Amino acid dipepetide frequency for Achromobacter sp. AONIH1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.743AlaAla: 19.743 ± 0.179
1.376AlaCys: 1.376 ± 0.031
6.926AlaAsp: 6.926 ± 0.067
6.482AlaGlu: 6.482 ± 0.069
4.025AlaPhe: 4.025 ± 0.052
12.753AlaGly: 12.753 ± 0.153
2.47AlaHis: 2.47 ± 0.043
5.255AlaIle: 5.255 ± 0.062
3.032AlaLys: 3.032 ± 0.055
16.239AlaLeu: 16.239 ± 0.125
3.502AlaMet: 3.502 ± 0.052
2.743AlaAsn: 2.743 ± 0.046
6.738AlaPro: 6.738 ± 0.08
5.853AlaGln: 5.853 ± 0.063
10.745AlaArg: 10.745 ± 0.095
7.155AlaSer: 7.155 ± 0.078
5.856AlaThr: 5.856 ± 0.064
9.075AlaVal: 9.075 ± 0.081
2.059AlaTrp: 2.059 ± 0.038
2.885AlaTyr: 2.885 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
1.24CysAla: 1.24 ± 0.026
0.131CysCys: 0.131 ± 0.008
0.486CysAsp: 0.486 ± 0.016
0.436CysGlu: 0.436 ± 0.016
0.305CysPhe: 0.305 ± 0.016
0.976CysGly: 0.976 ± 0.023
0.23CysHis: 0.23 ± 0.01
0.346CysIle: 0.346 ± 0.014
0.18CysLys: 0.18 ± 0.009
0.915CysLeu: 0.915 ± 0.024
0.207CysMet: 0.207 ± 0.01
0.214CysAsn: 0.214 ± 0.01
0.441CysPro: 0.441 ± 0.016
0.26CysGln: 0.26 ± 0.013
0.608CysArg: 0.608 ± 0.017
0.431CysSer: 0.431 ± 0.014
0.405CysThr: 0.405 ± 0.015
0.727CysVal: 0.727 ± 0.018
0.121CysTrp: 0.121 ± 0.008
0.228CysTyr: 0.228 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.839AspAla: 7.839 ± 0.071
0.491AspCys: 0.491 ± 0.019
2.778AspAsp: 2.778 ± 0.046
3.125AspGlu: 3.125 ± 0.052
1.904AspPhe: 1.904 ± 0.035
5.2AspGly: 5.2 ± 0.087
1.001AspHis: 1.001 ± 0.027
2.539AspIle: 2.539 ± 0.035
1.527AspLys: 1.527 ± 0.042
5.518AspLeu: 5.518 ± 0.062
1.289AspMet: 1.289 ± 0.027
1.171AspAsn: 1.171 ± 0.029
3.247AspPro: 3.247 ± 0.044
1.714AspGln: 1.714 ± 0.026
3.407AspArg: 3.407 ± 0.045
2.293AspSer: 2.293 ± 0.041
2.592AspThr: 2.592 ± 0.04
3.969AspVal: 3.969 ± 0.052
0.995AspTrp: 0.995 ± 0.026
1.507AspTyr: 1.507 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
6.315GluAla: 6.315 ± 0.066
0.365GluCys: 0.365 ± 0.015
2.372GluAsp: 2.372 ± 0.043
2.212GluGlu: 2.212 ± 0.037
1.649GluPhe: 1.649 ± 0.031
3.437GluGly: 3.437 ± 0.049
1.263GluHis: 1.263 ± 0.025
2.575GluIle: 2.575 ± 0.044
1.503GluLys: 1.503 ± 0.037
5.574GluLeu: 5.574 ± 0.06
1.132GluMet: 1.132 ± 0.025
1.283GluAsn: 1.283 ± 0.03
2.521GluPro: 2.521 ± 0.04
2.537GluGln: 2.537 ± 0.04
4.657GluArg: 4.657 ± 0.054
2.474GluSer: 2.474 ± 0.036
2.502GluThr: 2.502 ± 0.04
3.402GluVal: 3.402 ± 0.049
0.643GluTrp: 0.643 ± 0.02
1.087GluTyr: 1.087 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.765PheAla: 3.765 ± 0.048
0.34PheCys: 0.34 ± 0.013
2.226PheAsp: 2.226 ± 0.031
1.789PheGlu: 1.789 ± 0.034
1.197PhePhe: 1.197 ± 0.031
3.188PheGly: 3.188 ± 0.048
0.723PheHis: 0.723 ± 0.022
1.439PheIle: 1.439 ± 0.029
1.005PheLys: 1.005 ± 0.025
3.148PheLeu: 3.148 ± 0.048
0.774PheMet: 0.774 ± 0.022
1.084PheAsn: 1.084 ± 0.02
1.499PhePro: 1.499 ± 0.034
1.083PheGln: 1.083 ± 0.025
1.866PheArg: 1.866 ± 0.032
2.121PheSer: 2.121 ± 0.035
1.649PheThr: 1.649 ± 0.029
2.517PheVal: 2.517 ± 0.042
0.51PheTrp: 0.51 ± 0.017
0.885PheTyr: 0.885 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
10.638GlyAla: 10.638 ± 0.157
0.862GlyCys: 0.862 ± 0.024
4.18GlyAsp: 4.18 ± 0.066
4.293GlyGlu: 4.293 ± 0.058
3.102GlyPhe: 3.102 ± 0.043
7.709GlyGly: 7.709 ± 0.146
1.812GlyHis: 1.812 ± 0.03
4.003GlyIle: 4.003 ± 0.052
3.329GlyLys: 3.329 ± 0.053
9.673GlyLeu: 9.673 ± 0.086
2.588GlyMet: 2.588 ± 0.034
2.298GlyAsn: 2.298 ± 0.07
3.324GlyPro: 3.324 ± 0.043
3.658GlyGln: 3.658 ± 0.051
6.017GlyArg: 6.017 ± 0.061
4.699GlySer: 4.699 ± 0.094
4.208GlyThr: 4.208 ± 0.088
6.708GlyVal: 6.708 ± 0.085
1.512GlyTrp: 1.512 ± 0.029
2.586GlyTyr: 2.586 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.89HisAla: 2.89 ± 0.049
0.251HisCys: 0.251 ± 0.013
1.181HisAsp: 1.181 ± 0.029
1.036HisGlu: 1.036 ± 0.026
0.739HisPhe: 0.739 ± 0.021
2.098HisGly: 2.098 ± 0.031
0.537HisHis: 0.537 ± 0.018
0.841HisIle: 0.841 ± 0.023
0.462HisLys: 0.462 ± 0.017
1.989HisLeu: 1.989 ± 0.036
0.459HisMet: 0.459 ± 0.017
0.445HisAsn: 0.445 ± 0.018
1.449HisPro: 1.449 ± 0.035
0.666HisGln: 0.666 ± 0.018
1.343HisArg: 1.343 ± 0.028
0.906HisSer: 0.906 ± 0.024
0.919HisThr: 0.919 ± 0.021
1.478HisVal: 1.478 ± 0.026
0.359HisTrp: 0.359 ± 0.014
0.593HisTyr: 0.593 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.036IleAla: 6.036 ± 0.059
0.403IleCys: 0.403 ± 0.016
2.885IleAsp: 2.885 ± 0.043
2.781IleGlu: 2.781 ± 0.042
1.212IlePhe: 1.212 ± 0.026
4.177IleGly: 4.177 ± 0.055
0.815IleHis: 0.815 ± 0.019
1.634IleIle: 1.634 ± 0.035
1.311IleLys: 1.311 ± 0.028
3.659IleLeu: 3.659 ± 0.055
0.845IleMet: 0.845 ± 0.024
1.313IleAsn: 1.313 ± 0.028
2.015IlePro: 2.015 ± 0.033
1.365IleGln: 1.365 ± 0.028
2.714IleArg: 2.714 ± 0.036
2.512IleSer: 2.512 ± 0.04
2.277IleThr: 2.277 ± 0.05
3.564IleVal: 3.564 ± 0.047
0.54IleTrp: 0.54 ± 0.018
1.014IleTyr: 1.014 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.21LysAla: 3.21 ± 0.049
0.126LysCys: 0.126 ± 0.007
1.391LysAsp: 1.391 ± 0.034
1.229LysGlu: 1.229 ± 0.031
0.758LysPhe: 0.758 ± 0.021
2.063LysGly: 2.063 ± 0.037
0.565LysHis: 0.565 ± 0.02
1.274LysIle: 1.274 ± 0.034
1.027LysLys: 1.027 ± 0.032
3.198LysLeu: 3.198 ± 0.049
0.665LysMet: 0.665 ± 0.022
0.786LysAsn: 0.786 ± 0.023
1.881LysPro: 1.881 ± 0.038
1.221LysGln: 1.221 ± 0.026
2.072LysArg: 2.072 ± 0.039
1.549LysSer: 1.549 ± 0.037
1.645LysThr: 1.645 ± 0.031
2.117LysVal: 2.117 ± 0.04
0.355LysTrp: 0.355 ± 0.016
0.613LysTyr: 0.613 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
16.462LeuAla: 16.462 ± 0.131
1.041LeuCys: 1.041 ± 0.024
6.47LeuAsp: 6.47 ± 0.055
5.027LeuGlu: 5.027 ± 0.057
3.497LeuPhe: 3.497 ± 0.054
9.173LeuGly: 9.173 ± 0.098
2.105LeuHis: 2.105 ± 0.034
4.556LeuIle: 4.556 ± 0.058
3.065LeuLys: 3.065 ± 0.044
11.473LeuLeu: 11.473 ± 0.112
2.408LeuMet: 2.408 ± 0.042
2.917LeuAsn: 2.917 ± 0.048
6.373LeuPro: 6.373 ± 0.074
3.438LeuGln: 3.438 ± 0.048
8.793LeuArg: 8.793 ± 0.074
6.677LeuSer: 6.677 ± 0.066
5.531LeuThr: 5.531 ± 0.067
7.379LeuVal: 7.379 ± 0.075
1.246LeuTrp: 1.246 ± 0.028
2.366LeuTyr: 2.366 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
3.004MetAla: 3.004 ± 0.042
0.154MetCys: 0.154 ± 0.008
1.141MetAsp: 1.141 ± 0.025
0.964MetGlu: 0.964 ± 0.023
0.716MetPhe: 0.716 ± 0.017
1.773MetGly: 1.773 ± 0.031
0.51MetHis: 0.51 ± 0.018
0.966MetIle: 0.966 ± 0.026
0.862MetLys: 0.862 ± 0.023
2.832MetLeu: 2.832 ± 0.041
0.556MetMet: 0.556 ± 0.019
0.785MetAsn: 0.785 ± 0.017
1.531MetPro: 1.531 ± 0.036
1.02MetGln: 1.02 ± 0.021
1.838MetArg: 1.838 ± 0.033
1.668MetSer: 1.668 ± 0.029
1.542MetThr: 1.542 ± 0.027
1.569MetVal: 1.569 ± 0.032
0.196MetTrp: 0.196 ± 0.01
0.404MetTyr: 0.404 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.209AsnAla: 3.209 ± 0.046
0.22AsnCys: 0.22 ± 0.011
1.303AsnAsp: 1.303 ± 0.035
1.075AsnGlu: 1.075 ± 0.023
0.849AsnPhe: 0.849 ± 0.023
2.402AsnGly: 2.402 ± 0.057
0.477AsnHis: 0.477 ± 0.018
1.174AsnIle: 1.174 ± 0.029
0.719AsnLys: 0.719 ± 0.021
2.687AsnLeu: 2.687 ± 0.042
0.558AsnMet: 0.558 ± 0.017
0.759AsnAsn: 0.759 ± 0.032
1.834AsnPro: 1.834 ± 0.03
0.906AsnGln: 0.906 ± 0.023
1.692AsnArg: 1.692 ± 0.031
1.205AsnSer: 1.205 ± 0.034
1.392AsnThr: 1.392 ± 0.041
1.951AsnVal: 1.951 ± 0.043
0.422AsnTrp: 0.422 ± 0.018
0.657AsnTyr: 0.657 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.225ProAla: 8.225 ± 0.094
0.364ProCys: 0.364 ± 0.015
3.54ProAsp: 3.54 ± 0.051
3.2ProGlu: 3.2 ± 0.052
1.726ProPhe: 1.726 ± 0.029
5.032ProGly: 5.032 ± 0.057
1.014ProHis: 1.014 ± 0.024
1.82ProIle: 1.82 ± 0.032
1.334ProLys: 1.334 ± 0.03
5.376ProLeu: 5.376 ± 0.06
1.252ProMet: 1.252 ± 0.028
1.211ProAsn: 1.211 ± 0.026
2.678ProPro: 2.678 ± 0.048
2.106ProGln: 2.106 ± 0.038
3.288ProArg: 3.288 ± 0.048
2.771ProSer: 2.771 ± 0.04
2.293ProThr: 2.293 ± 0.034
4.256ProVal: 4.256 ± 0.055
0.827ProTrp: 0.827 ± 0.022
1.363ProTyr: 1.363 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
6.386GlnAla: 6.386 ± 0.074
0.249GlnCys: 0.249 ± 0.012
1.927GlnAsp: 1.927 ± 0.036
1.698GlnGlu: 1.698 ± 0.03
1.127GlnPhe: 1.127 ± 0.027
3.368GlnGly: 3.368 ± 0.05
0.806GlnHis: 0.806 ± 0.022
1.767GlnIle: 1.767 ± 0.033
0.914GlnLys: 0.914 ± 0.021
3.714GlnLeu: 3.714 ± 0.038
0.867GlnMet: 0.867 ± 0.024
0.837GlnAsn: 0.837 ± 0.023
2.33GlnPro: 2.33 ± 0.043
1.721GlnGln: 1.721 ± 0.037
3.159GlnArg: 3.159 ± 0.046
1.913GlnSer: 1.913 ± 0.03
1.848GlnThr: 1.848 ± 0.035
2.815GlnVal: 2.815 ± 0.042
0.616GlnTrp: 0.616 ± 0.021
0.854GlnTyr: 0.854 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
9.234ArgAla: 9.234 ± 0.081
0.568ArgCys: 0.568 ± 0.018
4.123ArgAsp: 4.123 ± 0.05
4.232ArgGlu: 4.232 ± 0.052
2.352ArgPhe: 2.352 ± 0.03
5.093ArgGly: 5.093 ± 0.062
1.981ArgHis: 1.981 ± 0.038
3.736ArgIle: 3.736 ± 0.039
2.061ArgLys: 2.061 ± 0.037
8.539ArgLeu: 8.539 ± 0.08
1.972ArgMet: 1.972 ± 0.031
1.938ArgAsn: 1.938 ± 0.033
3.558ArgPro: 3.558 ± 0.05
3.373ArgGln: 3.373 ± 0.045
5.908ArgArg: 5.908 ± 0.067
3.474ArgSer: 3.474 ± 0.041
2.837ArgThr: 2.837 ± 0.041
5.382ArgVal: 5.382 ± 0.055
1.155ArgTrp: 1.155 ± 0.025
2.329ArgTyr: 2.329 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.807SerAla: 6.807 ± 0.077
0.454SerCys: 0.454 ± 0.016
2.634SerAsp: 2.634 ± 0.042
2.29SerGlu: 2.29 ± 0.037
1.96SerPhe: 1.96 ± 0.036
5.434SerGly: 5.434 ± 0.08
1.137SerHis: 1.137 ± 0.025
2.384SerIle: 2.384 ± 0.039
1.353SerLys: 1.353 ± 0.028
5.838SerLeu: 5.838 ± 0.059
1.347SerMet: 1.347 ± 0.03
1.434SerAsn: 1.434 ± 0.035
2.884SerPro: 2.884 ± 0.04
1.927SerGln: 1.927 ± 0.037
3.851SerArg: 3.851 ± 0.049
2.985SerSer: 2.985 ± 0.049
2.694SerThr: 2.694 ± 0.046
4.206SerVal: 4.206 ± 0.061
0.836SerTrp: 0.836 ± 0.022
1.368SerTyr: 1.368 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
5.661ThrAla: 5.661 ± 0.066
0.364ThrCys: 0.364 ± 0.014
2.39ThrAsp: 2.39 ± 0.048
2.115ThrGlu: 2.115 ± 0.036
1.547ThrPhe: 1.547 ± 0.029
4.538ThrGly: 4.538 ± 0.07
1.042ThrHis: 1.042 ± 0.022
1.983ThrIle: 1.983 ± 0.039
0.899ThrLys: 0.899 ± 0.025
6.649ThrLeu: 6.649 ± 0.071
0.966ThrMet: 0.966 ± 0.022
1.077ThrAsn: 1.077 ± 0.029
3.477ThrPro: 3.477 ± 0.047
1.793ThrGln: 1.793 ± 0.03
3.427ThrArg: 3.427 ± 0.036
2.433ThrSer: 2.433 ± 0.039
2.365ThrThr: 2.365 ± 0.053
4.095ThrVal: 4.095 ± 0.076
0.639ThrTrp: 0.639 ± 0.017
1.111ThrTyr: 1.111 ± 0.026
0.0ThrXaa: 0.0 ± 0.0
Val
9.702ValAla: 9.702 ± 0.075
0.742ValCys: 0.742 ± 0.021
4.047ValAsp: 4.047 ± 0.049
3.793ValGlu: 3.793 ± 0.05
2.667ValPhe: 2.667 ± 0.047
5.549ValGly: 5.549 ± 0.07
1.361ValHis: 1.361 ± 0.03
3.22ValIle: 3.22 ± 0.049
2.105ValLys: 2.105 ± 0.042
8.222ValLeu: 8.222 ± 0.081
1.762ValMet: 1.762 ± 0.032
2.136ValAsn: 2.136 ± 0.054
3.831ValPro: 3.831 ± 0.049
2.672ValGln: 2.672 ± 0.033
5.087ValArg: 5.087 ± 0.057
4.453ValSer: 4.453 ± 0.066
3.935ValThr: 3.935 ± 0.064
5.761ValVal: 5.761 ± 0.076
0.905ValTrp: 0.905 ± 0.022
1.705ValTyr: 1.705 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.324TrpAla: 1.324 ± 0.028
0.127TrpCys: 0.127 ± 0.008
0.622TrpAsp: 0.622 ± 0.018
0.558TrpGlu: 0.558 ± 0.015
0.569TrpPhe: 0.569 ± 0.018
0.952TrpGly: 0.952 ± 0.023
0.345TrpHis: 0.345 ± 0.015
0.693TrpIle: 0.693 ± 0.019
0.425TrpLys: 0.425 ± 0.018
2.112TrpLeu: 2.112 ± 0.04
0.409TrpMet: 0.409 ± 0.015
0.45TrpAsn: 0.45 ± 0.015
0.757TrpPro: 0.757 ± 0.018
0.706TrpGln: 0.706 ± 0.017
1.418TrpArg: 1.418 ± 0.034
0.829TrpSer: 0.829 ± 0.021
0.778TrpThr: 0.778 ± 0.02
0.937TrpVal: 0.937 ± 0.022
0.249TrpTrp: 0.249 ± 0.011
0.326TrpTyr: 0.326 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.221TyrAla: 3.221 ± 0.046
0.259TyrCys: 0.259 ± 0.01
1.484TyrAsp: 1.484 ± 0.029
1.165TyrGlu: 1.165 ± 0.024
0.907TyrPhe: 0.907 ± 0.023
2.285TyrGly: 2.285 ± 0.038
0.445TyrHis: 0.445 ± 0.017
0.867TyrIle: 0.867 ± 0.023
0.632TyrLys: 0.632 ± 0.021
2.644TyrLeu: 2.644 ± 0.04
0.473TyrMet: 0.473 ± 0.016
0.606TyrAsn: 0.606 ± 0.019
1.31TyrPro: 1.31 ± 0.027
0.898TyrGln: 0.898 ± 0.024
1.954TyrArg: 1.954 ± 0.034
1.278TyrSer: 1.278 ± 0.026
1.304TyrThr: 1.304 ± 0.032
1.748TyrVal: 1.748 ± 0.031
0.402TyrTrp: 0.402 ± 0.016
0.656TyrTyr: 0.656 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5889 proteins (1952274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski