Amino acid dipepetide frequency for Vibrio sp. HA2012

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.656AlaAla: 7.656 ± 0.117
1.031AlaCys: 1.031 ± 0.028
4.844AlaAsp: 4.844 ± 0.071
6.242AlaGlu: 6.242 ± 0.087
3.129AlaPhe: 3.129 ± 0.058
6.379AlaGly: 6.379 ± 0.077
1.598AlaHis: 1.598 ± 0.042
5.809AlaIle: 5.809 ± 0.077
4.334AlaLys: 4.334 ± 0.068
9.467AlaLeu: 9.467 ± 0.101
2.634AlaMet: 2.634 ± 0.053
2.954AlaAsn: 2.954 ± 0.053
2.583AlaPro: 2.583 ± 0.056
3.525AlaGln: 3.525 ± 0.068
3.943AlaArg: 3.943 ± 0.064
4.902AlaSer: 4.902 ± 0.072
4.239AlaThr: 4.239 ± 0.064
6.122AlaVal: 6.122 ± 0.07
0.816AlaTrp: 0.816 ± 0.031
2.328AlaTyr: 2.328 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.777CysAla: 0.777 ± 0.03
0.191CysCys: 0.191 ± 0.014
0.641CysAsp: 0.641 ± 0.027
0.626CysGlu: 0.626 ± 0.023
0.509CysPhe: 0.509 ± 0.023
1.015CysGly: 1.015 ± 0.032
0.364CysHis: 0.364 ± 0.02
0.659CysIle: 0.659 ± 0.025
0.449CysLys: 0.449 ± 0.02
1.08CysLeu: 1.08 ± 0.03
0.262CysMet: 0.262 ± 0.016
0.397CysAsn: 0.397 ± 0.022
0.487CysPro: 0.487 ± 0.023
0.484CysGln: 0.484 ± 0.022
0.548CysArg: 0.548 ± 0.026
0.807CysSer: 0.807 ± 0.03
0.532CysThr: 0.532 ± 0.023
0.682CysVal: 0.682 ± 0.025
0.15CysTrp: 0.15 ± 0.012
0.355CysTyr: 0.355 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.347AspAla: 4.347 ± 0.063
0.571AspCys: 0.571 ± 0.024
3.064AspAsp: 3.064 ± 0.073
3.959AspGlu: 3.959 ± 0.071
2.38AspPhe: 2.38 ± 0.046
3.707AspGly: 3.707 ± 0.06
1.029AspHis: 1.029 ± 0.033
4.574AspIle: 4.574 ± 0.073
3.225AspLys: 3.225 ± 0.053
5.065AspLeu: 5.065 ± 0.072
1.558AspMet: 1.558 ± 0.038
2.464AspAsn: 2.464 ± 0.047
2.119AspPro: 2.119 ± 0.048
1.832AspGln: 1.832 ± 0.043
2.333AspArg: 2.333 ± 0.046
3.306AspSer: 3.306 ± 0.057
2.977AspThr: 2.977 ± 0.055
3.786AspVal: 3.786 ± 0.066
0.799AspTrp: 0.799 ± 0.028
2.114AspTyr: 2.114 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.488GluAla: 5.488 ± 0.091
0.596GluCys: 0.596 ± 0.024
2.951GluAsp: 2.951 ± 0.063
4.413GluGlu: 4.413 ± 0.081
2.442GluPhe: 2.442 ± 0.051
3.607GluGly: 3.607 ± 0.056
1.677GluHis: 1.677 ± 0.044
4.038GluIle: 4.038 ± 0.068
4.306GluLys: 4.306 ± 0.073
7.566GluLeu: 7.566 ± 0.084
1.913GluMet: 1.913 ± 0.047
2.734GluAsn: 2.734 ± 0.046
2.118GluPro: 2.118 ± 0.044
4.111GluGln: 4.111 ± 0.071
3.524GluArg: 3.524 ± 0.06
3.749GluSer: 3.749 ± 0.06
3.349GluThr: 3.349 ± 0.057
4.173GluVal: 4.173 ± 0.066
0.779GluTrp: 0.779 ± 0.03
1.957GluTyr: 1.957 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.216PheAla: 3.216 ± 0.063
0.559PheCys: 0.559 ± 0.025
2.511PheAsp: 2.511 ± 0.048
2.271PheGlu: 2.271 ± 0.049
1.721PhePhe: 1.721 ± 0.044
3.124PheGly: 3.124 ± 0.062
0.863PheHis: 0.863 ± 0.031
2.929PheIle: 2.929 ± 0.055
1.689PheLys: 1.689 ± 0.037
3.475PheLeu: 3.475 ± 0.074
1.02PheMet: 1.02 ± 0.031
1.867PheAsn: 1.867 ± 0.046
1.491PhePro: 1.491 ± 0.037
1.2PheGln: 1.2 ± 0.032
1.787PheArg: 1.787 ± 0.039
3.474PheSer: 3.474 ± 0.074
2.345PheThr: 2.345 ± 0.048
2.579PheVal: 2.579 ± 0.053
0.487PheTrp: 0.487 ± 0.023
1.335PheTyr: 1.335 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.182GlyAla: 5.182 ± 0.079
0.99GlyCys: 0.99 ± 0.031
3.616GlyAsp: 3.616 ± 0.069
4.593GlyGlu: 4.593 ± 0.068
3.14GlyPhe: 3.14 ± 0.055
4.884GlyGly: 4.884 ± 0.086
1.571GlyHis: 1.571 ± 0.037
5.352GlyIle: 5.352 ± 0.071
4.145GlyLys: 4.145 ± 0.061
7.041GlyLeu: 7.041 ± 0.091
2.251GlyMet: 2.251 ± 0.053
2.721GlyAsn: 2.721 ± 0.048
1.481GlyPro: 1.481 ± 0.044
2.701GlyGln: 2.701 ± 0.058
3.239GlyArg: 3.239 ± 0.059
4.285GlySer: 4.285 ± 0.063
3.482GlyThr: 3.482 ± 0.061
5.076GlyVal: 5.076 ± 0.081
0.943GlyTrp: 0.943 ± 0.03
2.692GlyTyr: 2.692 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.625HisAla: 1.625 ± 0.041
0.334HisCys: 0.334 ± 0.015
1.114HisAsp: 1.114 ± 0.037
1.108HisGlu: 1.108 ± 0.033
1.083HisPhe: 1.083 ± 0.03
1.514HisGly: 1.514 ± 0.043
0.693HisHis: 0.693 ± 0.03
1.569HisIle: 1.569 ± 0.041
1.095HisLys: 1.095 ± 0.028
2.343HisLeu: 2.343 ± 0.055
0.542HisMet: 0.542 ± 0.025
0.902HisAsn: 0.902 ± 0.031
1.17HisPro: 1.17 ± 0.029
1.122HisGln: 1.122 ± 0.034
1.065HisArg: 1.065 ± 0.036
1.437HisSer: 1.437 ± 0.033
1.188HisThr: 1.188 ± 0.03
1.194HisVal: 1.194 ± 0.031
0.377HisTrp: 0.377 ± 0.016
0.874HisTyr: 0.874 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.316IleAla: 6.316 ± 0.086
0.792IleCys: 0.792 ± 0.03
4.134IleAsp: 4.134 ± 0.067
4.465IleGlu: 4.465 ± 0.071
2.378IlePhe: 2.378 ± 0.056
4.826IleGly: 4.826 ± 0.076
1.45IleHis: 1.45 ± 0.037
4.254IleIle: 4.254 ± 0.077
3.35IleLys: 3.35 ± 0.059
5.952IleLeu: 5.952 ± 0.082
1.5IleMet: 1.5 ± 0.042
2.981IleAsn: 2.981 ± 0.061
2.964IlePro: 2.964 ± 0.06
2.559IleGln: 2.559 ± 0.046
3.624IleArg: 3.624 ± 0.06
5.054IleSer: 5.054 ± 0.076
3.927IleThr: 3.927 ± 0.067
4.117IleVal: 4.117 ± 0.066
0.692IleTrp: 0.692 ± 0.026
1.83IleTyr: 1.83 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.826LysAla: 4.826 ± 0.063
0.347LysCys: 0.347 ± 0.017
2.719LysAsp: 2.719 ± 0.051
3.678LysGlu: 3.678 ± 0.064
1.437LysPhe: 1.437 ± 0.041
3.402LysGly: 3.402 ± 0.066
1.273LysHis: 1.273 ± 0.032
3.062LysIle: 3.062 ± 0.048
3.143LysLys: 3.143 ± 0.065
5.249LysLeu: 5.249 ± 0.072
1.462LysMet: 1.462 ± 0.033
2.304LysAsn: 2.304 ± 0.047
2.244LysPro: 2.244 ± 0.044
2.759LysGln: 2.759 ± 0.054
2.693LysArg: 2.693 ± 0.05
3.002LysSer: 3.002 ± 0.058
2.902LysThr: 2.902 ± 0.058
3.659LysVal: 3.659 ± 0.058
0.498LysTrp: 0.498 ± 0.018
1.505LysTyr: 1.505 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
9.235LeuAla: 9.235 ± 0.114
1.21LeuCys: 1.21 ± 0.032
5.759LeuAsp: 5.759 ± 0.083
6.273LeuGlu: 6.273 ± 0.082
4.237LeuPhe: 4.237 ± 0.08
6.785LeuGly: 6.785 ± 0.094
2.096LeuHis: 2.096 ± 0.045
6.64LeuIle: 6.64 ± 0.102
5.402LeuLys: 5.402 ± 0.066
10.905LeuLeu: 10.905 ± 0.168
2.85LeuMet: 2.85 ± 0.054
4.576LeuAsn: 4.576 ± 0.069
4.743LeuPro: 4.743 ± 0.079
3.824LeuGln: 3.824 ± 0.073
4.523LeuArg: 4.523 ± 0.073
7.956LeuSer: 7.956 ± 0.085
6.086LeuThr: 6.086 ± 0.088
6.646LeuVal: 6.646 ± 0.085
1.049LeuTrp: 1.049 ± 0.036
2.777LeuTyr: 2.777 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.685MetAla: 2.685 ± 0.057
0.224MetCys: 0.224 ± 0.013
1.446MetAsp: 1.446 ± 0.035
1.449MetGlu: 1.449 ± 0.041
0.995MetPhe: 0.995 ± 0.031
1.873MetGly: 1.873 ± 0.043
0.532MetHis: 0.532 ± 0.025
1.662MetIle: 1.662 ± 0.043
1.529MetLys: 1.529 ± 0.036
2.961MetLeu: 2.961 ± 0.059
0.838MetMet: 0.838 ± 0.026
1.26MetAsn: 1.26 ± 0.033
1.201MetPro: 1.201 ± 0.039
1.284MetGln: 1.284 ± 0.03
1.203MetArg: 1.203 ± 0.033
1.923MetSer: 1.923 ± 0.041
1.7MetThr: 1.7 ± 0.039
2.013MetVal: 2.013 ± 0.043
0.213MetTrp: 0.213 ± 0.015
0.601MetTyr: 0.601 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.201AsnAla: 3.201 ± 0.057
0.418AsnCys: 0.418 ± 0.02
2.156AsnAsp: 2.156 ± 0.053
2.317AsnGlu: 2.317 ± 0.048
1.485AsnPhe: 1.485 ± 0.033
2.907AsnGly: 2.907 ± 0.059
0.916AsnHis: 0.916 ± 0.029
3.139AsnIle: 3.139 ± 0.055
2.221AsnLys: 2.221 ± 0.045
3.861AsnLeu: 3.861 ± 0.06
1.071AsnMet: 1.071 ± 0.033
1.875AsnAsn: 1.875 ± 0.05
2.076AsnPro: 2.076 ± 0.044
1.923AsnGln: 1.923 ± 0.047
2.218AsnArg: 2.218 ± 0.046
2.403AsnSer: 2.403 ± 0.048
2.252AsnThr: 2.252 ± 0.052
2.438AsnVal: 2.438 ± 0.049
0.552AsnTrp: 0.552 ± 0.021
1.346AsnTyr: 1.346 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.242ProAla: 3.242 ± 0.061
0.346ProCys: 0.346 ± 0.017
2.725ProAsp: 2.725 ± 0.058
3.632ProGlu: 3.632 ± 0.056
1.717ProPhe: 1.717 ± 0.041
2.489ProGly: 2.489 ± 0.048
0.818ProHis: 0.818 ± 0.032
2.054ProIle: 2.054 ± 0.046
1.768ProLys: 1.768 ± 0.042
4.01ProLeu: 4.01 ± 0.075
1.024ProMet: 1.024 ± 0.028
1.343ProAsn: 1.343 ± 0.033
1.108ProPro: 1.108 ± 0.033
1.545ProGln: 1.545 ± 0.039
1.353ProArg: 1.353 ± 0.036
2.121ProSer: 2.121 ± 0.043
1.899ProThr: 1.899 ± 0.039
3.662ProVal: 3.662 ± 0.067
0.447ProTrp: 0.447 ± 0.024
1.337ProTyr: 1.337 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.977GlnAla: 3.977 ± 0.066
0.413GlnCys: 0.413 ± 0.02
1.993GlnAsp: 1.993 ± 0.045
2.752GlnGlu: 2.752 ± 0.061
1.649GlnPhe: 1.649 ± 0.044
2.808GlnGly: 2.808 ± 0.051
1.094GlnHis: 1.094 ± 0.034
2.794GlnIle: 2.794 ± 0.054
2.349GlnLys: 2.349 ± 0.054
4.808GlnLeu: 4.808 ± 0.076
1.195GlnMet: 1.195 ± 0.031
1.701GlnAsn: 1.701 ± 0.048
1.7GlnPro: 1.7 ± 0.046
2.749GlnGln: 2.749 ± 0.075
2.202GlnArg: 2.202 ± 0.043
2.593GlnSer: 2.593 ± 0.05
2.235GlnThr: 2.235 ± 0.051
3.004GlnVal: 3.004 ± 0.057
0.587GlnTrp: 0.587 ± 0.024
1.326GlnTyr: 1.326 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.424ArgAla: 3.424 ± 0.056
0.508ArgCys: 0.508 ± 0.023
2.571ArgAsp: 2.571 ± 0.051
3.424ArgGlu: 3.424 ± 0.057
2.257ArgPhe: 2.257 ± 0.048
2.751ArgGly: 2.751 ± 0.048
1.215ArgHis: 1.215 ± 0.029
3.366ArgIle: 3.366 ± 0.057
2.718ArgLys: 2.718 ± 0.055
5.236ArgLeu: 5.236 ± 0.078
1.31ArgMet: 1.31 ± 0.037
2.026ArgAsn: 2.026 ± 0.046
1.675ArgPro: 1.675 ± 0.038
2.433ArgGln: 2.433 ± 0.053
2.542ArgArg: 2.542 ± 0.062
2.751ArgSer: 2.751 ± 0.054
2.383ArgThr: 2.383 ± 0.047
3.16ArgVal: 3.16 ± 0.056
0.626ArgTrp: 0.626 ± 0.027
1.798ArgTyr: 1.798 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.5SerAla: 5.5 ± 0.08
0.611SerCys: 0.611 ± 0.024
3.713SerAsp: 3.713 ± 0.066
4.185SerGlu: 4.185 ± 0.071
2.715SerPhe: 2.715 ± 0.048
5.61SerGly: 5.61 ± 0.085
1.517SerHis: 1.517 ± 0.039
4.124SerIle: 4.124 ± 0.068
2.805SerLys: 2.805 ± 0.057
6.7SerLeu: 6.7 ± 0.09
1.743SerMet: 1.743 ± 0.041
2.242SerAsn: 2.242 ± 0.051
2.414SerPro: 2.414 ± 0.048
2.744SerGln: 2.744 ± 0.056
3.297SerArg: 3.297 ± 0.056
4.254SerSer: 4.254 ± 0.087
3.06SerThr: 3.06 ± 0.053
5.045SerVal: 5.045 ± 0.073
0.711SerTrp: 0.711 ± 0.025
1.988SerTyr: 1.988 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.617ThrAla: 4.617 ± 0.079
0.491ThrCys: 0.491 ± 0.024
3.113ThrAsp: 3.113 ± 0.059
3.707ThrGlu: 3.707 ± 0.061
2.028ThrPhe: 2.028 ± 0.04
4.38ThrGly: 4.38 ± 0.07
1.222ThrHis: 1.222 ± 0.036
3.487ThrIle: 3.487 ± 0.065
2.235ThrLys: 2.235 ± 0.048
6.084ThrLeu: 6.084 ± 0.076
1.268ThrMet: 1.268 ± 0.039
1.869ThrAsn: 1.869 ± 0.048
2.558ThrPro: 2.558 ± 0.046
2.23ThrGln: 2.23 ± 0.043
2.48ThrArg: 2.48 ± 0.049
3.234ThrSer: 3.234 ± 0.058
2.942ThrThr: 2.942 ± 0.058
3.92ThrVal: 3.92 ± 0.065
0.46ThrTrp: 0.46 ± 0.022
1.447ThrTyr: 1.447 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
6.082ValAla: 6.082 ± 0.086
0.851ValCys: 0.851 ± 0.028
3.856ValAsp: 3.856 ± 0.068
4.259ValGlu: 4.259 ± 0.073
2.757ValPhe: 2.757 ± 0.053
4.525ValGly: 4.525 ± 0.076
1.306ValHis: 1.306 ± 0.035
5.071ValIle: 5.071 ± 0.072
3.423ValLys: 3.423 ± 0.051
6.777ValLeu: 6.777 ± 0.081
2.06ValMet: 2.06 ± 0.04
2.895ValAsn: 2.895 ± 0.052
2.678ValPro: 2.678 ± 0.05
2.368ValGln: 2.368 ± 0.045
3.213ValArg: 3.213 ± 0.056
5.036ValSer: 5.036 ± 0.073
4.171ValThr: 4.171 ± 0.06
5.113ValVal: 5.113 ± 0.082
0.71ValTrp: 0.71 ± 0.026
1.805ValTyr: 1.805 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.722TrpAla: 0.722 ± 0.024
0.141TrpCys: 0.141 ± 0.012
0.606TrpAsp: 0.606 ± 0.023
0.595TrpGlu: 0.595 ± 0.022
0.561TrpPhe: 0.561 ± 0.024
0.712TrpGly: 0.712 ± 0.026
0.323TrpHis: 0.323 ± 0.018
0.726TrpIle: 0.726 ± 0.028
0.569TrpLys: 0.569 ± 0.025
1.595TrpLeu: 1.595 ± 0.042
0.346TrpMet: 0.346 ± 0.019
0.491TrpAsn: 0.491 ± 0.02
0.424TrpPro: 0.424 ± 0.018
0.73TrpGln: 0.73 ± 0.031
0.557TrpArg: 0.557 ± 0.024
0.679TrpSer: 0.679 ± 0.026
0.421TrpThr: 0.421 ± 0.021
0.775TrpVal: 0.775 ± 0.027
0.182TrpTrp: 0.182 ± 0.014
0.359TrpTyr: 0.359 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.419TyrAla: 2.419 ± 0.051
0.389TyrCys: 0.389 ± 0.017
1.675TyrAsp: 1.675 ± 0.043
1.543TyrGlu: 1.543 ± 0.044
1.325TyrPhe: 1.325 ± 0.039
2.086TyrGly: 2.086 ± 0.04
0.792TyrHis: 0.792 ± 0.028
1.855TyrIle: 1.855 ± 0.047
1.407TyrLys: 1.407 ± 0.038
3.398TyrLeu: 3.398 ± 0.063
0.746TyrMet: 0.746 ± 0.026
1.174TyrAsn: 1.174 ± 0.034
1.406TyrPro: 1.406 ± 0.038
1.807TyrGln: 1.807 ± 0.044
1.832TyrArg: 1.832 ± 0.042
2.01TyrSer: 2.01 ± 0.043
1.682TyrThr: 1.682 ± 0.042
1.792TyrVal: 1.792 ± 0.042
0.435TyrTrp: 0.435 ± 0.02
1.064TyrTyr: 1.064 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3382 proteins (1105604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski