Amino acid dipepetide frequency for Sporomusaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.005AlaAla: 10.005 ± 0.125	1.045AlaCys: 1.045 ± 0.039	4.562AlaAsp: 4.562 ± 0.067	5.743AlaGlu: 5.743 ± 0.077	3.152AlaPhe: 3.152 ± 0.056	7.407AlaGly: 7.407 ± 0.103	1.454AlaHis: 1.454 ± 0.036	6.931AlaIle: 6.931 ± 0.083	5.324AlaLys: 5.324 ± 0.073	8.579AlaLeu: 8.579 ± 0.101	2.455AlaMet: 2.455 ± 0.051	3.437AlaAsn: 3.437 ± 0.059	2.469AlaPro: 2.469 ± 0.046	3.488AlaGln: 3.488 ± 0.065	3.677AlaArg: 3.677 ± 0.067	4.518AlaSer: 4.518 ± 0.075	4.463AlaThr: 4.463 ± 0.161	7.394AlaVal: 7.394 ± 0.092	0.706AlaTrp: 0.706 ± 0.028	2.593AlaTyr: 2.593 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.786CysAla: 0.786 ± 0.025	0.249CysCys: 0.249 ± 0.018	0.562CysAsp: 0.562 ± 0.024	0.567CysGlu: 0.567 ± 0.021	0.447CysPhe: 0.447 ± 0.02	1.19CysGly: 1.19 ± 0.038	0.299CysHis: 0.299 ± 0.018	0.804CysIle: 0.804 ± 0.029	0.567CysLys: 0.567 ± 0.022	1.072CysLeu: 1.072 ± 0.035	0.298CysMet: 0.298 ± 0.019	0.507CysAsn: 0.507 ± 0.023	0.651CysPro: 0.651 ± 0.033	0.502CysGln: 0.502 ± 0.023	0.61CysArg: 0.61 ± 0.024	0.84CysSer: 0.84 ± 0.028	0.563CysThr: 0.563 ± 0.026	0.657CysVal: 0.657 ± 0.024	0.123CysTrp: 0.123 ± 0.012	0.38CysTyr: 0.38 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.705AspAla: 3.705 ± 0.06	0.646AspCys: 0.646 ± 0.028	2.192AspAsp: 2.192 ± 0.047	3.22AspGlu: 3.22 ± 0.059	2.115AspPhe: 2.115 ± 0.038	3.339AspGly: 3.339 ± 0.058	1.113AspHis: 1.113 ± 0.031	4.334AspIle: 4.334 ± 0.069	3.163AspLys: 3.163 ± 0.052	4.801AspLeu: 4.801 ± 0.072	1.307AspMet: 1.307 ± 0.029	1.949AspAsn: 1.949 ± 0.038	1.802AspPro: 1.802 ± 0.041	1.928AspGln: 1.928 ± 0.04	2.284AspArg: 2.284 ± 0.043	2.622AspSer: 2.622 ± 0.044	2.505AspThr: 2.505 ± 0.059	3.541AspVal: 3.541 ± 0.06	0.563AspTrp: 0.563 ± 0.023	1.997AspTyr: 1.997 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.128GluAla: 5.128 ± 0.073	0.605GluCys: 0.605 ± 0.022	2.475GluAsp: 2.475 ± 0.052	4.028GluGlu: 4.028 ± 0.073	2.392GluPhe: 2.392 ± 0.051	3.232GluGly: 3.232 ± 0.054	1.302GluHis: 1.302 ± 0.033	4.978GluIle: 4.978 ± 0.062	4.295GluLys: 4.295 ± 0.074	6.805GluLeu: 6.805 ± 0.083	1.788GluMet: 1.788 ± 0.039	2.594GluAsn: 2.594 ± 0.051	1.781GluPro: 1.781 ± 0.045	3.338GluGln: 3.338 ± 0.06	3.185GluArg: 3.185 ± 0.06	2.853GluSer: 2.853 ± 0.05	2.998GluThr: 2.998 ± 0.061	4.355GluVal: 4.355 ± 0.067	0.573GluTrp: 0.573 ± 0.024	2.053GluTyr: 2.053 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.297PheAla: 3.297 ± 0.059	0.532PheCys: 0.532 ± 0.023	2.104PheAsp: 2.104 ± 0.038	1.965PheGlu: 1.965 ± 0.041	1.734PhePhe: 1.734 ± 0.045	3.144PheGly: 3.144 ± 0.053	0.744PheHis: 0.744 ± 0.025	3.218PheIle: 3.218 ± 0.061	1.928PheLys: 1.928 ± 0.039	3.643PheLeu: 3.643 ± 0.071	1.02PheMet: 1.02 ± 0.032	1.763PheAsn: 1.763 ± 0.038	1.436PhePro: 1.436 ± 0.037	1.155PheGln: 1.155 ± 0.031	1.53PheArg: 1.53 ± 0.037	2.912PheSer: 2.912 ± 0.051	2.297PheThr: 2.297 ± 0.046	2.61PheVal: 2.61 ± 0.053	0.413PheTrp: 0.413 ± 0.019	1.369PheTyr: 1.369 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	6.074GlyAla: 6.074 ± 0.181	1.09GlyCys: 1.09 ± 0.033	3.236GlyAsp: 3.236 ± 0.066	3.919GlyGlu: 3.919 ± 0.06	3.067GlyPhe: 3.067 ± 0.058	5.247GlyGly: 5.247 ± 0.091	1.501GlyHis: 1.501 ± 0.035	6.343GlyIle: 6.343 ± 0.081	4.562GlyLys: 4.562 ± 0.066	7.48GlyLeu: 7.48 ± 0.09	2.146GlyMet: 2.146 ± 0.047	2.791GlyAsn: 2.791 ± 0.053	1.989GlyPro: 1.989 ± 0.061	2.882GlyGln: 2.882 ± 0.05	3.257GlyArg: 3.257 ± 0.05	4.223GlySer: 4.223 ± 0.068	4.163GlyThr: 4.163 ± 0.074	5.489GlyVal: 5.489 ± 0.083	0.779GlyTrp: 0.779 ± 0.028	2.786GlyTyr: 2.786 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.582HisAla: 1.582 ± 0.044	0.305HisCys: 0.305 ± 0.018	1.054HisAsp: 1.054 ± 0.027	1.192HisGlu: 1.192 ± 0.033	0.803HisPhe: 0.803 ± 0.027	1.485HisGly: 1.485 ± 0.038	0.615HisHis: 0.615 ± 0.032	1.571HisIle: 1.571 ± 0.039	0.94HisLys: 0.94 ± 0.031	1.885HisLeu: 1.885 ± 0.047	0.484HisMet: 0.484 ± 0.02	0.796HisAsn: 0.796 ± 0.023	1.008HisPro: 1.008 ± 0.032	0.806HisGln: 0.806 ± 0.024	0.905HisArg: 0.905 ± 0.03	1.227HisSer: 1.227 ± 0.031	1.103HisThr: 1.103 ± 0.035	1.253HisVal: 1.253 ± 0.033	0.219HisTrp: 0.219 ± 0.013	0.795HisTyr: 0.795 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	7.586IleAla: 7.586 ± 0.095	0.915IleCys: 0.915 ± 0.029	4.215IleAsp: 4.215 ± 0.065	4.774IleGlu: 4.774 ± 0.076	2.652IlePhe: 2.652 ± 0.056	5.902IleGly: 5.902 ± 0.086	1.493IleHis: 1.493 ± 0.036	6.108IleIle: 6.108 ± 0.085	4.476IleLys: 4.476 ± 0.063	7.168IleLeu: 7.168 ± 0.093	1.871IleMet: 1.871 ± 0.043	3.365IleAsn: 3.365 ± 0.065	3.481IlePro: 3.481 ± 0.058	2.757IleGln: 2.757 ± 0.047	3.328IleArg: 3.328 ± 0.058	4.898IleSer: 4.898 ± 0.075	4.676IleThr: 4.676 ± 0.071	5.693IleVal: 5.693 ± 0.076	0.619IleTrp: 0.619 ± 0.025	2.142IleTyr: 2.142 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.025LysAla: 5.025 ± 0.078	0.507LysCys: 0.507 ± 0.023	2.654LysAsp: 2.654 ± 0.053	3.952LysGlu: 3.952 ± 0.056	1.869LysPhe: 1.869 ± 0.042	3.322LysGly: 3.322 ± 0.053	1.057LysHis: 1.057 ± 0.03	4.636LysIle: 4.636 ± 0.072	3.657LysLys: 3.657 ± 0.067	5.734LysLeu: 5.734 ± 0.079	1.706LysMet: 1.706 ± 0.043	2.743LysAsn: 2.743 ± 0.054	2.319LysPro: 2.319 ± 0.044	2.677LysGln: 2.677 ± 0.047	2.613LysArg: 2.613 ± 0.048	3.065LysSer: 3.065 ± 0.05	3.165LysThr: 3.165 ± 0.051	4.272LysVal: 4.272 ± 0.076	0.523LysTrp: 0.523 ± 0.019	1.908LysTyr: 1.908 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	10.07LeuAla: 10.07 ± 0.119	1.061LeuCys: 1.061 ± 0.03	4.792LeuAsp: 4.792 ± 0.061	5.794LeuGlu: 5.794 ± 0.079	3.958LeuPhe: 3.958 ± 0.08	7.161LeuGly: 7.161 ± 0.088	1.825LeuHis: 1.825 ± 0.043	6.983LeuIle: 6.983 ± 0.093	5.679LeuLys: 5.679 ± 0.076	10.259LeuLeu: 10.259 ± 0.139	2.501LeuMet: 2.501 ± 0.049	4.285LeuAsn: 4.285 ± 0.068	4.302LeuPro: 4.302 ± 0.063	3.706LeuGln: 3.706 ± 0.07	4.324LeuArg: 4.324 ± 0.074	6.584LeuSer: 6.584 ± 0.079	6.081LeuThr: 6.081 ± 0.077	7.0LeuVal: 7.0 ± 0.086	0.865LeuTrp: 0.865 ± 0.024	2.785LeuTyr: 2.785 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.557MetAla: 2.557 ± 0.049	0.221MetCys: 0.221 ± 0.014	1.303MetAsp: 1.303 ± 0.035	1.441MetGlu: 1.441 ± 0.04	0.861MetPhe: 0.861 ± 0.03	1.854MetGly: 1.854 ± 0.051	0.446MetHis: 0.446 ± 0.021	2.044MetIle: 2.044 ± 0.044	1.645MetLys: 1.645 ± 0.036	2.781MetLeu: 2.781 ± 0.052	0.754MetMet: 0.754 ± 0.023	1.24MetAsn: 1.24 ± 0.032	1.126MetPro: 1.126 ± 0.033	1.115MetGln: 1.115 ± 0.033	1.237MetArg: 1.237 ± 0.03	1.621MetSer: 1.621 ± 0.041	1.546MetThr: 1.546 ± 0.038	1.928MetVal: 1.928 ± 0.041	0.17MetTrp: 0.17 ± 0.012	0.613MetTyr: 0.613 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.087AsnAla: 3.087 ± 0.06	0.507AsnCys: 0.507 ± 0.022	1.976AsnAsp: 1.976 ± 0.043	2.325AsnGlu: 2.325 ± 0.054	1.624AsnPhe: 1.624 ± 0.036	2.755AsnGly: 2.755 ± 0.06	0.966AsnHis: 0.966 ± 0.028	3.576AsnIle: 3.576 ± 0.059	2.504AsnLys: 2.504 ± 0.055	4.16AsnLeu: 4.16 ± 0.063	1.127AsnMet: 1.127 ± 0.033	1.858AsnAsn: 1.858 ± 0.052	2.116AsnPro: 2.116 ± 0.047	1.933AsnGln: 1.933 ± 0.049	1.844AsnArg: 1.844 ± 0.038	2.468AsnSer: 2.468 ± 0.047	2.284AsnThr: 2.284 ± 0.047	2.76AsnVal: 2.76 ± 0.057	0.462AsnTrp: 0.462 ± 0.018	1.483AsnTyr: 1.483 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.278ProAla: 3.278 ± 0.065	0.439ProCys: 0.439 ± 0.02	2.286ProAsp: 2.286 ± 0.05	3.049ProGlu: 3.049 ± 0.054	1.589ProPhe: 1.589 ± 0.041	2.981ProGly: 2.981 ± 0.05	0.832ProHis: 0.832 ± 0.03	2.781ProIle: 2.781 ± 0.053	1.769ProLys: 1.769 ± 0.038	3.612ProLeu: 3.612 ± 0.055	0.847ProMet: 0.847 ± 0.029	1.479ProAsn: 1.479 ± 0.033	1.273ProPro: 1.273 ± 0.036	1.563ProGln: 1.563 ± 0.039	1.47ProArg: 1.47 ± 0.037	1.971ProSer: 1.971 ± 0.041	2.051ProThr: 2.051 ± 0.059	3.354ProVal: 3.354 ± 0.062	0.398ProTrp: 0.398 ± 0.016	1.259ProTyr: 1.259 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.316GlnAla: 4.316 ± 0.083	0.384GlnCys: 0.384 ± 0.017	1.91GlnAsp: 1.91 ± 0.044	2.736GlnGlu: 2.736 ± 0.055	1.378GlnPhe: 1.378 ± 0.036	2.659GlnGly: 2.659 ± 0.053	0.889GlnHis: 0.889 ± 0.027	2.883GlnIle: 2.883 ± 0.045	2.223GlnLys: 2.223 ± 0.047	4.222GlnLeu: 4.222 ± 0.063	1.061GlnMet: 1.061 ± 0.033	1.652GlnAsn: 1.652 ± 0.042	1.597GlnPro: 1.597 ± 0.038	2.336GlnGln: 2.336 ± 0.052	1.836GlnArg: 1.836 ± 0.046	2.356GlnSer: 2.356 ± 0.052	2.144GlnThr: 2.144 ± 0.048	2.99GlnVal: 2.99 ± 0.053	0.364GlnTrp: 0.364 ± 0.017	1.367GlnTyr: 1.367 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.093ArgAla: 3.093 ± 0.055	0.489ArgCys: 0.489 ± 0.021	2.215ArgAsp: 2.215 ± 0.046	3.039ArgGlu: 3.039 ± 0.054	1.789ArgPhe: 1.789 ± 0.04	2.722ArgGly: 2.722 ± 0.055	0.966ArgHis: 0.966 ± 0.03	3.497ArgIle: 3.497 ± 0.06	2.594ArgLys: 2.594 ± 0.045	4.606ArgLeu: 4.606 ± 0.075	1.347ArgMet: 1.347 ± 0.033	1.994ArgAsn: 1.994 ± 0.041	1.669ArgPro: 1.669 ± 0.037	2.285ArgGln: 2.285 ± 0.047	2.23ArgArg: 2.23 ± 0.044	2.472ArgSer: 2.472 ± 0.049	2.265ArgThr: 2.265 ± 0.046	3.017ArgVal: 3.017 ± 0.051	0.45ArgTrp: 0.45 ± 0.022	1.691ArgTyr: 1.691 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.814SerAla: 4.814 ± 0.068	0.697SerCys: 0.697 ± 0.026	2.76SerAsp: 2.76 ± 0.057	3.311SerGlu: 3.311 ± 0.054	2.492SerPhe: 2.492 ± 0.053	4.902SerGly: 4.902 ± 0.079	1.18SerHis: 1.18 ± 0.034	4.479SerIle: 4.479 ± 0.062	3.105SerLys: 3.105 ± 0.057	5.977SerLeu: 5.977 ± 0.084	1.593SerMet: 1.593 ± 0.039	2.308SerAsn: 2.308 ± 0.049	2.248SerPro: 2.248 ± 0.047	2.361SerGln: 2.361 ± 0.05	2.639SerArg: 2.639 ± 0.052	3.728SerSer: 3.728 ± 0.07	3.137SerThr: 3.137 ± 0.059	4.165SerVal: 4.165 ± 0.063	0.604SerTrp: 0.604 ± 0.023	1.988SerTyr: 1.988 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.358ThrAla: 5.358 ± 0.08	0.522ThrCys: 0.522 ± 0.022	2.716ThrAsp: 2.716 ± 0.05	3.052ThrGlu: 3.052 ± 0.055	2.026ThrPhe: 2.026 ± 0.043	5.326ThrGly: 5.326 ± 0.249	1.009ThrHis: 1.009 ± 0.029	4.287ThrIle: 4.287 ± 0.064	2.857ThrLys: 2.857 ± 0.051	5.203ThrLeu: 5.203 ± 0.064	1.32ThrMet: 1.32 ± 0.032	2.181ThrAsn: 2.181 ± 0.053	2.467ThrPro: 2.467 ± 0.045	1.772ThrGln: 1.772 ± 0.04	2.09ThrArg: 2.09 ± 0.044	2.947ThrSer: 2.947 ± 0.053	3.202ThrThr: 3.202 ± 0.065	4.661ThrVal: 4.661 ± 0.067	0.461ThrTrp: 0.461 ± 0.022	1.644ThrTyr: 1.644 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.636ValAla: 6.636 ± 0.085	0.902ValCys: 0.902 ± 0.03	3.878ValAsp: 3.878 ± 0.061	4.3ValGlu: 4.3 ± 0.062	3.047ValPhe: 3.047 ± 0.059	5.151ValGly: 5.151 ± 0.075	1.313ValHis: 1.313 ± 0.038	5.824ValIle: 5.824 ± 0.082	4.076ValLys: 4.076 ± 0.071	7.379ValLeu: 7.379 ± 0.091	1.938ValMet: 1.938 ± 0.041	3.119ValAsn: 3.119 ± 0.056	2.773ValPro: 2.773 ± 0.053	2.512ValGln: 2.512 ± 0.045	3.154ValArg: 3.154 ± 0.054	4.534ValSer: 4.534 ± 0.078	4.347ValThr: 4.347 ± 0.076	5.834ValVal: 5.834 ± 0.082	0.649ValTrp: 0.649 ± 0.024	2.202ValTyr: 2.202 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.66TrpAla: 0.66 ± 0.027	0.114TrpCys: 0.114 ± 0.01	0.449TrpAsp: 0.449 ± 0.017	0.545TrpGlu: 0.545 ± 0.02	0.399TrpPhe: 0.399 ± 0.02	0.681TrpGly: 0.681 ± 0.025	0.213TrpHis: 0.213 ± 0.015	0.594TrpIle: 0.594 ± 0.021	0.455TrpLys: 0.455 ± 0.019	1.274TrpLeu: 1.274 ± 0.035	0.245TrpMet: 0.245 ± 0.016	0.404TrpAsn: 0.404 ± 0.019	0.354TrpPro: 0.354 ± 0.019	0.601TrpGln: 0.601 ± 0.027	0.489TrpArg: 0.489 ± 0.02	0.533TrpSer: 0.533 ± 0.023	0.406TrpThr: 0.406 ± 0.019	0.608TrpVal: 0.608 ± 0.023	0.168TrpTrp: 0.168 ± 0.011	0.31TrpTyr: 0.31 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.343TyrAla: 2.343 ± 0.051	0.447TyrCys: 0.447 ± 0.02	1.785TyrAsp: 1.785 ± 0.04	1.803TyrGlu: 1.803 ± 0.04	1.422TyrPhe: 1.422 ± 0.034	2.567TyrGly: 2.567 ± 0.046	0.811TyrHis: 0.811 ± 0.029	2.247TyrIle: 2.247 ± 0.043	1.584TyrLys: 1.584 ± 0.039	3.376TyrLeu: 3.376 ± 0.062	0.693TyrMet: 0.693 ± 0.026	1.345TyrAsn: 1.345 ± 0.034	1.419TyrPro: 1.419 ± 0.039	1.586TyrGln: 1.586 ± 0.043	1.731TyrArg: 1.731 ± 0.039	2.118TyrSer: 2.118 ± 0.048	1.703TyrThr: 1.703 ± 0.038	1.988TyrVal: 1.988 ± 0.043	0.393TyrTrp: 0.393 ± 0.017	1.277TyrTyr: 1.277 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3820 proteins (1142366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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