Amino acid dipepetide frequency for Cohnella sp. AR92

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.52AlaAla: 10.52 ± 0.128	0.77AlaCys: 0.77 ± 0.022	4.962AlaAsp: 4.962 ± 0.072	6.453AlaGlu: 6.453 ± 0.076	3.541AlaPhe: 3.541 ± 0.049	7.424AlaGly: 7.424 ± 0.072	1.436AlaHis: 1.436 ± 0.033	5.766AlaIle: 5.766 ± 0.062	4.65AlaLys: 4.65 ± 0.064	9.066AlaLeu: 9.066 ± 0.076	2.457AlaMet: 2.457 ± 0.037	2.961AlaAsn: 2.961 ± 0.044	3.096AlaPro: 3.096 ± 0.047	2.621AlaGln: 2.621 ± 0.043	4.359AlaArg: 4.359 ± 0.059	6.486AlaSer: 6.486 ± 0.075	3.973AlaThr: 3.973 ± 0.069	6.827AlaVal: 6.827 ± 0.057	1.138AlaTrp: 1.138 ± 0.027	2.837AlaTyr: 2.837 ± 0.037	0.001AlaXaa: 0.001 ± 0.001
Cys	0.532CysAla: 0.532 ± 0.018	0.094CysCys: 0.094 ± 0.008	0.362CysAsp: 0.362 ± 0.014	0.439CysGlu: 0.439 ± 0.016	0.26CysPhe: 0.26 ± 0.014	0.774CysGly: 0.774 ± 0.021	0.167CysHis: 0.167 ± 0.01	0.385CysIle: 0.385 ± 0.016	0.266CysLys: 0.266 ± 0.013	0.701CysLeu: 0.701 ± 0.023	0.151CysMet: 0.151 ± 0.008	0.198CysAsn: 0.198 ± 0.012	0.365CysPro: 0.365 ± 0.016	0.177CysGln: 0.177 ± 0.011	0.494CysArg: 0.494 ± 0.017	0.514CysSer: 0.514 ± 0.015	0.342CysThr: 0.342 ± 0.017	0.469CysVal: 0.469 ± 0.017	0.088CysTrp: 0.088 ± 0.007	0.231CysTyr: 0.231 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.243AspAla: 4.243 ± 0.062	0.366AspCys: 0.366 ± 0.014	2.51AspAsp: 2.51 ± 0.037	3.812AspGlu: 3.812 ± 0.05	1.965AspPhe: 1.965 ± 0.037	4.418AspGly: 4.418 ± 0.07	0.987AspHis: 0.987 ± 0.025	3.127AspIle: 3.127 ± 0.042	2.613AspLys: 2.613 ± 0.046	4.954AspLeu: 4.954 ± 0.056	1.186AspMet: 1.186 ± 0.026	1.736AspAsn: 1.736 ± 0.037	2.614AspPro: 2.614 ± 0.037	1.657AspGln: 1.657 ± 0.034	3.432AspArg: 3.432 ± 0.051	3.353AspSer: 3.353 ± 0.047	2.465AspThr: 2.465 ± 0.044	3.494AspVal: 3.494 ± 0.05	0.937AspTrp: 0.937 ± 0.024	2.074AspTyr: 2.074 ± 0.039	0.001AspXaa: 0.001 ± 0.001
Glu	6.873GluAla: 6.873 ± 0.084	0.362GluCys: 0.362 ± 0.016	3.192GluAsp: 3.192 ± 0.046	5.776GluGlu: 5.776 ± 0.074	2.191GluPhe: 2.191 ± 0.036	4.841GluGly: 4.841 ± 0.06	1.303GluHis: 1.303 ± 0.03	3.984GluIle: 3.984 ± 0.048	3.87GluLys: 3.87 ± 0.053	7.496GluLeu: 7.496 ± 0.082	1.852GluMet: 1.852 ± 0.033	2.349GluAsn: 2.349 ± 0.038	2.57GluPro: 2.57 ± 0.047	3.212GluGln: 3.212 ± 0.047	4.76GluArg: 4.76 ± 0.066	3.832GluSer: 3.832 ± 0.055	3.382GluThr: 3.382 ± 0.048	4.078GluVal: 4.078 ± 0.053	1.114GluTrp: 1.114 ± 0.028	1.926GluTyr: 1.926 ± 0.037	0.001GluXaa: 0.001 ± 0.001
Phe	3.623PheAla: 3.623 ± 0.052	0.341PheCys: 0.341 ± 0.016	2.304PheAsp: 2.304 ± 0.038	2.441PheGlu: 2.441 ± 0.035	1.668PhePhe: 1.668 ± 0.039	3.431PheGly: 3.431 ± 0.053	0.778PheHis: 0.778 ± 0.024	2.369PheIle: 2.369 ± 0.036	1.787PheLys: 1.787 ± 0.038	3.924PheLeu: 3.924 ± 0.059	0.97PheMet: 0.97 ± 0.026	1.398PheAsn: 1.398 ± 0.029	1.504PhePro: 1.504 ± 0.027	1.233PheGln: 1.233 ± 0.029	2.277PheArg: 2.277 ± 0.043	2.648PheSer: 2.648 ± 0.038	2.028PheThr: 2.028 ± 0.039	2.966PheVal: 2.966 ± 0.046	0.493PheTrp: 0.493 ± 0.019	1.413PheTyr: 1.413 ± 0.034	0.001PheXaa: 0.001 ± 0.001
Gly	6.392GlyAla: 6.392 ± 0.082	0.667GlyCys: 0.667 ± 0.021	3.813GlyAsp: 3.813 ± 0.055	5.039GlyGlu: 5.039 ± 0.057	3.307GlyPhe: 3.307 ± 0.047	6.053GlyGly: 6.053 ± 0.083	1.492GlyHis: 1.492 ± 0.04	5.495GlyIle: 5.495 ± 0.055	4.367GlyLys: 4.367 ± 0.055	7.576GlyLeu: 7.576 ± 0.077	2.375GlyMet: 2.375 ± 0.036	2.674GlyAsn: 2.674 ± 0.066	2.143GlyPro: 2.143 ± 0.071	2.646GlyGln: 2.646 ± 0.042	4.335GlyArg: 4.335 ± 0.051	5.476GlySer: 5.476 ± 0.107	4.692GlyThr: 4.692 ± 0.069	5.429GlyVal: 5.429 ± 0.078	1.242GlyTrp: 1.242 ± 0.028	2.996GlyTyr: 2.996 ± 0.042	0.001GlyXaa: 0.001 ± 0.001
His	1.546HisAla: 1.546 ± 0.028	0.158HisCys: 0.158 ± 0.009	0.905HisAsp: 0.905 ± 0.027	1.135HisGlu: 1.135 ± 0.025	0.855HisPhe: 0.855 ± 0.024	1.544HisGly: 1.544 ± 0.029	0.514HisHis: 0.514 ± 0.019	1.034HisIle: 1.034 ± 0.027	0.68HisLys: 0.68 ± 0.023	1.987HisLeu: 1.987 ± 0.048	0.435HisMet: 0.435 ± 0.015	0.527HisAsn: 0.527 ± 0.018	1.197HisPro: 1.197 ± 0.029	0.589HisGln: 0.589 ± 0.018	1.2HisArg: 1.2 ± 0.03	1.209HisSer: 1.209 ± 0.028	0.847HisThr: 0.847 ± 0.022	1.256HisVal: 1.256 ± 0.028	0.302HisTrp: 0.302 ± 0.014	0.782HisTyr: 0.782 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.1IleAla: 6.1 ± 0.068	0.473IleCys: 0.473 ± 0.015	3.527IleAsp: 3.527 ± 0.049	4.167IleGlu: 4.167 ± 0.047	2.019IlePhe: 2.019 ± 0.043	5.59IleGly: 5.59 ± 0.061	1.158IleHis: 1.158 ± 0.028	3.11IleIle: 3.11 ± 0.051	2.512IleLys: 2.512 ± 0.042	5.506IleLeu: 5.506 ± 0.072	1.353IleMet: 1.353 ± 0.028	1.958IleAsn: 1.958 ± 0.032	3.014IlePro: 3.014 ± 0.049	2.03IleGln: 2.03 ± 0.035	4.1IleArg: 4.1 ± 0.054	3.768IleSer: 3.768 ± 0.048	2.969IleThr: 2.969 ± 0.047	5.278IleVal: 5.278 ± 0.053	0.653IleTrp: 0.653 ± 0.022	1.81IleTyr: 1.81 ± 0.033	0.001IleXaa: 0.001 ± 0.001
Lys	4.424LysAla: 4.424 ± 0.065	0.19LysCys: 0.19 ± 0.012	2.717LysAsp: 2.717 ± 0.044	3.927LysGlu: 3.927 ± 0.054	1.46LysPhe: 1.46 ± 0.028	3.292LysGly: 3.292 ± 0.05	0.981LysHis: 0.981 ± 0.024	2.694LysIle: 2.694 ± 0.048	2.873LysLys: 2.873 ± 0.049	5.637LysLeu: 5.637 ± 0.082	1.331LysMet: 1.331 ± 0.032	1.814LysAsn: 1.814 ± 0.035	2.33LysPro: 2.33 ± 0.041	2.089LysGln: 2.089 ± 0.039	2.976LysArg: 2.976 ± 0.049	2.804LysSer: 2.804 ± 0.046	2.549LysThr: 2.549 ± 0.044	3.325LysVal: 3.325 ± 0.048	0.675LysTrp: 0.675 ± 0.018	1.479LysTyr: 1.479 ± 0.033	0.001LysXaa: 0.001 ± 0.0
Leu	9.733LeuAla: 9.733 ± 0.119	0.739LeuCys: 0.739 ± 0.021	5.241LeuAsp: 5.241 ± 0.057	6.432LeuGlu: 6.432 ± 0.071	4.572LeuPhe: 4.572 ± 0.06	7.177LeuGly: 7.177 ± 0.076	1.969LeuHis: 1.969 ± 0.039	6.156LeuIle: 6.156 ± 0.072	5.072LeuLys: 5.072 ± 0.068	11.452LeuLeu: 11.452 ± 0.118	2.351LeuMet: 2.351 ± 0.046	3.67LeuAsn: 3.67 ± 0.048	4.76LeuPro: 4.76 ± 0.065	3.693LeuGln: 3.693 ± 0.057	5.903LeuArg: 5.903 ± 0.065	7.375LeuSer: 7.375 ± 0.079	5.67LeuThr: 5.67 ± 0.062	6.443LeuVal: 6.443 ± 0.07	1.101LeuTrp: 1.101 ± 0.031	3.089LeuTyr: 3.089 ± 0.041	0.001LeuXaa: 0.001 ± 0.001
Met	2.292MetAla: 2.292 ± 0.032	0.136MetCys: 0.136 ± 0.008	1.38MetAsp: 1.38 ± 0.028	1.749MetGlu: 1.749 ± 0.032	0.856MetPhe: 0.856 ± 0.023	1.735MetGly: 1.735 ± 0.031	0.425MetHis: 0.425 ± 0.016	1.581MetIle: 1.581 ± 0.028	1.624MetLys: 1.624 ± 0.032	2.621MetLeu: 2.621 ± 0.041	0.741MetMet: 0.741 ± 0.022	1.318MetAsn: 1.318 ± 0.029	1.112MetPro: 1.112 ± 0.031	0.859MetGln: 0.859 ± 0.023	1.481MetArg: 1.481 ± 0.033	1.762MetSer: 1.762 ± 0.033	1.649MetThr: 1.649 ± 0.033	1.553MetVal: 1.553 ± 0.031	0.216MetTrp: 0.216 ± 0.011	0.614MetTyr: 0.614 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.153AsnAla: 3.153 ± 0.051	0.229AsnCys: 0.229 ± 0.012	1.841AsnAsp: 1.841 ± 0.033	2.439AsnGlu: 2.439 ± 0.035	1.159AsnPhe: 1.159 ± 0.025	3.615AsnGly: 3.615 ± 0.071	0.671AsnHis: 0.671 ± 0.019	1.877AsnIle: 1.877 ± 0.035	1.699AsnLys: 1.699 ± 0.033	3.18AsnLeu: 3.18 ± 0.044	0.802AsnMet: 0.802 ± 0.022	1.4AsnAsn: 1.4 ± 0.037	2.018AsnPro: 2.018 ± 0.039	1.181AsnGln: 1.181 ± 0.028	2.327AsnArg: 2.327 ± 0.036	2.064AsnSer: 2.064 ± 0.041	1.63AsnThr: 1.63 ± 0.031	2.527AsnVal: 2.527 ± 0.044	0.494AsnTrp: 0.494 ± 0.017	1.217AsnTyr: 1.217 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.777ProAla: 3.777 ± 0.058	0.234ProCys: 0.234 ± 0.011	2.659ProAsp: 2.659 ± 0.039	3.533ProGlu: 3.533 ± 0.052	1.845ProPhe: 1.845 ± 0.031	3.193ProGly: 3.193 ± 0.052	0.851ProHis: 0.851 ± 0.024	2.625ProIle: 2.625 ± 0.039	1.775ProLys: 1.775 ± 0.032	4.075ProLeu: 4.075 ± 0.052	0.974ProMet: 0.974 ± 0.022	1.627ProAsn: 1.627 ± 0.035	1.436ProPro: 1.436 ± 0.03	1.317ProGln: 1.317 ± 0.031	1.745ProArg: 1.745 ± 0.03	3.195ProSer: 3.195 ± 0.052	2.04ProThr: 2.04 ± 0.068	3.162ProVal: 3.162 ± 0.041	0.534ProTrp: 0.534 ± 0.018	1.561ProTyr: 1.561 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.694GlnAla: 3.694 ± 0.058	0.171GlnCys: 0.171 ± 0.01	1.529GlnAsp: 1.529 ± 0.029	2.464GlnGlu: 2.464 ± 0.045	1.3GlnPhe: 1.3 ± 0.028	2.526GlnGly: 2.526 ± 0.049	0.579GlnHis: 0.579 ± 0.017	1.989GlnIle: 1.989 ± 0.036	1.54GlnLys: 1.54 ± 0.027	3.765GlnLeu: 3.765 ± 0.059	0.967GlnMet: 0.967 ± 0.023	1.072GlnAsn: 1.072 ± 0.025	1.459GlnPro: 1.459 ± 0.031	1.424GlnGln: 1.424 ± 0.037	1.823GlnArg: 1.823 ± 0.031	2.148GlnSer: 2.148 ± 0.038	1.837GlnThr: 1.837 ± 0.043	2.24GlnVal: 2.24 ± 0.041	0.511GlnTrp: 0.511 ± 0.018	1.14GlnTyr: 1.14 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.136ArgAla: 4.136 ± 0.059	0.395ArgCys: 0.395 ± 0.017	2.644ArgAsp: 2.644 ± 0.038	4.492ArgGlu: 4.492 ± 0.067	2.619ArgPhe: 2.619 ± 0.039	3.573ArgGly: 3.573 ± 0.055	1.144ArgHis: 1.144 ± 0.025	4.252ArgIle: 4.252 ± 0.051	3.211ArgLys: 3.211 ± 0.048	6.343ArgLeu: 6.343 ± 0.089	1.99ArgMet: 1.99 ± 0.037	2.13ArgAsn: 2.13 ± 0.044	1.984ArgPro: 1.984 ± 0.037	2.28ArgGln: 2.28 ± 0.037	3.829ArgArg: 3.829 ± 0.053	3.854ArgSer: 3.854 ± 0.058	3.146ArgThr: 3.146 ± 0.046	3.481ArgVal: 3.481 ± 0.046	0.833ArgTrp: 0.833 ± 0.023	2.097ArgTyr: 2.097 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.913SerAla: 5.913 ± 0.075	0.423SerCys: 0.423 ± 0.017	3.403SerAsp: 3.403 ± 0.047	4.167SerGlu: 4.167 ± 0.052	3.028SerPhe: 3.028 ± 0.044	5.922SerGly: 5.922 ± 0.063	1.146SerHis: 1.146 ± 0.026	4.106SerIle: 4.106 ± 0.059	3.134SerLys: 3.134 ± 0.048	6.814SerLeu: 6.814 ± 0.076	1.69SerMet: 1.69 ± 0.039	2.33SerAsn: 2.33 ± 0.039	2.873SerPro: 2.873 ± 0.042	1.917SerGln: 1.917 ± 0.036	3.631SerArg: 3.631 ± 0.05	4.87SerSer: 4.87 ± 0.066	3.116SerThr: 3.116 ± 0.053	4.832SerVal: 4.832 ± 0.106	0.924SerTrp: 0.924 ± 0.027	2.267SerTyr: 2.267 ± 0.039	0.001SerXaa: 0.001 ± 0.001
Thr	4.89ThrAla: 4.89 ± 0.058	0.3ThrCys: 0.3 ± 0.013	2.824ThrAsp: 2.824 ± 0.051	3.123ThrGlu: 3.123 ± 0.041	2.168ThrPhe: 2.168 ± 0.038	4.562ThrGly: 4.562 ± 0.117	0.855ThrHis: 0.855 ± 0.022	3.576ThrIle: 3.576 ± 0.046	2.269ThrLys: 2.269 ± 0.039	5.269ThrLeu: 5.269 ± 0.062	1.204ThrMet: 1.204 ± 0.027	1.803ThrAsn: 1.803 ± 0.037	2.438ThrPro: 2.438 ± 0.039	1.342ThrGln: 1.342 ± 0.031	2.422ThrArg: 2.422 ± 0.034	3.233ThrSer: 3.233 ± 0.051	2.761ThrThr: 2.761 ± 0.058	4.422ThrVal: 4.422 ± 0.075	0.605ThrTrp: 0.605 ± 0.02	1.702ThrTyr: 1.702 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	5.85ValAla: 5.85 ± 0.068	0.605ValCys: 0.605 ± 0.019	3.56ValAsp: 3.56 ± 0.045	4.238ValGlu: 4.238 ± 0.046	2.801ValPhe: 2.801 ± 0.049	4.805ValGly: 4.805 ± 0.068	1.319ValHis: 1.319 ± 0.031	4.346ValIle: 4.346 ± 0.053	3.49ValLys: 3.49 ± 0.05	7.252ValLeu: 7.252 ± 0.074	1.723ValMet: 1.723 ± 0.031	2.661ValAsn: 2.661 ± 0.048	3.248ValPro: 3.248 ± 0.049	2.369ValGln: 2.369 ± 0.039	4.146ValArg: 4.146 ± 0.057	4.91ValSer: 4.91 ± 0.057	4.261ValThr: 4.261 ± 0.073	5.2ValVal: 5.2 ± 0.066	0.881ValTrp: 0.881 ± 0.023	2.312ValTyr: 2.312 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.931TrpAla: 0.931 ± 0.027	0.099TrpCys: 0.099 ± 0.008	0.67TrpAsp: 0.67 ± 0.019	0.833TrpGlu: 0.833 ± 0.022	0.568TrpPhe: 0.568 ± 0.02	0.955TrpGly: 0.955 ± 0.026	0.259TrpHis: 0.259 ± 0.012	0.9TrpIle: 0.9 ± 0.023	0.679TrpLys: 0.679 ± 0.019	1.541TrpLeu: 1.541 ± 0.033	0.408TrpMet: 0.408 ± 0.017	0.714TrpAsn: 0.714 ± 0.022	0.446TrpPro: 0.446 ± 0.018	0.484TrpGln: 0.484 ± 0.014	0.797TrpArg: 0.797 ± 0.025	0.886TrpSer: 0.886 ± 0.023	0.833TrpThr: 0.833 ± 0.023	0.785TrpVal: 0.785 ± 0.02	0.195TrpTrp: 0.195 ± 0.01	0.418TrpTyr: 0.418 ± 0.018	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.724TyrAla: 2.724 ± 0.046	0.26TyrCys: 0.26 ± 0.013	1.898TyrAsp: 1.898 ± 0.048	2.305TyrGlu: 2.305 ± 0.039	1.41TyrPhe: 1.41 ± 0.026	2.781TyrGly: 2.781 ± 0.048	0.668TyrHis: 0.668 ± 0.018	1.722TyrIle: 1.722 ± 0.035	1.455TyrLys: 1.455 ± 0.031	3.441TyrLeu: 3.441 ± 0.044	0.74TyrMet: 0.74 ± 0.021	1.181TyrAsn: 1.181 ± 0.03	1.553TyrPro: 1.553 ± 0.034	1.057TyrGln: 1.057 ± 0.025	2.396TyrArg: 2.396 ± 0.041	2.121TyrSer: 2.121 ± 0.041	1.575TyrThr: 1.575 ± 0.037	2.213TyrVal: 2.213 ± 0.042	0.464TyrTrp: 0.464 ± 0.018	1.353TyrTyr: 1.353 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5378 proteins (1738542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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