Amino acid dipepetide frequency for Vibrio phage V07

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.138AlaAla: 6.138 ± 0.377
0.793AlaCys: 0.793 ± 0.11
4.429AlaAsp: 4.429 ± 0.242
5.808AlaGlu: 5.808 ± 0.281
2.871AlaPhe: 2.871 ± 0.205
4.429AlaGly: 4.429 ± 0.28
1.332AlaHis: 1.332 ± 0.109
4.911AlaIle: 4.911 ± 0.212
4.901AlaLys: 4.901 ± 0.275
6.129AlaLeu: 6.129 ± 0.265
2.314AlaMet: 2.314 ± 0.161
3.456AlaAsn: 3.456 ± 0.163
2.408AlaPro: 2.408 ± 0.183
2.842AlaGln: 2.842 ± 0.201
3.862AlaArg: 3.862 ± 0.178
4.193AlaSer: 4.193 ± 0.19
4.863AlaThr: 4.863 ± 0.244
4.977AlaVal: 4.977 ± 0.234
0.954AlaTrp: 0.954 ± 0.093
2.757AlaTyr: 2.757 ± 0.176
0.0AlaXaa: 0.0 ± 0.0
Cys
0.765CysAla: 0.765 ± 0.087
0.189CysCys: 0.189 ± 0.042
0.963CysAsp: 0.963 ± 0.089
0.869CysGlu: 0.869 ± 0.111
0.368CysPhe: 0.368 ± 0.057
0.963CysGly: 0.963 ± 0.104
0.406CysHis: 0.406 ± 0.065
0.68CysIle: 0.68 ± 0.079
0.954CysLys: 0.954 ± 0.088
0.718CysLeu: 0.718 ± 0.093
0.302CysMet: 0.302 ± 0.058
0.614CysAsn: 0.614 ± 0.07
0.387CysPro: 0.387 ± 0.062
0.406CysGln: 0.406 ± 0.07
0.67CysArg: 0.67 ± 0.086
0.689CysSer: 0.689 ± 0.097
0.652CysThr: 0.652 ± 0.078
0.737CysVal: 0.737 ± 0.089
0.161CysTrp: 0.161 ± 0.044
0.453CysTyr: 0.453 ± 0.069
0.0CysXaa: 0.0 ± 0.0
Asp
4.703AspAla: 4.703 ± 0.223
0.822AspCys: 0.822 ± 0.089
4.608AspAsp: 4.608 ± 0.22
5.203AspGlu: 5.203 ± 0.256
3.003AspPhe: 3.003 ± 0.186
5.213AspGly: 5.213 ± 0.273
1.369AspHis: 1.369 ± 0.112
4.486AspIle: 4.486 ± 0.22
4.174AspLys: 4.174 ± 0.219
4.514AspLeu: 4.514 ± 0.199
2.011AspMet: 2.011 ± 0.155
3.192AspAsn: 3.192 ± 0.176
2.427AspPro: 2.427 ± 0.148
1.7AspGln: 1.7 ± 0.141
2.663AspArg: 2.663 ± 0.141
3.617AspSer: 3.617 ± 0.19
3.362AspThr: 3.362 ± 0.18
4.646AspVal: 4.646 ± 0.244
1.341AspTrp: 1.341 ± 0.128
3.012AspTyr: 3.012 ± 0.199
0.0AspXaa: 0.0 ± 0.0
Glu
5.94GluAla: 5.94 ± 0.278
0.793GluCys: 0.793 ± 0.097
3.853GluAsp: 3.853 ± 0.218
5.449GluGlu: 5.449 ± 0.327
3.475GluPhe: 3.475 ± 0.198
3.343GluGly: 3.343 ± 0.174
1.945GluHis: 1.945 ± 0.147
5.232GluIle: 5.232 ± 0.246
4.844GluLys: 4.844 ± 0.282
7.243GluLeu: 7.243 ± 0.295
2.191GluMet: 2.191 ± 0.148
3.352GluAsn: 3.352 ± 0.181
1.851GluPro: 1.851 ± 0.163
3.126GluGln: 3.126 ± 0.18
4.287GluArg: 4.287 ± 0.219
3.522GluSer: 3.522 ± 0.199
4.306GluThr: 4.306 ± 0.213
4.826GluVal: 4.826 ± 0.211
1.001GluTrp: 1.001 ± 0.1
3.164GluTyr: 3.164 ± 0.178
0.0GluXaa: 0.0 ± 0.0
Phe
3.05PheAla: 3.05 ± 0.168
0.416PheCys: 0.416 ± 0.061
3.768PheAsp: 3.768 ± 0.184
3.003PheGlu: 3.003 ± 0.159
1.445PhePhe: 1.445 ± 0.123
2.88PheGly: 2.88 ± 0.163
0.859PheHis: 0.859 ± 0.107
2.701PheIle: 2.701 ± 0.196
2.842PheLys: 2.842 ± 0.162
2.351PheLeu: 2.351 ± 0.159
1.379PheMet: 1.379 ± 0.11
2.446PheAsn: 2.446 ± 0.162
1.237PhePro: 1.237 ± 0.099
1.275PheGln: 1.275 ± 0.12
1.662PheArg: 1.662 ± 0.133
2.417PheSer: 2.417 ± 0.154
2.559PheThr: 2.559 ± 0.186
2.861PheVal: 2.861 ± 0.174
0.623PheTrp: 0.623 ± 0.085
1.492PheTyr: 1.492 ± 0.126
0.0PheXaa: 0.0 ± 0.0
Gly
4.533GlyAla: 4.533 ± 0.271
1.029GlyCys: 1.029 ± 0.107
4.24GlyAsp: 4.24 ± 0.27
4.174GlyGlu: 4.174 ± 0.207
2.805GlyPhe: 2.805 ± 0.173
4.854GlyGly: 4.854 ± 0.316
1.247GlyHis: 1.247 ± 0.138
4.08GlyIle: 4.08 ± 0.214
4.259GlyLys: 4.259 ± 0.213
4.353GlyLeu: 4.353 ± 0.227
1.851GlyMet: 1.851 ± 0.12
3.532GlyAsn: 3.532 ± 0.263
0.859GlyPro: 0.859 ± 0.101
2.37GlyGln: 2.37 ± 0.17
2.909GlyArg: 2.909 ± 0.162
4.41GlySer: 4.41 ± 0.278
4.136GlyThr: 4.136 ± 0.287
4.826GlyVal: 4.826 ± 0.234
1.133GlyTrp: 1.133 ± 0.115
2.72GlyTyr: 2.72 ± 0.162
0.0GlyXaa: 0.0 ± 0.0
His
1.804HisAla: 1.804 ± 0.132
0.34HisCys: 0.34 ± 0.055
1.52HisAsp: 1.52 ± 0.147
1.577HisGlu: 1.577 ± 0.163
1.067HisPhe: 1.067 ± 0.1
1.483HisGly: 1.483 ± 0.132
0.51HisHis: 0.51 ± 0.077
1.501HisIle: 1.501 ± 0.127
1.265HisLys: 1.265 ± 0.121
1.596HisLeu: 1.596 ± 0.121
0.614HisMet: 0.614 ± 0.083
1.048HisAsn: 1.048 ± 0.103
1.048HisPro: 1.048 ± 0.111
0.585HisGln: 0.585 ± 0.076
0.878HisArg: 0.878 ± 0.104
1.209HisSer: 1.209 ± 0.122
1.398HisThr: 1.398 ± 0.128
1.785HisVal: 1.785 ± 0.135
0.321HisTrp: 0.321 ± 0.055
1.02HisTyr: 1.02 ± 0.103
0.0HisXaa: 0.0 ± 0.0
Ile
4.986IleAla: 4.986 ± 0.216
0.642IleCys: 0.642 ± 0.071
5.137IleAsp: 5.137 ± 0.221
5.723IleGlu: 5.723 ± 0.252
2.248IlePhe: 2.248 ± 0.147
3.806IleGly: 3.806 ± 0.204
1.294IleHis: 1.294 ± 0.116
3.645IleIle: 3.645 ± 0.213
4.287IleLys: 4.287 ± 0.187
3.56IleLeu: 3.56 ± 0.209
1.738IleMet: 1.738 ± 0.131
3.588IleAsn: 3.588 ± 0.191
2.484IlePro: 2.484 ± 0.193
2.096IleGln: 2.096 ± 0.151
2.88IleArg: 2.88 ± 0.192
3.447IleSer: 3.447 ± 0.179
3.711IleThr: 3.711 ± 0.204
4.504IleVal: 4.504 ± 0.21
0.576IleTrp: 0.576 ± 0.088
1.823IleTyr: 1.823 ± 0.121
0.0IleXaa: 0.0 ± 0.0
Lys
5.383LysAla: 5.383 ± 0.28
0.614LysCys: 0.614 ± 0.085
3.862LysAsp: 3.862 ± 0.199
4.646LysGlu: 4.646 ± 0.237
2.701LysPhe: 2.701 ± 0.152
3.532LysGly: 3.532 ± 0.195
1.738LysHis: 1.738 ± 0.14
3.825LysIle: 3.825 ± 0.169
4.731LysLys: 4.731 ± 0.281
5.515LysLeu: 5.515 ± 0.251
2.219LysMet: 2.219 ± 0.151
2.72LysAsn: 2.72 ± 0.147
2.512LysPro: 2.512 ± 0.178
2.937LysGln: 2.937 ± 0.179
3.862LysArg: 3.862 ± 0.187
3.456LysSer: 3.456 ± 0.167
3.74LysThr: 3.74 ± 0.197
4.457LysVal: 4.457 ± 0.195
0.973LysTrp: 0.973 ± 0.108
2.739LysTyr: 2.739 ± 0.171
0.0LysXaa: 0.0 ± 0.0
Leu
5.713LeuAla: 5.713 ± 0.256
0.935LeuCys: 0.935 ± 0.106
5.279LeuAsp: 5.279 ± 0.252
5.893LeuGlu: 5.893 ± 0.274
2.663LeuPhe: 2.663 ± 0.17
4.693LeuGly: 4.693 ± 0.231
1.69LeuHis: 1.69 ± 0.11
3.928LeuIle: 3.928 ± 0.231
4.759LeuLys: 4.759 ± 0.206
5.477LeuLeu: 5.477 ± 0.282
2.266LeuMet: 2.266 ± 0.159
4.155LeuAsn: 4.155 ± 0.196
3.22LeuPro: 3.22 ± 0.175
2.531LeuGln: 2.531 ± 0.162
4.438LeuArg: 4.438 ± 0.183
4.759LeuSer: 4.759 ± 0.212
4.627LeuThr: 4.627 ± 0.17
4.438LeuVal: 4.438 ± 0.198
0.869LeuTrp: 0.869 ± 0.076
2.937LeuTyr: 2.937 ± 0.169
0.0LeuXaa: 0.0 ± 0.0
Met
1.775MetAla: 1.775 ± 0.127
0.472MetCys: 0.472 ± 0.076
1.19MetAsp: 1.19 ± 0.11
1.492MetGlu: 1.492 ± 0.14
1.228MetPhe: 1.228 ± 0.111
1.445MetGly: 1.445 ± 0.112
0.661MetHis: 0.661 ± 0.073
1.813MetIle: 1.813 ± 0.14
2.436MetLys: 2.436 ± 0.17
2.163MetLeu: 2.163 ± 0.161
0.888MetMet: 0.888 ± 0.091
1.785MetAsn: 1.785 ± 0.15
1.18MetPro: 1.18 ± 0.105
1.313MetGln: 1.313 ± 0.111
1.294MetArg: 1.294 ± 0.114
2.436MetSer: 2.436 ± 0.134
2.002MetThr: 2.002 ± 0.137
1.294MetVal: 1.294 ± 0.124
0.264MetTrp: 0.264 ± 0.051
1.01MetTyr: 1.01 ± 0.105
0.0MetXaa: 0.0 ± 0.0
Asn
3.796AsnAla: 3.796 ± 0.225
0.519AsnCys: 0.519 ± 0.072
3.145AsnAsp: 3.145 ± 0.171
3.485AsnGlu: 3.485 ± 0.193
2.04AsnPhe: 2.04 ± 0.137
4.249AsnGly: 4.249 ± 0.268
1.105AsnHis: 1.105 ± 0.106
3.428AsnIle: 3.428 ± 0.185
3.381AsnLys: 3.381 ± 0.208
3.655AsnLeu: 3.655 ± 0.178
1.162AsnMet: 1.162 ± 0.105
2.739AsnAsn: 2.739 ± 0.184
2.295AsnPro: 2.295 ± 0.159
1.69AsnGln: 1.69 ± 0.137
2.512AsnArg: 2.512 ± 0.13
2.786AsnSer: 2.786 ± 0.179
2.767AsnThr: 2.767 ± 0.17
3.494AsnVal: 3.494 ± 0.221
0.746AsnTrp: 0.746 ± 0.085
2.068AsnTyr: 2.068 ± 0.144
0.0AsnXaa: 0.0 ± 0.0
Pro
2.172ProAla: 2.172 ± 0.155
0.425ProCys: 0.425 ± 0.06
2.484ProAsp: 2.484 ± 0.151
3.154ProGlu: 3.154 ± 0.164
1.615ProPhe: 1.615 ± 0.108
1.586ProGly: 1.586 ± 0.148
0.85ProHis: 0.85 ± 0.095
1.804ProIle: 1.804 ± 0.115
2.04ProLys: 2.04 ± 0.166
2.474ProLeu: 2.474 ± 0.143
0.869ProMet: 0.869 ± 0.07
1.917ProAsn: 1.917 ± 0.139
0.907ProPro: 0.907 ± 0.106
1.379ProGln: 1.379 ± 0.143
1.416ProArg: 1.416 ± 0.111
2.238ProSer: 2.238 ± 0.188
2.125ProThr: 2.125 ± 0.156
2.701ProVal: 2.701 ± 0.169
0.491ProTrp: 0.491 ± 0.061
1.483ProTyr: 1.483 ± 0.105
0.0ProXaa: 0.0 ± 0.0
Gln
2.814GlnAla: 2.814 ± 0.175
0.444GlnCys: 0.444 ± 0.066
1.841GlnAsp: 1.841 ± 0.148
2.88GlnGlu: 2.88 ± 0.178
1.577GlnPhe: 1.577 ± 0.111
2.21GlnGly: 2.21 ± 0.178
0.737GlnHis: 0.737 ± 0.086
2.285GlnIle: 2.285 ± 0.143
2.248GlnLys: 2.248 ± 0.136
3.192GlnLeu: 3.192 ± 0.172
1.114GlnMet: 1.114 ± 0.088
1.634GlnAsn: 1.634 ± 0.142
1.284GlnPro: 1.284 ± 0.142
1.766GlnGln: 1.766 ± 0.499
1.832GlnArg: 1.832 ± 0.134
2.106GlnSer: 2.106 ± 0.152
1.917GlnThr: 1.917 ± 0.163
2.134GlnVal: 2.134 ± 0.146
0.737GlnTrp: 0.737 ± 0.084
1.53GlnTyr: 1.53 ± 0.125
0.0GlnXaa: 0.0 ± 0.0
Arg
3.485ArgAla: 3.485 ± 0.2
0.614ArgCys: 0.614 ± 0.084
3.126ArgAsp: 3.126 ± 0.177
3.806ArgGlu: 3.806 ± 0.231
2.172ArgPhe: 2.172 ± 0.147
3.05ArgGly: 3.05 ± 0.194
1.152ArgHis: 1.152 ± 0.107
3.305ArgIle: 3.305 ± 0.167
3.513ArgLys: 3.513 ± 0.207
3.966ArgLeu: 3.966 ± 0.217
1.237ArgMet: 1.237 ± 0.126
2.446ArgAsn: 2.446 ± 0.149
1.435ArgPro: 1.435 ± 0.097
1.483ArgGln: 1.483 ± 0.112
2.446ArgArg: 2.446 ± 0.202
2.654ArgSer: 2.654 ± 0.168
2.757ArgThr: 2.757 ± 0.176
3.579ArgVal: 3.579 ± 0.203
0.85ArgTrp: 0.85 ± 0.088
2.191ArgTyr: 2.191 ± 0.15
0.0ArgXaa: 0.0 ± 0.0
Ser
4.042SerAla: 4.042 ± 0.233
0.699SerCys: 0.699 ± 0.092
3.985SerAsp: 3.985 ± 0.189
3.522SerGlu: 3.522 ± 0.19
2.531SerPhe: 2.531 ± 0.158
4.344SerGly: 4.344 ± 0.3
1.332SerHis: 1.332 ± 0.116
3.447SerIle: 3.447 ± 0.198
3.947SerLys: 3.947 ± 0.209
4.58SerLeu: 4.58 ± 0.25
1.558SerMet: 1.558 ± 0.117
3.069SerAsn: 3.069 ± 0.186
1.756SerPro: 1.756 ± 0.113
1.955SerGln: 1.955 ± 0.134
2.805SerArg: 2.805 ± 0.18
3.891SerSer: 3.891 ± 0.284
4.004SerThr: 4.004 ± 0.265
4.07SerVal: 4.07 ± 0.19
0.68SerTrp: 0.68 ± 0.074
2.474SerTyr: 2.474 ± 0.179
0.0SerXaa: 0.0 ± 0.0
Thr
4.693ThrAla: 4.693 ± 0.307
0.557ThrCys: 0.557 ± 0.087
3.532ThrAsp: 3.532 ± 0.166
4.193ThrGlu: 4.193 ± 0.219
2.531ThrPhe: 2.531 ± 0.159
4.627ThrGly: 4.627 ± 0.264
1.284ThrHis: 1.284 ± 0.114
4.504ThrIle: 4.504 ± 0.268
3.211ThrLys: 3.211 ± 0.174
4.92ThrLeu: 4.92 ± 0.243
1.294ThrMet: 1.294 ± 0.12
2.852ThrAsn: 2.852 ± 0.168
2.757ThrPro: 2.757 ± 0.195
2.38ThrGln: 2.38 ± 0.173
2.701ThrArg: 2.701 ± 0.156
3.494ThrSer: 3.494 ± 0.206
3.834ThrThr: 3.834 ± 0.328
4.457ThrVal: 4.457 ± 0.219
0.812ThrTrp: 0.812 ± 0.091
2.266ThrTyr: 2.266 ± 0.156
0.0ThrXaa: 0.0 ± 0.0
Val
4.863ValAla: 4.863 ± 0.255
0.85ValCys: 0.85 ± 0.09
4.844ValAsp: 4.844 ± 0.236
5.137ValGlu: 5.137 ± 0.238
2.842ValPhe: 2.842 ± 0.157
4.089ValGly: 4.089 ± 0.21
1.558ValHis: 1.558 ± 0.126
3.947ValIle: 3.947 ± 0.223
4.646ValLys: 4.646 ± 0.213
4.731ValLeu: 4.731 ± 0.232
1.634ValMet: 1.634 ± 0.128
3.381ValAsn: 3.381 ± 0.166
2.493ValPro: 2.493 ± 0.162
2.465ValGln: 2.465 ± 0.138
3.362ValArg: 3.362 ± 0.157
4.061ValSer: 4.061 ± 0.182
4.75ValThr: 4.75 ± 0.244
5.081ValVal: 5.081 ± 0.231
1.143ValTrp: 1.143 ± 0.112
2.88ValTyr: 2.88 ± 0.171
0.0ValXaa: 0.0 ± 0.0
Trp
0.869TrpAla: 0.869 ± 0.095
0.208TrpCys: 0.208 ± 0.052
1.058TrpAsp: 1.058 ± 0.109
0.992TrpGlu: 0.992 ± 0.08
0.68TrpPhe: 0.68 ± 0.086
0.822TrpGly: 0.822 ± 0.089
0.387TrpHis: 0.387 ± 0.063
0.567TrpIle: 0.567 ± 0.07
1.02TrpLys: 1.02 ± 0.111
1.18TrpLeu: 1.18 ± 0.113
0.5TrpMet: 0.5 ± 0.072
0.793TrpAsn: 0.793 ± 0.1
0.217TrpPro: 0.217 ± 0.04
0.595TrpGln: 0.595 ± 0.081
0.803TrpArg: 0.803 ± 0.071
1.029TrpSer: 1.029 ± 0.114
0.784TrpThr: 0.784 ± 0.095
1.067TrpVal: 1.067 ± 0.094
0.255TrpTrp: 0.255 ± 0.047
0.774TrpTyr: 0.774 ± 0.083
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.842TyrAla: 2.842 ± 0.149
0.585TyrCys: 0.585 ± 0.067
3.201TyrAsp: 3.201 ± 0.179
2.739TyrGlu: 2.739 ± 0.225
1.407TyrPhe: 1.407 ± 0.11
2.701TyrGly: 2.701 ± 0.184
1.114TyrHis: 1.114 ± 0.125
2.087TyrIle: 2.087 ± 0.157
2.701TyrLys: 2.701 ± 0.17
2.956TyrLeu: 2.956 ± 0.168
0.992TyrMet: 0.992 ± 0.111
2.351TyrAsn: 2.351 ± 0.162
1.369TyrPro: 1.369 ± 0.104
1.388TyrGln: 1.388 ± 0.126
1.983TyrArg: 1.983 ± 0.159
2.276TyrSer: 2.276 ± 0.15
2.606TyrThr: 2.606 ± 0.188
2.824TyrVal: 2.824 ± 0.157
0.67TyrTrp: 0.67 ± 0.079
1.501TyrTyr: 1.501 ± 0.156
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 516 proteins (105896 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski