Amino acid dipepetide frequency for Extensimonas vulgaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.357AlaAla: 20.357 ± 0.237	1.438AlaCys: 1.438 ± 0.046	6.253AlaAsp: 6.253 ± 0.085	7.284AlaGlu: 7.284 ± 0.098	3.953AlaPhe: 3.953 ± 0.074	10.539AlaGly: 10.539 ± 0.129	3.38AlaHis: 3.38 ± 0.074	5.101AlaIle: 5.101 ± 0.069	3.792AlaLys: 3.792 ± 0.081	16.824AlaLeu: 16.824 ± 0.215	3.339AlaMet: 3.339 ± 0.065	2.649AlaAsn: 2.649 ± 0.057	7.501AlaPro: 7.501 ± 0.129	8.501AlaGln: 8.501 ± 0.126	10.171AlaArg: 10.171 ± 0.1	6.396AlaSer: 6.396 ± 0.095	6.103AlaThr: 6.103 ± 0.081	8.96AlaVal: 8.96 ± 0.11	2.114AlaTrp: 2.114 ± 0.054	2.585AlaTyr: 2.585 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.401CysAla: 1.401 ± 0.04	0.128CysCys: 0.128 ± 0.012	0.561CysAsp: 0.561 ± 0.027	0.522CysGlu: 0.522 ± 0.024	0.317CysPhe: 0.317 ± 0.016	1.008CysGly: 1.008 ± 0.039	0.26CysHis: 0.26 ± 0.022	0.475CysIle: 0.475 ± 0.023	0.232CysLys: 0.232 ± 0.017	0.871CysLeu: 0.871 ± 0.033	0.228CysMet: 0.228 ± 0.014	0.254CysAsn: 0.254 ± 0.017	0.531CysPro: 0.531 ± 0.026	0.264CysGln: 0.264 ± 0.016	0.617CysArg: 0.617 ± 0.03	0.495CysSer: 0.495 ± 0.028	0.582CysThr: 0.582 ± 0.027	0.735CysVal: 0.735 ± 0.033	0.118CysTrp: 0.118 ± 0.012	0.22CysTyr: 0.22 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.55AspAla: 7.55 ± 0.104	0.469AspCys: 0.469 ± 0.025	2.333AspAsp: 2.333 ± 0.053	2.968AspGlu: 2.968 ± 0.062	2.001AspPhe: 2.001 ± 0.044	3.925AspGly: 3.925 ± 0.067	0.961AspHis: 0.961 ± 0.034	2.294AspIle: 2.294 ± 0.051	1.651AspLys: 1.651 ± 0.051	5.263AspLeu: 5.263 ± 0.085	1.185AspMet: 1.185 ± 0.038	1.034AspAsn: 1.034 ± 0.037	2.802AspPro: 2.802 ± 0.051	1.426AspGln: 1.426 ± 0.038	2.725AspArg: 2.725 ± 0.056	1.945AspSer: 1.945 ± 0.048	2.382AspThr: 2.382 ± 0.063	3.643AspVal: 3.643 ± 0.067	0.948AspTrp: 0.948 ± 0.033	1.404AspTyr: 1.404 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.122GluAla: 7.122 ± 0.096	0.446GluCys: 0.446 ± 0.023	2.286GluAsp: 2.286 ± 0.051	2.634GluGlu: 2.634 ± 0.067	1.758GluPhe: 1.758 ± 0.048	3.752GluGly: 3.752 ± 0.075	1.399GluHis: 1.399 ± 0.047	2.675GluIle: 2.675 ± 0.066	2.05GluLys: 2.05 ± 0.058	6.04GluLeu: 6.04 ± 0.085	1.197GluMet: 1.197 ± 0.041	1.32GluAsn: 1.32 ± 0.033	2.604GluPro: 2.604 ± 0.06	2.791GluGln: 2.791 ± 0.066	5.05GluArg: 5.05 ± 0.088	2.382GluSer: 2.382 ± 0.051	2.267GluThr: 2.267 ± 0.049	4.366GluVal: 4.366 ± 0.081	0.69GluTrp: 0.69 ± 0.029	1.086GluTyr: 1.086 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.559PheAla: 4.559 ± 0.08	0.431PheCys: 0.431 ± 0.023	2.332PheAsp: 2.332 ± 0.048	1.98PheGlu: 1.98 ± 0.044	1.372PhePhe: 1.372 ± 0.048	3.183PheGly: 3.183 ± 0.068	0.759PheHis: 0.759 ± 0.029	1.512PheIle: 1.512 ± 0.041	1.111PheLys: 1.111 ± 0.034	2.938PheLeu: 2.938 ± 0.072	0.802PheMet: 0.802 ± 0.033	0.915PheAsn: 0.915 ± 0.031	1.447PhePro: 1.447 ± 0.038	1.022PheGln: 1.022 ± 0.034	1.723PheArg: 1.723 ± 0.041	1.951PheSer: 1.951 ± 0.049	1.751PheThr: 1.751 ± 0.044	2.686PheVal: 2.686 ± 0.055	0.543PheTrp: 0.543 ± 0.03	0.86PheTyr: 0.86 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.928GlyAla: 9.928 ± 0.119	0.874GlyCys: 0.874 ± 0.034	3.595GlyAsp: 3.595 ± 0.067	4.18GlyGlu: 4.18 ± 0.065	3.096GlyPhe: 3.096 ± 0.058	6.556GlyGly: 6.556 ± 0.115	1.937GlyHis: 1.937 ± 0.047	3.864GlyIle: 3.864 ± 0.073	3.274GlyLys: 3.274 ± 0.069	8.756GlyLeu: 8.756 ± 0.107	2.377GlyMet: 2.377 ± 0.05	1.932GlyAsn: 1.932 ± 0.042	3.059GlyPro: 3.059 ± 0.055	3.536GlyGln: 3.536 ± 0.066	5.492GlyArg: 5.492 ± 0.074	4.161GlySer: 4.161 ± 0.085	4.144GlyThr: 4.144 ± 0.063	6.431GlyVal: 6.431 ± 0.092	1.476GlyTrp: 1.476 ± 0.047	2.2GlyTyr: 2.2 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	3.268HisAla: 3.268 ± 0.07	0.327HisCys: 0.327 ± 0.018	1.137HisAsp: 1.137 ± 0.035	1.333HisGlu: 1.333 ± 0.038	0.913HisPhe: 0.913 ± 0.032	2.243HisGly: 2.243 ± 0.056	0.581HisHis: 0.581 ± 0.026	1.039HisIle: 1.039 ± 0.037	0.662HisLys: 0.662 ± 0.027	2.303HisLeu: 2.303 ± 0.05	0.53HisMet: 0.53 ± 0.026	0.52HisAsn: 0.52 ± 0.024	1.69HisPro: 1.69 ± 0.042	0.756HisGln: 0.756 ± 0.032	1.351HisArg: 1.351 ± 0.038	1.149HisSer: 1.149 ± 0.033	1.258HisThr: 1.258 ± 0.036	1.595HisVal: 1.595 ± 0.043	0.473HisTrp: 0.473 ± 0.024	0.726HisTyr: 0.726 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.298IleAla: 6.298 ± 0.082	0.402IleCys: 0.402 ± 0.022	2.977IleAsp: 2.977 ± 0.053	3.122IleGlu: 3.122 ± 0.067	1.357IlePhe: 1.357 ± 0.047	3.705IleGly: 3.705 ± 0.077	0.973IleHis: 0.973 ± 0.035	1.585IleIle: 1.585 ± 0.05	1.395IleLys: 1.395 ± 0.049	3.278IleLeu: 3.278 ± 0.055	0.803IleMet: 0.803 ± 0.03	1.263IleAsn: 1.263 ± 0.041	2.134IlePro: 2.134 ± 0.048	1.288IleGln: 1.288 ± 0.041	2.405IleArg: 2.405 ± 0.05	1.942IleSer: 1.942 ± 0.053	2.499IleThr: 2.499 ± 0.055	3.524IleVal: 3.524 ± 0.063	0.418IleTrp: 0.418 ± 0.02	1.005IleTyr: 1.005 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.835LysAla: 3.835 ± 0.082	0.155LysCys: 0.155 ± 0.014	1.533LysAsp: 1.533 ± 0.048	1.598LysGlu: 1.598 ± 0.046	0.888LysPhe: 0.888 ± 0.034	2.287LysGly: 2.287 ± 0.056	0.625LysHis: 0.625 ± 0.03	1.597LysIle: 1.597 ± 0.045	1.471LysLys: 1.471 ± 0.048	3.298LysLeu: 3.298 ± 0.064	0.784LysMet: 0.784 ± 0.029	0.974LysAsn: 0.974 ± 0.03	1.957LysPro: 1.957 ± 0.048	1.152LysGln: 1.152 ± 0.042	2.024LysArg: 2.024 ± 0.05	1.688LysSer: 1.688 ± 0.048	1.903LysThr: 1.903 ± 0.054	2.463LysVal: 2.463 ± 0.057	0.318LysTrp: 0.318 ± 0.017	0.672LysTyr: 0.672 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	16.125LeuAla: 16.125 ± 0.173	1.19LeuCys: 1.19 ± 0.037	5.623LeuAsp: 5.623 ± 0.082	5.449LeuGlu: 5.449 ± 0.085	3.269LeuPhe: 3.269 ± 0.079	8.989LeuGly: 8.989 ± 0.126	2.846LeuHis: 2.846 ± 0.055	4.113LeuIle: 4.113 ± 0.07	2.97LeuLys: 2.97 ± 0.071	12.396LeuLeu: 12.396 ± 0.187	2.227LeuMet: 2.227 ± 0.045	2.352LeuAsn: 2.352 ± 0.051	6.603LeuPro: 6.603 ± 0.09	5.599LeuGln: 5.599 ± 0.092	8.739LeuArg: 8.739 ± 0.121	5.341LeuSer: 5.341 ± 0.085	5.028LeuThr: 5.028 ± 0.09	7.706LeuVal: 7.706 ± 0.115	1.44LeuTrp: 1.44 ± 0.049	2.141LeuTyr: 2.141 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.035MetAla: 3.035 ± 0.058	0.188MetCys: 0.188 ± 0.014	1.029MetAsp: 1.029 ± 0.032	1.076MetGlu: 1.076 ± 0.037	0.686MetPhe: 0.686 ± 0.027	1.904MetGly: 1.904 ± 0.044	0.539MetHis: 0.539 ± 0.023	0.822MetIle: 0.822 ± 0.03	0.889MetLys: 0.889 ± 0.033	2.663MetLeu: 2.663 ± 0.056	0.499MetMet: 0.499 ± 0.021	0.794MetAsn: 0.794 ± 0.036	1.506MetPro: 1.506 ± 0.042	1.217MetGln: 1.217 ± 0.041	1.559MetArg: 1.559 ± 0.041	1.362MetSer: 1.362 ± 0.038	1.37MetThr: 1.37 ± 0.038	1.701MetVal: 1.701 ± 0.045	0.187MetTrp: 0.187 ± 0.015	0.392MetTyr: 0.392 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.262AsnAla: 3.262 ± 0.058	0.257AsnCys: 0.257 ± 0.018	1.145AsnAsp: 1.145 ± 0.034	1.116AsnGlu: 1.116 ± 0.034	0.901AsnPhe: 0.901 ± 0.033	1.916AsnGly: 1.916 ± 0.052	0.475AsnHis: 0.475 ± 0.021	1.154AsnIle: 1.154 ± 0.036	0.707AsnLys: 0.707 ± 0.036	2.506AsnLeu: 2.506 ± 0.053	0.517AsnMet: 0.517 ± 0.024	0.603AsnAsn: 0.603 ± 0.028	1.784AsnPro: 1.784 ± 0.046	0.865AsnGln: 0.865 ± 0.033	1.385AsnArg: 1.385 ± 0.037	0.948AsnSer: 0.948 ± 0.034	1.319AsnThr: 1.319 ± 0.042	1.816AsnVal: 1.816 ± 0.048	0.388AsnTrp: 0.388 ± 0.02	0.668AsnTyr: 0.668 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	8.034ProAla: 8.034 ± 0.117	0.435ProCys: 0.435 ± 0.022	3.117ProAsp: 3.117 ± 0.062	3.761ProGlu: 3.761 ± 0.065	1.75ProPhe: 1.75 ± 0.048	4.802ProGly: 4.802 ± 0.08	1.223ProHis: 1.223 ± 0.035	1.951ProIle: 1.951 ± 0.047	1.603ProLys: 1.603 ± 0.041	5.589ProLeu: 5.589 ± 0.088	1.294ProMet: 1.294 ± 0.037	1.226ProAsn: 1.226 ± 0.039	3.249ProPro: 3.249 ± 0.073	2.741ProGln: 2.741 ± 0.05	3.19ProArg: 3.19 ± 0.066	2.719ProSer: 2.719 ± 0.061	2.748ProThr: 2.748 ± 0.063	3.963ProVal: 3.963 ± 0.065	0.834ProTrp: 0.834 ± 0.032	1.218ProTyr: 1.218 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	6.945GlnAla: 6.945 ± 0.107	0.334GlnCys: 0.334 ± 0.021	1.876GlnAsp: 1.876 ± 0.047	2.215GlnGlu: 2.215 ± 0.058	1.351GlnPhe: 1.351 ± 0.04	3.623GlnGly: 3.623 ± 0.064	1.145GlnHis: 1.145 ± 0.037	1.881GlnIle: 1.881 ± 0.044	1.381GlnLys: 1.381 ± 0.04	4.734GlnLeu: 4.734 ± 0.082	1.033GlnMet: 1.033 ± 0.033	0.965GlnAsn: 0.965 ± 0.036	2.602GlnPro: 2.602 ± 0.059	2.447GlnGln: 2.447 ± 0.072	4.092GlnArg: 4.092 ± 0.077	2.104GlnSer: 2.104 ± 0.046	2.249GlnThr: 2.249 ± 0.051	3.308GlnVal: 3.308 ± 0.065	0.776GlnTrp: 0.776 ± 0.032	0.811GlnTyr: 0.811 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.196ArgAla: 9.196 ± 0.115	0.643ArgCys: 0.643 ± 0.028	3.191ArgAsp: 3.191 ± 0.062	4.09ArgGlu: 4.09 ± 0.076	2.761ArgPhe: 2.761 ± 0.055	4.687ArgGly: 4.687 ± 0.082	1.88ArgHis: 1.88 ± 0.044	3.592ArgIle: 3.592 ± 0.059	2.253ArgLys: 2.253 ± 0.057	8.109ArgLeu: 8.109 ± 0.096	1.885ArgMet: 1.885 ± 0.042	1.761ArgAsn: 1.761 ± 0.046	3.373ArgPro: 3.373 ± 0.064	2.93ArgGln: 2.93 ± 0.056	5.162ArgArg: 5.162 ± 0.081	3.327ArgSer: 3.327 ± 0.06	3.312ArgThr: 3.312 ± 0.056	4.911ArgVal: 4.911 ± 0.072	1.279ArgTrp: 1.279 ± 0.042	1.88ArgTyr: 1.88 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.67SerAla: 6.67 ± 0.101	0.445SerCys: 0.445 ± 0.024	2.371SerAsp: 2.371 ± 0.065	2.404SerGlu: 2.404 ± 0.049	1.806SerPhe: 1.806 ± 0.044	4.648SerGly: 4.648 ± 0.079	0.99SerHis: 0.99 ± 0.029	2.145SerIle: 2.145 ± 0.05	1.443SerLys: 1.443 ± 0.044	4.92SerLeu: 4.92 ± 0.079	1.225SerMet: 1.225 ± 0.033	1.246SerAsn: 1.246 ± 0.036	2.631SerPro: 2.631 ± 0.056	1.641SerGln: 1.641 ± 0.043	2.772SerArg: 2.772 ± 0.05	2.638SerSer: 2.638 ± 0.061	2.706SerThr: 2.706 ± 0.052	3.539SerVal: 3.539 ± 0.063	0.703SerTrp: 0.703 ± 0.028	1.266SerTyr: 1.266 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.962ThrAla: 5.962 ± 0.087	0.42ThrCys: 0.42 ± 0.019	2.278ThrAsp: 2.278 ± 0.053	2.343ThrGlu: 2.343 ± 0.056	1.48ThrPhe: 1.48 ± 0.043	4.582ThrGly: 4.582 ± 0.078	1.204ThrHis: 1.204 ± 0.035	2.061ThrIle: 2.061 ± 0.053	1.223ThrLys: 1.223 ± 0.035	6.244ThrLeu: 6.244 ± 0.094	1.034ThrMet: 1.034 ± 0.034	1.1ThrAsn: 1.1 ± 0.039	3.907ThrPro: 3.907 ± 0.073	2.234ThrGln: 2.234 ± 0.049	3.217ThrArg: 3.217 ± 0.062	2.451ThrSer: 2.451 ± 0.051	2.549ThrThr: 2.549 ± 0.063	3.798ThrVal: 3.798 ± 0.062	0.604ThrTrp: 0.604 ± 0.026	0.978ThrTyr: 0.978 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.237ValAla: 9.237 ± 0.114	0.764ValCys: 0.764 ± 0.027	3.42ValAsp: 3.42 ± 0.06	4.021ValGlu: 4.021 ± 0.074	2.72ValPhe: 2.72 ± 0.061	5.44ValGly: 5.44 ± 0.078	1.833ValHis: 1.833 ± 0.042	3.067ValIle: 3.067 ± 0.063	2.089ValLys: 2.089 ± 0.065	8.688ValLeu: 8.688 ± 0.121	1.655ValMet: 1.655 ± 0.045	1.906ValAsn: 1.906 ± 0.039	4.21ValPro: 4.21 ± 0.069	3.625ValGln: 3.625 ± 0.068	5.474ValArg: 5.474 ± 0.08	3.467ValSer: 3.467 ± 0.059	3.662ValThr: 3.662 ± 0.067	5.853ValVal: 5.853 ± 0.094	1.04ValTrp: 1.04 ± 0.036	1.492ValTyr: 1.492 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.569TrpAla: 1.569 ± 0.046	0.202TrpCys: 0.202 ± 0.017	0.643TrpAsp: 0.643 ± 0.025	0.62TrpGlu: 0.62 ± 0.024	0.553TrpPhe: 0.553 ± 0.027	1.075TrpGly: 1.075 ± 0.037	0.354TrpHis: 0.354 ± 0.02	0.635TrpIle: 0.635 ± 0.03	0.413TrpLys: 0.413 ± 0.02	2.222TrpLeu: 2.222 ± 0.061	0.427TrpMet: 0.427 ± 0.021	0.38TrpAsn: 0.38 ± 0.023	0.729TrpPro: 0.729 ± 0.028	0.91TrpGln: 0.91 ± 0.036	1.343TrpArg: 1.343 ± 0.045	0.717TrpSer: 0.717 ± 0.024	0.621TrpThr: 0.621 ± 0.029	0.993TrpVal: 0.993 ± 0.03	0.303TrpTrp: 0.303 ± 0.019	0.303TrpTyr: 0.303 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.884TyrAla: 2.884 ± 0.059	0.271TyrCys: 0.271 ± 0.017	1.212TyrAsp: 1.212 ± 0.039	1.2TyrGlu: 1.2 ± 0.04	0.946TyrPhe: 0.946 ± 0.033	2.003TyrGly: 2.003 ± 0.051	0.49TyrHis: 0.49 ± 0.024	0.81TyrIle: 0.81 ± 0.033	0.61TyrLys: 0.61 ± 0.029	2.505TyrLeu: 2.505 ± 0.051	0.378TyrMet: 0.378 ± 0.021	0.536TyrAsn: 0.536 ± 0.027	1.132TyrPro: 1.132 ± 0.037	0.928TyrGln: 0.928 ± 0.031	1.733TyrArg: 1.733 ± 0.044	1.023TyrSer: 1.023 ± 0.036	1.217TyrThr: 1.217 ± 0.038	1.671TyrVal: 1.671 ± 0.044	0.358TyrTrp: 0.358 ± 0.019	0.618TyrTyr: 0.618 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2789 proteins (930153 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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