Amino acid dipepetide frequency for Podoviridae sp. ctka020

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.981AlaAla: 8.981 ± 1.745
0.781AlaCys: 0.781 ± 0.264
4.979AlaAsp: 4.979 ± 0.702
4.002AlaGlu: 4.002 ± 0.775
3.221AlaPhe: 3.221 ± 0.496
6.248AlaGly: 6.248 ± 0.941
0.879AlaHis: 0.879 ± 0.336
5.564AlaIle: 5.564 ± 0.847
5.662AlaLys: 5.662 ± 0.997
7.321AlaLeu: 7.321 ± 0.671
1.66AlaMet: 1.66 ± 0.395
3.905AlaAsn: 3.905 ± 0.61
2.538AlaPro: 2.538 ± 0.441
3.417AlaGln: 3.417 ± 0.657
3.319AlaArg: 3.319 ± 0.678
5.467AlaSer: 5.467 ± 1.216
5.662AlaThr: 5.662 ± 0.642
4.198AlaVal: 4.198 ± 0.794
0.781AlaTrp: 0.781 ± 0.327
2.929AlaTyr: 2.929 ± 0.516
0.0AlaXaa: 0.0 ± 0.0
Cys
0.781CysAla: 0.781 ± 0.28
0.195CysCys: 0.195 ± 0.151
0.195CysAsp: 0.195 ± 0.124
0.39CysGlu: 0.39 ± 0.21
0.293CysPhe: 0.293 ± 0.184
1.269CysGly: 1.269 ± 0.318
0.0CysHis: 0.0 ± 0.0
0.586CysIle: 0.586 ± 0.275
0.879CysLys: 0.879 ± 0.299
0.879CysLeu: 0.879 ± 0.278
0.0CysMet: 0.0 ± 0.0
0.488CysAsn: 0.488 ± 0.179
0.879CysPro: 0.879 ± 0.259
0.293CysGln: 0.293 ± 0.184
0.488CysArg: 0.488 ± 0.238
0.39CysSer: 0.39 ± 0.213
0.683CysThr: 0.683 ± 0.262
1.074CysVal: 1.074 ± 0.38
0.098CysTrp: 0.098 ± 0.109
0.098CysTyr: 0.098 ± 0.097
0.0CysXaa: 0.0 ± 0.0
Asp
3.807AspAla: 3.807 ± 0.601
0.683AspCys: 0.683 ± 0.258
3.221AspAsp: 3.221 ± 0.483
3.514AspGlu: 3.514 ± 0.674
2.538AspPhe: 2.538 ± 0.396
4.002AspGly: 4.002 ± 0.547
0.195AspHis: 0.195 ± 0.148
4.002AspIle: 4.002 ± 0.743
2.929AspLys: 2.929 ± 0.606
5.174AspLeu: 5.174 ± 0.581
1.464AspMet: 1.464 ± 0.433
2.148AspAsn: 2.148 ± 0.547
2.831AspPro: 2.831 ± 0.4
1.367AspGln: 1.367 ± 0.354
1.66AspArg: 1.66 ± 0.367
3.319AspSer: 3.319 ± 0.561
4.1AspThr: 4.1 ± 0.771
3.417AspVal: 3.417 ± 0.515
1.074AspTrp: 1.074 ± 0.35
2.148AspTyr: 2.148 ± 0.385
0.0AspXaa: 0.0 ± 0.0
Glu
4.1GluAla: 4.1 ± 0.671
0.683GluCys: 0.683 ± 0.372
2.929GluAsp: 2.929 ± 0.58
6.052GluGlu: 6.052 ± 1.151
3.709GluPhe: 3.709 ± 0.681
3.319GluGly: 3.319 ± 0.567
1.074GluHis: 1.074 ± 0.271
4.002GluIle: 4.002 ± 0.641
6.345GluLys: 6.345 ± 1.436
5.369GluLeu: 5.369 ± 0.95
1.855GluMet: 1.855 ± 0.406
2.733GluAsn: 2.733 ± 0.599
1.757GluPro: 1.757 ± 0.461
2.05GluGln: 2.05 ± 0.454
2.733GluArg: 2.733 ± 0.494
2.636GluSer: 2.636 ± 0.52
3.221GluThr: 3.221 ± 0.485
4.295GluVal: 4.295 ± 0.651
0.488GluTrp: 0.488 ± 0.217
3.221GluTyr: 3.221 ± 0.529
0.0GluXaa: 0.0 ± 0.0
Phe
1.855PheAla: 1.855 ± 0.339
0.586PheCys: 0.586 ± 0.229
3.221PheAsp: 3.221 ± 0.567
1.952PheGlu: 1.952 ± 0.408
1.757PhePhe: 1.757 ± 0.53
2.733PheGly: 2.733 ± 0.535
0.39PheHis: 0.39 ± 0.167
2.343PheIle: 2.343 ± 0.424
2.538PheLys: 2.538 ± 0.515
3.612PheLeu: 3.612 ± 0.689
1.074PheMet: 1.074 ± 0.313
1.66PheAsn: 1.66 ± 0.331
1.562PhePro: 1.562 ± 0.498
2.245PheGln: 2.245 ± 0.443
1.562PheArg: 1.562 ± 0.379
3.612PheSer: 3.612 ± 0.587
3.026PheThr: 3.026 ± 0.628
1.464PheVal: 1.464 ± 0.315
0.39PheTrp: 0.39 ± 0.183
1.269PheTyr: 1.269 ± 0.388
0.0PheXaa: 0.0 ± 0.0
Gly
7.126GlyAla: 7.126 ± 1.326
0.683GlyCys: 0.683 ± 0.318
3.905GlyAsp: 3.905 ± 0.611
4.393GlyGlu: 4.393 ± 0.589
3.124GlyPhe: 3.124 ± 0.637
5.759GlyGly: 5.759 ± 1.172
1.171GlyHis: 1.171 ± 0.368
5.467GlyIle: 5.467 ± 0.602
4.783GlyLys: 4.783 ± 0.73
4.783GlyLeu: 4.783 ± 0.802
1.171GlyMet: 1.171 ± 0.382
3.417GlyAsn: 3.417 ± 0.651
1.171GlyPro: 1.171 ± 0.294
2.636GlyGln: 2.636 ± 0.513
2.245GlyArg: 2.245 ± 0.527
4.881GlySer: 4.881 ± 1.342
7.126GlyThr: 7.126 ± 1.739
4.783GlyVal: 4.783 ± 0.839
1.269GlyTrp: 1.269 ± 0.372
3.124GlyTyr: 3.124 ± 0.548
0.0GlyXaa: 0.0 ± 0.0
His
1.464HisAla: 1.464 ± 0.344
0.195HisCys: 0.195 ± 0.13
0.976HisAsp: 0.976 ± 0.272
1.464HisGlu: 1.464 ± 0.507
0.488HisPhe: 0.488 ± 0.218
0.781HisGly: 0.781 ± 0.271
0.098HisHis: 0.098 ± 0.092
1.367HisIle: 1.367 ± 0.367
1.269HisLys: 1.269 ± 0.365
1.269HisLeu: 1.269 ± 0.361
0.293HisMet: 0.293 ± 0.172
0.586HisAsn: 0.586 ± 0.189
0.488HisPro: 0.488 ± 0.217
0.586HisGln: 0.586 ± 0.275
0.39HisArg: 0.39 ± 0.2
1.171HisSer: 1.171 ± 0.318
1.269HisThr: 1.269 ± 0.302
0.488HisVal: 0.488 ± 0.218
0.293HisTrp: 0.293 ± 0.164
0.781HisTyr: 0.781 ± 0.271
0.0HisXaa: 0.0 ± 0.0
Ile
4.393IleAla: 4.393 ± 0.487
0.488IleCys: 0.488 ± 0.204
4.588IleAsp: 4.588 ± 0.497
2.929IleGlu: 2.929 ± 0.609
1.757IlePhe: 1.757 ± 0.339
3.709IleGly: 3.709 ± 0.4
0.976IleHis: 0.976 ± 0.302
4.49IleIle: 4.49 ± 0.676
4.49IleLys: 4.49 ± 0.669
4.979IleLeu: 4.979 ± 0.624
1.171IleMet: 1.171 ± 0.275
3.417IleAsn: 3.417 ± 0.59
3.417IlePro: 3.417 ± 0.777
2.636IleGln: 2.636 ± 0.486
2.733IleArg: 2.733 ± 0.515
4.881IleSer: 4.881 ± 0.895
5.271IleThr: 5.271 ± 0.825
3.319IleVal: 3.319 ± 0.565
0.976IleTrp: 0.976 ± 0.328
1.562IleTyr: 1.562 ± 0.407
0.0IleXaa: 0.0 ± 0.0
Lys
5.174LysAla: 5.174 ± 0.967
0.586LysCys: 0.586 ± 0.275
3.319LysAsp: 3.319 ± 0.527
6.443LysGlu: 6.443 ± 1.286
2.636LysPhe: 2.636 ± 0.438
4.588LysGly: 4.588 ± 0.858
1.464LysHis: 1.464 ± 0.443
4.1LysIle: 4.1 ± 0.664
9.274LysLys: 9.274 ± 1.446
4.49LysLeu: 4.49 ± 0.827
2.538LysMet: 2.538 ± 0.601
3.514LysAsn: 3.514 ± 0.663
1.757LysPro: 1.757 ± 0.413
2.831LysGln: 2.831 ± 0.561
4.002LysArg: 4.002 ± 0.713
4.881LysSer: 4.881 ± 0.896
5.564LysThr: 5.564 ± 0.842
4.393LysVal: 4.393 ± 0.727
0.781LysTrp: 0.781 ± 0.338
2.343LysTyr: 2.343 ± 0.5
0.0LysXaa: 0.0 ± 0.0
Leu
5.564LeuAla: 5.564 ± 0.765
0.879LeuCys: 0.879 ± 0.277
4.002LeuAsp: 4.002 ± 0.627
3.905LeuGlu: 3.905 ± 0.896
1.855LeuPhe: 1.855 ± 0.443
4.783LeuGly: 4.783 ± 0.473
1.757LeuHis: 1.757 ± 0.403
4.686LeuIle: 4.686 ± 0.709
5.662LeuLys: 5.662 ± 0.884
6.736LeuLeu: 6.736 ± 0.91
1.855LeuMet: 1.855 ± 0.356
4.002LeuAsn: 4.002 ± 0.64
4.686LeuPro: 4.686 ± 0.593
4.49LeuGln: 4.49 ± 0.79
5.174LeuArg: 5.174 ± 0.593
5.759LeuSer: 5.759 ± 0.768
6.833LeuThr: 6.833 ± 0.869
4.686LeuVal: 4.686 ± 0.627
0.879LeuTrp: 0.879 ± 0.275
2.05LeuTyr: 2.05 ± 0.343
0.0LeuXaa: 0.0 ± 0.0
Met
2.733MetAla: 2.733 ± 0.509
0.195MetCys: 0.195 ± 0.128
1.074MetAsp: 1.074 ± 0.27
1.269MetGlu: 1.269 ± 0.431
0.488MetPhe: 0.488 ± 0.198
1.367MetGly: 1.367 ± 0.389
0.098MetHis: 0.098 ± 0.092
1.074MetIle: 1.074 ± 0.314
2.343MetLys: 2.343 ± 0.463
1.074MetLeu: 1.074 ± 0.329
0.781MetMet: 0.781 ± 0.311
2.05MetAsn: 2.05 ± 0.357
1.171MetPro: 1.171 ± 0.387
1.171MetGln: 1.171 ± 0.317
1.171MetArg: 1.171 ± 0.343
1.562MetSer: 1.562 ± 0.424
0.683MetThr: 0.683 ± 0.233
1.562MetVal: 1.562 ± 0.352
0.098MetTrp: 0.098 ± 0.098
1.074MetTyr: 1.074 ± 0.289
0.0MetXaa: 0.0 ± 0.0
Asn
4.393AsnAla: 4.393 ± 0.757
0.488AsnCys: 0.488 ± 0.231
2.831AsnAsp: 2.831 ± 0.638
3.221AsnGlu: 3.221 ± 0.546
1.464AsnPhe: 1.464 ± 0.544
4.198AsnGly: 4.198 ± 0.952
0.781AsnHis: 0.781 ± 0.249
3.514AsnIle: 3.514 ± 0.474
3.514AsnLys: 3.514 ± 0.654
4.295AsnLeu: 4.295 ± 0.577
0.781AsnMet: 0.781 ± 0.295
2.44AsnAsn: 2.44 ± 0.551
3.026AsnPro: 3.026 ± 0.564
2.148AsnGln: 2.148 ± 0.579
1.855AsnArg: 1.855 ± 0.363
2.343AsnSer: 2.343 ± 0.605
3.514AsnThr: 3.514 ± 0.936
3.417AsnVal: 3.417 ± 0.851
0.39AsnTrp: 0.39 ± 0.21
1.367AsnTyr: 1.367 ± 0.358
0.0AsnXaa: 0.0 ± 0.0
Pro
2.636ProAla: 2.636 ± 0.536
0.0ProCys: 0.0 ± 0.0
1.952ProAsp: 1.952 ± 0.384
4.198ProGlu: 4.198 ± 0.897
1.464ProPhe: 1.464 ± 0.411
1.855ProGly: 1.855 ± 0.483
0.879ProHis: 0.879 ± 0.3
1.66ProIle: 1.66 ± 0.409
3.514ProLys: 3.514 ± 0.739
3.514ProLeu: 3.514 ± 0.637
1.074ProMet: 1.074 ± 0.306
1.66ProAsn: 1.66 ± 0.404
2.538ProPro: 2.538 ± 0.739
1.757ProGln: 1.757 ± 0.344
1.562ProArg: 1.562 ± 0.361
3.709ProSer: 3.709 ± 0.507
2.636ProThr: 2.636 ± 0.552
3.124ProVal: 3.124 ± 0.498
0.39ProTrp: 0.39 ± 0.203
1.464ProTyr: 1.464 ± 0.32
0.0ProXaa: 0.0 ± 0.0
Gln
3.709GlnAla: 3.709 ± 0.85
0.195GlnCys: 0.195 ± 0.129
2.05GlnAsp: 2.05 ± 0.397
1.952GlnGlu: 1.952 ± 0.463
0.976GlnPhe: 0.976 ± 0.308
1.952GlnGly: 1.952 ± 0.328
0.586GlnHis: 0.586 ± 0.242
2.44GlnIle: 2.44 ± 0.432
5.271GlnLys: 5.271 ± 1.036
3.709GlnLeu: 3.709 ± 0.48
1.171GlnMet: 1.171 ± 0.313
3.221GlnAsn: 3.221 ± 0.597
1.269GlnPro: 1.269 ± 0.322
2.05GlnGln: 2.05 ± 0.619
1.952GlnArg: 1.952 ± 0.462
1.757GlnSer: 1.757 ± 0.339
2.44GlnThr: 2.44 ± 0.663
1.952GlnVal: 1.952 ± 0.354
0.683GlnTrp: 0.683 ± 0.239
1.464GlnTyr: 1.464 ± 0.382
0.0GlnXaa: 0.0 ± 0.0
Arg
3.612ArgAla: 3.612 ± 0.588
0.976ArgCys: 0.976 ± 0.297
2.44ArgAsp: 2.44 ± 0.518
3.514ArgGlu: 3.514 ± 0.707
1.757ArgPhe: 1.757 ± 0.398
2.538ArgGly: 2.538 ± 0.588
1.171ArgHis: 1.171 ± 0.255
3.124ArgIle: 3.124 ± 0.593
3.807ArgLys: 3.807 ± 0.598
3.709ArgLeu: 3.709 ± 0.622
0.879ArgMet: 0.879 ± 0.257
1.562ArgAsn: 1.562 ± 0.367
1.074ArgPro: 1.074 ± 0.307
1.757ArgGln: 1.757 ± 0.496
2.929ArgArg: 2.929 ± 0.737
2.44ArgSer: 2.44 ± 0.481
2.148ArgThr: 2.148 ± 0.311
2.44ArgVal: 2.44 ± 0.4
0.683ArgTrp: 0.683 ± 0.262
2.05ArgTyr: 2.05 ± 0.437
0.0ArgXaa: 0.0 ± 0.0
Ser
7.126SerAla: 7.126 ± 1.092
0.683SerCys: 0.683 ± 0.246
3.221SerAsp: 3.221 ± 0.439
2.831SerGlu: 2.831 ± 0.419
3.319SerPhe: 3.319 ± 0.553
6.638SerGly: 6.638 ± 1.437
1.562SerHis: 1.562 ± 0.458
3.709SerIle: 3.709 ± 0.613
2.733SerLys: 2.733 ± 0.618
4.49SerLeu: 4.49 ± 0.599
1.562SerMet: 1.562 ± 0.321
3.417SerAsn: 3.417 ± 0.672
3.124SerPro: 3.124 ± 0.599
2.148SerGln: 2.148 ± 0.405
3.319SerArg: 3.319 ± 0.581
5.174SerSer: 5.174 ± 1.067
5.369SerThr: 5.369 ± 1.592
3.026SerVal: 3.026 ± 0.636
1.171SerTrp: 1.171 ± 0.419
1.952SerTyr: 1.952 ± 0.478
0.0SerXaa: 0.0 ± 0.0
Thr
6.833ThrAla: 6.833 ± 1.295
0.586ThrCys: 0.586 ± 0.194
3.514ThrAsp: 3.514 ± 0.648
3.807ThrGlu: 3.807 ± 0.592
3.221ThrPhe: 3.221 ± 0.633
8.981ThrGly: 8.981 ± 1.285
1.367ThrHis: 1.367 ± 0.36
4.198ThrIle: 4.198 ± 0.473
2.636ThrLys: 2.636 ± 0.478
5.076ThrLeu: 5.076 ± 0.724
1.562ThrMet: 1.562 ± 0.412
2.831ThrAsn: 2.831 ± 0.742
4.1ThrPro: 4.1 ± 0.458
3.221ThrGln: 3.221 ± 0.667
1.952ThrArg: 1.952 ± 0.364
6.248ThrSer: 6.248 ± 1.258
5.759ThrThr: 5.759 ± 1.574
5.369ThrVal: 5.369 ± 0.921
0.683ThrTrp: 0.683 ± 0.269
2.245ThrTyr: 2.245 ± 0.486
0.0ThrXaa: 0.0 ± 0.0
Val
4.393ValAla: 4.393 ± 0.734
0.586ValCys: 0.586 ± 0.214
2.929ValAsp: 2.929 ± 0.418
3.514ValGlu: 3.514 ± 0.612
1.855ValPhe: 1.855 ± 0.557
4.783ValGly: 4.783 ± 0.887
0.976ValHis: 0.976 ± 0.28
2.831ValIle: 2.831 ± 0.517
3.612ValLys: 3.612 ± 0.662
5.759ValLeu: 5.759 ± 0.512
1.171ValMet: 1.171 ± 0.275
3.807ValAsn: 3.807 ± 0.714
2.929ValPro: 2.929 ± 0.611
2.245ValGln: 2.245 ± 0.388
2.831ValArg: 2.831 ± 0.547
4.002ValSer: 4.002 ± 0.605
5.271ValThr: 5.271 ± 0.766
3.514ValVal: 3.514 ± 0.54
0.976ValTrp: 0.976 ± 0.27
1.952ValTyr: 1.952 ± 0.462
0.0ValXaa: 0.0 ± 0.0
Trp
0.879TrpAla: 0.879 ± 0.251
0.293TrpCys: 0.293 ± 0.168
0.293TrpAsp: 0.293 ± 0.157
0.488TrpGlu: 0.488 ± 0.159
1.171TrpPhe: 1.171 ± 0.414
0.488TrpGly: 0.488 ± 0.23
0.098TrpHis: 0.098 ± 0.098
0.683TrpIle: 0.683 ± 0.279
1.074TrpLys: 1.074 ± 0.368
1.269TrpLeu: 1.269 ± 0.4
0.488TrpMet: 0.488 ± 0.238
0.683TrpAsn: 0.683 ± 0.217
0.098TrpPro: 0.098 ± 0.092
0.488TrpGln: 0.488 ± 0.219
1.074TrpArg: 1.074 ± 0.365
0.488TrpSer: 0.488 ± 0.215
0.781TrpThr: 0.781 ± 0.296
0.879TrpVal: 0.879 ± 0.289
0.098TrpTrp: 0.098 ± 0.098
0.586TrpTyr: 0.586 ± 0.214
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.952TyrAla: 1.952 ± 0.389
0.195TyrCys: 0.195 ± 0.131
1.952TyrAsp: 1.952 ± 0.431
2.733TyrGlu: 2.733 ± 0.7
1.757TyrPhe: 1.757 ± 0.527
3.026TyrGly: 3.026 ± 0.524
0.195TyrHis: 0.195 ± 0.142
2.343TyrIle: 2.343 ± 0.5
2.44TyrLys: 2.44 ± 0.468
2.733TyrLeu: 2.733 ± 0.439
0.39TyrMet: 0.39 ± 0.176
2.44TyrAsn: 2.44 ± 0.509
1.171TyrPro: 1.171 ± 0.396
1.269TyrGln: 1.269 ± 0.298
1.66TyrArg: 1.66 ± 0.361
1.855TyrSer: 1.855 ± 0.409
2.831TyrThr: 2.831 ± 0.489
2.538TyrVal: 2.538 ± 0.517
0.195TyrTrp: 0.195 ± 0.135
0.879TyrTyr: 0.879 ± 0.3
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (10245 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski