Amino acid dipepetide frequency for Sulfolobales Virus YNP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.88AlaAla: 2.88 ± 0.559
0.096AlaCys: 0.096 ± 0.1
2.016AlaAsp: 2.016 ± 0.439
2.976AlaGlu: 2.976 ± 0.438
2.784AlaPhe: 2.784 ± 0.82
3.168AlaGly: 3.168 ± 0.743
0.576AlaHis: 0.576 ± 0.263
6.24AlaIle: 6.24 ± 0.699
4.608AlaLys: 4.608 ± 0.819
7.584AlaLeu: 7.584 ± 0.866
1.536AlaMet: 1.536 ± 0.459
1.824AlaAsn: 1.824 ± 0.558
2.016AlaPro: 2.016 ± 0.472
2.304AlaGln: 2.304 ± 0.843
2.496AlaArg: 2.496 ± 0.529
3.456AlaSer: 3.456 ± 0.517
3.36AlaThr: 3.36 ± 0.717
4.704AlaVal: 4.704 ± 0.526
0.672AlaTrp: 0.672 ± 0.244
3.168AlaTyr: 3.168 ± 0.585
0.0AlaXaa: 0.0 ± 0.0
Cys
0.384CysAla: 0.384 ± 0.215
0.0CysCys: 0.0 ± 0.0
0.384CysAsp: 0.384 ± 0.23
0.288CysGlu: 0.288 ± 0.174
0.192CysPhe: 0.192 ± 0.142
0.288CysGly: 0.288 ± 0.203
0.0CysHis: 0.0 ± 0.0
0.288CysIle: 0.288 ± 0.188
0.384CysLys: 0.384 ± 0.171
0.672CysLeu: 0.672 ± 0.239
0.096CysMet: 0.096 ± 0.097
0.096CysAsn: 0.096 ± 0.086
0.288CysPro: 0.288 ± 0.163
0.192CysGln: 0.192 ± 0.141
0.192CysArg: 0.192 ± 0.131
0.384CysSer: 0.384 ± 0.246
0.384CysThr: 0.384 ± 0.208
0.096CysVal: 0.096 ± 0.102
0.192CysTrp: 0.192 ± 0.117
0.096CysTyr: 0.096 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
2.016AspAla: 2.016 ± 0.444
0.384AspCys: 0.384 ± 0.216
2.4AspAsp: 2.4 ± 0.508
3.552AspGlu: 3.552 ± 0.78
1.728AspPhe: 1.728 ± 0.466
1.248AspGly: 1.248 ± 0.43
0.576AspHis: 0.576 ± 0.258
3.264AspIle: 3.264 ± 0.54
3.168AspLys: 3.168 ± 0.711
4.896AspLeu: 4.896 ± 1.023
1.056AspMet: 1.056 ± 0.399
1.632AspAsn: 1.632 ± 0.505
1.92AspPro: 1.92 ± 0.431
0.768AspGln: 0.768 ± 0.255
1.248AspArg: 1.248 ± 0.375
1.152AspSer: 1.152 ± 0.267
2.112AspThr: 2.112 ± 0.442
3.84AspVal: 3.84 ± 0.586
0.384AspTrp: 0.384 ± 0.163
2.4AspTyr: 2.4 ± 0.644
0.0AspXaa: 0.0 ± 0.0
Glu
4.32GluAla: 4.32 ± 0.735
0.576GluCys: 0.576 ± 0.265
2.976GluAsp: 2.976 ± 0.675
6.24GluGlu: 6.24 ± 1.426
2.304GluPhe: 2.304 ± 0.578
2.496GluGly: 2.496 ± 0.53
0.768GluHis: 0.768 ± 0.219
5.856GluIle: 5.856 ± 0.687
4.8GluLys: 4.8 ± 0.992
6.144GluLeu: 6.144 ± 0.837
1.44GluMet: 1.44 ± 0.391
3.552GluAsn: 3.552 ± 0.571
2.976GluPro: 2.976 ± 1.385
2.208GluGln: 2.208 ± 0.406
4.128GluArg: 4.128 ± 0.871
2.976GluSer: 2.976 ± 0.54
2.688GluThr: 2.688 ± 0.503
4.992GluVal: 4.992 ± 0.71
0.576GluTrp: 0.576 ± 0.272
2.304GluTyr: 2.304 ± 0.426
0.0GluXaa: 0.0 ± 0.0
Phe
2.976PheAla: 2.976 ± 0.612
0.096PheCys: 0.096 ± 0.098
2.112PheAsp: 2.112 ± 0.552
2.016PheGlu: 2.016 ± 0.461
2.784PhePhe: 2.784 ± 0.461
1.92PheGly: 1.92 ± 0.448
0.48PheHis: 0.48 ± 0.224
3.456PheIle: 3.456 ± 0.698
2.016PheLys: 2.016 ± 0.604
4.704PheLeu: 4.704 ± 0.799
0.864PheMet: 0.864 ± 0.341
1.92PheAsn: 1.92 ± 0.415
2.304PhePro: 2.304 ± 0.536
1.056PheGln: 1.056 ± 0.346
2.592PheArg: 2.592 ± 0.606
3.456PheSer: 3.456 ± 0.472
3.264PheThr: 3.264 ± 0.843
4.224PheVal: 4.224 ± 0.679
0.288PheTrp: 0.288 ± 0.184
2.88PheTyr: 2.88 ± 0.511
0.096PheXaa: 0.096 ± 0.089
Gly
3.264GlyAla: 3.264 ± 0.802
0.288GlyCys: 0.288 ± 0.167
1.92GlyAsp: 1.92 ± 0.371
3.456GlyGlu: 3.456 ± 0.821
1.728GlyPhe: 1.728 ± 0.4
4.512GlyGly: 4.512 ± 1.205
0.384GlyHis: 0.384 ± 0.176
4.992GlyIle: 4.992 ± 0.619
4.128GlyLys: 4.128 ± 0.602
4.896GlyLeu: 4.896 ± 0.863
1.344GlyMet: 1.344 ± 0.32
3.264GlyAsn: 3.264 ± 0.78
1.536GlyPro: 1.536 ± 0.478
2.304GlyGln: 2.304 ± 0.664
2.304GlyArg: 2.304 ± 0.684
4.032GlySer: 4.032 ± 0.638
2.592GlyThr: 2.592 ± 0.594
4.224GlyVal: 4.224 ± 0.693
1.152GlyTrp: 1.152 ± 0.278
2.784GlyTyr: 2.784 ± 0.526
0.0GlyXaa: 0.0 ± 0.0
His
0.384HisAla: 0.384 ± 0.181
0.288HisCys: 0.288 ± 0.187
0.384HisAsp: 0.384 ± 0.177
0.672HisGlu: 0.672 ± 0.209
0.192HisPhe: 0.192 ± 0.148
0.864HisGly: 0.864 ± 0.296
0.0HisHis: 0.0 ± 0.0
1.344HisIle: 1.344 ± 0.291
0.672HisLys: 0.672 ± 0.235
0.768HisLeu: 0.768 ± 0.223
0.672HisMet: 0.672 ± 0.314
0.096HisAsn: 0.096 ± 0.102
0.48HisPro: 0.48 ± 0.2
0.384HisGln: 0.384 ± 0.189
0.576HisArg: 0.576 ± 0.329
0.96HisSer: 0.96 ± 0.254
0.576HisThr: 0.576 ± 0.264
0.768HisVal: 0.768 ± 0.205
0.0HisTrp: 0.0 ± 0.0
0.48HisTyr: 0.48 ± 0.298
0.0HisXaa: 0.0 ± 0.0
Ile
5.28IleAla: 5.28 ± 0.739
0.48IleCys: 0.48 ± 0.253
4.128IleAsp: 4.128 ± 0.88
4.032IleGlu: 4.032 ± 0.641
3.744IlePhe: 3.744 ± 0.672
4.896IleGly: 4.896 ± 0.664
1.248IleHis: 1.248 ± 0.37
8.256IleIle: 8.256 ± 0.972
4.512IleLys: 4.512 ± 0.826
7.392IleLeu: 7.392 ± 1.12
1.824IleMet: 1.824 ± 0.465
4.416IleAsn: 4.416 ± 0.933
5.088IlePro: 5.088 ± 0.506
2.592IleGln: 2.592 ± 0.619
3.744IleArg: 3.744 ± 0.706
4.992IleSer: 4.992 ± 0.628
4.704IleThr: 4.704 ± 0.828
7.296IleVal: 7.296 ± 0.982
1.056IleTrp: 1.056 ± 0.397
4.32IleTyr: 4.32 ± 0.868
0.096IleXaa: 0.096 ± 0.087
Lys
2.784LysAla: 2.784 ± 0.689
0.384LysCys: 0.384 ± 0.246
3.84LysAsp: 3.84 ± 0.764
5.856LysGlu: 5.856 ± 1.095
2.688LysPhe: 2.688 ± 0.599
3.456LysGly: 3.456 ± 0.762
0.864LysHis: 0.864 ± 0.325
5.376LysIle: 5.376 ± 0.92
5.568LysLys: 5.568 ± 1.208
7.008LysLeu: 7.008 ± 1.192
2.112LysMet: 2.112 ± 0.568
2.688LysAsn: 2.688 ± 0.731
3.552LysPro: 3.552 ± 0.628
2.304LysGln: 2.304 ± 0.61
3.936LysArg: 3.936 ± 0.7
2.976LysSer: 2.976 ± 0.652
2.976LysThr: 2.976 ± 0.546
3.84LysVal: 3.84 ± 0.65
0.672LysTrp: 0.672 ± 0.357
2.88LysTyr: 2.88 ± 0.62
0.0LysXaa: 0.0 ± 0.0
Leu
7.008LeuAla: 7.008 ± 0.774
0.288LeuCys: 0.288 ± 0.168
3.744LeuAsp: 3.744 ± 0.875
6.144LeuGlu: 6.144 ± 0.809
5.28LeuPhe: 5.28 ± 0.663
5.376LeuGly: 5.376 ± 0.726
1.056LeuHis: 1.056 ± 0.361
8.928LeuIle: 8.928 ± 1.157
7.008LeuLys: 7.008 ± 1.276
12.192LeuLeu: 12.192 ± 1.676
2.784LeuMet: 2.784 ± 0.419
4.224LeuAsn: 4.224 ± 0.631
4.896LeuPro: 4.896 ± 0.682
3.936LeuGln: 3.936 ± 0.917
4.608LeuArg: 4.608 ± 0.733
6.528LeuSer: 6.528 ± 0.762
5.664LeuThr: 5.664 ± 0.831
7.392LeuVal: 7.392 ± 0.774
0.96LeuTrp: 0.96 ± 0.303
4.992LeuTyr: 4.992 ± 0.788
0.0LeuXaa: 0.0 ± 0.0
Met
1.536MetAla: 1.536 ± 0.482
0.192MetCys: 0.192 ± 0.195
0.672MetAsp: 0.672 ± 0.277
1.248MetGlu: 1.248 ± 0.409
1.248MetPhe: 1.248 ± 0.28
1.056MetGly: 1.056 ± 0.316
0.096MetHis: 0.096 ± 0.103
2.4MetIle: 2.4 ± 0.592
1.44MetLys: 1.44 ± 0.405
2.112MetLeu: 2.112 ± 0.47
0.48MetMet: 0.48 ± 0.244
1.44MetAsn: 1.44 ± 0.416
1.152MetPro: 1.152 ± 0.294
0.864MetGln: 0.864 ± 0.316
2.4MetArg: 2.4 ± 0.596
1.152MetSer: 1.152 ± 0.358
0.96MetThr: 0.96 ± 0.415
1.728MetVal: 1.728 ± 0.428
0.192MetTrp: 0.192 ± 0.148
1.152MetTyr: 1.152 ± 0.365
0.0MetXaa: 0.0 ± 0.0
Asn
4.704AsnAla: 4.704 ± 0.68
0.48AsnCys: 0.48 ± 0.212
1.92AsnAsp: 1.92 ± 0.435
2.592AsnGlu: 2.592 ± 0.471
2.208AsnPhe: 2.208 ± 0.449
3.936AsnGly: 3.936 ± 0.994
0.48AsnHis: 0.48 ± 0.219
4.128AsnIle: 4.128 ± 0.789
2.784AsnLys: 2.784 ± 0.657
4.608AsnLeu: 4.608 ± 0.78
1.056AsnMet: 1.056 ± 0.337
3.36AsnAsn: 3.36 ± 0.674
3.552AsnPro: 3.552 ± 0.701
2.88AsnGln: 2.88 ± 0.888
1.92AsnArg: 1.92 ± 0.397
3.168AsnSer: 3.168 ± 0.782
2.688AsnThr: 2.688 ± 0.46
4.608AsnVal: 4.608 ± 0.688
0.384AsnTrp: 0.384 ± 0.212
2.112AsnTyr: 2.112 ± 0.961
0.0AsnXaa: 0.0 ± 0.0
Pro
2.016ProAla: 2.016 ± 0.437
0.192ProCys: 0.192 ± 0.142
1.152ProAsp: 1.152 ± 0.338
3.936ProGlu: 3.936 ± 1.267
3.456ProPhe: 3.456 ± 0.708
2.304ProGly: 2.304 ± 0.613
0.576ProHis: 0.576 ± 0.25
4.416ProIle: 4.416 ± 0.757
2.688ProLys: 2.688 ± 0.464
4.512ProLeu: 4.512 ± 0.625
0.768ProMet: 0.768 ± 0.275
2.976ProAsn: 2.976 ± 1.045
4.992ProPro: 4.992 ± 1.509
2.208ProGln: 2.208 ± 0.436
1.824ProArg: 1.824 ± 0.47
4.128ProSer: 4.128 ± 0.678
3.36ProThr: 3.36 ± 0.892
3.36ProVal: 3.36 ± 0.675
0.576ProTrp: 0.576 ± 0.278
2.688ProTyr: 2.688 ± 0.556
0.0ProXaa: 0.0 ± 0.0
Gln
2.208GlnAla: 2.208 ± 0.749
0.096GlnCys: 0.096 ± 0.088
0.96GlnAsp: 0.96 ± 0.293
2.112GlnGlu: 2.112 ± 0.528
1.824GlnPhe: 1.824 ± 0.499
1.728GlnGly: 1.728 ± 0.381
0.576GlnHis: 0.576 ± 0.229
2.208GlnIle: 2.208 ± 0.391
1.44GlnLys: 1.44 ± 0.418
3.264GlnLeu: 3.264 ± 0.98
0.48GlnMet: 0.48 ± 0.17
2.496GlnAsn: 2.496 ± 1.053
2.496GlnPro: 2.496 ± 0.459
4.416GlnGln: 4.416 ± 2.367
1.152GlnArg: 1.152 ± 0.35
1.824GlnSer: 1.824 ± 0.559
2.4GlnThr: 2.4 ± 0.474
2.304GlnVal: 2.304 ± 0.423
0.192GlnTrp: 0.192 ± 0.119
2.688GlnTyr: 2.688 ± 0.627
0.0GlnXaa: 0.0 ± 0.0
Arg
1.536ArgAla: 1.536 ± 0.288
0.384ArgCys: 0.384 ± 0.193
1.728ArgAsp: 1.728 ± 0.425
4.992ArgGlu: 4.992 ± 0.778
2.208ArgPhe: 2.208 ± 0.411
2.496ArgGly: 2.496 ± 0.401
0.288ArgHis: 0.288 ± 0.19
4.416ArgIle: 4.416 ± 0.708
4.512ArgLys: 4.512 ± 1.148
5.376ArgLeu: 5.376 ± 0.761
1.056ArgMet: 1.056 ± 0.331
2.496ArgAsn: 2.496 ± 0.457
1.536ArgPro: 1.536 ± 0.485
0.576ArgGln: 0.576 ± 0.247
3.552ArgArg: 3.552 ± 0.706
1.632ArgSer: 1.632 ± 0.34
1.92ArgThr: 1.92 ± 0.435
2.784ArgVal: 2.784 ± 0.488
0.768ArgTrp: 0.768 ± 0.359
2.688ArgTyr: 2.688 ± 0.535
0.0ArgXaa: 0.0 ± 0.0
Ser
3.456SerAla: 3.456 ± 0.676
0.0SerCys: 0.0 ± 0.0
1.92SerAsp: 1.92 ± 0.383
3.168SerGlu: 3.168 ± 0.503
1.728SerPhe: 1.728 ± 0.389
4.416SerGly: 4.416 ± 0.87
0.192SerHis: 0.192 ± 0.158
3.072SerIle: 3.072 ± 0.6
4.32SerLys: 4.32 ± 0.615
6.24SerLeu: 6.24 ± 0.962
1.248SerMet: 1.248 ± 0.371
3.936SerAsn: 3.936 ± 1.063
4.224SerPro: 4.224 ± 0.611
3.072SerGln: 3.072 ± 0.856
2.304SerArg: 2.304 ± 0.536
4.608SerSer: 4.608 ± 1.088
3.552SerThr: 3.552 ± 0.692
4.416SerVal: 4.416 ± 0.779
0.864SerTrp: 0.864 ± 0.294
3.648SerTyr: 3.648 ± 0.509
0.0SerXaa: 0.0 ± 0.0
Thr
2.304ThrAla: 2.304 ± 0.404
0.096ThrCys: 0.096 ± 0.101
2.112ThrAsp: 2.112 ± 0.384
3.168ThrGlu: 3.168 ± 1.107
3.168ThrPhe: 3.168 ± 0.59
3.072ThrGly: 3.072 ± 1.338
0.864ThrHis: 0.864 ± 0.29
3.36ThrIle: 3.36 ± 0.859
3.744ThrLys: 3.744 ± 0.607
5.856ThrLeu: 5.856 ± 0.667
1.152ThrMet: 1.152 ± 0.363
3.168ThrAsn: 3.168 ± 0.548
3.84ThrPro: 3.84 ± 0.699
1.632ThrGln: 1.632 ± 0.398
1.824ThrArg: 1.824 ± 0.516
4.128ThrSer: 4.128 ± 0.813
3.072ThrThr: 3.072 ± 0.577
4.704ThrVal: 4.704 ± 0.981
0.96ThrTrp: 0.96 ± 0.34
1.92ThrTyr: 1.92 ± 0.397
0.0ThrXaa: 0.0 ± 0.0
Val
5.856ValAla: 5.856 ± 0.729
0.48ValCys: 0.48 ± 0.208
2.976ValAsp: 2.976 ± 0.567
4.8ValGlu: 4.8 ± 0.866
3.264ValPhe: 3.264 ± 0.775
4.128ValGly: 4.128 ± 0.733
0.576ValHis: 0.576 ± 0.273
6.336ValIle: 6.336 ± 0.911
4.32ValLys: 4.32 ± 0.746
8.928ValLeu: 8.928 ± 1.101
1.632ValMet: 1.632 ± 0.37
5.568ValAsn: 5.568 ± 0.739
3.264ValPro: 3.264 ± 0.46
1.056ValGln: 1.056 ± 0.25
2.784ValArg: 2.784 ± 0.495
5.088ValSer: 5.088 ± 0.743
3.552ValThr: 3.552 ± 0.626
7.104ValVal: 7.104 ± 1.179
1.152ValTrp: 1.152 ± 0.294
4.32ValTyr: 4.32 ± 0.76
0.0ValXaa: 0.0 ± 0.0
Trp
0.576TrpAla: 0.576 ± 0.234
0.096TrpCys: 0.096 ± 0.098
0.384TrpAsp: 0.384 ± 0.19
0.864TrpGlu: 0.864 ± 0.239
0.096TrpPhe: 0.096 ± 0.084
0.672TrpGly: 0.672 ± 0.233
0.096TrpHis: 0.096 ± 0.098
0.864TrpIle: 0.864 ± 0.275
1.152TrpLys: 1.152 ± 0.366
0.672TrpLeu: 0.672 ± 0.289
0.48TrpMet: 0.48 ± 0.277
0.864TrpAsn: 0.864 ± 0.255
0.288TrpPro: 0.288 ± 0.132
0.48TrpGln: 0.48 ± 0.197
1.44TrpArg: 1.44 ± 0.435
0.864TrpSer: 0.864 ± 0.289
0.384TrpThr: 0.384 ± 0.24
0.864TrpVal: 0.864 ± 0.255
0.192TrpTrp: 0.192 ± 0.14
0.768TrpTyr: 0.768 ± 0.263
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.976TyrAla: 2.976 ± 0.677
0.0TyrCys: 0.0 ± 0.0
2.016TyrAsp: 2.016 ± 0.526
2.112TyrGlu: 2.112 ± 0.456
2.88TyrPhe: 2.88 ± 0.561
3.072TyrGly: 3.072 ± 0.546
0.864TyrHis: 0.864 ± 0.25
4.896TyrIle: 4.896 ± 0.808
2.496TyrLys: 2.496 ± 0.56
5.184TyrLeu: 5.184 ± 0.782
1.344TyrMet: 1.344 ± 0.402
3.552TyrAsn: 3.552 ± 0.746
1.632TyrPro: 1.632 ± 0.471
1.632TyrGln: 1.632 ± 0.596
2.016TyrArg: 2.016 ± 0.36
2.88TyrSer: 2.88 ± 0.686
3.936TyrThr: 3.936 ± 0.439
3.936TyrVal: 3.936 ± 0.604
0.864TyrTrp: 0.864 ± 0.294
3.264TyrTyr: 3.264 ± 0.716
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.096XaaGlu: 0.096 ± 0.089
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.096XaaPro: 0.096 ± 0.087
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (10418 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski