Amino acid dipepetide frequency for Paracoccus homiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.572AlaAla: 17.572 ± 0.204	1.059AlaCys: 1.059 ± 0.031	7.709AlaAsp: 7.709 ± 0.104	7.946AlaGlu: 7.946 ± 0.114	4.041AlaPhe: 4.041 ± 0.063	11.222AlaGly: 11.222 ± 0.143	2.315AlaHis: 2.315 ± 0.04	6.389AlaIle: 6.389 ± 0.085	3.351AlaLys: 3.351 ± 0.064	13.303AlaLeu: 13.303 ± 0.149	4.085AlaMet: 4.085 ± 0.063	2.6AlaAsn: 2.6 ± 0.046	5.751AlaPro: 5.751 ± 0.09	5.105AlaGln: 5.105 ± 0.077	9.453AlaArg: 9.453 ± 0.114	5.508AlaSer: 5.508 ± 0.078	6.262AlaThr: 6.262 ± 0.079	8.421AlaVal: 8.421 ± 0.098	1.581AlaTrp: 1.581 ± 0.039	2.424AlaTyr: 2.424 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.036CysAla: 1.036 ± 0.029	0.115CysCys: 0.115 ± 0.011	0.633CysAsp: 0.633 ± 0.023	0.409CysGlu: 0.409 ± 0.018	0.3CysPhe: 0.3 ± 0.016	0.957CysGly: 0.957 ± 0.031	0.295CysHis: 0.295 ± 0.016	0.386CysIle: 0.386 ± 0.02	0.178CysLys: 0.178 ± 0.012	0.839CysLeu: 0.839 ± 0.03	0.2CysMet: 0.2 ± 0.012	0.205CysAsn: 0.205 ± 0.012	0.488CysPro: 0.488 ± 0.02	0.256CysGln: 0.256 ± 0.015	0.59CysArg: 0.59 ± 0.024	0.426CysSer: 0.426 ± 0.021	0.409CysThr: 0.409 ± 0.018	0.618CysVal: 0.618 ± 0.024	0.125CysTrp: 0.125 ± 0.011	0.207CysTyr: 0.207 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.727AspAla: 7.727 ± 0.094	0.537AspCys: 0.537 ± 0.022	3.82AspAsp: 3.82 ± 0.072	3.492AspGlu: 3.492 ± 0.061	2.322AspPhe: 2.322 ± 0.052	5.735AspGly: 5.735 ± 0.101	1.704AspHis: 1.704 ± 0.041	3.103AspIle: 3.103 ± 0.052	1.601AspLys: 1.601 ± 0.038	7.298AspLeu: 7.298 ± 0.089	1.773AspMet: 1.773 ± 0.041	1.369AspAsn: 1.369 ± 0.036	4.048AspPro: 4.048 ± 0.059	2.651AspGln: 2.651 ± 0.049	5.24AspArg: 5.24 ± 0.077	2.618AspSer: 2.618 ± 0.063	2.631AspThr: 2.631 ± 0.055	3.71AspVal: 3.71 ± 0.061	1.285AspTrp: 1.285 ± 0.032	1.611AspTyr: 1.611 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.039GluAla: 7.039 ± 0.098	0.355GluCys: 0.355 ± 0.02	3.159GluAsp: 3.159 ± 0.064	2.844GluGlu: 2.844 ± 0.067	1.753GluPhe: 1.753 ± 0.043	4.482GluGly: 4.482 ± 0.068	1.005GluHis: 1.005 ± 0.029	3.161GluIle: 3.161 ± 0.053	1.77GluLys: 1.77 ± 0.047	4.808GluLeu: 4.808 ± 0.073	1.601GluMet: 1.601 ± 0.036	1.477GluAsn: 1.477 ± 0.037	2.204GluPro: 2.204 ± 0.046	2.075GluGln: 2.075 ± 0.05	3.816GluArg: 3.816 ± 0.06	2.069GluSer: 2.069 ± 0.039	3.176GluThr: 3.176 ± 0.054	3.751GluVal: 3.751 ± 0.06	0.793GluTrp: 0.793 ± 0.028	1.028GluTyr: 1.028 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.409PheAla: 4.409 ± 0.065	0.406PheCys: 0.406 ± 0.018	2.81PheAsp: 2.81 ± 0.053	1.743PheGlu: 1.743 ± 0.039	1.274PhePhe: 1.274 ± 0.038	3.709PheGly: 3.709 ± 0.066	0.756PheHis: 0.756 ± 0.026	1.583PheIle: 1.583 ± 0.042	0.748PheLys: 0.748 ± 0.026	3.444PheLeu: 3.444 ± 0.059	0.889PheMet: 0.889 ± 0.031	0.912PheAsn: 0.912 ± 0.025	1.545PhePro: 1.545 ± 0.041	1.141PheGln: 1.141 ± 0.039	2.21PheArg: 2.21 ± 0.043	1.968PheSer: 1.968 ± 0.043	1.951PheThr: 1.951 ± 0.047	2.552PheVal: 2.552 ± 0.053	0.607PheTrp: 0.607 ± 0.027	0.817PheTyr: 0.817 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.986GlyAla: 9.986 ± 0.127	0.85GlyCys: 0.85 ± 0.025	5.277GlyAsp: 5.277 ± 0.111	4.234GlyGlu: 4.234 ± 0.066	3.812GlyPhe: 3.812 ± 0.065	7.945GlyGly: 7.945 ± 0.375	2.025GlyHis: 2.025 ± 0.046	4.71GlyIle: 4.71 ± 0.072	2.914GlyLys: 2.914 ± 0.057	9.624GlyLeu: 9.624 ± 0.114	2.728GlyMet: 2.728 ± 0.05	2.241GlyAsn: 2.241 ± 0.082	3.821GlyPro: 3.821 ± 0.058	3.718GlyGln: 3.718 ± 0.071	6.333GlyArg: 6.333 ± 0.082	4.408GlySer: 4.408 ± 0.1	4.508GlyThr: 4.508 ± 0.077	6.394GlyVal: 6.394 ± 0.081	1.656GlyTrp: 1.656 ± 0.036	2.21GlyTyr: 2.21 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.421HisAla: 2.421 ± 0.045	0.238HisCys: 0.238 ± 0.015	1.506HisAsp: 1.506 ± 0.04	1.008HisGlu: 1.008 ± 0.029	0.764HisPhe: 0.764 ± 0.026	2.013HisGly: 2.013 ± 0.045	0.592HisHis: 0.592 ± 0.024	0.944HisIle: 0.944 ± 0.031	0.437HisLys: 0.437 ± 0.018	2.233HisLeu: 2.233 ± 0.045	0.535HisMet: 0.535 ± 0.023	0.397HisAsn: 0.397 ± 0.019	1.45HisPro: 1.45 ± 0.036	0.684HisGln: 0.684 ± 0.024	1.532HisArg: 1.532 ± 0.038	0.918HisSer: 0.918 ± 0.029	0.663HisThr: 0.663 ± 0.024	1.544HisVal: 1.544 ± 0.04	0.293HisTrp: 0.293 ± 0.017	0.524HisTyr: 0.524 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.696IleAla: 7.696 ± 0.085	0.654IleCys: 0.654 ± 0.026	3.702IleAsp: 3.702 ± 0.058	3.243IleGlu: 3.243 ± 0.059	1.845IlePhe: 1.845 ± 0.048	5.19IleGly: 5.19 ± 0.071	0.986IleHis: 0.986 ± 0.029	2.237IleIle: 2.237 ± 0.059	1.157IleLys: 1.157 ± 0.034	4.928IleLeu: 4.928 ± 0.064	1.182IleMet: 1.182 ± 0.035	1.283IleAsn: 1.283 ± 0.032	2.434IlePro: 2.434 ± 0.048	1.295IleGln: 1.295 ± 0.033	3.63IleArg: 3.63 ± 0.056	2.85IleSer: 2.85 ± 0.05	2.872IleThr: 2.872 ± 0.047	3.777IleVal: 3.777 ± 0.058	0.771IleTrp: 0.771 ± 0.025	1.145IleTyr: 1.145 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.556LysAla: 3.556 ± 0.065	0.158LysCys: 0.158 ± 0.011	1.613LysAsp: 1.613 ± 0.037	1.217LysGlu: 1.217 ± 0.039	0.793LysPhe: 0.793 ± 0.033	2.522LysGly: 2.522 ± 0.057	0.477LysHis: 0.477 ± 0.022	1.435LysIle: 1.435 ± 0.037	0.951LysLys: 0.951 ± 0.03	2.656LysLeu: 2.656 ± 0.053	0.792LysMet: 0.792 ± 0.028	0.689LysAsn: 0.689 ± 0.025	1.69LysPro: 1.69 ± 0.041	0.853LysGln: 0.853 ± 0.027	1.855LysArg: 1.855 ± 0.047	1.573LysSer: 1.573 ± 0.041	1.596LysThr: 1.596 ± 0.038	2.029LysVal: 2.029 ± 0.043	0.332LysTrp: 0.332 ± 0.019	0.552LysTyr: 0.552 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.079LeuAla: 13.079 ± 0.126	0.974LeuCys: 0.974 ± 0.032	6.18LeuAsp: 6.18 ± 0.082	4.356LeuGlu: 4.356 ± 0.073	3.373LeuPhe: 3.373 ± 0.069	8.543LeuGly: 8.543 ± 0.103	1.916LeuHis: 1.916 ± 0.04	5.876LeuIle: 5.876 ± 0.068	2.715LeuLys: 2.715 ± 0.057	8.918LeuLeu: 8.918 ± 0.124	2.684LeuMet: 2.684 ± 0.049	2.641LeuAsn: 2.641 ± 0.046	6.009LeuPro: 6.009 ± 0.084	3.146LeuGln: 3.146 ± 0.053	7.676LeuArg: 7.676 ± 0.089	6.614LeuSer: 6.614 ± 0.082	6.442LeuThr: 6.442 ± 0.083	6.451LeuVal: 6.451 ± 0.085	1.325LeuTrp: 1.325 ± 0.035	1.867LeuTyr: 1.867 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.775MetAla: 3.775 ± 0.063	0.2MetCys: 0.2 ± 0.014	1.477MetAsp: 1.477 ± 0.033	1.098MetGlu: 1.098 ± 0.031	0.816MetPhe: 0.816 ± 0.022	2.384MetGly: 2.384 ± 0.044	0.423MetHis: 0.423 ± 0.02	1.583MetIle: 1.583 ± 0.036	1.016MetLys: 1.016 ± 0.032	2.764MetLeu: 2.764 ± 0.053	0.83MetMet: 0.83 ± 0.027	0.867MetAsn: 0.867 ± 0.027	1.652MetPro: 1.652 ± 0.037	1.113MetGln: 1.113 ± 0.033	2.061MetArg: 2.061 ± 0.044	1.812MetSer: 1.812 ± 0.037	2.172MetThr: 2.172 ± 0.041	1.863MetVal: 1.863 ± 0.039	0.274MetTrp: 0.274 ± 0.016	0.34MetTyr: 0.34 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.015AsnAla: 3.015 ± 0.053	0.254AsnCys: 0.254 ± 0.015	1.483AsnAsp: 1.483 ± 0.042	1.031AsnGlu: 1.031 ± 0.025	0.92AsnPhe: 0.92 ± 0.026	2.343AsnGly: 2.343 ± 0.068	0.494AsnHis: 0.494 ± 0.021	1.346AsnIle: 1.346 ± 0.034	0.561AsnLys: 0.561 ± 0.021	2.472AsnLeu: 2.472 ± 0.052	0.686AsnMet: 0.686 ± 0.025	0.611AsnAsn: 0.611 ± 0.023	1.789AsnPro: 1.789 ± 0.037	0.751AsnGln: 0.751 ± 0.025	1.819AsnArg: 1.819 ± 0.042	1.243AsnSer: 1.243 ± 0.031	1.106AsnThr: 1.106 ± 0.032	1.685AsnVal: 1.685 ± 0.039	0.455AsnTrp: 0.455 ± 0.021	0.596AsnTyr: 0.596 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.461ProAla: 6.461 ± 0.097	0.354ProCys: 0.354 ± 0.02	4.485ProAsp: 4.485 ± 0.061	3.647ProGlu: 3.647 ± 0.063	1.918ProPhe: 1.918 ± 0.043	4.689ProGly: 4.689 ± 0.059	1.077ProHis: 1.077 ± 0.035	2.392ProIle: 2.392 ± 0.052	1.447ProLys: 1.447 ± 0.04	4.635ProLeu: 4.635 ± 0.065	1.368ProMet: 1.368 ± 0.03	1.243ProAsn: 1.243 ± 0.031	2.303ProPro: 2.303 ± 0.047	2.071ProGln: 2.071 ± 0.047	3.212ProArg: 3.212 ± 0.051	2.389ProSer: 2.389 ± 0.045	2.387ProThr: 2.387 ± 0.044	4.334ProVal: 4.334 ± 0.059	0.749ProTrp: 0.749 ± 0.031	1.055ProTyr: 1.055 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.949GlnAla: 4.949 ± 0.076	0.194GlnCys: 0.194 ± 0.012	2.302GlnAsp: 2.302 ± 0.047	1.477GlnGlu: 1.477 ± 0.037	1.087GlnPhe: 1.087 ± 0.033	3.297GlnGly: 3.297 ± 0.058	0.673GlnHis: 0.673 ± 0.024	2.471GlnIle: 2.471 ± 0.046	1.08GlnLys: 1.08 ± 0.035	3.191GlnLeu: 3.191 ± 0.058	1.259GlnMet: 1.259 ± 0.034	0.991GlnAsn: 0.991 ± 0.031	2.095GlnPro: 2.095 ± 0.039	1.471GlnGln: 1.471 ± 0.044	2.552GlnArg: 2.552 ± 0.061	1.821GlnSer: 1.821 ± 0.064	1.974GlnThr: 1.974 ± 0.036	2.734GlnVal: 2.734 ± 0.047	0.387GlnTrp: 0.387 ± 0.017	0.533GlnTyr: 0.533 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.444ArgAla: 8.444 ± 0.108	0.491ArgCys: 0.491 ± 0.02	5.161ArgAsp: 5.161 ± 0.069	3.736ArgGlu: 3.736 ± 0.065	2.704ArgPhe: 2.704 ± 0.053	5.001ArgGly: 5.001 ± 0.078	1.781ArgHis: 1.781 ± 0.048	4.285ArgIle: 4.285 ± 0.062	2.171ArgLys: 2.171 ± 0.049	8.0ArgLeu: 8.0 ± 0.089	2.263ArgMet: 2.263 ± 0.043	1.854ArgAsn: 1.854 ± 0.038	3.711ArgPro: 3.711 ± 0.068	2.938ArgGln: 2.938 ± 0.052	5.722ArgArg: 5.722 ± 0.084	3.436ArgSer: 3.436 ± 0.055	2.887ArgThr: 2.887 ± 0.054	4.817ArgVal: 4.817 ± 0.073	0.999ArgTrp: 0.999 ± 0.031	1.437ArgTyr: 1.437 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.92SerAla: 5.92 ± 0.067	0.448SerCys: 0.448 ± 0.021	3.384SerAsp: 3.384 ± 0.062	2.518SerGlu: 2.518 ± 0.045	2.211SerPhe: 2.211 ± 0.048	5.537SerGly: 5.537 ± 0.106	1.075SerHis: 1.075 ± 0.033	2.387SerIle: 2.387 ± 0.053	1.237SerLys: 1.237 ± 0.032	4.943SerLeu: 4.943 ± 0.065	1.273SerMet: 1.273 ± 0.035	1.222SerAsn: 1.222 ± 0.035	2.554SerPro: 2.554 ± 0.04	1.742SerGln: 1.742 ± 0.04	3.462SerArg: 3.462 ± 0.055	2.408SerSer: 2.408 ± 0.053	2.362SerThr: 2.362 ± 0.047	3.683SerVal: 3.683 ± 0.068	0.74SerTrp: 0.74 ± 0.026	1.165SerTyr: 1.165 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.375ThrAla: 6.375 ± 0.085	0.459ThrCys: 0.459 ± 0.019	3.231ThrAsp: 3.231 ± 0.056	2.781ThrGlu: 2.781 ± 0.054	1.622ThrPhe: 1.622 ± 0.035	5.457ThrGly: 5.457 ± 0.095	1.053ThrHis: 1.053 ± 0.029	2.653ThrIle: 2.653 ± 0.046	1.194ThrLys: 1.194 ± 0.032	5.48ThrLeu: 5.48 ± 0.069	1.261ThrMet: 1.261 ± 0.029	1.217ThrAsn: 1.217 ± 0.034	3.43ThrPro: 3.43 ± 0.05	1.719ThrGln: 1.719 ± 0.032	3.782ThrArg: 3.782 ± 0.054	2.399ThrSer: 2.399 ± 0.051	2.75ThrThr: 2.75 ± 0.051	4.06ThrVal: 4.06 ± 0.07	0.632ThrTrp: 0.632 ± 0.024	1.098ThrTyr: 1.098 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.894ValAla: 8.894 ± 0.089	0.557ValCys: 0.557 ± 0.021	3.96ValAsp: 3.96 ± 0.065	3.949ValGlu: 3.949 ± 0.058	2.53ValPhe: 2.53 ± 0.055	5.265ValGly: 5.265 ± 0.075	1.16ValHis: 1.16 ± 0.034	4.415ValIle: 4.415 ± 0.065	1.868ValLys: 1.868 ± 0.049	7.264ValLeu: 7.264 ± 0.088	2.228ValMet: 2.228 ± 0.045	1.867ValAsn: 1.867 ± 0.042	3.444ValPro: 3.444 ± 0.058	2.34ValGln: 2.34 ± 0.045	4.041ValArg: 4.041 ± 0.061	3.938ValSer: 3.938 ± 0.065	4.735ValThr: 4.735 ± 0.067	5.23ValVal: 5.23 ± 0.078	0.991ValTrp: 0.991 ± 0.032	1.322ValTyr: 1.322 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.412TrpAla: 1.412 ± 0.039	0.15TrpCys: 0.15 ± 0.012	0.822TrpAsp: 0.822 ± 0.03	0.556TrpGlu: 0.556 ± 0.023	0.602TrpPhe: 0.602 ± 0.024	1.093TrpGly: 1.093 ± 0.033	0.372TrpHis: 0.372 ± 0.018	0.717TrpIle: 0.717 ± 0.025	0.448TrpLys: 0.448 ± 0.02	1.789TrpLeu: 1.789 ± 0.044	0.408TrpMet: 0.408 ± 0.02	0.427TrpAsn: 0.427 ± 0.021	0.731TrpPro: 0.731 ± 0.027	0.742TrpGln: 0.742 ± 0.026	1.245TrpArg: 1.245 ± 0.037	0.807TrpSer: 0.807 ± 0.028	0.81TrpThr: 0.81 ± 0.027	0.93TrpVal: 0.93 ± 0.029	0.251TrpTrp: 0.251 ± 0.017	0.279TrpTyr: 0.279 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.329TyrAla: 2.329 ± 0.045	0.22TyrCys: 0.22 ± 0.013	1.561TyrAsp: 1.561 ± 0.043	1.083TyrGlu: 1.083 ± 0.035	0.789TyrPhe: 0.789 ± 0.026	2.01TyrGly: 2.01 ± 0.041	0.513TyrHis: 0.513 ± 0.024	0.805TyrIle: 0.805 ± 0.027	0.497TyrLys: 0.497 ± 0.019	2.194TyrLeu: 2.194 ± 0.044	0.474TyrMet: 0.474 ± 0.021	0.546TyrAsn: 0.546 ± 0.022	1.067TyrPro: 1.067 ± 0.027	0.73TyrGln: 0.73 ± 0.024	1.608TyrArg: 1.608 ± 0.039	1.066TyrSer: 1.066 ± 0.033	0.957TyrThr: 0.957 ± 0.031	1.417TyrVal: 1.417 ± 0.035	0.341TyrTrp: 0.341 ± 0.015	0.534TyrTyr: 0.534 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3828 proteins (1177105 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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