Amino acid dipepetide frequency for Stieleria varia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.621AlaAla: 10.621 ± 0.096	1.106AlaCys: 1.106 ± 0.026	6.471AlaAsp: 6.471 ± 0.062	6.035AlaGlu: 6.035 ± 0.066	3.225AlaPhe: 3.225 ± 0.035	7.395AlaGly: 7.395 ± 0.082	1.508AlaHis: 1.508 ± 0.026	5.754AlaIle: 5.754 ± 0.048	3.813AlaLys: 3.813 ± 0.054	7.864AlaLeu: 7.864 ± 0.06	2.653AlaMet: 2.653 ± 0.037	3.13AlaAsn: 3.13 ± 0.043	3.774AlaPro: 3.774 ± 0.051	3.267AlaGln: 3.267 ± 0.035	4.896AlaArg: 4.896 ± 0.058	6.662AlaSer: 6.662 ± 0.069	6.002AlaThr: 6.002 ± 0.069	6.791AlaVal: 6.791 ± 0.056	1.241AlaTrp: 1.241 ± 0.026	1.881AlaTyr: 1.881 ± 0.028	0.002AlaXaa: 0.002 ± 0.001
Cys	0.739CysAla: 0.739 ± 0.019	0.244CysCys: 0.244 ± 0.012	0.791CysAsp: 0.791 ± 0.022	0.682CysGlu: 0.682 ± 0.021	0.465CysPhe: 0.465 ± 0.014	1.04CysGly: 1.04 ± 0.031	0.423CysHis: 0.423 ± 0.016	0.471CysIle: 0.471 ± 0.014	0.337CysLys: 0.337 ± 0.012	1.125CysLeu: 1.125 ± 0.029	0.231CysMet: 0.231 ± 0.011	0.338CysAsn: 0.338 ± 0.012	0.588CysPro: 0.588 ± 0.019	0.437CysGln: 0.437 ± 0.014	0.823CysArg: 0.823 ± 0.023	0.735CysSer: 0.735 ± 0.021	0.493CysThr: 0.493 ± 0.016	0.942CysVal: 0.942 ± 0.022	0.172CysTrp: 0.172 ± 0.009	0.293CysTyr: 0.293 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.98AspAla: 6.98 ± 0.066	0.645AspCys: 0.645 ± 0.02	4.743AspAsp: 4.743 ± 0.069	4.476AspGlu: 4.476 ± 0.043	2.533AspPhe: 2.533 ± 0.037	6.077AspGly: 6.077 ± 0.098	1.57AspHis: 1.57 ± 0.027	2.627AspIle: 2.627 ± 0.039	1.766AspLys: 1.766 ± 0.028	6.023AspLeu: 6.023 ± 0.073	1.05AspMet: 1.05 ± 0.022	1.807AspAsn: 1.807 ± 0.038	3.809AspPro: 3.809 ± 0.046	2.875AspGln: 2.875 ± 0.033	4.396AspArg: 4.396 ± 0.05	4.592AspSer: 4.592 ± 0.056	2.999AspThr: 2.999 ± 0.054	4.711AspVal: 4.711 ± 0.058	1.076AspTrp: 1.076 ± 0.021	1.522AspTyr: 1.522 ± 0.028	0.003AspXaa: 0.003 ± 0.002
Glu	4.72GluAla: 4.72 ± 0.054	0.527GluCys: 0.527 ± 0.016	2.612GluAsp: 2.612 ± 0.038	2.677GluGlu: 2.677 ± 0.042	2.315GluPhe: 2.315 ± 0.027	3.109GluGly: 3.109 ± 0.033	1.345GluHis: 1.345 ± 0.026	3.754GluIle: 3.754 ± 0.044	2.428GluLys: 2.428 ± 0.043	6.618GluLeu: 6.618 ± 0.064	1.625GluMet: 1.625 ± 0.026	2.154GluAsn: 2.154 ± 0.027	2.844GluPro: 2.844 ± 0.043	2.849GluGln: 2.849 ± 0.044	3.746GluArg: 3.746 ± 0.047	5.008GluSer: 5.008 ± 0.054	3.964GluThr: 3.964 ± 0.039	3.649GluVal: 3.649 ± 0.035	0.626GluTrp: 0.626 ± 0.016	1.324GluTyr: 1.324 ± 0.021	0.001GluXaa: 0.001 ± 0.001
Phe	3.807PheAla: 3.807 ± 0.037	0.491PheCys: 0.491 ± 0.015	2.97PheAsp: 2.97 ± 0.046	2.063PheGlu: 2.063 ± 0.027	1.422PhePhe: 1.422 ± 0.026	3.236PheGly: 3.236 ± 0.046	0.838PheHis: 0.838 ± 0.02	1.465PheIle: 1.465 ± 0.024	0.859PheLys: 0.859 ± 0.019	3.321PheLeu: 3.321 ± 0.037	0.621PheMet: 0.621 ± 0.016	1.164PheAsn: 1.164 ± 0.03	1.595PhePro: 1.595 ± 0.027	1.449PheGln: 1.449 ± 0.024	2.37PheArg: 2.37 ± 0.033	2.569PheSer: 2.569 ± 0.033	1.977PheThr: 1.977 ± 0.039	2.854PheVal: 2.854 ± 0.038	0.538PheTrp: 0.538 ± 0.017	0.917PheTyr: 0.917 ± 0.018	0.001PheXaa: 0.001 ± 0.001
Gly	5.543GlyAla: 5.543 ± 0.076	1.01GlyCys: 1.01 ± 0.027	5.311GlyAsp: 5.311 ± 0.085	4.466GlyGlu: 4.466 ± 0.046	3.036GlyPhe: 3.036 ± 0.038	6.603GlyGly: 6.603 ± 0.13	1.646GlyHis: 1.646 ± 0.024	3.966GlyIle: 3.966 ± 0.05	3.335GlyLys: 3.335 ± 0.048	6.688GlyLeu: 6.688 ± 0.054	1.907GlyMet: 1.907 ± 0.028	3.084GlyAsn: 3.084 ± 0.073	2.958GlyPro: 2.958 ± 0.037	3.223GlyGln: 3.223 ± 0.041	4.873GlyArg: 4.873 ± 0.053	5.146GlySer: 5.146 ± 0.077	4.628GlyThr: 4.628 ± 0.089	5.492GlyVal: 5.492 ± 0.051	1.235GlyTrp: 1.235 ± 0.026	2.062GlyTyr: 2.062 ± 0.031	0.005GlyXaa: 0.005 ± 0.002
His	2.05HisAla: 2.05 ± 0.032	0.378HisCys: 0.378 ± 0.012	1.379HisAsp: 1.379 ± 0.023	1.208HisGlu: 1.208 ± 0.021	0.911HisPhe: 0.911 ± 0.018	1.775HisGly: 1.775 ± 0.028	0.723HisHis: 0.723 ± 0.019	0.786HisIle: 0.786 ± 0.02	0.511HisLys: 0.511 ± 0.015	2.157HisLeu: 2.157 ± 0.032	0.371HisMet: 0.371 ± 0.012	0.592HisAsn: 0.592 ± 0.016	1.388HisPro: 1.388 ± 0.023	0.95HisGln: 0.95 ± 0.021	1.739HisArg: 1.739 ± 0.027	1.441HisSer: 1.441 ± 0.026	0.943HisThr: 0.943 ± 0.02	1.535HisVal: 1.535 ± 0.026	0.475HisTrp: 0.475 ± 0.014	0.616HisTyr: 0.616 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.219IleAla: 6.219 ± 0.05	0.603IleCys: 0.603 ± 0.017	4.525IleAsp: 4.525 ± 0.053	3.746IleGlu: 3.746 ± 0.036	1.353IlePhe: 1.353 ± 0.023	4.306IleGly: 4.306 ± 0.051	1.147IleHis: 1.147 ± 0.022	1.916IleIle: 1.916 ± 0.031	1.508IleLys: 1.508 ± 0.024	4.003IleLeu: 4.003 ± 0.045	0.709IleMet: 0.709 ± 0.015	1.751IleAsn: 1.751 ± 0.041	2.481IlePro: 2.481 ± 0.034	1.991IleGln: 1.991 ± 0.027	3.562IleArg: 3.562 ± 0.043	3.399IleSer: 3.399 ± 0.048	2.952IleThr: 2.952 ± 0.049	4.056IleVal: 4.056 ± 0.042	0.633IleTrp: 0.633 ± 0.016	1.075IleTyr: 1.075 ± 0.021	0.001IleXaa: 0.001 ± 0.001
Lys	2.719LysAla: 2.719 ± 0.04	0.321LysCys: 0.321 ± 0.013	1.657LysAsp: 1.657 ± 0.032	1.783LysGlu: 1.783 ± 0.031	1.062LysPhe: 1.062 ± 0.02	1.834LysGly: 1.834 ± 0.031	0.804LysHis: 0.804 ± 0.019	1.761LysIle: 1.761 ± 0.031	1.493LysLys: 1.493 ± 0.037	3.602LysLeu: 3.602 ± 0.046	0.833LysMet: 0.833 ± 0.02	1.103LysAsn: 1.103 ± 0.02	2.162LysPro: 2.162 ± 0.035	1.644LysGln: 1.644 ± 0.034	2.535LysArg: 2.535 ± 0.039	2.561LysSer: 2.561 ± 0.042	2.179LysThr: 2.179 ± 0.033	2.105LysVal: 2.105 ± 0.033	0.497LysTrp: 0.497 ± 0.014	0.78LysTyr: 0.78 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	10.067LeuAla: 10.067 ± 0.082	1.126LeuCys: 1.126 ± 0.023	6.116LeuAsp: 6.116 ± 0.054	4.953LeuGlu: 4.953 ± 0.053	3.236LeuPhe: 3.236 ± 0.041	6.83LeuGly: 6.83 ± 0.061	1.939LeuHis: 1.939 ± 0.031	5.083LeuIle: 5.083 ± 0.048	3.164LeuLys: 3.164 ± 0.049	9.199LeuLeu: 9.199 ± 0.081	2.142LeuMet: 2.142 ± 0.032	2.998LeuAsn: 2.998 ± 0.04	5.321LeuPro: 5.321 ± 0.052	3.907LeuGln: 3.907 ± 0.046	6.361LeuArg: 6.361 ± 0.063	7.118LeuSer: 7.118 ± 0.053	5.832LeuThr: 5.832 ± 0.058	6.747LeuVal: 6.747 ± 0.057	1.185LeuTrp: 1.185 ± 0.025	1.951LeuTyr: 1.951 ± 0.029	0.002LeuXaa: 0.002 ± 0.001
Met	2.048MetAla: 2.048 ± 0.032	0.201MetCys: 0.201 ± 0.009	1.15MetAsp: 1.15 ± 0.022	1.059MetGlu: 1.059 ± 0.023	0.726MetPhe: 0.726 ± 0.017	1.499MetGly: 1.499 ± 0.027	0.495MetHis: 0.495 ± 0.015	1.367MetIle: 1.367 ± 0.024	0.932MetLys: 0.932 ± 0.023	2.38MetLeu: 2.38 ± 0.031	0.627MetMet: 0.627 ± 0.018	0.89MetAsn: 0.89 ± 0.019	1.423MetPro: 1.423 ± 0.028	1.011MetGln: 1.011 ± 0.017	1.527MetArg: 1.527 ± 0.028	1.667MetSer: 1.667 ± 0.026	1.594MetThr: 1.594 ± 0.029	1.521MetVal: 1.521 ± 0.027	0.247MetTrp: 0.247 ± 0.01	0.368MetTyr: 0.368 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.292AsnAla: 3.292 ± 0.044	0.345AsnCys: 0.345 ± 0.013	2.384AsnAsp: 2.384 ± 0.055	2.1AsnGlu: 2.1 ± 0.025	0.986AsnPhe: 0.986 ± 0.024	2.976AsnGly: 2.976 ± 0.065	0.824AsnHis: 0.824 ± 0.017	1.327AsnIle: 1.327 ± 0.026	0.827AsnLys: 0.827 ± 0.018	2.921AsnLeu: 2.921 ± 0.042	0.563AsnMet: 0.563 ± 0.016	1.108AsnAsn: 1.108 ± 0.035	2.106AsnPro: 2.106 ± 0.034	1.51AsnGln: 1.51 ± 0.027	2.375AsnArg: 2.375 ± 0.033	2.1AsnSer: 2.1 ± 0.042	1.683AsnThr: 1.683 ± 0.033	2.547AsnVal: 2.547 ± 0.043	0.507AsnTrp: 0.507 ± 0.015	0.761AsnTyr: 0.761 ± 0.016	0.001AsnXaa: 0.001 ± 0.001
Pro	4.85ProAla: 4.85 ± 0.066	0.402ProCys: 0.402 ± 0.012	3.644ProAsp: 3.644 ± 0.041	3.578ProGlu: 3.578 ± 0.041	1.73ProPhe: 1.73 ± 0.026	3.841ProGly: 3.841 ± 0.043	1.085ProHis: 1.085 ± 0.023	2.829ProIle: 2.829 ± 0.035	1.816ProLys: 1.816 ± 0.031	4.389ProLeu: 4.389 ± 0.043	1.238ProMet: 1.238 ± 0.024	1.874ProAsn: 1.874 ± 0.028	2.818ProPro: 2.818 ± 0.045	1.98ProGln: 1.98 ± 0.029	2.649ProArg: 2.649 ± 0.036	3.8ProSer: 3.8 ± 0.046	3.377ProThr: 3.377 ± 0.042	3.717ProVal: 3.717 ± 0.037	0.678ProTrp: 0.678 ± 0.019	1.088ProTyr: 1.088 ± 0.023	0.003ProXaa: 0.003 ± 0.001
Gln	3.736GlnAla: 3.736 ± 0.044	0.495GlnCys: 0.495 ± 0.015	1.964GlnAsp: 1.964 ± 0.026	1.809GlnGlu: 1.809 ± 0.029	1.602GlnPhe: 1.602 ± 0.028	2.318GlnGly: 2.318 ± 0.031	0.994GlnHis: 0.994 ± 0.021	2.345GlnIle: 2.345 ± 0.029	1.267GlnLys: 1.267 ± 0.026	4.491GlnLeu: 4.491 ± 0.046	1.05GlnMet: 1.05 ± 0.025	1.334GlnAsn: 1.334 ± 0.02	2.394GlnPro: 2.394 ± 0.034	2.32GlnGln: 2.32 ± 0.043	3.389GlnArg: 3.389 ± 0.045	3.44GlnSer: 3.44 ± 0.038	2.612GlnThr: 2.612 ± 0.034	2.698GlnVal: 2.698 ± 0.032	0.923GlnTrp: 0.923 ± 0.021	1.032GlnTyr: 1.032 ± 0.021	0.001GlnXaa: 0.001 ± 0.001
Arg	4.589ArgAla: 4.589 ± 0.051	0.839ArgCys: 0.839 ± 0.021	4.073ArgAsp: 4.073 ± 0.047	3.865ArgGlu: 3.865 ± 0.048	2.99ArgPhe: 2.99 ± 0.039	4.13ArgGly: 4.13 ± 0.041	1.474ArgHis: 1.474 ± 0.024	3.606ArgIle: 3.606 ± 0.043	2.242ArgLys: 2.242 ± 0.039	7.133ArgLeu: 7.133 ± 0.067	1.834ArgMet: 1.834 ± 0.031	2.129ArgAsn: 2.129 ± 0.028	3.058ArgPro: 3.058 ± 0.041	2.944ArgGln: 2.944 ± 0.041	5.097ArgArg: 5.097 ± 0.068	4.483ArgSer: 4.483 ± 0.047	3.206ArgThr: 3.206 ± 0.041	4.78ArgVal: 4.78 ± 0.047	1.285ArgTrp: 1.285 ± 0.025	1.909ArgTyr: 1.909 ± 0.028	0.002ArgXaa: 0.002 ± 0.001
Ser	6.022SerAla: 6.022 ± 0.057	0.663SerCys: 0.663 ± 0.019	5.142SerAsp: 5.142 ± 0.054	4.229SerGlu: 4.229 ± 0.05	2.505SerPhe: 2.505 ± 0.035	6.443SerGly: 6.443 ± 0.087	1.505SerHis: 1.505 ± 0.026	3.835SerIle: 3.835 ± 0.046	2.186SerLys: 2.186 ± 0.033	6.9SerLeu: 6.9 ± 0.053	1.612SerMet: 1.612 ± 0.028	2.326SerAsn: 2.326 ± 0.035	3.841SerPro: 3.841 ± 0.044	2.91SerGln: 2.91 ± 0.036	4.359SerArg: 4.359 ± 0.053	4.962SerSer: 4.962 ± 0.066	4.028SerThr: 4.028 ± 0.064	5.411SerVal: 5.411 ± 0.064	0.913SerTrp: 0.913 ± 0.02	1.428SerTyr: 1.428 ± 0.025	0.003SerXaa: 0.003 ± 0.002
Thr	5.527ThrAla: 5.527 ± 0.06	0.549ThrCys: 0.549 ± 0.016	3.846ThrAsp: 3.846 ± 0.057	3.14ThrGlu: 3.14 ± 0.043	2.099ThrPhe: 2.099 ± 0.047	4.808ThrGly: 4.808 ± 0.072	1.185ThrHis: 1.185 ± 0.022	3.452ThrIle: 3.452 ± 0.061	1.794ThrLys: 1.794 ± 0.029	5.882ThrLeu: 5.882 ± 0.061	1.246ThrMet: 1.246 ± 0.021	1.906ThrAsn: 1.906 ± 0.037	3.538ThrPro: 3.538 ± 0.04	2.39ThrGln: 2.39 ± 0.03	3.322ThrArg: 3.322 ± 0.039	3.817ThrSer: 3.817 ± 0.061	3.544ThrThr: 3.544 ± 0.08	4.53ThrVal: 4.53 ± 0.076	0.789ThrTrp: 0.789 ± 0.019	1.296ThrTyr: 1.296 ± 0.029	0.003ThrXaa: 0.003 ± 0.001
Val	7.501ValAla: 7.501 ± 0.057	0.918ValCys: 0.918 ± 0.024	5.1ValAsp: 5.1 ± 0.063	3.967ValGlu: 3.967 ± 0.045	2.753ValPhe: 2.753 ± 0.037	5.288ValGly: 5.288 ± 0.051	1.424ValHis: 1.424 ± 0.025	3.914ValIle: 3.914 ± 0.043	2.013ValLys: 2.013 ± 0.033	6.623ValLeu: 6.623 ± 0.053	1.595ValMet: 1.595 ± 0.03	2.326ValAsn: 2.326 ± 0.048	3.535ValPro: 3.535 ± 0.042	2.632ValGln: 2.632 ± 0.033	4.599ValArg: 4.599 ± 0.043	5.199ValSer: 5.199 ± 0.06	4.6ValThr: 4.6 ± 0.084	5.681ValVal: 5.681 ± 0.065	0.966ValTrp: 0.966 ± 0.019	1.624ValTyr: 1.624 ± 0.027	0.004ValXaa: 0.004 ± 0.001
Trp	0.992TrpAla: 0.992 ± 0.02	0.207TrpCys: 0.207 ± 0.01	0.811TrpAsp: 0.811 ± 0.02	0.645TrpGlu: 0.645 ± 0.018	0.575TrpPhe: 0.575 ± 0.017	0.873TrpGly: 0.873 ± 0.017	0.395TrpHis: 0.395 ± 0.014	0.899TrpIle: 0.899 ± 0.019	0.583TrpLys: 0.583 ± 0.017	1.664TrpLeu: 1.664 ± 0.033	0.457TrpMet: 0.457 ± 0.012	0.569TrpAsn: 0.569 ± 0.017	0.666TrpPro: 0.666 ± 0.018	0.785TrpGln: 0.785 ± 0.021	1.017TrpArg: 1.017 ± 0.022	1.073TrpSer: 1.073 ± 0.022	0.921TrpThr: 0.921 ± 0.021	0.901TrpVal: 0.901 ± 0.019	0.275TrpTrp: 0.275 ± 0.012	0.356TrpTyr: 0.356 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.065TyrAla: 2.065 ± 0.027	0.302TyrCys: 0.302 ± 0.011	1.59TyrAsp: 1.59 ± 0.035	1.413TyrGlu: 1.413 ± 0.023	1.002TyrPhe: 1.002 ± 0.021	1.832TyrGly: 1.832 ± 0.033	0.603TyrHis: 0.603 ± 0.017	0.777TyrIle: 0.777 ± 0.017	0.56TyrLys: 0.56 ± 0.015	2.29TyrLeu: 2.29 ± 0.031	0.368TyrMet: 0.368 ± 0.011	0.66TyrAsn: 0.66 ± 0.018	1.085TyrPro: 1.085 ± 0.023	1.137TyrGln: 1.137 ± 0.022	2.029TyrArg: 2.029 ± 0.032	1.447TyrSer: 1.447 ± 0.025	1.126TyrThr: 1.126 ± 0.033	1.588TyrVal: 1.588 ± 0.022	0.405TyrTrp: 0.405 ± 0.013	0.653TyrTyr: 0.653 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.004XaaSer: 0.004 ± 0.002	0.003XaaThr: 0.003 ± 0.001	0.004XaaVal: 0.004 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.017XaaXaa: 0.017 ± 0.006

Statistics based on 6986 proteins (2762882 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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