysTyr: 2.77 ± 0.035	0.002LysXaa: 0.002 ± 0.001
Leu	5.079LeuAla: 5.079 ± 0.056	1.186LeuCys: 1.186 ± 0.024	5.524LeuAsp: 5.524 ± 0.046	6.156LeuGlu: 6.156 ± 0.062	4.091LeuPhe: 4.091 ± 0.048	4.29LeuGly: 4.29 ± 0.04	2.057LeuHis: 2.057 ± 0.031	6.444LeuIle: 6.444 ± 0.065	7.952LeuLys: 7.952 ± 0.067	9.057LeuLeu: 9.057 ± 0.095	1.989LeuMet: 1.989 ± 0.03	6.336LeuAsn: 6.336 ± 0.065	4.352LeuPro: 4.352 ± 0.05	3.907LeuGln: 3.907 ± 0.044	4.125LeuArg: 4.125 ± 0.045	8.221LeuSer: 8.221 ± 0.064	5.344LeuThr: 5.344 ± 0.045	5.105LeuVal: 5.105 ± 0.049	0.808LeuTrp: 0.808 ± 0.019	2.976LeuTyr: 2.976 ± 0.04	0.002LeuXaa: 0.002 ± 0.001
Met	1.12MetAla: 1.12 ± 0.022	0.237MetCys: 0.237 ± 0.01	1.147MetAsp: 1.147 ± 0.024	1.271MetGlu: 1.271 ± 0.025	0.905MetPhe: 0.905 ± 0.019	0.97MetGly: 0.97 ± 0.021	0.384MetHis: 0.384 ± 0.012	1.482MetIle: 1.482 ± 0.029	1.691MetLys: 1.691 ± 0.031	1.804MetLeu: 1.804 ± 0.027	0.552MetMet: 0.552 ± 0.016	1.4MetAsn: 1.4 ± 0.027	0.748MetPro: 0.748 ± 0.021	0.714MetGln: 0.714 ± 0.018	0.847MetArg: 0.847 ± 0.018	1.895MetSer: 1.895 ± 0.027	1.158MetThr: 1.158 ± 0.02	1.118MetVal: 1.118 ± 0.022	0.172MetTrp: 0.172 ± 0.008	0.646MetTyr: 0.646 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.007AsnAla: 3.007 ± 0.033	0.702AsnCys: 0.702 ± 0.017	4.412AsnAsp: 4.412 ± 0.05	4.46AsnGlu: 4.46 ± 0.051	2.737AsnPhe: 2.737 ± 0.042	3.214AsnGly: 3.214 ± 0.045	1.284AsnHis: 1.284 ± 0.024	4.458AsnIle: 4.458 ± 0.045	4.263AsnLys: 4.263 ± 0.047	5.659AsnLeu: 5.659 ± 0.059	1.263AsnMet: 1.263 ± 0.026	4.669AsnAsn: 4.669 ± 0.078	2.509AsnPro: 2.509 ± 0.035	2.273AsnGln: 2.273 ± 0.037	2.223AsnArg: 2.223 ± 0.031	5.809AsnSer: 5.809 ± 0.064	3.663AsnThr: 3.663 ± 0.053	3.571AsnVal: 3.571 ± 0.048	0.58AsnTrp: 0.58 ± 0.015	2.336AsnTyr: 2.336 ± 0.034	0.001AsnXaa: 0.001 ± 0.001
Pro	2.053ProAla: 2.053 ± 0.034	0.334ProCys: 0.334 ± 0.011	2.21ProAsp: 2.21 ± 0.032	2.822ProGlu: 2.822 ± 0.035	1.845ProPhe: 1.845 ± 0.028	1.725ProGly: 1.725 ± 0.034	0.857ProHis: 0.857 ± 0.021	2.969ProIle: 2.969 ± 0.036	2.81ProLys: 2.81 ± 0.04	3.84ProLeu: 3.84 ± 0.039	0.706ProMet: 0.706 ± 0.019	2.491ProAsn: 2.491 ± 0.034	2.412ProPro: 2.412 ± 0.082	1.791ProGln: 1.791 ± 0.04	1.424ProArg: 1.424 ± 0.026	3.732ProSer: 3.732 ± 0.058	2.929ProThr: 2.929 ± 0.047	2.658ProVal: 2.658 ± 0.04	0.344ProTrp: 0.344 ± 0.012	1.354ProTyr: 1.354 ± 0.023	0.002ProXaa: 0.002 ± 0.001
Gln	1.714GlnAla: 1.714 ± 0.033	0.4GlnCys: 0.4 ± 0.012	1.645GlnAsp: 1.645 ± 0.026	2.077GlnGlu: 2.077 ± 0.033	1.666GlnPhe: 1.666 ± 0.023	1.446GlnGly: 1.446 ± 0.033	0.974GlnHis: 0.974 ± 0.025	2.689GlnIle: 2.689 ± 0.034	2.619GlnLys: 2.619 ± 0.037	4.084GlnLeu: 4.084 ± 0.041	0.854GlnMet: 0.854 ± 0.022	2.355GlnAsn: 2.355 ± 0.035	1.628GlnPro: 1.628 ± 0.037	3.31GlnGln: 3.31 ± 0.16	1.684GlnArg: 1.684 ± 0.027	3.063GlnSer: 3.063 ± 0.044	2.078GlnThr: 2.078 ± 0.032	1.815GlnVal: 1.815 ± 0.022	0.338GlnTrp: 0.338 ± 0.011	1.351GlnTyr: 1.351 ± 0.026	0.003GlnXaa: 0.003 ± 0.001
Arg	2.074ArgAla: 2.074 ± 0.031	0.51ArgCys: 0.51 ± 0.015	2.151ArgAsp: 2.151 ± 0.031	2.726ArgGlu: 2.726 ± 0.037	1.88ArgPhe: 1.88 ± 0.032	2.0ArgGly: 2.0 ± 0.036	0.855ArgHis: 0.855 ± 0.018	2.779ArgIle: 2.779 ± 0.035	3.538ArgLys: 3.538 ± 0.043	3.922ArgLeu: 3.922 ± 0.046	0.878ArgMet: 0.878 ± 0.019	2.502ArgAsn: 2.502 ± 0.032	1.404ArgPro: 1.404 ± 0.026	1.508ArgGln: 1.508 ± 0.024	2.41ArgArg: 2.41 ± 0.036	3.288ArgSer: 3.288 ± 0.038	2.092ArgThr: 2.092 ± 0.033	2.316ArgVal: 2.316 ± 0.033	0.439ArgTrp: 0.439 ± 0.014	1.438ArgTyr: 1.438 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	4.202SerAla: 4.202 ± 0.048	0.93SerCys: 0.93 ± 0.025	5.014SerAsp: 5.014 ± 0.052	4.925SerGlu: 4.925 ± 0.05	3.968SerPhe: 3.968 ± 0.047	4.127SerGly: 4.127 ± 0.065	1.703SerHis: 1.703 ± 0.029	6.243SerIle: 6.243 ± 0.054	6.394SerLys: 6.394 ± 0.053	8.086SerLeu: 8.086 ± 0.06	1.68SerMet: 1.68 ± 0.025	6.03SerAsn: 6.03 ± 0.072	3.553SerPro: 3.553 ± 0.062	3.086SerGln: 3.086 ± 0.04	3.26SerArg: 3.26 ± 0.04	9.079SerSer: 9.079 ± 0.13	6.056SerThr: 6.056 ± 0.083	4.725SerVal: 4.725 ± 0.047	0.76SerTrp: 0.76 ± 0.017	2.605SerTyr: 2.605 ± 0.034	0.003SerXaa: 0.003 ± 0.001
Thr	3.209ThrAla: 3.209 ± 0.044	0.741ThrCys: 0.741 ± 0.023	3.249ThrAsp: 3.249 ± 0.035	3.545ThrGlu: 3.545 ± 0.04	2.629ThrPhe: 2.629 ± 0.035	3.015ThrGly: 3.015 ± 0.044	1.13ThrHis: 1.13 ± 0.021	4.265ThrIle: 4.265 ± 0.05	4.1ThrLys: 4.1 ± 0.044	5.579ThrLeu: 5.579 ± 0.045	1.032ThrMet: 1.032 ± 0.02	3.607ThrAsn: 3.607 ± 0.052	3.162ThrPro: 3.162 ± 0.058	1.954ThrGln: 1.954 ± 0.029	2.158ThrArg: 2.158 ± 0.029	5.515ThrSer: 5.515 ± 0.076	4.507ThrThr: 4.507 ± 0.107	3.541ThrVal: 3.541 ± 0.054	0.506ThrTrp: 0.506 ± 0.013	1.872ThrTyr: 1.872 ± 0.028	0.002ThrXaa: 0.002 ± 0.001
Val	3.318ValAla: 3.318 ± 0.043	0.797ValCys: 0.797 ± 0.015	3.967ValAsp: 3.967 ± 0.044	4.236ValGlu: 4.236 ± 0.045	2.532ValPhe: 2.532 ± 0.035	2.957ValGly: 2.957 ± 0.045	1.163ValHis: 1.163 ± 0.022	3.768ValIle: 3.768 ± 0.037	4.249ValLys: 4.249 ± 0.045	5.19ValLeu: 5.19 ± 0.046	1.077ValMet: 1.077 ± 0.022	3.321ValAsn: 3.321 ± 0.054	2.621ValPro: 2.621 ± 0.034	2.001ValGln: 2.001 ± 0.029	2.255ValArg: 2.255 ± 0.03	4.981ValSer: 4.981 ± 0.046	3.289ValThr: 3.289 ± 0.052	3.654ValVal: 3.654 ± 0.044	0.561ValTrp: 0.561 ± 0.015	1.991ValTyr: 1.991 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.446TrpAla: 0.446 ± 0.015	0.214TrpCys: 0.214 ± 0.01	0.618TrpAsp: 0.618 ± 0.018	0.597TrpGlu: 0.597 ± 0.014	0.494TrpPhe: 0.494 ± 0.016	0.467TrpGly: 0.467 ± 0.015	0.179TrpHis: 0.179 ± 0.008	0.746TrpIle: 0.746 ± 0.019	0.882TrpLys: 0.882 ± 0.018	0.847TrpLeu: 0.847 ± 0.021	0.234TrpMet: 0.234 ± 0.009	0.676TrpAsn: 0.676 ± 0.018	0.264TrpPro: 0.264 ± 0.011	0.263TrpGln: 0.263 ± 0.01	0.461TrpArg: 0.461 ± 0.013	0.76TrpSer: 0.76 ± 0.019	0.511TrpThr: 0.511 ± 0.014	0.512TrpVal: 0.512 ± 0.015	0.144TrpTrp: 0.144 ± 0.008	0.355TrpTyr: 0.355 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.81TyrAla: 1.81 ± 0.03	0.499TyrCys: 0.499 ± 0.014	2.268TyrAsp: 2.268 ± 0.035	2.187TyrGlu: 2.187 ± 0.031	1.703TyrPhe: 1.703 ± 0.03	1.845TyrGly: 1.845 ± 0.031	0.802TyrHis: 0.802 ± 0.019	2.336TyrIle: 2.336 ± 0.032	2.357TyrLys: 2.357 ± 0.029	3.374TyrLeu: 3.374 ± 0.044	0.699TyrMet: 0.699 ± 0.015	2.168TyrAsn: 2.168 ± 0.032	1.389TyrPro: 1.389 ± 0.024	1.377TyrGln: 1.377 ± 0.027	1.4TyrArg: 1.4 ± 0.025	2.671TyrSer: 2.671 ± 0.033	1.933TyrThr: 1.933 ± 0.029	1.952TyrVal: 1.952 ± 0.028	0.394TyrTrp: 0.394 ± 0.012	1.451TyrTyr: 1.451 ± 0.026	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.041XaaXaa: 0.041 ± 0.034

Statistics based on 5046 proteins (2593241 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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