Amino acid dipepetide frequency for Gloeocapsa sp. PCC 73106

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.581AlaAla: 5.581 ± 0.087
0.768AlaCys: 0.768 ± 0.03
3.406AlaAsp: 3.406 ± 0.069
4.754AlaGlu: 4.754 ± 0.074
2.749AlaPhe: 2.749 ± 0.047
4.996AlaGly: 4.996 ± 0.089
1.252AlaHis: 1.252 ± 0.04
6.861AlaIle: 6.861 ± 0.073
3.889AlaLys: 3.889 ± 0.065
8.232AlaLeu: 8.232 ± 0.096
1.493AlaMet: 1.493 ± 0.036
3.245AlaAsn: 3.245 ± 0.071
2.576AlaPro: 2.576 ± 0.05
4.414AlaGln: 4.414 ± 0.07
3.407AlaArg: 3.407 ± 0.057
4.429AlaSer: 4.429 ± 0.06
4.339AlaThr: 4.339 ± 0.063
4.557AlaVal: 4.557 ± 0.07
0.976AlaTrp: 0.976 ± 0.03
2.374AlaTyr: 2.374 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.581CysAla: 0.581 ± 0.023
0.16CysCys: 0.16 ± 0.013
0.477CysAsp: 0.477 ± 0.022
0.466CysGlu: 0.466 ± 0.019
0.422CysPhe: 0.422 ± 0.02
0.714CysGly: 0.714 ± 0.024
0.248CysHis: 0.248 ± 0.015
0.499CysIle: 0.499 ± 0.019
0.281CysLys: 0.281 ± 0.019
1.251CysLeu: 1.251 ± 0.043
0.133CysMet: 0.133 ± 0.011
0.321CysAsn: 0.321 ± 0.017
0.497CysPro: 0.497 ± 0.019
0.669CysGln: 0.669 ± 0.025
0.491CysArg: 0.491 ± 0.02
0.599CysSer: 0.599 ± 0.022
0.444CysThr: 0.444 ± 0.019
0.525CysVal: 0.525 ± 0.022
0.128CysTrp: 0.128 ± 0.009
0.362CysTyr: 0.362 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.1AspAla: 3.1 ± 0.054
0.52AspCys: 0.52 ± 0.022
2.198AspAsp: 2.198 ± 0.065
2.759AspGlu: 2.759 ± 0.049
2.467AspPhe: 2.467 ± 0.048
3.329AspGly: 3.329 ± 0.081
0.822AspHis: 0.822 ± 0.028
3.308AspIle: 3.308 ± 0.056
1.797AspLys: 1.797 ± 0.048
6.501AspLeu: 6.501 ± 0.085
0.655AspMet: 0.655 ± 0.023
2.218AspAsn: 2.218 ± 0.054
2.554AspPro: 2.554 ± 0.055
2.052AspGln: 2.052 ± 0.042
2.974AspArg: 2.974 ± 0.047
3.09AspSer: 3.09 ± 0.06
2.602AspThr: 2.602 ± 0.062
2.705AspVal: 2.705 ± 0.048
0.942AspTrp: 0.942 ± 0.03
2.187AspTyr: 2.187 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
5.612GluAla: 5.612 ± 0.089
0.394GluCys: 0.394 ± 0.019
2.932GluAsp: 2.932 ± 0.062
4.23GluGlu: 4.23 ± 0.074
2.396GluPhe: 2.396 ± 0.048
3.57GluGly: 3.57 ± 0.061
1.047GluHis: 1.047 ± 0.034
5.733GluIle: 5.733 ± 0.08
3.687GluLys: 3.687 ± 0.063
7.458GluLeu: 7.458 ± 0.091
1.342GluMet: 1.342 ± 0.037
2.809GluAsn: 2.809 ± 0.051
2.357GluPro: 2.357 ± 0.053
3.848GluGln: 3.848 ± 0.06
3.201GluArg: 3.201 ± 0.055
3.778GluSer: 3.778 ± 0.055
4.052GluThr: 4.052 ± 0.069
4.32GluVal: 4.32 ± 0.063
0.706GluTrp: 0.706 ± 0.023
1.952GluTyr: 1.952 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
2.935PheAla: 2.935 ± 0.055
0.504PheCys: 0.504 ± 0.021
2.243PheAsp: 2.243 ± 0.049
2.215PheGlu: 2.215 ± 0.044
1.784PhePhe: 1.784 ± 0.043
2.955PheGly: 2.955 ± 0.061
0.659PheHis: 0.659 ± 0.024
2.457PheIle: 2.457 ± 0.052
1.604PheLys: 1.604 ± 0.036
4.326PheLeu: 4.326 ± 0.068
0.642PheMet: 0.642 ± 0.023
2.098PheAsn: 2.098 ± 0.046
1.933PhePro: 1.933 ± 0.043
1.656PheGln: 1.656 ± 0.038
1.767PheArg: 1.767 ± 0.033
3.146PheSer: 3.146 ± 0.052
2.49PheThr: 2.49 ± 0.051
2.254PheVal: 2.254 ± 0.051
0.7PheTrp: 0.7 ± 0.027
1.43PheTyr: 1.43 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.921GlyAla: 4.921 ± 0.1
0.711GlyCys: 0.711 ± 0.022
3.778GlyAsp: 3.778 ± 0.085
4.374GlyGlu: 4.374 ± 0.067
3.075GlyPhe: 3.075 ± 0.06
5.186GlyGly: 5.186 ± 0.11
1.112GlyHis: 1.112 ± 0.029
5.733GlyIle: 5.733 ± 0.073
3.876GlyLys: 3.876 ± 0.06
6.939GlyLeu: 6.939 ± 0.087
1.437GlyMet: 1.437 ± 0.035
3.372GlyAsn: 3.372 ± 0.1
1.71GlyPro: 1.71 ± 0.044
2.67GlyGln: 2.67 ± 0.066
3.11GlyArg: 3.11 ± 0.058
4.256GlySer: 4.256 ± 0.093
4.073GlyThr: 4.073 ± 0.068
4.904GlyVal: 4.904 ± 0.065
1.074GlyTrp: 1.074 ± 0.034
2.457GlyTyr: 2.457 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
0.89HisAla: 0.89 ± 0.028
0.254HisCys: 0.254 ± 0.016
0.723HisAsp: 0.723 ± 0.021
0.761HisGlu: 0.761 ± 0.027
0.784HisPhe: 0.784 ± 0.03
1.102HisGly: 1.102 ± 0.033
0.581HisHis: 0.581 ± 0.031
0.966HisIle: 0.966 ± 0.032
0.654HisLys: 0.654 ± 0.026
2.384HisLeu: 2.384 ± 0.054
0.209HisMet: 0.209 ± 0.014
0.775HisAsn: 0.775 ± 0.027
1.3HisPro: 1.3 ± 0.033
1.222HisGln: 1.222 ± 0.035
1.069HisArg: 1.069 ± 0.034
1.094HisSer: 1.094 ± 0.03
0.777HisThr: 0.777 ± 0.026
0.682HisVal: 0.682 ± 0.026
0.328HisTrp: 0.328 ± 0.016
0.673HisTyr: 0.673 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
7.469IleAla: 7.469 ± 0.09
0.756IleCys: 0.756 ± 0.025
3.909IleAsp: 3.909 ± 0.056
4.881IleGlu: 4.881 ± 0.076
2.855IlePhe: 2.855 ± 0.057
4.75IleGly: 4.75 ± 0.074
1.171IleHis: 1.171 ± 0.033
5.12IleIle: 5.12 ± 0.075
3.34IleLys: 3.34 ± 0.061
7.727IleLeu: 7.727 ± 0.097
1.033IleMet: 1.033 ± 0.03
3.646IleAsn: 3.646 ± 0.076
3.997IlePro: 3.997 ± 0.063
2.895IleGln: 2.895 ± 0.052
3.172IleArg: 3.172 ± 0.057
4.87IleSer: 4.87 ± 0.072
4.417IleThr: 4.417 ± 0.062
4.594IleVal: 4.594 ± 0.07
0.918IleTrp: 0.918 ± 0.029
2.28IleTyr: 2.28 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
3.758LysAla: 3.758 ± 0.065
0.282LysCys: 0.282 ± 0.015
2.013LysAsp: 2.013 ± 0.047
2.988LysGlu: 2.988 ± 0.057
1.521LysPhe: 1.521 ± 0.043
2.626LysGly: 2.626 ± 0.046
0.815LysHis: 0.815 ± 0.028
4.071LysIle: 4.071 ± 0.059
2.355LysLys: 2.355 ± 0.062
5.411LysLeu: 5.411 ± 0.071
0.95LysMet: 0.95 ± 0.029
1.977LysAsn: 1.977 ± 0.044
2.196LysPro: 2.196 ± 0.044
2.61LysGln: 2.61 ± 0.047
2.351LysArg: 2.351 ± 0.043
2.779LysSer: 2.779 ± 0.053
2.937LysThr: 2.937 ± 0.054
3.044LysVal: 3.044 ± 0.053
0.464LysTrp: 0.464 ± 0.019
1.444LysTyr: 1.444 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
9.543LeuAla: 9.543 ± 0.109
0.925LeuCys: 0.925 ± 0.031
5.632LeuAsp: 5.632 ± 0.069
8.285LeuGlu: 8.285 ± 0.107
3.823LeuPhe: 3.823 ± 0.06
8.194LeuGly: 8.194 ± 0.09
1.706LeuHis: 1.706 ± 0.042
8.437LeuIle: 8.437 ± 0.098
5.954LeuLys: 5.954 ± 0.086
11.595LeuLeu: 11.595 ± 0.158
2.043LeuMet: 2.043 ± 0.045
5.436LeuAsn: 5.436 ± 0.078
5.563LeuPro: 5.563 ± 0.082
4.926LeuGln: 4.926 ± 0.079
5.293LeuArg: 5.293 ± 0.073
8.091LeuSer: 8.091 ± 0.095
7.1LeuThr: 7.1 ± 0.088
7.557LeuVal: 7.557 ± 0.089
1.413LeuTrp: 1.413 ± 0.039
2.866LeuTyr: 2.866 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
1.407MetAla: 1.407 ± 0.04
0.128MetCys: 0.128 ± 0.011
0.664MetAsp: 0.664 ± 0.019
0.937MetGlu: 0.937 ± 0.03
0.559MetPhe: 0.559 ± 0.023
1.388MetGly: 1.388 ± 0.036
0.248MetHis: 0.248 ± 0.016
1.319MetIle: 1.319 ± 0.035
0.935MetLys: 0.935 ± 0.03
1.846MetLeu: 1.846 ± 0.043
0.389MetMet: 0.389 ± 0.017
0.775MetAsn: 0.775 ± 0.028
0.672MetPro: 0.672 ± 0.024
0.693MetGln: 0.693 ± 0.026
0.88MetArg: 0.88 ± 0.027
1.414MetSer: 1.414 ± 0.031
1.354MetThr: 1.354 ± 0.033
1.215MetVal: 1.215 ± 0.033
0.151MetTrp: 0.151 ± 0.012
0.384MetTyr: 0.384 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.587AsnAla: 2.587 ± 0.061
0.509AsnCys: 0.509 ± 0.023
1.956AsnAsp: 1.956 ± 0.067
1.856AsnGlu: 1.856 ± 0.044
2.133AsnPhe: 2.133 ± 0.044
2.915AsnGly: 2.915 ± 0.112
0.914AsnHis: 0.914 ± 0.029
2.856AsnIle: 2.856 ± 0.054
1.559AsnLys: 1.559 ± 0.038
6.435AsnLeu: 6.435 ± 0.088
0.625AsnMet: 0.625 ± 0.023
2.269AsnAsn: 2.269 ± 0.068
3.064AsnPro: 3.064 ± 0.05
3.001AsnGln: 3.001 ± 0.05
2.36AsnArg: 2.36 ± 0.047
3.179AsnSer: 3.179 ± 0.068
2.262AsnThr: 2.262 ± 0.051
2.181AsnVal: 2.181 ± 0.048
0.848AsnTrp: 0.848 ± 0.026
1.722AsnTyr: 1.722 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
2.499ProAla: 2.499 ± 0.047
0.349ProCys: 0.349 ± 0.018
2.771ProAsp: 2.771 ± 0.058
4.52ProGlu: 4.52 ± 0.077
1.707ProPhe: 1.707 ± 0.044
3.229ProGly: 3.229 ± 0.064
0.909ProHis: 0.909 ± 0.029
3.046ProIle: 3.046 ± 0.056
1.91ProLys: 1.91 ± 0.044
4.903ProLeu: 4.903 ± 0.072
0.727ProMet: 0.727 ± 0.028
2.163ProAsn: 2.163 ± 0.05
2.158ProPro: 2.158 ± 0.051
2.621ProGln: 2.621 ± 0.051
1.833ProArg: 1.833 ± 0.041
2.915ProSer: 2.915 ± 0.052
2.621ProThr: 2.621 ± 0.053
3.098ProVal: 3.098 ± 0.055
0.634ProTrp: 0.634 ± 0.025
1.423ProTyr: 1.423 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
4.248GlnAla: 4.248 ± 0.073
0.297GlnCys: 0.297 ± 0.016
2.306GlnAsp: 2.306 ± 0.05
3.926GlnGlu: 3.926 ± 0.058
1.663GlnPhe: 1.663 ± 0.041
3.669GlnGly: 3.669 ± 0.057
0.75GlnHis: 0.75 ± 0.027
3.996GlnIle: 3.996 ± 0.065
2.81GlnLys: 2.81 ± 0.062
5.9GlnLeu: 5.9 ± 0.091
0.907GlnMet: 0.907 ± 0.025
1.994GlnAsn: 1.994 ± 0.044
2.208GlnPro: 2.208 ± 0.048
3.298GlnGln: 3.298 ± 0.069
2.524GlnArg: 2.524 ± 0.04
3.158GlnSer: 3.158 ± 0.06
2.837GlnThr: 2.837 ± 0.044
3.467GlnVal: 3.467 ± 0.054
0.741GlnTrp: 0.741 ± 0.028
1.286GlnTyr: 1.286 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
3.107ArgAla: 3.107 ± 0.056
0.464ArgCys: 0.464 ± 0.022
2.567ArgAsp: 2.567 ± 0.051
3.488ArgGlu: 3.488 ± 0.058
2.223ArgPhe: 2.223 ± 0.043
2.972ArgGly: 2.972 ± 0.056
0.888ArgHis: 0.888 ± 0.03
3.258ArgIle: 3.258 ± 0.052
2.096ArgLys: 2.096 ± 0.049
5.9ArgLeu: 5.9 ± 0.087
0.888ArgMet: 0.888 ± 0.028
2.007ArgAsn: 2.007 ± 0.046
1.87ArgPro: 1.87 ± 0.037
2.868ArgGln: 2.868 ± 0.05
2.773ArgArg: 2.773 ± 0.052
3.135ArgSer: 3.135 ± 0.053
2.141ArgThr: 2.141 ± 0.048
3.354ArgVal: 3.354 ± 0.056
0.754ArgTrp: 0.754 ± 0.027
1.822ArgTyr: 1.822 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.2SerAla: 4.2 ± 0.071
0.639SerCys: 0.639 ± 0.026
3.236SerAsp: 3.236 ± 0.056
3.983SerGlu: 3.983 ± 0.064
2.839SerPhe: 2.839 ± 0.056
4.959SerGly: 4.959 ± 0.091
1.199SerHis: 1.199 ± 0.036
4.05SerIle: 4.05 ± 0.057
2.64SerLys: 2.64 ± 0.056
8.354SerLeu: 8.354 ± 0.1
1.076SerMet: 1.076 ± 0.033
2.831SerAsn: 2.831 ± 0.058
3.301SerPro: 3.301 ± 0.062
3.619SerGln: 3.619 ± 0.066
3.101SerArg: 3.101 ± 0.053
4.488SerSer: 4.488 ± 0.09
3.478SerThr: 3.478 ± 0.059
4.174SerVal: 4.174 ± 0.071
0.92SerTrp: 0.92 ± 0.028
2.108SerTyr: 2.108 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.126ThrAla: 4.126 ± 0.06
0.436ThrCys: 0.436 ± 0.02
2.638ThrAsp: 2.638 ± 0.045
3.922ThrGlu: 3.922 ± 0.058
2.107ThrPhe: 2.107 ± 0.048
4.717ThrGly: 4.717 ± 0.089
0.954ThrHis: 0.954 ± 0.029
4.409ThrIle: 4.409 ± 0.067
2.401ThrLys: 2.401 ± 0.046
6.612ThrLeu: 6.612 ± 0.084
0.871ThrMet: 0.871 ± 0.025
2.442ThrAsn: 2.442 ± 0.044
3.452ThrPro: 3.452 ± 0.056
2.955ThrGln: 2.955 ± 0.052
2.419ThrArg: 2.419 ± 0.05
3.552ThrSer: 3.552 ± 0.058
3.422ThrThr: 3.422 ± 0.063
3.818ThrVal: 3.818 ± 0.063
0.8ThrTrp: 0.8 ± 0.028
1.68ThrTyr: 1.68 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.023ValAla: 5.023 ± 0.07
0.606ValCys: 0.606 ± 0.023
3.217ValAsp: 3.217 ± 0.058
4.436ValGlu: 4.436 ± 0.075
2.63ValPhe: 2.63 ± 0.059
4.41ValGly: 4.41 ± 0.066
0.889ValHis: 0.889 ± 0.026
5.143ValIle: 5.143 ± 0.067
3.252ValLys: 3.252 ± 0.055
6.133ValLeu: 6.133 ± 0.079
1.262ValMet: 1.262 ± 0.034
3.089ValAsn: 3.089 ± 0.053
2.561ValPro: 2.561 ± 0.057
2.344ValGln: 2.344 ± 0.047
2.847ValArg: 2.847 ± 0.045
4.239ValSer: 4.239 ± 0.072
4.073ValThr: 4.073 ± 0.057
4.402ValVal: 4.402 ± 0.079
0.795ValTrp: 0.795 ± 0.024
1.96ValTyr: 1.96 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.739TrpAla: 0.739 ± 0.03
0.155TrpCys: 0.155 ± 0.012
0.575TrpAsp: 0.575 ± 0.023
1.04TrpGlu: 1.04 ± 0.031
0.592TrpPhe: 0.592 ± 0.019
0.977TrpGly: 0.977 ± 0.031
0.289TrpHis: 0.289 ± 0.019
0.84TrpIle: 0.84 ± 0.031
0.54TrpLys: 0.54 ± 0.022
2.14TrpLeu: 2.14 ± 0.057
0.271TrpMet: 0.271 ± 0.016
0.549TrpAsn: 0.549 ± 0.021
0.263TrpPro: 0.263 ± 0.016
1.156TrpGln: 1.156 ± 0.035
0.93TrpArg: 0.93 ± 0.03
1.014TrpSer: 1.014 ± 0.03
0.614TrpThr: 0.614 ± 0.025
0.755TrpVal: 0.755 ± 0.026
0.248TrpTrp: 0.248 ± 0.016
0.466TrpTyr: 0.466 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.968TyrAla: 1.968 ± 0.04
0.413TyrCys: 0.413 ± 0.02
1.539TyrAsp: 1.539 ± 0.043
1.601TyrGlu: 1.601 ± 0.038
1.468TyrPhe: 1.468 ± 0.034
2.109TyrGly: 2.109 ± 0.044
0.777TyrHis: 0.777 ± 0.027
1.697TyrIle: 1.697 ± 0.041
1.01TyrLys: 1.01 ± 0.034
4.334TyrLeu: 4.334 ± 0.064
0.403TyrMet: 0.403 ± 0.017
1.216TyrAsn: 1.216 ± 0.037
1.807TyrPro: 1.807 ± 0.042
2.471TyrGln: 2.471 ± 0.049
2.074TyrArg: 2.074 ± 0.048
1.972TyrSer: 1.972 ± 0.04
1.697TyrThr: 1.697 ± 0.039
1.707TyrVal: 1.707 ± 0.04
0.613TyrTrp: 0.613 ± 0.026
1.201TyrTyr: 1.201 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4062 proteins (1199467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski