Amino acid dipepetide frequency for Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.858AlaAla: 10.858 ± 0.13	1.142AlaCys: 1.142 ± 0.03	5.922AlaAsp: 5.922 ± 0.087	6.512AlaGlu: 6.512 ± 0.085	3.822AlaPhe: 3.822 ± 0.059	7.46AlaGly: 7.46 ± 0.09	1.947AlaHis: 1.947 ± 0.047	5.894AlaIle: 5.894 ± 0.089	4.911AlaLys: 4.911 ± 0.064	12.279AlaLeu: 12.279 ± 0.126	3.267AlaMet: 3.267 ± 0.058	3.755AlaAsn: 3.755 ± 0.051	3.837AlaPro: 3.837 ± 0.065	4.023AlaGln: 4.023 ± 0.064	5.36AlaArg: 5.36 ± 0.078	6.249AlaSer: 6.249 ± 0.075	4.744AlaThr: 4.744 ± 0.071	6.655AlaVal: 6.655 ± 0.079	1.152AlaTrp: 1.152 ± 0.031	2.31AlaTyr: 2.31 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.925CysAla: 0.925 ± 0.03	0.152CysCys: 0.152 ± 0.013	0.626CysAsp: 0.626 ± 0.021	0.618CysGlu: 0.618 ± 0.021	0.448CysPhe: 0.448 ± 0.019	0.938CysGly: 0.938 ± 0.031	0.463CysHis: 0.463 ± 0.031	0.532CysIle: 0.532 ± 0.023	0.356CysLys: 0.356 ± 0.018	1.059CysLeu: 1.059 ± 0.031	0.219CysMet: 0.219 ± 0.012	0.32CysAsn: 0.32 ± 0.018	0.479CysPro: 0.479 ± 0.02	0.52CysGln: 0.52 ± 0.022	0.63CysArg: 0.63 ± 0.022	0.625CysSer: 0.625 ± 0.021	0.413CysThr: 0.413 ± 0.017	0.625CysVal: 0.625 ± 0.023	0.127CysTrp: 0.127 ± 0.011	0.307CysTyr: 0.307 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.013AspAla: 6.013 ± 0.096	0.563AspCys: 0.563 ± 0.021	3.195AspAsp: 3.195 ± 0.093	4.056AspGlu: 4.056 ± 0.058	2.515AspPhe: 2.515 ± 0.051	4.553AspGly: 4.553 ± 0.1	0.959AspHis: 0.959 ± 0.033	3.609AspIle: 3.609 ± 0.055	3.218AspLys: 3.218 ± 0.053	5.005AspLeu: 5.005 ± 0.069	1.647AspMet: 1.647 ± 0.036	2.433AspAsn: 2.433 ± 0.054	2.188AspPro: 2.188 ± 0.047	1.283AspGln: 1.283 ± 0.034	2.429AspArg: 2.429 ± 0.054	3.264AspSer: 3.264 ± 0.062	3.206AspThr: 3.206 ± 0.09	3.727AspVal: 3.727 ± 0.053	0.952AspTrp: 0.952 ± 0.03	1.965AspTyr: 1.965 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.502GluAla: 6.502 ± 0.079	0.502GluCys: 0.502 ± 0.019	2.954GluAsp: 2.954 ± 0.055	3.28GluGlu: 3.28 ± 0.064	2.226GluPhe: 2.226 ± 0.043	4.145GluGly: 4.145 ± 0.06	1.51GluHis: 1.51 ± 0.036	3.164GluIle: 3.164 ± 0.055	2.8GluLys: 2.8 ± 0.052	7.569GluLeu: 7.569 ± 0.084	1.575GluMet: 1.575 ± 0.038	1.99GluAsn: 1.99 ± 0.044	2.356GluPro: 2.356 ± 0.048	3.409GluGln: 3.409 ± 0.062	3.773GluArg: 3.773 ± 0.064	3.378GluSer: 3.378 ± 0.061	2.904GluThr: 2.904 ± 0.056	4.315GluVal: 4.315 ± 0.069	0.69GluTrp: 0.69 ± 0.024	1.656GluTyr: 1.656 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.024PheAla: 4.024 ± 0.062	0.475PheCys: 0.475 ± 0.02	2.799PheAsp: 2.799 ± 0.053	2.499PheGlu: 2.499 ± 0.047	1.598PhePhe: 1.598 ± 0.046	3.376PheGly: 3.376 ± 0.058	0.832PheHis: 0.832 ± 0.028	2.269PheIle: 2.269 ± 0.051	1.578PheLys: 1.578 ± 0.037	3.24PheLeu: 3.24 ± 0.059	1.041PheMet: 1.041 ± 0.03	1.725PheAsn: 1.725 ± 0.036	1.446PhePro: 1.446 ± 0.037	1.106PheGln: 1.106 ± 0.035	1.711PheArg: 1.711 ± 0.04	2.996PheSer: 2.996 ± 0.05	2.087PheThr: 2.087 ± 0.042	2.705PheVal: 2.705 ± 0.047	0.523PheTrp: 0.523 ± 0.022	1.347PheTyr: 1.347 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.735GlyAla: 6.735 ± 0.086	0.941GlyCys: 0.941 ± 0.033	4.28GlyAsp: 4.28 ± 0.09	4.834GlyGlu: 4.834 ± 0.063	3.605GlyPhe: 3.605 ± 0.055	5.399GlyGly: 5.399 ± 0.071	1.847GlyHis: 1.847 ± 0.045	4.658GlyIle: 4.658 ± 0.069	4.167GlyLys: 4.167 ± 0.07	8.128GlyLeu: 8.128 ± 0.093	2.309GlyMet: 2.309 ± 0.042	2.866GlyAsn: 2.866 ± 0.064	2.059GlyPro: 2.059 ± 0.042	3.052GlyGln: 3.052 ± 0.055	3.942GlyArg: 3.942 ± 0.049	4.6GlySer: 4.6 ± 0.068	3.744GlyThr: 3.744 ± 0.061	5.58GlyVal: 5.58 ± 0.082	1.035GlyTrp: 1.035 ± 0.028	2.604GlyTyr: 2.604 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.721HisAla: 1.721 ± 0.036	0.348HisCys: 0.348 ± 0.018	1.033HisAsp: 1.033 ± 0.032	1.166HisGlu: 1.166 ± 0.037	1.094HisPhe: 1.094 ± 0.03	1.867HisGly: 1.867 ± 0.045	0.686HisHis: 0.686 ± 0.028	1.237HisIle: 1.237 ± 0.036	0.969HisLys: 0.969 ± 0.029	2.409HisLeu: 2.409 ± 0.049	0.514HisMet: 0.514 ± 0.019	0.793HisAsn: 0.793 ± 0.024	1.268HisPro: 1.268 ± 0.031	1.13HisGln: 1.13 ± 0.031	1.229HisArg: 1.229 ± 0.033	1.429HisSer: 1.429 ± 0.034	1.064HisThr: 1.064 ± 0.033	1.145HisVal: 1.145 ± 0.031	0.433HisTrp: 0.433 ± 0.022	0.805HisTyr: 0.805 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.17IleAla: 6.17 ± 0.072	0.588IleCys: 0.588 ± 0.022	3.549IleAsp: 3.549 ± 0.062	3.692IleGlu: 3.692 ± 0.057	1.708IlePhe: 1.708 ± 0.041	4.241IleGly: 4.241 ± 0.065	1.137IleHis: 1.137 ± 0.03	2.637IleIle: 2.637 ± 0.055	2.572IleLys: 2.572 ± 0.049	4.593IleLeu: 4.593 ± 0.071	1.089IleMet: 1.089 ± 0.031	2.33IleAsn: 2.33 ± 0.047	2.391IlePro: 2.391 ± 0.044	1.804IleGln: 1.804 ± 0.038	2.924IleArg: 2.924 ± 0.049	3.723IleSer: 3.723 ± 0.062	2.762IleThr: 2.762 ± 0.061	3.101IleVal: 3.101 ± 0.061	0.569IleTrp: 0.569 ± 0.023	1.376IleTyr: 1.376 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.28LysAla: 5.28 ± 0.074	0.266LysCys: 0.266 ± 0.015	2.572LysAsp: 2.572 ± 0.042	2.518LysGlu: 2.518 ± 0.054	1.275LysPhe: 1.275 ± 0.036	3.455LysGly: 3.455 ± 0.059	1.041LysHis: 1.041 ± 0.029	2.022LysIle: 2.022 ± 0.048	1.843LysLys: 1.843 ± 0.048	5.117LysLeu: 5.117 ± 0.069	1.089LysMet: 1.089 ± 0.027	1.362LysAsn: 1.362 ± 0.033	2.248LysPro: 2.248 ± 0.048	2.141LysGln: 2.141 ± 0.046	2.598LysArg: 2.598 ± 0.048	2.604LysSer: 2.604 ± 0.044	2.303LysThr: 2.303 ± 0.045	3.598LysVal: 3.598 ± 0.065	0.431LysTrp: 0.431 ± 0.019	1.123LysTyr: 1.123 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	12.377LeuAla: 12.377 ± 0.134	1.311LeuCys: 1.311 ± 0.038	6.335LeuAsp: 6.335 ± 0.08	6.534LeuGlu: 6.534 ± 0.092	4.167LeuPhe: 4.167 ± 0.07	8.733LeuGly: 8.733 ± 0.095	2.057LeuHis: 2.057 ± 0.037	5.553LeuIle: 5.553 ± 0.074	5.564LeuLys: 5.564 ± 0.068	12.466LeuLeu: 12.466 ± 0.173	3.151LeuMet: 3.151 ± 0.053	3.833LeuAsn: 3.833 ± 0.067	5.568LeuPro: 5.568 ± 0.069	3.46LeuGln: 3.46 ± 0.057	4.933LeuArg: 4.933 ± 0.074	7.988LeuSer: 7.988 ± 0.093	6.201LeuThr: 6.201 ± 0.073	7.812LeuVal: 7.812 ± 0.086	1.387LeuTrp: 1.387 ± 0.041	2.849LeuTyr: 2.849 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	3.215MetAla: 3.215 ± 0.057	0.194MetCys: 0.194 ± 0.013	1.371MetAsp: 1.371 ± 0.037	1.392MetGlu: 1.392 ± 0.036	0.788MetPhe: 0.788 ± 0.026	2.027MetGly: 2.027 ± 0.042	0.527MetHis: 0.527 ± 0.02	1.064MetIle: 1.064 ± 0.031	1.279MetLys: 1.279 ± 0.029	3.14MetLeu: 3.14 ± 0.058	0.783MetMet: 0.783 ± 0.027	0.974MetAsn: 0.974 ± 0.03	1.341MetPro: 1.341 ± 0.029	1.17MetGln: 1.17 ± 0.028	1.233MetArg: 1.233 ± 0.032	1.848MetSer: 1.848 ± 0.04	1.611MetThr: 1.611 ± 0.033	1.94MetVal: 1.94 ± 0.04	0.219MetTrp: 0.219 ± 0.015	0.503MetTyr: 0.503 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.517AsnAla: 3.517 ± 0.055	0.374AsnCys: 0.374 ± 0.019	1.983AsnAsp: 1.983 ± 0.05	1.898AsnGlu: 1.898 ± 0.037	1.338AsnPhe: 1.338 ± 0.034	2.83AsnGly: 2.83 ± 0.068	0.842AsnHis: 0.842 ± 0.027	1.963AsnIle: 1.963 ± 0.043	1.491AsnLys: 1.491 ± 0.037	3.781AsnLeu: 3.781 ± 0.061	0.852AsnMet: 0.852 ± 0.025	1.375AsnAsn: 1.375 ± 0.045	2.06AsnPro: 2.06 ± 0.045	1.714AsnGln: 1.714 ± 0.041	1.979AsnArg: 1.979 ± 0.046	1.928AsnSer: 1.928 ± 0.046	1.933AsnThr: 1.933 ± 0.044	2.178AsnVal: 2.178 ± 0.053	0.522AsnTrp: 0.522 ± 0.019	1.074AsnTyr: 1.074 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.114ProAla: 4.114 ± 0.068	0.358ProCys: 0.358 ± 0.018	2.579ProAsp: 2.579 ± 0.048	3.353ProGlu: 3.353 ± 0.058	1.819ProPhe: 1.819 ± 0.04	3.425ProGly: 3.425 ± 0.057	0.905ProHis: 0.905 ± 0.027	1.975ProIle: 1.975 ± 0.039	1.958ProLys: 1.958 ± 0.046	4.987ProLeu: 4.987 ± 0.079	1.277ProMet: 1.277 ± 0.034	1.425ProAsn: 1.425 ± 0.034	1.371ProPro: 1.371 ± 0.037	1.73ProGln: 1.73 ± 0.041	1.802ProArg: 1.802 ± 0.037	2.463ProSer: 2.463 ± 0.046	1.914ProThr: 1.914 ± 0.041	3.513ProVal: 3.513 ± 0.055	0.65ProTrp: 0.65 ± 0.023	1.13ProTyr: 1.13 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.518GlnAla: 4.518 ± 0.07	0.341GlnCys: 0.341 ± 0.017	1.963GlnAsp: 1.963 ± 0.043	2.122GlnGlu: 2.122 ± 0.049	1.527GlnPhe: 1.527 ± 0.037	3.29GlnGly: 3.29 ± 0.05	1.001GlnHis: 1.001 ± 0.028	2.147GlnIle: 2.147 ± 0.049	1.65GlnLys: 1.65 ± 0.036	5.079GlnLeu: 5.079 ± 0.08	1.071GlnMet: 1.071 ± 0.026	1.153GlnAsn: 1.153 ± 0.03	1.691GlnPro: 1.691 ± 0.037	2.489GlnGln: 2.489 ± 0.051	2.321GlnArg: 2.321 ± 0.056	2.721GlnSer: 2.721 ± 0.055	2.073GlnThr: 2.073 ± 0.044	3.005GlnVal: 3.005 ± 0.048	0.593GlnTrp: 0.593 ± 0.02	1.172GlnTyr: 1.172 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.584ArgAla: 4.584 ± 0.063	0.513ArgCys: 0.513 ± 0.02	2.882ArgAsp: 2.882 ± 0.053	3.449ArgGlu: 3.449 ± 0.06	2.52ArgPhe: 2.52 ± 0.046	3.279ArgGly: 3.279 ± 0.051	1.443ArgHis: 1.443 ± 0.032	3.114ArgIle: 3.114 ± 0.055	2.132ArgLys: 2.132 ± 0.043	6.468ArgLeu: 6.468 ± 0.1	1.388ArgMet: 1.388 ± 0.035	1.689ArgAsn: 1.689 ± 0.043	2.018ArgPro: 2.018 ± 0.04	2.622ArgGln: 2.622 ± 0.051	3.083ArgArg: 3.083 ± 0.055	2.713ArgSer: 2.713 ± 0.043	2.203ArgThr: 2.203 ± 0.045	3.706ArgVal: 3.706 ± 0.062	0.748ArgTrp: 0.748 ± 0.025	1.806ArgTyr: 1.806 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.251SerAla: 6.251 ± 0.064	0.622SerCys: 0.622 ± 0.024	3.471SerAsp: 3.471 ± 0.064	3.573SerGlu: 3.573 ± 0.063	2.695SerPhe: 2.695 ± 0.05	5.271SerGly: 5.271 ± 0.069	1.592SerHis: 1.592 ± 0.038	3.056SerIle: 3.056 ± 0.056	2.245SerLys: 2.245 ± 0.042	7.684SerLeu: 7.684 ± 0.098	1.549SerMet: 1.549 ± 0.039	2.029SerAsn: 2.029 ± 0.047	2.806SerPro: 2.806 ± 0.049	2.86SerGln: 2.86 ± 0.055	3.645SerArg: 3.645 ± 0.056	3.811SerSer: 3.811 ± 0.071	2.735SerThr: 2.735 ± 0.052	4.171SerVal: 4.171 ± 0.073	0.837SerTrp: 0.837 ± 0.021	1.765SerTyr: 1.765 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.864ThrAla: 4.864 ± 0.081	0.46ThrCys: 0.46 ± 0.021	2.991ThrAsp: 2.991 ± 0.073	3.159ThrGlu: 3.159 ± 0.052	1.758ThrPhe: 1.758 ± 0.04	4.28ThrGly: 4.28 ± 0.063	1.109ThrHis: 1.109 ± 0.032	2.327ThrIle: 2.327 ± 0.048	1.723ThrLys: 1.723 ± 0.037	6.687ThrLeu: 6.687 ± 0.082	1.02ThrMet: 1.02 ± 0.03	1.571ThrAsn: 1.571 ± 0.037	2.756ThrPro: 2.756 ± 0.051	2.366ThrGln: 2.366 ± 0.045	2.517ThrArg: 2.517 ± 0.048	2.867ThrSer: 2.867 ± 0.049	2.399ThrThr: 2.399 ± 0.052	3.61ThrVal: 3.61 ± 0.07	0.527ThrTrp: 0.527 ± 0.023	1.113ThrTyr: 1.113 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	7.202ValAla: 7.202 ± 0.085	0.741ValCys: 0.741 ± 0.025	4.091ValAsp: 4.091 ± 0.081	4.118ValGlu: 4.118 ± 0.058	2.618ValPhe: 2.618 ± 0.048	4.672ValGly: 4.672 ± 0.072	1.304ValHis: 1.304 ± 0.03	3.938ValIle: 3.938 ± 0.071	3.1ValLys: 3.1 ± 0.047	7.401ValLeu: 7.401 ± 0.087	1.884ValMet: 1.884 ± 0.035	2.701ValAsn: 2.701 ± 0.05	2.951ValPro: 2.951 ± 0.052	2.274ValGln: 2.274 ± 0.047	3.321ValArg: 3.321 ± 0.05	4.882ValSer: 4.882 ± 0.061	4.074ValThr: 4.074 ± 0.078	5.076ValVal: 5.076 ± 0.079	0.779ValTrp: 0.779 ± 0.026	1.837ValTyr: 1.837 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.899TrpAla: 0.899 ± 0.025	0.163TrpCys: 0.163 ± 0.011	0.665TrpAsp: 0.665 ± 0.026	0.542TrpGlu: 0.542 ± 0.021	0.561TrpPhe: 0.561 ± 0.023	0.849TrpGly: 0.849 ± 0.028	0.435TrpHis: 0.435 ± 0.018	0.571TrpIle: 0.571 ± 0.025	0.36TrpLys: 0.36 ± 0.017	1.834TrpLeu: 1.834 ± 0.047	0.328TrpMet: 0.328 ± 0.016	0.36TrpAsn: 0.36 ± 0.018	0.543TrpPro: 0.543 ± 0.022	1.156TrpGln: 1.156 ± 0.036	0.852TrpArg: 0.852 ± 0.028	0.715TrpSer: 0.715 ± 0.027	0.472TrpThr: 0.472 ± 0.018	0.865TrpVal: 0.865 ± 0.033	0.197TrpTrp: 0.197 ± 0.013	0.415TrpTyr: 0.415 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.331TyrAla: 2.331 ± 0.042	0.327TyrCys: 0.327 ± 0.016	1.522TyrAsp: 1.522 ± 0.043	1.382TyrGlu: 1.382 ± 0.033	1.294TyrPhe: 1.294 ± 0.033	2.296TyrGly: 2.296 ± 0.053	0.706TyrHis: 0.706 ± 0.022	1.228TyrIle: 1.228 ± 0.034	0.967TyrLys: 0.967 ± 0.03	3.355TyrLeu: 3.355 ± 0.06	0.565TyrMet: 0.565 ± 0.023	0.944TyrAsn: 0.944 ± 0.032	1.37TyrPro: 1.37 ± 0.038	1.62TyrGln: 1.62 ± 0.034	2.075TyrArg: 2.075 ± 0.04	1.864TyrSer: 1.864 ± 0.045	1.259TyrThr: 1.259 ± 0.037	1.637TyrVal: 1.637 ± 0.039	0.414TyrTrp: 0.414 ± 0.02	0.864TyrTyr: 0.864 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3638 proteins (1259955 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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