Amino acid dipepetide frequency for Bat coronavirus Rp/Shaanxi2011

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.282AlaAla: 6.282 ± 0.78
2.058AlaCys: 2.058 ± 0.439
2.925AlaAsp: 2.925 ± 0.486
2.275AlaGlu: 2.275 ± 0.391
2.383AlaPhe: 2.383 ± 0.67
4.224AlaGly: 4.224 ± 0.773
1.083AlaHis: 1.083 ± 0.427
4.658AlaIle: 4.658 ± 0.751
3.683AlaLys: 3.683 ± 0.776
6.716AlaLeu: 6.716 ± 0.995
2.491AlaMet: 2.491 ± 0.481
4.441AlaAsn: 4.441 ± 0.603
2.383AlaPro: 2.383 ± 0.332
2.491AlaGln: 2.491 ± 0.528
3.141AlaArg: 3.141 ± 0.448
5.416AlaSer: 5.416 ± 1.478
4.874AlaThr: 4.874 ± 0.432
5.199AlaVal: 5.199 ± 1.319
1.192AlaTrp: 1.192 ± 0.372
3.899AlaTyr: 3.899 ± 0.656
0.0AlaXaa: 0.0 ± 0.0
Cys
2.383CysAla: 2.383 ± 0.599
1.625CysCys: 1.625 ± 0.31
2.383CysAsp: 2.383 ± 0.743
1.083CysGlu: 1.083 ± 0.483
1.3CysPhe: 1.3 ± 0.419
2.383CysGly: 2.383 ± 0.544
0.542CysHis: 0.542 ± 0.109
1.841CysIle: 1.841 ± 0.518
0.758CysLys: 0.758 ± 0.147
2.491CysLeu: 2.491 ± 0.459
0.758CysMet: 0.758 ± 0.346
1.516CysAsn: 1.516 ± 0.386
0.758CysPro: 0.758 ± 0.118
0.542CysGln: 0.542 ± 0.248
1.192CysArg: 1.192 ± 0.455
1.95CysSer: 1.95 ± 0.662
2.166CysThr: 2.166 ± 0.707
2.708CysVal: 2.708 ± 0.57
0.542CysTrp: 0.542 ± 0.547
1.408CysTyr: 1.408 ± 0.402
0.0CysXaa: 0.0 ± 0.0
Asp
4.008AspAla: 4.008 ± 0.9
1.083AspCys: 1.083 ± 0.32
2.383AspAsp: 2.383 ± 0.41
2.708AspGlu: 2.708 ± 0.306
2.925AspPhe: 2.925 ± 0.913
4.116AspGly: 4.116 ± 0.771
0.867AspHis: 0.867 ± 0.303
2.708AspIle: 2.708 ± 0.722
3.033AspLys: 3.033 ± 0.712
4.766AspLeu: 4.766 ± 0.279
1.3AspMet: 1.3 ± 0.555
2.708AspAsn: 2.708 ± 0.51
1.516AspPro: 1.516 ± 0.527
1.841AspGln: 1.841 ± 0.291
1.516AspArg: 1.516 ± 0.562
2.925AspSer: 2.925 ± 0.312
3.141AspThr: 3.141 ± 0.937
4.224AspVal: 4.224 ± 0.597
0.65AspTrp: 0.65 ± 0.258
3.791AspTyr: 3.791 ± 0.538
0.0AspXaa: 0.0 ± 0.0
Glu
2.925GluAla: 2.925 ± 0.773
1.95GluCys: 1.95 ± 0.332
2.058GluAsp: 2.058 ± 0.529
4.116GluGlu: 4.116 ± 1.384
2.058GluPhe: 2.058 ± 0.577
2.708GluGly: 2.708 ± 0.383
1.3GluHis: 1.3 ± 0.339
2.383GluIle: 2.383 ± 0.274
1.95GluLys: 1.95 ± 0.569
4.441GluLeu: 4.441 ± 0.393
0.758GluMet: 0.758 ± 0.216
2.491GluAsn: 2.491 ± 0.555
1.841GluPro: 1.841 ± 0.412
1.95GluGln: 1.95 ± 0.478
1.516GluArg: 1.516 ± 0.441
2.708GluSer: 2.708 ± 0.671
3.466GluThr: 3.466 ± 0.671
4.008GluVal: 4.008 ± 1.024
0.325GluTrp: 0.325 ± 0.122
1.841GluTyr: 1.841 ± 0.683
0.0GluXaa: 0.0 ± 0.0
Phe
2.6PheAla: 2.6 ± 0.514
1.841PheCys: 1.841 ± 0.421
3.141PheAsp: 3.141 ± 0.676
1.516PheGlu: 1.516 ± 0.226
2.058PhePhe: 2.058 ± 0.52
2.816PheGly: 2.816 ± 0.899
0.433PheHis: 0.433 ± 0.258
2.491PheIle: 2.491 ± 0.38
3.141PheLys: 3.141 ± 0.756
4.766PheLeu: 4.766 ± 1.127
1.083PheMet: 1.083 ± 0.197
3.25PheAsn: 3.25 ± 1.454
2.058PhePro: 2.058 ± 0.384
1.083PheGln: 1.083 ± 0.794
1.408PheArg: 1.408 ± 0.311
3.25PheSer: 3.25 ± 0.212
3.791PheThr: 3.791 ± 0.256
3.899PheVal: 3.899 ± 0.884
0.325PheTrp: 0.325 ± 0.167
2.925PheTyr: 2.925 ± 0.388
0.0PheXaa: 0.0 ± 0.0
Gly
4.766GlyAla: 4.766 ± 0.923
1.733GlyCys: 1.733 ± 0.28
3.683GlyAsp: 3.683 ± 0.541
2.275GlyGlu: 2.275 ± 0.419
3.466GlyPhe: 3.466 ± 0.426
4.116GlyGly: 4.116 ± 0.928
1.3GlyHis: 1.3 ± 0.408
3.575GlyIle: 3.575 ± 1.258
2.816GlyLys: 2.816 ± 0.595
3.683GlyLeu: 3.683 ± 0.588
1.192GlyMet: 1.192 ± 0.348
2.6GlyAsn: 2.6 ± 0.783
2.166GlyPro: 2.166 ± 0.625
2.275GlyGln: 2.275 ± 0.441
1.733GlyArg: 1.733 ± 0.393
3.791GlySer: 3.791 ± 0.291
5.524GlyThr: 5.524 ± 0.76
6.824GlyVal: 6.824 ± 0.721
0.542GlyTrp: 0.542 ± 0.389
2.708GlyTyr: 2.708 ± 0.456
0.0GlyXaa: 0.0 ± 0.0
His
1.408HisAla: 1.408 ± 0.348
0.542HisCys: 0.542 ± 0.199
0.867HisAsp: 0.867 ± 0.517
1.083HisGlu: 1.083 ± 0.223
1.3HisPhe: 1.3 ± 0.669
1.516HisGly: 1.516 ± 0.317
0.542HisHis: 0.542 ± 0.199
1.083HisIle: 1.083 ± 0.296
0.758HisLys: 0.758 ± 0.259
2.166HisLeu: 2.166 ± 0.211
0.433HisMet: 0.433 ± 0.258
0.758HisAsn: 0.758 ± 0.298
0.542HisPro: 0.542 ± 0.248
0.325HisGln: 0.325 ± 0.122
0.217HisArg: 0.217 ± 0.19
1.841HisSer: 1.841 ± 0.511
1.841HisThr: 1.841 ± 0.299
1.841HisVal: 1.841 ± 0.248
0.325HisTrp: 0.325 ± 0.194
0.758HisTyr: 0.758 ± 0.203
0.0HisXaa: 0.0 ± 0.0
Ile
3.358IleAla: 3.358 ± 1.263
1.192IleCys: 1.192 ± 0.494
2.816IleAsp: 2.816 ± 0.17
1.733IleGlu: 1.733 ± 0.484
1.841IlePhe: 1.841 ± 0.398
3.683IleGly: 3.683 ± 1.219
0.542IleHis: 0.542 ± 0.358
2.816IleIle: 2.816 ± 0.274
3.358IleLys: 3.358 ± 0.512
4.224IleLeu: 4.224 ± 0.349
1.516IleMet: 1.516 ± 0.427
3.25IleAsn: 3.25 ± 0.441
2.275IlePro: 2.275 ± 0.57
1.625IleGln: 1.625 ± 0.302
1.841IleArg: 1.841 ± 0.443
3.683IleSer: 3.683 ± 0.793
4.333IleThr: 4.333 ± 0.413
4.658IleVal: 4.658 ± 0.396
0.433IleTrp: 0.433 ± 0.171
1.408IleTyr: 1.408 ± 0.783
0.0IleXaa: 0.0 ± 0.0
Lys
3.033LysAla: 3.033 ± 0.492
2.058LysCys: 2.058 ± 0.313
2.491LysAsp: 2.491 ± 0.822
3.25LysGlu: 3.25 ± 0.362
2.708LysPhe: 2.708 ± 0.46
4.983LysGly: 4.983 ± 0.537
1.841LysHis: 1.841 ± 0.631
2.491LysIle: 2.491 ± 0.628
3.033LysLys: 3.033 ± 1.26
6.174LysLeu: 6.174 ± 0.698
1.625LysMet: 1.625 ± 0.403
2.491LysAsn: 2.491 ± 0.841
3.683LysPro: 3.683 ± 0.304
1.516LysGln: 1.516 ± 0.639
2.383LysArg: 2.383 ± 0.213
3.791LysSer: 3.791 ± 0.871
2.925LysThr: 2.925 ± 0.489
3.466LysVal: 3.466 ± 0.394
0.758LysTrp: 0.758 ± 0.147
2.058LysTyr: 2.058 ± 0.62
0.0LysXaa: 0.0 ± 0.0
Leu
5.958LeuAla: 5.958 ± 1.322
2.708LeuCys: 2.708 ± 0.442
5.091LeuAsp: 5.091 ± 1.224
4.441LeuGlu: 4.441 ± 0.947
3.141LeuPhe: 3.141 ± 0.561
5.308LeuGly: 5.308 ± 0.471
1.733LeuHis: 1.733 ± 0.398
3.358LeuIle: 3.358 ± 0.862
7.041LeuLys: 7.041 ± 0.814
10.182LeuLeu: 10.182 ± 1.847
2.383LeuMet: 2.383 ± 0.5
5.958LeuAsn: 5.958 ± 1.103
4.983LeuPro: 4.983 ± 0.743
4.549LeuGln: 4.549 ± 0.558
4.116LeuArg: 4.116 ± 0.904
7.366LeuSer: 7.366 ± 0.818
5.524LeuThr: 5.524 ± 0.385
5.633LeuVal: 5.633 ± 0.848
1.192LeuTrp: 1.192 ± 0.451
3.466LeuTyr: 3.466 ± 0.785
0.0LeuXaa: 0.0 ± 0.0
Met
1.733MetAla: 1.733 ± 0.5
0.758MetCys: 0.758 ± 0.298
1.3MetAsp: 1.3 ± 0.423
0.758MetGlu: 0.758 ± 0.283
0.975MetPhe: 0.975 ± 0.171
0.758MetGly: 0.758 ± 0.281
0.542MetHis: 0.542 ± 0.199
0.867MetIle: 0.867 ± 0.56
0.975MetLys: 0.975 ± 0.149
2.816MetLeu: 2.816 ± 0.752
0.758MetMet: 0.758 ± 0.331
0.758MetAsn: 0.758 ± 0.281
1.3MetPro: 1.3 ± 0.289
1.083MetGln: 1.083 ± 0.299
0.867MetArg: 0.867 ± 0.156
2.491MetSer: 2.491 ± 0.531
1.408MetThr: 1.408 ± 0.197
1.083MetVal: 1.083 ± 0.222
0.65MetTrp: 0.65 ± 0.379
1.408MetTyr: 1.408 ± 0.198
0.0MetXaa: 0.0 ± 0.0
Asn
4.874AsnAla: 4.874 ± 1.135
1.516AsnCys: 1.516 ± 0.194
1.841AsnAsp: 1.841 ± 0.238
1.516AsnGlu: 1.516 ± 0.433
2.275AsnPhe: 2.275 ± 1.909
4.224AsnGly: 4.224 ± 1.005
1.408AsnHis: 1.408 ± 0.372
2.6AsnIle: 2.6 ± 0.595
2.708AsnLys: 2.708 ± 0.331
4.658AsnLeu: 4.658 ± 1.065
1.3AsnMet: 1.3 ± 0.497
3.25AsnAsn: 3.25 ± 0.493
1.841AsnPro: 1.841 ± 0.505
1.95AsnGln: 1.95 ± 1.07
2.058AsnArg: 2.058 ± 0.595
3.791AsnSer: 3.791 ± 0.85
3.575AsnThr: 3.575 ± 1.084
4.983AsnVal: 4.983 ± 1.034
0.433AsnTrp: 0.433 ± 0.168
2.383AsnTyr: 2.383 ± 0.715
0.0AsnXaa: 0.0 ± 0.0
Pro
3.466ProAla: 3.466 ± 0.51
0.867ProCys: 0.867 ± 0.172
1.516ProAsp: 1.516 ± 0.299
2.058ProGlu: 2.058 ± 0.367
1.95ProPhe: 1.95 ± 0.524
2.166ProGly: 2.166 ± 0.577
0.758ProHis: 0.758 ± 0.264
2.166ProIle: 2.166 ± 0.261
3.25ProLys: 3.25 ± 0.729
4.549ProLeu: 4.549 ± 0.425
0.433ProMet: 0.433 ± 0.092
1.95ProAsn: 1.95 ± 0.392
1.408ProPro: 1.408 ± 0.342
1.841ProGln: 1.841 ± 1.209
1.625ProArg: 1.625 ± 0.66
2.383ProSer: 2.383 ± 1.038
2.925ProThr: 2.925 ± 0.656
3.683ProVal: 3.683 ± 1.145
0.325ProTrp: 0.325 ± 0.12
1.083ProTyr: 1.083 ± 0.323
0.0ProXaa: 0.0 ± 0.0
Gln
3.25GlnAla: 3.25 ± 0.439
0.975GlnCys: 0.975 ± 0.345
2.166GlnAsp: 2.166 ± 0.78
1.841GlnGlu: 1.841 ± 0.774
1.841GlnPhe: 1.841 ± 0.567
2.058GlnGly: 2.058 ± 0.974
1.083GlnHis: 1.083 ± 0.551
2.166GlnIle: 2.166 ± 1.046
1.192GlnLys: 1.192 ± 0.608
3.899GlnLeu: 3.899 ± 0.681
0.975GlnMet: 0.975 ± 0.2
1.516GlnAsn: 1.516 ± 0.376
1.95GlnPro: 1.95 ± 0.602
1.841GlnGln: 1.841 ± 0.528
1.841GlnArg: 1.841 ± 0.474
2.058GlnSer: 2.058 ± 0.46
2.491GlnThr: 2.491 ± 0.273
2.491GlnVal: 2.491 ± 0.535
0.65GlnTrp: 0.65 ± 0.204
1.408GlnTyr: 1.408 ± 0.65
0.0GlnXaa: 0.0 ± 0.0
Arg
3.141ArgAla: 3.141 ± 0.499
1.192ArgCys: 1.192 ± 0.344
1.841ArgAsp: 1.841 ± 0.343
2.383ArgGlu: 2.383 ± 0.508
1.625ArgPhe: 1.625 ± 0.388
2.275ArgGly: 2.275 ± 1.084
0.867ArgHis: 0.867 ± 0.319
1.841ArgIle: 1.841 ± 0.53
2.058ArgLys: 2.058 ± 0.448
3.033ArgLeu: 3.033 ± 0.775
0.542ArgMet: 0.542 ± 0.235
2.275ArgAsn: 2.275 ± 0.809
1.083ArgPro: 1.083 ± 0.378
1.841ArgGln: 1.841 ± 0.522
1.083ArgArg: 1.083 ± 0.742
3.141ArgSer: 3.141 ± 1.152
1.95ArgThr: 1.95 ± 0.435
3.358ArgVal: 3.358 ± 0.592
0.433ArgTrp: 0.433 ± 0.278
1.408ArgTyr: 1.408 ± 0.274
0.0ArgXaa: 0.0 ± 0.0
Ser
5.633SerAla: 5.633 ± 0.977
1.733SerCys: 1.733 ± 0.566
4.008SerAsp: 4.008 ± 0.875
3.575SerGlu: 3.575 ± 0.734
4.008SerPhe: 4.008 ± 1.168
3.575SerGly: 3.575 ± 1.354
1.733SerHis: 1.733 ± 0.708
2.491SerIle: 2.491 ± 0.502
3.466SerLys: 3.466 ± 0.441
6.391SerLeu: 6.391 ± 0.789
1.408SerMet: 1.408 ± 0.262
2.708SerAsn: 2.708 ± 0.843
2.383SerPro: 2.383 ± 0.69
2.383SerGln: 2.383 ± 0.575
2.6SerArg: 2.6 ± 1.574
4.658SerSer: 4.658 ± 1.077
5.199SerThr: 5.199 ± 0.933
6.282SerVal: 6.282 ± 0.774
1.192SerTrp: 1.192 ± 0.147
3.25SerTyr: 3.25 ± 0.542
0.0SerXaa: 0.0 ± 0.0
Thr
3.899ThrAla: 3.899 ± 1.201
2.383ThrCys: 2.383 ± 0.88
3.141ThrAsp: 3.141 ± 0.591
3.683ThrGlu: 3.683 ± 0.233
4.441ThrPhe: 4.441 ± 1.141
4.441ThrGly: 4.441 ± 0.645
1.192ThrHis: 1.192 ± 0.278
4.008ThrIle: 4.008 ± 0.987
3.575ThrLys: 3.575 ± 0.353
6.391ThrLeu: 6.391 ± 0.546
1.516ThrMet: 1.516 ± 0.503
3.466ThrAsn: 3.466 ± 0.302
2.708ThrPro: 2.708 ± 0.559
3.899ThrGln: 3.899 ± 1.069
3.033ThrArg: 3.033 ± 0.598
5.091ThrSer: 5.091 ± 0.556
5.524ThrThr: 5.524 ± 1.486
4.983ThrVal: 4.983 ± 0.354
0.542ThrTrp: 0.542 ± 0.277
2.708ThrTyr: 2.708 ± 0.232
0.0ThrXaa: 0.0 ± 0.0
Val
5.958ValAla: 5.958 ± 0.464
2.491ValCys: 2.491 ± 0.426
5.091ValAsp: 5.091 ± 1.008
4.224ValGlu: 4.224 ± 1.183
3.575ValPhe: 3.575 ± 0.301
3.25ValGly: 3.25 ± 0.689
1.083ValHis: 1.083 ± 0.345
4.658ValIle: 4.658 ± 0.683
5.091ValLys: 5.091 ± 0.685
7.907ValLeu: 7.907 ± 0.922
1.733ValMet: 1.733 ± 0.428
3.791ValAsn: 3.791 ± 1.258
3.25ValPro: 3.25 ± 0.303
2.925ValGln: 2.925 ± 0.831
2.6ValArg: 2.6 ± 0.274
4.766ValSer: 4.766 ± 0.717
6.716ValThr: 6.716 ± 0.968
6.282ValVal: 6.282 ± 0.581
0.433ValTrp: 0.433 ± 0.185
4.549ValTyr: 4.549 ± 0.646
0.0ValXaa: 0.0 ± 0.0
Trp
0.65TrpAla: 0.65 ± 0.244
0.217TrpCys: 0.217 ± 0.085
0.542TrpAsp: 0.542 ± 0.476
0.542TrpGlu: 0.542 ± 0.104
1.083TrpPhe: 1.083 ± 0.447
0.217TrpGly: 0.217 ± 0.19
0.433TrpHis: 0.433 ± 0.348
0.65TrpIle: 0.65 ± 0.189
0.542TrpLys: 0.542 ± 0.217
1.516TrpLeu: 1.516 ± 0.577
0.108TrpMet: 0.108 ± 0.068
1.3TrpAsn: 1.3 ± 0.278
0.433TrpPro: 0.433 ± 0.336
0.325TrpGln: 0.325 ± 0.174
0.325TrpArg: 0.325 ± 0.212
0.758TrpSer: 0.758 ± 0.29
0.542TrpThr: 0.542 ± 0.224
0.65TrpVal: 0.65 ± 0.3
0.108TrpTrp: 0.108 ± 0.095
0.433TrpTyr: 0.433 ± 0.284
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.491TyrAla: 2.491 ± 0.737
1.408TyrCys: 1.408 ± 0.584
2.925TyrAsp: 2.925 ± 0.885
1.733TyrGlu: 1.733 ± 0.421
2.925TyrPhe: 2.925 ± 0.542
1.95TyrGly: 1.95 ± 0.159
0.867TyrHis: 0.867 ± 0.244
1.733TyrIle: 1.733 ± 0.332
4.333TyrLys: 4.333 ± 0.57
3.358TyrLeu: 3.358 ± 0.754
0.867TyrMet: 0.867 ± 0.548
2.708TyrAsn: 2.708 ± 0.414
1.841TyrPro: 1.841 ± 0.553
1.516TyrGln: 1.516 ± 0.573
2.275TyrArg: 2.275 ± 0.322
2.816TyrSer: 2.816 ± 0.566
2.708TyrThr: 2.708 ± 0.398
4.116TyrVal: 4.116 ± 0.56
0.325TyrTrp: 0.325 ± 0.167
2.708TyrTyr: 2.708 ± 0.331
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (9233 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski