Amino acid dipepetide frequency for Salmonella phage 118970_sal3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.541AlaAla: 11.541 ± 0.824
1.18AlaCys: 1.18 ± 0.256
6.258AlaAsp: 6.258 ± 0.608
4.514AlaGlu: 4.514 ± 0.546
3.847AlaPhe: 3.847 ± 0.56
9.541AlaGly: 9.541 ± 0.717
1.488AlaHis: 1.488 ± 0.276
5.848AlaIle: 5.848 ± 0.502
4.873AlaLys: 4.873 ± 0.476
8.207AlaLeu: 8.207 ± 0.577
2.411AlaMet: 2.411 ± 0.27
3.385AlaAsn: 3.385 ± 0.398
3.95AlaPro: 3.95 ± 0.412
3.078AlaGln: 3.078 ± 0.348
5.899AlaArg: 5.899 ± 0.596
4.36AlaSer: 4.36 ± 0.473
5.54AlaThr: 5.54 ± 0.479
7.54AlaVal: 7.54 ± 0.79
1.231AlaTrp: 1.231 ± 0.213
2.719AlaTyr: 2.719 ± 0.417
0.0AlaXaa: 0.0 ± 0.0
Cys
1.026CysAla: 1.026 ± 0.236
0.41CysCys: 0.41 ± 0.148
0.872CysAsp: 0.872 ± 0.216
0.769CysGlu: 0.769 ± 0.196
0.359CysPhe: 0.359 ± 0.163
0.616CysGly: 0.616 ± 0.177
0.359CysHis: 0.359 ± 0.137
0.359CysIle: 0.359 ± 0.152
0.564CysLys: 0.564 ± 0.147
1.231CysLeu: 1.231 ± 0.258
0.308CysMet: 0.308 ± 0.108
0.205CysAsn: 0.205 ± 0.103
0.769CysPro: 0.769 ± 0.166
0.821CysGln: 0.821 ± 0.179
1.436CysArg: 1.436 ± 0.285
0.718CysSer: 0.718 ± 0.225
0.308CysThr: 0.308 ± 0.111
1.026CysVal: 1.026 ± 0.269
0.564CysTrp: 0.564 ± 0.201
0.256CysTyr: 0.256 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
5.796AspAla: 5.796 ± 0.579
1.231AspCys: 1.231 ± 0.264
5.335AspAsp: 5.335 ± 0.614
3.026AspGlu: 3.026 ± 0.392
1.59AspPhe: 1.59 ± 0.322
5.13AspGly: 5.13 ± 0.569
0.821AspHis: 0.821 ± 0.2
3.437AspIle: 3.437 ± 0.497
2.462AspLys: 2.462 ± 0.371
5.078AspLeu: 5.078 ± 0.46
1.026AspMet: 1.026 ± 0.197
2.513AspAsn: 2.513 ± 0.32
2.77AspPro: 2.77 ± 0.348
1.641AspGln: 1.641 ± 0.232
2.36AspArg: 2.36 ± 0.38
3.026AspSer: 3.026 ± 0.372
2.821AspThr: 2.821 ± 0.353
5.13AspVal: 5.13 ± 0.654
0.975AspTrp: 0.975 ± 0.21
2.308AspTyr: 2.308 ± 0.32
0.0AspXaa: 0.0 ± 0.0
Glu
5.027GluAla: 5.027 ± 0.482
1.282GluCys: 1.282 ± 0.313
2.924GluAsp: 2.924 ± 0.409
3.796GluGlu: 3.796 ± 0.453
1.641GluPhe: 1.641 ± 0.315
2.77GluGly: 2.77 ± 0.332
1.539GluHis: 1.539 ± 0.261
3.898GluIle: 3.898 ± 0.408
3.129GluLys: 3.129 ± 0.426
6.822GluLeu: 6.822 ± 0.65
1.898GluMet: 1.898 ± 0.365
2.462GluAsn: 2.462 ± 0.353
2.513GluPro: 2.513 ± 0.316
3.95GluGln: 3.95 ± 0.461
3.847GluArg: 3.847 ± 0.447
4.668GluSer: 4.668 ± 0.642
3.437GluThr: 3.437 ± 0.435
3.026GluVal: 3.026 ± 0.376
0.975GluTrp: 0.975 ± 0.212
1.128GluTyr: 1.128 ± 0.21
0.0GluXaa: 0.0 ± 0.0
Phe
2.873PheAla: 2.873 ± 0.405
0.256PheCys: 0.256 ± 0.135
2.616PheAsp: 2.616 ± 0.371
2.154PheGlu: 2.154 ± 0.355
0.872PhePhe: 0.872 ± 0.197
2.77PheGly: 2.77 ± 0.387
0.718PheHis: 0.718 ± 0.199
2.001PheIle: 2.001 ± 0.276
1.488PheLys: 1.488 ± 0.268
2.513PheLeu: 2.513 ± 0.347
1.334PheMet: 1.334 ± 0.268
2.103PheAsn: 2.103 ± 0.335
1.693PhePro: 1.693 ± 0.261
1.334PheGln: 1.334 ± 0.238
2.513PheArg: 2.513 ± 0.33
1.641PheSer: 1.641 ± 0.36
2.513PheThr: 2.513 ± 0.38
1.693PheVal: 1.693 ± 0.253
0.718PheTrp: 0.718 ± 0.18
0.975PheTyr: 0.975 ± 0.254
0.0PheXaa: 0.0 ± 0.0
Gly
7.848GlyAla: 7.848 ± 0.677
0.667GlyCys: 0.667 ± 0.184
5.335GlyAsp: 5.335 ± 0.644
4.77GlyGlu: 4.77 ± 0.457
3.129GlyPhe: 3.129 ± 0.31
6.976GlyGly: 6.976 ± 0.565
0.718GlyHis: 0.718 ± 0.211
4.052GlyIle: 4.052 ± 0.502
3.95GlyLys: 3.95 ± 0.355
5.027GlyLeu: 5.027 ± 0.526
2.206GlyMet: 2.206 ± 0.362
4.309GlyAsn: 4.309 ± 0.476
1.59GlyPro: 1.59 ± 0.282
2.462GlyGln: 2.462 ± 0.318
4.514GlyArg: 4.514 ± 0.478
5.027GlySer: 5.027 ± 0.504
4.052GlyThr: 4.052 ± 0.553
6.104GlyVal: 6.104 ± 0.629
1.436GlyTrp: 1.436 ± 0.259
2.462GlyTyr: 2.462 ± 0.347
0.0GlyXaa: 0.0 ± 0.0
His
1.847HisAla: 1.847 ± 0.351
0.513HisCys: 0.513 ± 0.16
0.872HisAsp: 0.872 ± 0.166
1.795HisGlu: 1.795 ± 0.314
0.359HisPhe: 0.359 ± 0.144
1.282HisGly: 1.282 ± 0.249
0.667HisHis: 0.667 ± 0.182
1.18HisIle: 1.18 ± 0.234
0.769HisLys: 0.769 ± 0.207
1.436HisLeu: 1.436 ± 0.224
0.718HisMet: 0.718 ± 0.157
1.026HisAsn: 1.026 ± 0.2
0.513HisPro: 0.513 ± 0.228
0.513HisGln: 0.513 ± 0.151
0.975HisArg: 0.975 ± 0.207
1.436HisSer: 1.436 ± 0.301
1.18HisThr: 1.18 ± 0.195
0.564HisVal: 0.564 ± 0.178
0.103HisTrp: 0.103 ± 0.071
0.41HisTyr: 0.41 ± 0.13
0.0HisXaa: 0.0 ± 0.0
Ile
5.489IleAla: 5.489 ± 0.566
0.718IleCys: 0.718 ± 0.181
3.18IleAsp: 3.18 ± 0.44
4.309IleGlu: 4.309 ± 0.454
1.026IlePhe: 1.026 ± 0.232
4.052IleGly: 4.052 ± 0.511
0.513IleHis: 0.513 ± 0.181
2.308IleIle: 2.308 ± 0.4
2.206IleLys: 2.206 ± 0.358
3.026IleLeu: 3.026 ± 0.405
1.231IleMet: 1.231 ± 0.272
2.873IleAsn: 2.873 ± 0.432
3.129IlePro: 3.129 ± 0.337
1.436IleGln: 1.436 ± 0.271
3.591IleArg: 3.591 ± 0.368
4.309IleSer: 4.309 ± 0.468
4.617IleThr: 4.617 ± 0.489
2.052IleVal: 2.052 ± 0.338
0.821IleTrp: 0.821 ± 0.171
1.898IleTyr: 1.898 ± 0.341
0.0IleXaa: 0.0 ± 0.0
Lys
5.796LysAla: 5.796 ± 0.516
0.205LysCys: 0.205 ± 0.089
2.565LysAsp: 2.565 ± 0.395
3.129LysGlu: 3.129 ± 0.5
1.488LysPhe: 1.488 ± 0.25
3.95LysGly: 3.95 ± 0.457
0.769LysHis: 0.769 ± 0.236
2.873LysIle: 2.873 ± 0.424
3.539LysLys: 3.539 ± 0.43
4.411LysLeu: 4.411 ± 0.526
1.334LysMet: 1.334 ± 0.272
2.308LysAsn: 2.308 ± 0.306
2.257LysPro: 2.257 ± 0.328
2.36LysGln: 2.36 ± 0.349
3.898LysArg: 3.898 ± 0.571
3.129LysSer: 3.129 ± 0.369
2.616LysThr: 2.616 ± 0.374
3.026LysVal: 3.026 ± 0.385
0.41LysTrp: 0.41 ± 0.134
1.488LysTyr: 1.488 ± 0.258
0.0LysXaa: 0.0 ± 0.0
Leu
8.31LeuAla: 8.31 ± 0.675
1.436LeuCys: 1.436 ± 0.34
4.411LeuAsp: 4.411 ± 0.429
5.745LeuGlu: 5.745 ± 0.653
3.95LeuPhe: 3.95 ± 0.432
4.309LeuGly: 4.309 ± 0.477
1.385LeuHis: 1.385 ± 0.272
4.206LeuIle: 4.206 ± 0.366
4.873LeuLys: 4.873 ± 0.687
6.617LeuLeu: 6.617 ± 0.595
1.795LeuMet: 1.795 ± 0.267
4.309LeuAsn: 4.309 ± 0.428
4.001LeuPro: 4.001 ± 0.4
2.667LeuGln: 2.667 ± 0.364
5.899LeuArg: 5.899 ± 0.608
6.258LeuSer: 6.258 ± 0.703
5.489LeuThr: 5.489 ± 0.51
5.796LeuVal: 5.796 ± 0.575
1.231LeuTrp: 1.231 ± 0.252
2.821LeuTyr: 2.821 ± 0.407
0.0LeuXaa: 0.0 ± 0.0
Met
2.77MetAla: 2.77 ± 0.447
0.308MetCys: 0.308 ± 0.11
1.026MetAsp: 1.026 ± 0.243
0.975MetGlu: 0.975 ± 0.243
0.769MetPhe: 0.769 ± 0.196
1.898MetGly: 1.898 ± 0.361
0.564MetHis: 0.564 ± 0.18
0.975MetIle: 0.975 ± 0.252
1.59MetLys: 1.59 ± 0.275
2.667MetLeu: 2.667 ± 0.331
0.256MetMet: 0.256 ± 0.139
1.744MetAsn: 1.744 ± 0.299
1.334MetPro: 1.334 ± 0.228
1.488MetGln: 1.488 ± 0.324
1.744MetArg: 1.744 ± 0.329
1.744MetSer: 1.744 ± 0.297
1.744MetThr: 1.744 ± 0.23
1.641MetVal: 1.641 ± 0.258
0.513MetTrp: 0.513 ± 0.139
0.359MetTyr: 0.359 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
3.847AsnAla: 3.847 ± 0.508
0.154AsnCys: 0.154 ± 0.075
2.462AsnAsp: 2.462 ± 0.419
2.052AsnGlu: 2.052 ± 0.288
1.488AsnPhe: 1.488 ± 0.211
4.617AsnGly: 4.617 ± 0.602
0.564AsnHis: 0.564 ± 0.163
2.257AsnIle: 2.257 ± 0.252
2.462AsnLys: 2.462 ± 0.391
2.052AsnLeu: 2.052 ± 0.322
1.231AsnMet: 1.231 ± 0.258
2.36AsnAsn: 2.36 ± 0.41
2.308AsnPro: 2.308 ± 0.31
2.206AsnGln: 2.206 ± 0.294
2.719AsnArg: 2.719 ± 0.357
2.975AsnSer: 2.975 ± 0.532
2.36AsnThr: 2.36 ± 0.3
1.744AsnVal: 1.744 ± 0.216
0.256AsnTrp: 0.256 ± 0.112
1.282AsnTyr: 1.282 ± 0.25
0.0AsnXaa: 0.0 ± 0.0
Pro
4.976ProAla: 4.976 ± 0.458
0.718ProCys: 0.718 ± 0.209
3.129ProAsp: 3.129 ± 0.397
4.206ProGlu: 4.206 ± 0.647
1.488ProPhe: 1.488 ± 0.326
3.693ProGly: 3.693 ± 0.382
1.128ProHis: 1.128 ± 0.246
1.385ProIle: 1.385 ± 0.253
2.052ProLys: 2.052 ± 0.318
3.847ProLeu: 3.847 ± 0.462
0.975ProMet: 0.975 ± 0.218
1.436ProAsn: 1.436 ± 0.234
1.282ProPro: 1.282 ± 0.277
2.103ProGln: 2.103 ± 0.319
2.001ProArg: 2.001 ± 0.275
2.513ProSer: 2.513 ± 0.332
1.744ProThr: 1.744 ± 0.291
4.565ProVal: 4.565 ± 0.572
0.205ProTrp: 0.205 ± 0.107
1.18ProTyr: 1.18 ± 0.251
0.0ProXaa: 0.0 ± 0.0
Gln
3.745GlnAla: 3.745 ± 0.413
0.308GlnCys: 0.308 ± 0.126
1.949GlnAsp: 1.949 ± 0.327
2.616GlnGlu: 2.616 ± 0.372
2.206GlnPhe: 2.206 ± 0.313
2.513GlnGly: 2.513 ± 0.357
1.026GlnHis: 1.026 ± 0.233
1.949GlnIle: 1.949 ± 0.335
3.437GlnLys: 3.437 ± 0.418
4.258GlnLeu: 4.258 ± 0.375
1.026GlnMet: 1.026 ± 0.214
1.282GlnAsn: 1.282 ± 0.317
2.206GlnPro: 2.206 ± 0.285
2.462GlnGln: 2.462 ± 0.354
2.821GlnArg: 2.821 ± 0.342
1.949GlnSer: 1.949 ± 0.276
2.206GlnThr: 2.206 ± 0.343
2.001GlnVal: 2.001 ± 0.282
0.872GlnTrp: 0.872 ± 0.194
0.821GlnTyr: 0.821 ± 0.213
0.0GlnXaa: 0.0 ± 0.0
Arg
5.386ArgAla: 5.386 ± 0.493
0.975ArgCys: 0.975 ± 0.222
3.334ArgAsp: 3.334 ± 0.52
3.334ArgGlu: 3.334 ± 0.352
2.77ArgPhe: 2.77 ± 0.455
3.539ArgGly: 3.539 ± 0.411
1.795ArgHis: 1.795 ± 0.276
3.437ArgIle: 3.437 ± 0.349
3.488ArgLys: 3.488 ± 0.496
6.207ArgLeu: 6.207 ± 0.548
2.462ArgMet: 2.462 ± 0.319
2.001ArgAsn: 2.001 ± 0.348
2.975ArgPro: 2.975 ± 0.398
2.462ArgGln: 2.462 ± 0.405
4.206ArgArg: 4.206 ± 0.641
3.385ArgSer: 3.385 ± 0.354
4.104ArgThr: 4.104 ± 0.395
3.847ArgVal: 3.847 ± 0.434
1.026ArgTrp: 1.026 ± 0.257
2.257ArgTyr: 2.257 ± 0.331
0.0ArgXaa: 0.0 ± 0.0
Ser
5.078SerAla: 5.078 ± 0.478
0.769SerCys: 0.769 ± 0.188
3.796SerAsp: 3.796 ± 0.472
3.539SerGlu: 3.539 ± 0.436
1.539SerPhe: 1.539 ± 0.294
6.207SerGly: 6.207 ± 0.59
0.872SerHis: 0.872 ± 0.207
3.026SerIle: 3.026 ± 0.389
2.924SerLys: 2.924 ± 0.395
5.694SerLeu: 5.694 ± 0.591
1.59SerMet: 1.59 ± 0.254
2.001SerAsn: 2.001 ± 0.248
2.924SerPro: 2.924 ± 0.372
2.924SerGln: 2.924 ± 0.322
3.642SerArg: 3.642 ± 0.473
3.693SerSer: 3.693 ± 0.446
3.693SerThr: 3.693 ± 0.464
5.54SerVal: 5.54 ± 0.556
1.385SerTrp: 1.385 ± 0.242
1.641SerTyr: 1.641 ± 0.265
0.0SerXaa: 0.0 ± 0.0
Thr
6.361ThrAla: 6.361 ± 0.635
0.41ThrCys: 0.41 ± 0.17
3.283ThrAsp: 3.283 ± 0.344
3.847ThrGlu: 3.847 ± 0.451
2.257ThrPhe: 2.257 ± 0.308
5.95ThrGly: 5.95 ± 0.6
0.923ThrHis: 0.923 ± 0.223
2.719ThrIle: 2.719 ± 0.346
1.898ThrLys: 1.898 ± 0.278
5.591ThrLeu: 5.591 ± 0.463
1.334ThrMet: 1.334 ± 0.247
1.077ThrAsn: 1.077 ± 0.211
2.719ThrPro: 2.719 ± 0.373
2.052ThrGln: 2.052 ± 0.346
3.847ThrArg: 3.847 ± 0.322
4.258ThrSer: 4.258 ± 0.48
3.488ThrThr: 3.488 ± 0.296
4.411ThrVal: 4.411 ± 0.447
1.18ThrTrp: 1.18 ± 0.246
1.744ThrTyr: 1.744 ± 0.284
0.0ThrXaa: 0.0 ± 0.0
Val
6.002ValAla: 6.002 ± 0.778
0.769ValCys: 0.769 ± 0.221
3.129ValAsp: 3.129 ± 0.35
3.745ValGlu: 3.745 ± 0.46
2.719ValPhe: 2.719 ± 0.327
3.745ValGly: 3.745 ± 0.428
1.077ValHis: 1.077 ± 0.245
4.976ValIle: 4.976 ± 0.507
4.104ValLys: 4.104 ± 0.442
6.822ValLeu: 6.822 ± 0.557
1.949ValMet: 1.949 ± 0.298
2.924ValAsn: 2.924 ± 0.411
3.796ValPro: 3.796 ± 0.421
2.77ValGln: 2.77 ± 0.337
3.539ValArg: 3.539 ± 0.383
4.104ValSer: 4.104 ± 0.449
4.668ValThr: 4.668 ± 0.484
3.898ValVal: 3.898 ± 0.47
1.077ValTrp: 1.077 ± 0.243
1.59ValTyr: 1.59 ± 0.306
0.0ValXaa: 0.0 ± 0.0
Trp
1.026TrpAla: 1.026 ± 0.266
0.256TrpCys: 0.256 ± 0.124
0.462TrpAsp: 0.462 ± 0.128
0.821TrpGlu: 0.821 ± 0.232
0.462TrpPhe: 0.462 ± 0.163
1.128TrpGly: 1.128 ± 0.225
0.718TrpHis: 0.718 ± 0.215
0.359TrpIle: 0.359 ± 0.118
0.975TrpLys: 0.975 ± 0.241
1.898TrpLeu: 1.898 ± 0.267
0.462TrpMet: 0.462 ± 0.167
0.308TrpAsn: 0.308 ± 0.114
0.975TrpPro: 0.975 ± 0.245
0.872TrpGln: 0.872 ± 0.216
1.641TrpArg: 1.641 ± 0.275
0.821TrpSer: 0.821 ± 0.222
0.564TrpThr: 0.564 ± 0.146
1.385TrpVal: 1.385 ± 0.306
0.256TrpTrp: 0.256 ± 0.124
0.718TrpTyr: 0.718 ± 0.196
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.667TyrAla: 2.667 ± 0.349
0.41TyrCys: 0.41 ± 0.135
1.539TyrAsp: 1.539 ± 0.277
1.59TyrGlu: 1.59 ± 0.293
0.821TyrPhe: 0.821 ± 0.201
1.949TyrGly: 1.949 ± 0.383
0.513TyrHis: 0.513 ± 0.138
1.539TyrIle: 1.539 ± 0.311
0.769TyrLys: 0.769 ± 0.182
2.103TyrLeu: 2.103 ± 0.254
0.513TyrMet: 0.513 ± 0.147
0.769TyrAsn: 0.769 ± 0.185
0.923TyrPro: 0.923 ± 0.207
2.103TyrGln: 2.103 ± 0.26
1.898TyrArg: 1.898 ± 0.32
2.462TyrSer: 2.462 ± 0.273
2.206TyrThr: 2.206 ± 0.335
2.411TyrVal: 2.411 ± 0.408
0.872TyrTrp: 0.872 ± 0.187
0.821TyrTyr: 0.821 ± 0.216
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 111 proteins (19496 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski