Amino acid dipepetide frequency for Sulfuricaulis limicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.088AlaAla: 13.088 ± 0.162
1.254AlaCys: 1.254 ± 0.048
5.379AlaAsp: 5.379 ± 0.085
6.45AlaGlu: 6.45 ± 0.099
3.428AlaPhe: 3.428 ± 0.074
9.478AlaGly: 9.478 ± 0.139
2.344AlaHis: 2.344 ± 0.054
5.298AlaIle: 5.298 ± 0.09
3.991AlaLys: 3.991 ± 0.084
11.667AlaLeu: 11.667 ± 0.151
2.932AlaMet: 2.932 ± 0.063
2.778AlaAsn: 2.778 ± 0.055
4.738AlaPro: 4.738 ± 0.109
3.995AlaGln: 3.995 ± 0.082
8.486AlaArg: 8.486 ± 0.124
5.273AlaSer: 5.273 ± 0.085
5.206AlaThr: 5.206 ± 0.087
8.05AlaVal: 8.05 ± 0.104
1.58AlaTrp: 1.58 ± 0.043
2.462AlaTyr: 2.462 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.039
0.121CysCys: 0.121 ± 0.012
0.496CysAsp: 0.496 ± 0.029
0.531CysGlu: 0.531 ± 0.026
0.342CysPhe: 0.342 ± 0.02
0.989CysGly: 0.989 ± 0.039
0.448CysHis: 0.448 ± 0.05
0.368CysIle: 0.368 ± 0.02
0.262CysLys: 0.262 ± 0.02
0.905CysLeu: 0.905 ± 0.031
0.172CysMet: 0.172 ± 0.015
0.27CysAsn: 0.27 ± 0.02
0.578CysPro: 0.578 ± 0.03
0.322CysGln: 0.322 ± 0.021
0.757CysArg: 0.757 ± 0.029
0.455CysSer: 0.455 ± 0.025
0.446CysThr: 0.446 ± 0.025
0.68CysVal: 0.68 ± 0.031
0.119CysTrp: 0.119 ± 0.018
0.254CysTyr: 0.254 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.274AspAla: 5.274 ± 0.085
0.454AspCys: 0.454 ± 0.024
2.668AspAsp: 2.668 ± 0.056
3.154AspGlu: 3.154 ± 0.07
2.116AspPhe: 2.116 ± 0.05
4.11AspGly: 4.11 ± 0.083
1.145AspHis: 1.145 ± 0.037
3.141AspIle: 3.141 ± 0.067
2.413AspLys: 2.413 ± 0.058
5.125AspLeu: 5.125 ± 0.078
1.4AspMet: 1.4 ± 0.043
1.503AspAsn: 1.503 ± 0.043
2.967AspPro: 2.967 ± 0.055
1.568AspGln: 1.568 ± 0.042
3.578AspArg: 3.578 ± 0.073
2.371AspSer: 2.371 ± 0.045
2.609AspThr: 2.609 ± 0.057
3.817AspVal: 3.817 ± 0.072
0.844AspTrp: 0.844 ± 0.031
1.655AspTyr: 1.655 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
6.578GluAla: 6.578 ± 0.108
0.497GluCys: 0.497 ± 0.028
2.432GluAsp: 2.432 ± 0.061
3.314GluGlu: 3.314 ± 0.08
2.19GluPhe: 2.19 ± 0.05
3.619GluGly: 3.619 ± 0.081
1.565GluHis: 1.565 ± 0.05
3.753GluIle: 3.753 ± 0.08
3.324GluLys: 3.324 ± 0.066
6.174GluLeu: 6.174 ± 0.084
1.587GluMet: 1.587 ± 0.048
1.972GluAsn: 1.972 ± 0.051
2.47GluPro: 2.47 ± 0.057
2.683GluGln: 2.683 ± 0.077
4.663GluArg: 4.663 ± 0.094
2.978GluSer: 2.978 ± 0.068
3.513GluThr: 3.513 ± 0.068
3.913GluVal: 3.913 ± 0.078
0.757GluTrp: 0.757 ± 0.033
1.504GluTyr: 1.504 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.635PheAla: 3.635 ± 0.074
0.368PheCys: 0.368 ± 0.021
2.255PheAsp: 2.255 ± 0.051
2.102PheGlu: 2.102 ± 0.049
1.554PhePhe: 1.554 ± 0.059
3.176PheGly: 3.176 ± 0.065
0.912PheHis: 0.912 ± 0.031
1.929PheIle: 1.929 ± 0.051
1.218PheLys: 1.218 ± 0.041
3.638PheLeu: 3.638 ± 0.076
0.911PheMet: 0.911 ± 0.035
1.34PheAsn: 1.34 ± 0.049
1.644PhePro: 1.644 ± 0.04
1.178PheGln: 1.178 ± 0.033
2.337PheArg: 2.337 ± 0.057
2.356PheSer: 2.356 ± 0.058
2.121PheThr: 2.121 ± 0.064
2.701PheVal: 2.701 ± 0.065
0.518PheTrp: 0.518 ± 0.025
1.107PheTyr: 1.107 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
7.628GlyAla: 7.628 ± 0.108
0.894GlyCys: 0.894 ± 0.033
3.902GlyAsp: 3.902 ± 0.069
4.518GlyGlu: 4.518 ± 0.073
3.492GlyPhe: 3.492 ± 0.071
6.487GlyGly: 6.487 ± 0.122
2.003GlyHis: 2.003 ± 0.05
4.663GlyIle: 4.663 ± 0.081
4.197GlyLys: 4.197 ± 0.088
8.035GlyLeu: 8.035 ± 0.114
2.476GlyMet: 2.476 ± 0.068
2.423GlyAsn: 2.423 ± 0.061
2.752GlyPro: 2.752 ± 0.052
2.751GlyGln: 2.751 ± 0.052
5.268GlyArg: 5.268 ± 0.081
4.301GlySer: 4.301 ± 0.088
4.294GlyThr: 4.294 ± 0.109
6.168GlyVal: 6.168 ± 0.102
1.253GlyTrp: 1.253 ± 0.042
2.46GlyTyr: 2.46 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.646HisAla: 2.646 ± 0.055
0.29HisCys: 0.29 ± 0.017
1.325HisAsp: 1.325 ± 0.048
1.48HisGlu: 1.48 ± 0.039
0.938HisPhe: 0.938 ± 0.033
2.206HisGly: 2.206 ± 0.056
0.722HisHis: 0.722 ± 0.035
1.137HisIle: 1.137 ± 0.036
0.881HisLys: 0.881 ± 0.037
2.505HisLeu: 2.505 ± 0.062
0.605HisMet: 0.605 ± 0.03
0.662HisAsn: 0.662 ± 0.03
1.431HisPro: 1.431 ± 0.042
0.802HisGln: 0.802 ± 0.031
1.719HisArg: 1.719 ± 0.048
1.111HisSer: 1.111 ± 0.036
1.131HisThr: 1.131 ± 0.035
1.685HisVal: 1.685 ± 0.051
0.354HisTrp: 0.354 ± 0.02
0.817HisTyr: 0.817 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.798IleAla: 5.798 ± 0.088
0.477IleCys: 0.477 ± 0.024
2.997IleAsp: 2.997 ± 0.063
3.638IleGlu: 3.638 ± 0.065
1.758IlePhe: 1.758 ± 0.046
4.411IleGly: 4.411 ± 0.077
1.165IleHis: 1.165 ± 0.037
2.449IleIle: 2.449 ± 0.063
2.026IleLys: 2.026 ± 0.059
4.96IleLeu: 4.96 ± 0.073
1.113IleMet: 1.113 ± 0.037
1.768IleAsn: 1.768 ± 0.052
2.739IlePro: 2.739 ± 0.058
1.637IleGln: 1.637 ± 0.049
3.639IleArg: 3.639 ± 0.065
2.97IleSer: 2.97 ± 0.065
3.054IleThr: 3.054 ± 0.073
3.834IleVal: 3.834 ± 0.073
0.479IleTrp: 0.479 ± 0.025
1.4IleTyr: 1.4 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
3.873LysAla: 3.873 ± 0.083
0.269LysCys: 0.269 ± 0.021
2.115LysAsp: 2.115 ± 0.056
2.36LysGlu: 2.36 ± 0.063
1.298LysPhe: 1.298 ± 0.039
2.73LysGly: 2.73 ± 0.066
1.011LysHis: 1.011 ± 0.041
2.545LysIle: 2.545 ± 0.062
2.448LysLys: 2.448 ± 0.063
4.323LysLeu: 4.323 ± 0.068
1.152LysMet: 1.152 ± 0.046
1.505LysAsn: 1.505 ± 0.046
2.581LysPro: 2.581 ± 0.068
1.854LysGln: 1.854 ± 0.054
2.703LysArg: 2.703 ± 0.066
2.25LysSer: 2.25 ± 0.05
2.488LysThr: 2.488 ± 0.06
2.686LysVal: 2.686 ± 0.059
0.415LysTrp: 0.415 ± 0.023
1.059LysTyr: 1.059 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
12.616LeuAla: 12.616 ± 0.148
0.894LeuCys: 0.894 ± 0.034
5.694LeuAsp: 5.694 ± 0.091
6.174LeuGlu: 6.174 ± 0.1
3.954LeuPhe: 3.954 ± 0.088
8.156LeuGly: 8.156 ± 0.116
2.385LeuHis: 2.385 ± 0.059
5.119LeuIle: 5.119 ± 0.085
4.626LeuLys: 4.626 ± 0.085
11.116LeuLeu: 11.116 ± 0.162
2.519LeuMet: 2.519 ± 0.058
3.171LeuAsn: 3.171 ± 0.059
5.717LeuPro: 5.717 ± 0.085
3.224LeuGln: 3.224 ± 0.065
7.515LeuArg: 7.515 ± 0.105
5.887LeuSer: 5.887 ± 0.081
5.71LeuThr: 5.71 ± 0.09
7.401LeuVal: 7.401 ± 0.104
1.323LeuTrp: 1.323 ± 0.046
2.563LeuTyr: 2.563 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.674MetAla: 2.674 ± 0.055
0.176MetCys: 0.176 ± 0.017
1.3MetAsp: 1.3 ± 0.039
1.403MetGlu: 1.403 ± 0.049
0.734MetPhe: 0.734 ± 0.03
1.713MetGly: 1.713 ± 0.05
0.668MetHis: 0.668 ± 0.028
1.234MetIle: 1.234 ± 0.037
1.413MetLys: 1.413 ± 0.044
2.741MetLeu: 2.741 ± 0.065
0.593MetMet: 0.593 ± 0.033
0.918MetAsn: 0.918 ± 0.034
1.387MetPro: 1.387 ± 0.041
1.137MetGln: 1.137 ± 0.037
1.791MetArg: 1.791 ± 0.045
1.459MetSer: 1.459 ± 0.04
1.453MetThr: 1.453 ± 0.038
1.661MetVal: 1.661 ± 0.041
0.228MetTrp: 0.228 ± 0.015
0.469MetTyr: 0.469 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.933AsnAla: 2.933 ± 0.065
0.323AsnCys: 0.323 ± 0.021
1.461AsnAsp: 1.461 ± 0.045
1.547AsnGlu: 1.547 ± 0.045
1.158AsnPhe: 1.158 ± 0.036
2.444AsnGly: 2.444 ± 0.067
0.677AsnHis: 0.677 ± 0.032
1.751AsnIle: 1.751 ± 0.051
1.093AsnLys: 1.093 ± 0.037
3.266AsnLeu: 3.266 ± 0.065
0.727AsnMet: 0.727 ± 0.033
0.984AsnAsn: 0.984 ± 0.037
2.236AsnPro: 2.236 ± 0.06
0.952AsnGln: 0.952 ± 0.029
2.186AsnArg: 2.186 ± 0.051
1.432AsnSer: 1.432 ± 0.05
1.542AsnThr: 1.542 ± 0.044
2.09AsnVal: 2.09 ± 0.056
0.383AsnTrp: 0.383 ± 0.02
0.943AsnTyr: 0.943 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
6.239ProAla: 6.239 ± 0.111
0.394ProCys: 0.394 ± 0.023
3.22ProAsp: 3.22 ± 0.06
3.82ProGlu: 3.82 ± 0.075
1.688ProPhe: 1.688 ± 0.046
4.593ProGly: 4.593 ± 0.085
1.131ProHis: 1.131 ± 0.036
1.93ProIle: 1.93 ± 0.053
1.858ProLys: 1.858 ± 0.052
4.672ProLeu: 4.672 ± 0.081
1.18ProMet: 1.18 ± 0.04
1.291ProAsn: 1.291 ± 0.042
2.639ProPro: 2.639 ± 0.07
1.621ProGln: 1.621 ± 0.045
2.971ProArg: 2.971 ± 0.06
2.282ProSer: 2.282 ± 0.05
2.092ProThr: 2.092 ± 0.053
4.642ProVal: 4.642 ± 0.081
0.657ProTrp: 0.657 ± 0.028
1.263ProTyr: 1.263 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.319GlnAla: 4.319 ± 0.07
0.292GlnCys: 0.292 ± 0.019
1.687GlnAsp: 1.687 ± 0.049
2.109GlnGlu: 2.109 ± 0.058
1.149GlnPhe: 1.149 ± 0.041
2.718GlnGly: 2.718 ± 0.056
0.886GlnHis: 0.886 ± 0.031
1.833GlnIle: 1.833 ± 0.048
1.47GlnLys: 1.47 ± 0.043
3.544GlnLeu: 3.544 ± 0.077
0.917GlnMet: 0.917 ± 0.034
1.016GlnAsn: 1.016 ± 0.033
1.776GlnPro: 1.776 ± 0.047
1.578GlnGln: 1.578 ± 0.049
2.666GlnArg: 2.666 ± 0.058
1.731GlnSer: 1.731 ± 0.041
1.813GlnThr: 1.813 ± 0.053
2.578GlnVal: 2.578 ± 0.052
0.509GlnTrp: 0.509 ± 0.027
0.897GlnTyr: 0.897 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
7.406ArgAla: 7.406 ± 0.119
0.553ArgCys: 0.553 ± 0.029
3.848ArgAsp: 3.848 ± 0.085
5.173ArgGlu: 5.173 ± 0.084
2.912ArgPhe: 2.912 ± 0.062
4.56ArgGly: 4.56 ± 0.076
2.222ArgHis: 2.222 ± 0.059
3.847ArgIle: 3.847 ± 0.068
2.751ArgLys: 2.751 ± 0.06
8.428ArgLeu: 8.428 ± 0.117
1.781ArgMet: 1.781 ± 0.05
2.088ArgAsn: 2.088 ± 0.054
3.083ArgPro: 3.083 ± 0.064
2.893ArgGln: 2.893 ± 0.055
5.719ArgArg: 5.719 ± 0.091
2.974ArgSer: 2.974 ± 0.066
3.089ArgThr: 3.089 ± 0.063
4.995ArgVal: 4.995 ± 0.082
1.048ArgTrp: 1.048 ± 0.036
2.124ArgTyr: 2.124 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.354SerAla: 5.354 ± 0.083
0.538SerCys: 0.538 ± 0.033
2.515SerAsp: 2.515 ± 0.057
2.644SerGlu: 2.644 ± 0.052
2.106SerPhe: 2.106 ± 0.058
5.361SerGly: 5.361 ± 0.098
1.281SerHis: 1.281 ± 0.043
2.563SerIle: 2.563 ± 0.06
1.659SerLys: 1.659 ± 0.045
5.77SerLeu: 5.77 ± 0.094
1.251SerMet: 1.251 ± 0.042
1.478SerAsn: 1.478 ± 0.051
2.634SerPro: 2.634 ± 0.055
1.688SerGln: 1.688 ± 0.047
3.656SerArg: 3.656 ± 0.075
2.768SerSer: 2.768 ± 0.069
2.556SerThr: 2.556 ± 0.063
3.747SerVal: 3.747 ± 0.08
0.772SerTrp: 0.772 ± 0.029
1.314SerTyr: 1.314 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.459ThrAla: 5.459 ± 0.087
0.52ThrCys: 0.52 ± 0.034
2.722ThrAsp: 2.722 ± 0.07
2.763ThrGlu: 2.763 ± 0.057
1.634ThrPhe: 1.634 ± 0.053
5.221ThrGly: 5.221 ± 0.106
1.231ThrHis: 1.231 ± 0.038
2.542ThrIle: 2.542 ± 0.065
1.606ThrLys: 1.606 ± 0.05
6.124ThrLeu: 6.124 ± 0.092
1.032ThrMet: 1.032 ± 0.033
1.371ThrAsn: 1.371 ± 0.046
3.271ThrPro: 3.271 ± 0.064
1.726ThrGln: 1.726 ± 0.048
3.702ThrArg: 3.702 ± 0.072
2.69ThrSer: 2.69 ± 0.074
2.703ThrThr: 2.703 ± 0.081
4.178ThrVal: 4.178 ± 0.077
0.615ThrTrp: 0.615 ± 0.029
1.205ThrTyr: 1.205 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
7.857ValAla: 7.857 ± 0.11
0.734ValCys: 0.734 ± 0.031
3.795ValAsp: 3.795 ± 0.073
4.264ValGlu: 4.264 ± 0.08
2.8ValPhe: 2.8 ± 0.067
4.867ValGly: 4.867 ± 0.084
1.606ValHis: 1.606 ± 0.046
4.375ValIle: 4.375 ± 0.074
2.882ValLys: 2.882 ± 0.066
7.894ValLeu: 7.894 ± 0.113
1.927ValMet: 1.927 ± 0.052
2.351ValAsn: 2.351 ± 0.052
3.578ValPro: 3.578 ± 0.066
2.231ValGln: 2.231 ± 0.052
4.88ValArg: 4.88 ± 0.075
4.205ValSer: 4.205 ± 0.085
4.416ValThr: 4.416 ± 0.072
5.813ValVal: 5.813 ± 0.1
0.951ValTrp: 0.951 ± 0.04
2.019ValTyr: 2.019 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.033TrpAla: 1.033 ± 0.036
0.143TrpCys: 0.143 ± 0.012
0.59TrpAsp: 0.59 ± 0.029
0.649TrpGlu: 0.649 ± 0.033
0.578TrpPhe: 0.578 ± 0.029
0.891TrpGly: 0.891 ± 0.037
0.373TrpHis: 0.373 ± 0.018
0.698TrpIle: 0.698 ± 0.03
0.629TrpLys: 0.629 ± 0.029
1.869TrpLeu: 1.869 ± 0.053
0.381TrpMet: 0.381 ± 0.021
0.486TrpAsn: 0.486 ± 0.026
0.601TrpPro: 0.601 ± 0.029
0.589TrpGln: 0.589 ± 0.028
1.103TrpArg: 1.103 ± 0.039
0.7TrpSer: 0.7 ± 0.033
0.624TrpThr: 0.624 ± 0.033
0.931TrpVal: 0.931 ± 0.037
0.261TrpTrp: 0.261 ± 0.017
0.348TrpTyr: 0.348 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.504TyrAla: 2.504 ± 0.053
0.287TyrCys: 0.287 ± 0.019
1.512TyrAsp: 1.512 ± 0.053
1.392TyrGlu: 1.392 ± 0.045
1.171TyrPhe: 1.171 ± 0.035
2.233TyrGly: 2.233 ± 0.053
0.67TyrHis: 0.67 ± 0.028
1.137TyrIle: 1.137 ± 0.037
0.919TyrLys: 0.919 ± 0.035
3.009TyrLeu: 3.009 ± 0.065
0.493TyrMet: 0.493 ± 0.027
0.756TyrAsn: 0.756 ± 0.037
1.361TyrPro: 1.361 ± 0.036
1.058TyrGln: 1.058 ± 0.036
2.156TyrArg: 2.156 ± 0.054
1.464TyrSer: 1.464 ± 0.045
1.455TyrThr: 1.455 ± 0.038
1.875TyrVal: 1.875 ± 0.04
0.411TyrTrp: 0.411 ± 0.025
0.886TyrTyr: 0.886 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2756 proteins (850570 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski