Amino acid dipepetide frequency for Streptococcus phage phi-SsuFJNP9_rum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.007AlaAla: 4.007 ± 0.885
0.406AlaCys: 0.406 ± 0.146
3.949AlaAsp: 3.949 ± 0.684
5.226AlaGlu: 5.226 ± 0.577
3.31AlaPhe: 3.31 ± 0.373
4.007AlaGly: 4.007 ± 0.501
0.523AlaHis: 0.523 ± 0.181
5.691AlaIle: 5.691 ± 0.697
5.807AlaLys: 5.807 ± 0.428
5.633AlaLeu: 5.633 ± 0.62
1.568AlaMet: 1.568 ± 0.255
3.6AlaAsn: 3.6 ± 0.494
1.278AlaPro: 1.278 ± 0.305
2.555AlaGln: 2.555 ± 0.567
2.323AlaArg: 2.323 ± 0.325
4.007AlaSer: 4.007 ± 0.52
4.007AlaThr: 4.007 ± 0.695
3.658AlaVal: 3.658 ± 0.557
0.813AlaTrp: 0.813 ± 0.273
2.671AlaTyr: 2.671 ± 0.339
0.0AlaXaa: 0.0 ± 0.0
Cys
0.465CysAla: 0.465 ± 0.173
0.174CysCys: 0.174 ± 0.092
0.29CysAsp: 0.29 ± 0.122
0.465CysGlu: 0.465 ± 0.169
0.174CysPhe: 0.174 ± 0.097
0.813CysGly: 0.813 ± 0.199
0.116CysHis: 0.116 ± 0.076
0.29CysIle: 0.29 ± 0.126
0.929CysLys: 0.929 ± 0.297
0.523CysLeu: 0.523 ± 0.18
0.174CysMet: 0.174 ± 0.1
0.465CysAsn: 0.465 ± 0.181
0.523CysPro: 0.523 ± 0.175
0.697CysGln: 0.697 ± 0.206
0.581CysArg: 0.581 ± 0.184
0.639CysSer: 0.639 ± 0.221
0.058CysThr: 0.058 ± 0.064
0.697CysVal: 0.697 ± 0.219
0.0CysTrp: 0.0 ± 0.0
0.697CysTyr: 0.697 ± 0.222
0.0CysXaa: 0.0 ± 0.0
Asp
3.252AspAla: 3.252 ± 0.393
0.639AspCys: 0.639 ± 0.201
3.194AspAsp: 3.194 ± 0.517
5.284AspGlu: 5.284 ± 0.598
3.368AspPhe: 3.368 ± 0.384
5.633AspGly: 5.633 ± 0.469
0.639AspHis: 0.639 ± 0.177
4.704AspIle: 4.704 ± 0.468
3.6AspLys: 3.6 ± 0.378
4.878AspLeu: 4.878 ± 0.628
1.8AspMet: 1.8 ± 0.312
3.02AspAsn: 3.02 ± 0.429
1.568AspPro: 1.568 ± 0.3
1.742AspGln: 1.742 ± 0.33
2.149AspArg: 2.149 ± 0.394
3.31AspSer: 3.31 ± 0.477
2.439AspThr: 2.439 ± 0.373
2.613AspVal: 2.613 ± 0.398
0.639AspTrp: 0.639 ± 0.216
3.02AspTyr: 3.02 ± 0.432
0.0AspXaa: 0.0 ± 0.0
Glu
4.529GluAla: 4.529 ± 0.498
0.697GluCys: 0.697 ± 0.211
4.355GluAsp: 4.355 ± 0.493
6.388GluGlu: 6.388 ± 0.861
2.962GluPhe: 2.962 ± 0.416
4.123GluGly: 4.123 ± 0.42
1.103GluHis: 1.103 ± 0.254
5.052GluIle: 5.052 ± 0.635
6.852GluLys: 6.852 ± 0.714
8.478GluLeu: 8.478 ± 0.721
2.381GluMet: 2.381 ± 0.458
4.239GluAsn: 4.239 ± 0.53
1.394GluPro: 1.394 ± 0.315
4.355GluGln: 4.355 ± 0.427
3.194GluArg: 3.194 ± 0.408
4.123GluSer: 4.123 ± 0.474
4.704GluThr: 4.704 ± 0.447
4.181GluVal: 4.181 ± 0.469
0.755GluTrp: 0.755 ± 0.201
2.497GluTyr: 2.497 ± 0.506
0.0GluXaa: 0.0 ± 0.0
Phe
2.613PheAla: 2.613 ± 0.509
0.581PheCys: 0.581 ± 0.17
2.787PheAsp: 2.787 ± 0.431
3.484PheGlu: 3.484 ± 0.469
1.742PhePhe: 1.742 ± 0.331
2.671PheGly: 2.671 ± 0.354
0.871PheHis: 0.871 ± 0.196
3.02PheIle: 3.02 ± 0.415
2.845PheLys: 2.845 ± 0.435
3.542PheLeu: 3.542 ± 0.575
0.871PheMet: 0.871 ± 0.216
2.207PheAsn: 2.207 ± 0.281
0.929PhePro: 0.929 ± 0.255
1.452PheGln: 1.452 ± 0.317
1.858PheArg: 1.858 ± 0.296
2.439PheSer: 2.439 ± 0.36
2.439PheThr: 2.439 ± 0.463
2.671PheVal: 2.671 ± 0.431
0.697PheTrp: 0.697 ± 0.181
2.323PheTyr: 2.323 ± 0.352
0.0PheXaa: 0.0 ± 0.0
Gly
3.368GlyAla: 3.368 ± 0.481
0.406GlyCys: 0.406 ± 0.163
3.484GlyAsp: 3.484 ± 0.595
3.949GlyGlu: 3.949 ± 0.477
3.136GlyPhe: 3.136 ± 0.433
3.136GlyGly: 3.136 ± 0.355
1.916GlyHis: 1.916 ± 0.339
5.342GlyIle: 5.342 ± 0.684
4.297GlyLys: 4.297 ± 0.509
5.284GlyLeu: 5.284 ± 0.615
1.742GlyMet: 1.742 ± 0.389
3.6GlyAsn: 3.6 ± 0.513
0.987GlyPro: 0.987 ± 0.347
3.194GlyGln: 3.194 ± 0.416
3.252GlyArg: 3.252 ± 0.381
3.716GlySer: 3.716 ± 0.487
3.949GlyThr: 3.949 ± 0.466
3.774GlyVal: 3.774 ± 0.42
0.639GlyTrp: 0.639 ± 0.191
3.02GlyTyr: 3.02 ± 0.422
0.0GlyXaa: 0.0 ± 0.0
His
0.755HisAla: 0.755 ± 0.153
0.174HisCys: 0.174 ± 0.101
0.987HisAsp: 0.987 ± 0.241
0.987HisGlu: 0.987 ± 0.215
0.929HisPhe: 0.929 ± 0.275
1.394HisGly: 1.394 ± 0.236
0.523HisHis: 0.523 ± 0.195
1.452HisIle: 1.452 ± 0.226
0.929HisLys: 0.929 ± 0.196
1.394HisLeu: 1.394 ± 0.26
0.29HisMet: 0.29 ± 0.117
0.755HisAsn: 0.755 ± 0.165
1.103HisPro: 1.103 ± 0.223
0.871HisGln: 0.871 ± 0.224
1.045HisArg: 1.045 ± 0.221
0.871HisSer: 0.871 ± 0.214
0.987HisThr: 0.987 ± 0.268
1.161HisVal: 1.161 ± 0.261
0.232HisTrp: 0.232 ± 0.119
0.871HisTyr: 0.871 ± 0.199
0.0HisXaa: 0.0 ± 0.0
Ile
5.052IleAla: 5.052 ± 0.571
0.581IleCys: 0.581 ± 0.174
5.458IleAsp: 5.458 ± 0.469
5.284IleGlu: 5.284 ± 0.593
2.497IlePhe: 2.497 ± 0.446
5.168IleGly: 5.168 ± 0.72
1.278IleHis: 1.278 ± 0.273
3.658IleIle: 3.658 ± 0.456
5.11IleLys: 5.11 ± 0.566
6.097IleLeu: 6.097 ± 0.837
1.219IleMet: 1.219 ± 0.244
3.542IleAsn: 3.542 ± 0.415
2.497IlePro: 2.497 ± 0.421
2.671IleGln: 2.671 ± 0.293
2.845IleArg: 2.845 ± 0.368
5.226IleSer: 5.226 ± 0.668
5.11IleThr: 5.11 ± 0.763
4.645IleVal: 4.645 ± 0.648
0.813IleTrp: 0.813 ± 0.271
2.613IleTyr: 2.613 ± 0.418
0.0IleXaa: 0.0 ± 0.0
Lys
5.168LysAla: 5.168 ± 0.547
0.348LysCys: 0.348 ± 0.144
3.716LysAsp: 3.716 ± 0.493
6.039LysGlu: 6.039 ± 0.6
3.252LysPhe: 3.252 ± 0.468
3.833LysGly: 3.833 ± 0.351
1.452LysHis: 1.452 ± 0.267
6.039LysIle: 6.039 ± 0.675
6.213LysLys: 6.213 ± 0.846
6.794LysLeu: 6.794 ± 0.583
2.09LysMet: 2.09 ± 0.336
3.891LysAsn: 3.891 ± 0.555
2.497LysPro: 2.497 ± 0.281
3.136LysGln: 3.136 ± 0.494
3.949LysArg: 3.949 ± 0.66
4.123LysSer: 4.123 ± 0.471
3.833LysThr: 3.833 ± 0.406
4.587LysVal: 4.587 ± 0.546
1.278LysTrp: 1.278 ± 0.289
2.613LysTyr: 2.613 ± 0.431
0.0LysXaa: 0.0 ± 0.0
Leu
6.562LeuAla: 6.562 ± 0.814
0.523LeuCys: 0.523 ± 0.159
5.168LeuAsp: 5.168 ± 0.441
7.723LeuGlu: 7.723 ± 0.739
3.252LeuPhe: 3.252 ± 0.451
4.878LeuGly: 4.878 ± 0.469
1.394LeuHis: 1.394 ± 0.228
5.168LeuIle: 5.168 ± 0.603
6.388LeuLys: 6.388 ± 0.516
7.897LeuLeu: 7.897 ± 1.102
2.032LeuMet: 2.032 ± 0.328
4.239LeuAsn: 4.239 ± 0.509
3.542LeuPro: 3.542 ± 0.496
3.252LeuGln: 3.252 ± 0.468
3.658LeuArg: 3.658 ± 0.404
7.317LeuSer: 7.317 ± 0.679
6.504LeuThr: 6.504 ± 0.577
6.155LeuVal: 6.155 ± 0.685
0.871LeuTrp: 0.871 ± 0.37
3.658LeuTyr: 3.658 ± 0.525
0.0LeuXaa: 0.0 ± 0.0
Met
1.974MetAla: 1.974 ± 0.323
0.232MetCys: 0.232 ± 0.12
1.684MetAsp: 1.684 ± 0.318
1.452MetGlu: 1.452 ± 0.328
0.813MetPhe: 0.813 ± 0.202
1.394MetGly: 1.394 ± 0.316
0.116MetHis: 0.116 ± 0.08
2.207MetIle: 2.207 ± 0.4
1.684MetLys: 1.684 ± 0.274
1.858MetLeu: 1.858 ± 0.319
0.697MetMet: 0.697 ± 0.247
1.045MetAsn: 1.045 ± 0.273
0.755MetPro: 0.755 ± 0.196
0.755MetGln: 0.755 ± 0.213
1.103MetArg: 1.103 ± 0.217
2.207MetSer: 2.207 ± 0.425
1.452MetThr: 1.452 ± 0.333
1.394MetVal: 1.394 ± 0.268
0.29MetTrp: 0.29 ± 0.112
0.348MetTyr: 0.348 ± 0.117
0.0MetXaa: 0.0 ± 0.0
Asn
3.949AsnAla: 3.949 ± 0.601
0.581AsnCys: 0.581 ± 0.157
2.265AsnAsp: 2.265 ± 0.383
2.962AsnGlu: 2.962 ± 0.526
2.381AsnPhe: 2.381 ± 0.377
4.181AsnGly: 4.181 ± 0.516
1.336AsnHis: 1.336 ± 0.269
3.252AsnIle: 3.252 ± 0.398
3.716AsnLys: 3.716 ± 0.524
4.587AsnLeu: 4.587 ± 0.787
0.987AsnMet: 0.987 ± 0.24
2.787AsnAsn: 2.787 ± 0.537
2.265AsnPro: 2.265 ± 0.349
2.265AsnGln: 2.265 ± 0.36
2.613AsnArg: 2.613 ± 0.31
2.845AsnSer: 2.845 ± 0.385
1.916AsnThr: 1.916 ± 0.464
3.136AsnVal: 3.136 ± 0.505
1.045AsnTrp: 1.045 ± 0.263
1.568AsnTyr: 1.568 ± 0.281
0.0AsnXaa: 0.0 ± 0.0
Pro
1.51ProAla: 1.51 ± 0.237
0.29ProCys: 0.29 ± 0.135
2.265ProAsp: 2.265 ± 0.372
2.497ProGlu: 2.497 ± 0.354
1.336ProPhe: 1.336 ± 0.273
0.871ProGly: 0.871 ± 0.22
0.697ProHis: 0.697 ± 0.199
1.684ProIle: 1.684 ± 0.287
2.439ProLys: 2.439 ± 0.353
3.02ProLeu: 3.02 ± 0.381
0.465ProMet: 0.465 ± 0.155
1.684ProAsn: 1.684 ± 0.314
0.871ProPro: 0.871 ± 0.238
0.871ProGln: 0.871 ± 0.259
1.742ProArg: 1.742 ± 0.266
2.265ProSer: 2.265 ± 0.411
2.265ProThr: 2.265 ± 0.474
2.207ProVal: 2.207 ± 0.434
0.29ProTrp: 0.29 ± 0.123
1.452ProTyr: 1.452 ± 0.336
0.0ProXaa: 0.0 ± 0.0
Gln
3.833GlnAla: 3.833 ± 0.587
0.406GlnCys: 0.406 ± 0.154
1.8GlnAsp: 1.8 ± 0.316
3.02GlnGlu: 3.02 ± 0.456
1.858GlnPhe: 1.858 ± 0.322
2.149GlnGly: 2.149 ± 0.35
0.639GlnHis: 0.639 ± 0.131
2.729GlnIle: 2.729 ± 0.419
3.136GlnLys: 3.136 ± 0.478
4.297GlnLeu: 4.297 ± 0.497
1.219GlnMet: 1.219 ± 0.273
1.858GlnAsn: 1.858 ± 0.401
1.278GlnPro: 1.278 ± 0.276
1.626GlnGln: 1.626 ± 0.295
1.742GlnArg: 1.742 ± 0.344
2.555GlnSer: 2.555 ± 0.398
2.787GlnThr: 2.787 ± 0.707
3.542GlnVal: 3.542 ± 0.476
0.697GlnTrp: 0.697 ± 0.226
0.929GlnTyr: 0.929 ± 0.266
0.0GlnXaa: 0.0 ± 0.0
Arg
2.381ArgAla: 2.381 ± 0.401
0.523ArgCys: 0.523 ± 0.151
2.613ArgAsp: 2.613 ± 0.386
3.716ArgGlu: 3.716 ± 0.402
1.51ArgPhe: 1.51 ± 0.297
2.555ArgGly: 2.555 ± 0.364
0.929ArgHis: 0.929 ± 0.212
3.716ArgIle: 3.716 ± 0.58
4.065ArgLys: 4.065 ± 0.664
4.355ArgLeu: 4.355 ± 0.443
0.813ArgMet: 0.813 ± 0.209
2.323ArgAsn: 2.323 ± 0.295
1.51ArgPro: 1.51 ± 0.252
2.323ArgGln: 2.323 ± 0.394
1.452ArgArg: 1.452 ± 0.246
2.323ArgSer: 2.323 ± 0.312
2.555ArgThr: 2.555 ± 0.53
2.729ArgVal: 2.729 ± 0.431
0.813ArgTrp: 0.813 ± 0.254
1.568ArgTyr: 1.568 ± 0.403
0.0ArgXaa: 0.0 ± 0.0
Ser
4.181SerAla: 4.181 ± 0.447
0.465SerCys: 0.465 ± 0.151
3.774SerAsp: 3.774 ± 0.476
4.123SerGlu: 4.123 ± 0.537
2.613SerPhe: 2.613 ± 0.447
4.471SerGly: 4.471 ± 0.515
1.103SerHis: 1.103 ± 0.229
4.878SerIle: 4.878 ± 0.536
4.645SerLys: 4.645 ± 0.481
4.936SerLeu: 4.936 ± 0.506
1.394SerMet: 1.394 ± 0.243
3.252SerAsn: 3.252 ± 0.437
2.149SerPro: 2.149 ± 0.39
2.903SerGln: 2.903 ± 0.525
3.31SerArg: 3.31 ± 0.433
4.878SerSer: 4.878 ± 0.729
4.355SerThr: 4.355 ± 0.444
3.949SerVal: 3.949 ± 0.526
1.278SerTrp: 1.278 ± 0.223
2.555SerTyr: 2.555 ± 0.397
0.0SerXaa: 0.0 ± 0.0
Thr
4.007ThrAla: 4.007 ± 0.539
0.174ThrCys: 0.174 ± 0.113
2.903ThrAsp: 2.903 ± 0.505
4.645ThrGlu: 4.645 ± 0.561
2.09ThrPhe: 2.09 ± 0.45
4.181ThrGly: 4.181 ± 0.578
0.929ThrHis: 0.929 ± 0.235
4.936ThrIle: 4.936 ± 0.662
4.355ThrLys: 4.355 ± 0.401
5.517ThrLeu: 5.517 ± 0.452
1.219ThrMet: 1.219 ± 0.239
2.787ThrAsn: 2.787 ± 0.448
2.032ThrPro: 2.032 ± 0.309
2.09ThrGln: 2.09 ± 0.556
1.974ThrArg: 1.974 ± 0.436
4.878ThrSer: 4.878 ± 0.628
4.645ThrThr: 4.645 ± 0.585
5.342ThrVal: 5.342 ± 0.622
0.755ThrTrp: 0.755 ± 0.216
2.381ThrTyr: 2.381 ± 0.459
0.0ThrXaa: 0.0 ± 0.0
Val
4.297ValAla: 4.297 ± 0.596
0.639ValCys: 0.639 ± 0.201
3.368ValAsp: 3.368 ± 0.521
5.284ValGlu: 5.284 ± 0.635
2.497ValPhe: 2.497 ± 0.386
3.426ValGly: 3.426 ± 0.463
0.929ValHis: 0.929 ± 0.204
3.833ValIle: 3.833 ± 0.453
4.471ValLys: 4.471 ± 0.495
6.213ValLeu: 6.213 ± 0.497
1.045ValMet: 1.045 ± 0.231
2.439ValAsn: 2.439 ± 0.403
1.974ValPro: 1.974 ± 0.245
2.497ValGln: 2.497 ± 0.368
3.31ValArg: 3.31 ± 0.647
4.239ValSer: 4.239 ± 0.541
4.762ValThr: 4.762 ± 0.566
3.542ValVal: 3.542 ± 0.417
1.045ValTrp: 1.045 ± 0.227
2.787ValTyr: 2.787 ± 0.491
0.0ValXaa: 0.0 ± 0.0
Trp
0.871TrpAla: 0.871 ± 0.227
0.174TrpCys: 0.174 ± 0.094
0.406TrpAsp: 0.406 ± 0.15
1.161TrpGlu: 1.161 ± 0.312
1.045TrpPhe: 1.045 ± 0.437
0.697TrpGly: 0.697 ± 0.177
0.29TrpHis: 0.29 ± 0.114
0.987TrpIle: 0.987 ± 0.257
0.639TrpLys: 0.639 ± 0.274
0.929TrpLeu: 0.929 ± 0.237
0.348TrpMet: 0.348 ± 0.129
1.336TrpAsn: 1.336 ± 0.307
0.116TrpPro: 0.116 ± 0.082
0.755TrpGln: 0.755 ± 0.224
0.639TrpArg: 0.639 ± 0.241
0.755TrpSer: 0.755 ± 0.252
1.103TrpThr: 1.103 ± 0.266
0.697TrpVal: 0.697 ± 0.206
0.348TrpTrp: 0.348 ± 0.152
0.348TrpTyr: 0.348 ± 0.134
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.265TyrAla: 2.265 ± 0.332
0.755TyrCys: 0.755 ± 0.269
3.02TyrAsp: 3.02 ± 0.472
2.671TyrGlu: 2.671 ± 0.423
1.278TyrPhe: 1.278 ± 0.278
2.671TyrGly: 2.671 ± 0.525
0.929TyrHis: 0.929 ± 0.255
2.729TyrIle: 2.729 ± 0.367
2.729TyrLys: 2.729 ± 0.462
3.949TyrLeu: 3.949 ± 0.448
1.045TyrMet: 1.045 ± 0.235
1.568TyrAsn: 1.568 ± 0.284
1.452TyrPro: 1.452 ± 0.312
2.09TyrGln: 2.09 ± 0.311
2.032TyrArg: 2.032 ± 0.277
2.497TyrSer: 2.497 ± 0.42
1.974TyrThr: 1.974 ± 0.382
1.916TyrVal: 1.916 ± 0.232
0.348TyrTrp: 0.348 ± 0.132
1.103TyrTyr: 1.103 ± 0.253
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (17222 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski