Amino acid dipepetide frequency for Erwinia phage vB_EamM_Asesino

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.493AlaAla: 7.493 ± 0.505
0.696AlaCys: 0.696 ± 0.099
4.875AlaAsp: 4.875 ± 0.308
5.107AlaGlu: 5.107 ± 0.222
3.379AlaPhe: 3.379 ± 0.232
5.648AlaGly: 5.648 ± 0.34
1.548AlaHis: 1.548 ± 0.139
4.578AlaIle: 4.578 ± 0.267
4.398AlaLys: 4.398 ± 0.281
7.17AlaLeu: 7.17 ± 0.307
2.489AlaMet: 2.489 ± 0.19
3.572AlaAsn: 3.572 ± 0.233
2.889AlaPro: 2.889 ± 0.211
3.043AlaGln: 3.043 ± 0.255
3.766AlaArg: 3.766 ± 0.211
4.552AlaSer: 4.552 ± 0.28
4.797AlaThr: 4.797 ± 0.287
5.777AlaVal: 5.777 ± 0.298
1.161AlaTrp: 1.161 ± 0.133
2.992AlaTyr: 2.992 ± 0.198
0.0AlaXaa: 0.0 ± 0.0
Cys
0.49CysAla: 0.49 ± 0.079
0.052CysCys: 0.052 ± 0.025
0.374CysAsp: 0.374 ± 0.066
0.464CysGlu: 0.464 ± 0.08
0.232CysPhe: 0.232 ± 0.047
0.645CysGly: 0.645 ± 0.112
0.31CysHis: 0.31 ± 0.071
0.49CysIle: 0.49 ± 0.085
0.426CysLys: 0.426 ± 0.072
0.812CysLeu: 0.812 ± 0.089
0.284CysMet: 0.284 ± 0.057
0.451CysAsn: 0.451 ± 0.087
0.387CysPro: 0.387 ± 0.065
0.258CysGln: 0.258 ± 0.061
0.555CysArg: 0.555 ± 0.08
0.929CysSer: 0.929 ± 0.222
0.671CysThr: 0.671 ± 0.103
0.8CysVal: 0.8 ± 0.129
0.103CysTrp: 0.103 ± 0.044
0.413CysTyr: 0.413 ± 0.064
0.0CysXaa: 0.0 ± 0.0
Asp
5.623AspAla: 5.623 ± 0.192
0.503AspCys: 0.503 ± 0.092
4.462AspAsp: 4.462 ± 0.295
4.23AspGlu: 4.23 ± 0.285
2.566AspPhe: 2.566 ± 0.184
4.707AspGly: 4.707 ± 0.273
1.238AspHis: 1.238 ± 0.106
3.779AspIle: 3.779 ± 0.194
3.237AspLys: 3.237 ± 0.197
5.906AspLeu: 5.906 ± 0.253
1.56AspMet: 1.56 ± 0.132
2.979AspAsn: 2.979 ± 0.198
2.953AspPro: 2.953 ± 0.17
1.999AspGln: 1.999 ± 0.175
2.811AspArg: 2.811 ± 0.202
2.889AspSer: 2.889 ± 0.213
3.521AspThr: 3.521 ± 0.205
5.133AspVal: 5.133 ± 0.261
1.212AspTrp: 1.212 ± 0.113
2.566AspTyr: 2.566 ± 0.18
0.0AspXaa: 0.0 ± 0.0
Glu
4.462GluAla: 4.462 ± 0.239
0.503GluCys: 0.503 ± 0.095
3.546GluAsp: 3.546 ± 0.235
3.791GluGlu: 3.791 ± 0.289
2.528GluPhe: 2.528 ± 0.163
3.74GluGly: 3.74 ± 0.224
1.328GluHis: 1.328 ± 0.133
3.495GluIle: 3.495 ± 0.193
3.559GluLys: 3.559 ± 0.227
6.667GluLeu: 6.667 ± 0.317
1.844GluMet: 1.844 ± 0.158
2.992GluAsn: 2.992 ± 0.223
2.179GluPro: 2.179 ± 0.174
2.424GluGln: 2.424 ± 0.17
3.675GluArg: 3.675 ± 0.253
3.108GluSer: 3.108 ± 0.213
3.65GluThr: 3.65 ± 0.256
4.32GluVal: 4.32 ± 0.246
1.006GluTrp: 1.006 ± 0.104
2.592GluTyr: 2.592 ± 0.181
0.0GluXaa: 0.0 ± 0.0
Phe
2.837PheAla: 2.837 ± 0.193
0.413PheCys: 0.413 ± 0.066
2.94PheAsp: 2.94 ± 0.218
2.386PheGlu: 2.386 ± 0.218
1.664PhePhe: 1.664 ± 0.149
2.85PheGly: 2.85 ± 0.175
0.658PheHis: 0.658 ± 0.098
2.038PheIle: 2.038 ± 0.142
2.102PheLys: 2.102 ± 0.162
3.018PheLeu: 3.018 ± 0.203
1.186PheMet: 1.186 ± 0.138
2.644PheAsn: 2.644 ± 0.183
1.664PhePro: 1.664 ± 0.171
1.186PheGln: 1.186 ± 0.133
1.986PheArg: 1.986 ± 0.163
2.644PheSer: 2.644 ± 0.158
2.966PheThr: 2.966 ± 0.227
2.657PheVal: 2.657 ± 0.223
0.632PheTrp: 0.632 ± 0.089
1.947PheTyr: 1.947 ± 0.162
0.0PheXaa: 0.0 ± 0.0
Gly
4.359GlyAla: 4.359 ± 0.286
0.735GlyCys: 0.735 ± 0.13
3.985GlyAsp: 3.985 ± 0.249
4.333GlyGlu: 4.333 ± 0.179
3.314GlyPhe: 3.314 ± 0.194
5.171GlyGly: 5.171 ± 0.469
1.096GlyHis: 1.096 ± 0.116
3.675GlyIle: 3.675 ± 0.226
4.423GlyLys: 4.423 ± 0.297
5.842GlyLeu: 5.842 ± 0.318
2.012GlyMet: 2.012 ± 0.171
3.508GlyAsn: 3.508 ± 0.197
1.793GlyPro: 1.793 ± 0.203
2.541GlyGln: 2.541 ± 0.175
3.598GlyArg: 3.598 ± 0.209
3.662GlySer: 3.662 ± 0.24
4.243GlyThr: 4.243 ± 0.27
5.339GlyVal: 5.339 ± 0.222
1.161GlyTrp: 1.161 ± 0.124
2.889GlyTyr: 2.889 ± 0.173
0.0GlyXaa: 0.0 ± 0.0
His
1.548HisAla: 1.548 ± 0.145
0.193HisCys: 0.193 ± 0.054
1.109HisAsp: 1.109 ± 0.133
1.225HisGlu: 1.225 ± 0.13
0.967HisPhe: 0.967 ± 0.12
1.251HisGly: 1.251 ± 0.131
0.722HisHis: 0.722 ± 0.088
1.174HisIle: 1.174 ± 0.134
0.864HisLys: 0.864 ± 0.107
1.87HisLeu: 1.87 ± 0.135
0.658HisMet: 0.658 ± 0.094
0.825HisAsn: 0.825 ± 0.125
1.29HisPro: 1.29 ± 0.156
0.877HisGln: 0.877 ± 0.112
1.135HisArg: 1.135 ± 0.126
0.98HisSer: 0.98 ± 0.119
1.303HisThr: 1.303 ± 0.133
1.264HisVal: 1.264 ± 0.129
0.297HisTrp: 0.297 ± 0.056
1.07HisTyr: 1.07 ± 0.118
0.0HisXaa: 0.0 ± 0.0
Ile
4.475IleAla: 4.475 ± 0.287
0.49IleCys: 0.49 ± 0.086
3.933IleAsp: 3.933 ± 0.234
3.585IleGlu: 3.585 ± 0.205
1.535IlePhe: 1.535 ± 0.128
3.314IleGly: 3.314 ± 0.211
1.212IleHis: 1.212 ± 0.139
2.541IleIle: 2.541 ± 0.199
2.631IleLys: 2.631 ± 0.212
4.191IleLeu: 4.191 ± 0.218
1.109IleMet: 1.109 ± 0.11
3.095IleAsn: 3.095 ± 0.234
2.966IlePro: 2.966 ± 0.191
1.999IleGln: 1.999 ± 0.145
3.25IleArg: 3.25 ± 0.203
3.366IleSer: 3.366 ± 0.218
3.546IleThr: 3.546 ± 0.189
3.288IleVal: 3.288 ± 0.198
0.567IleTrp: 0.567 ± 0.079
2.167IleTyr: 2.167 ± 0.18
0.0IleXaa: 0.0 ± 0.0
Lys
4.772LysAla: 4.772 ± 0.267
0.31LysCys: 0.31 ± 0.062
3.263LysAsp: 3.263 ± 0.226
3.804LysGlu: 3.804 ± 0.25
2.179LysPhe: 2.179 ± 0.184
3.301LysGly: 3.301 ± 0.268
1.225LysHis: 1.225 ± 0.119
2.695LysIle: 2.695 ± 0.176
2.863LysLys: 2.863 ± 0.195
5.584LysLeu: 5.584 ± 0.285
1.728LysMet: 1.728 ± 0.142
2.192LysAsn: 2.192 ± 0.196
2.334LysPro: 2.334 ± 0.157
2.115LysGln: 2.115 ± 0.15
2.979LysArg: 2.979 ± 0.224
2.863LysSer: 2.863 ± 0.203
3.263LysThr: 3.263 ± 0.218
3.804LysVal: 3.804 ± 0.238
0.683LysTrp: 0.683 ± 0.094
1.87LysTyr: 1.87 ± 0.153
0.0LysXaa: 0.0 ± 0.0
Leu
7.119LeuAla: 7.119 ± 0.293
0.89LeuCys: 0.89 ± 0.119
6.113LeuAsp: 6.113 ± 0.275
4.926LeuGlu: 4.926 ± 0.247
3.417LeuPhe: 3.417 ± 0.208
5.429LeuGly: 5.429 ± 0.27
1.831LeuHis: 1.831 ± 0.163
4.062LeuIle: 4.062 ± 0.203
5.274LeuLys: 5.274 ± 0.231
7.093LeuLeu: 7.093 ± 0.309
2.502LeuMet: 2.502 ± 0.196
5.133LeuAsn: 5.133 ± 0.305
5.029LeuPro: 5.029 ± 0.248
3.314LeuGln: 3.314 ± 0.226
5.365LeuArg: 5.365 ± 0.291
6.087LeuSer: 6.087 ± 0.239
6.809LeuThr: 6.809 ± 0.287
5.429LeuVal: 5.429 ± 0.239
1.045LeuTrp: 1.045 ± 0.118
3.172LeuTyr: 3.172 ± 0.213
0.0LeuXaa: 0.0 ± 0.0
Met
2.489MetAla: 2.489 ± 0.154
0.4MetCys: 0.4 ± 0.07
1.56MetAsp: 1.56 ± 0.146
1.586MetGlu: 1.586 ± 0.151
1.032MetPhe: 1.032 ± 0.113
1.702MetGly: 1.702 ± 0.167
0.464MetHis: 0.464 ± 0.07
1.135MetIle: 1.135 ± 0.111
1.896MetLys: 1.896 ± 0.15
2.566MetLeu: 2.566 ± 0.179
0.761MetMet: 0.761 ± 0.106
1.303MetAsn: 1.303 ± 0.128
0.954MetPro: 0.954 ± 0.112
1.032MetGln: 1.032 ± 0.099
1.651MetArg: 1.651 ± 0.137
2.102MetSer: 2.102 ± 0.143
1.664MetThr: 1.664 ± 0.149
1.78MetVal: 1.78 ± 0.161
0.4MetTrp: 0.4 ± 0.072
1.045MetTyr: 1.045 ± 0.116
0.0MetXaa: 0.0 ± 0.0
Asn
4.333AsnAla: 4.333 ± 0.254
0.271AsnCys: 0.271 ± 0.057
2.876AsnAsp: 2.876 ± 0.172
2.837AsnGlu: 2.837 ± 0.202
1.78AsnPhe: 1.78 ± 0.144
4.256AsnGly: 4.256 ± 0.265
0.993AsnHis: 0.993 ± 0.116
2.592AsnIle: 2.592 ± 0.178
2.399AsnLys: 2.399 ± 0.15
4.539AsnLeu: 4.539 ± 0.241
1.225AsnMet: 1.225 ± 0.123
2.063AsnAsn: 2.063 ± 0.172
3.018AsnPro: 3.018 ± 0.223
1.664AsnGln: 1.664 ± 0.155
2.553AsnArg: 2.553 ± 0.153
2.412AsnSer: 2.412 ± 0.175
3.031AsnThr: 3.031 ± 0.166
3.611AsnVal: 3.611 ± 0.219
0.864AsnTrp: 0.864 ± 0.106
1.651AsnTyr: 1.651 ± 0.118
0.0AsnXaa: 0.0 ± 0.0
Pro
3.366ProAla: 3.366 ± 0.188
0.245ProCys: 0.245 ± 0.053
3.417ProAsp: 3.417 ± 0.218
3.288ProGlu: 3.288 ± 0.206
1.728ProPhe: 1.728 ± 0.176
2.902ProGly: 2.902 ± 0.2
0.98ProHis: 0.98 ± 0.117
2.321ProIle: 2.321 ± 0.173
2.128ProLys: 2.128 ± 0.166
3.43ProLeu: 3.43 ± 0.192
1.186ProMet: 1.186 ± 0.11
2.063ProAsn: 2.063 ± 0.179
1.754ProPro: 1.754 ± 0.146
1.625ProGln: 1.625 ± 0.16
2.154ProArg: 2.154 ± 0.186
2.476ProSer: 2.476 ± 0.153
3.495ProThr: 3.495 ± 0.211
3.766ProVal: 3.766 ± 0.264
0.516ProTrp: 0.516 ± 0.071
1.509ProTyr: 1.509 ± 0.167
0.0ProXaa: 0.0 ± 0.0
Gln
3.172GlnAla: 3.172 ± 0.241
0.374GlnCys: 0.374 ± 0.069
1.818GlnAsp: 1.818 ± 0.167
2.141GlnGlu: 2.141 ± 0.151
1.599GlnPhe: 1.599 ± 0.121
2.347GlnGly: 2.347 ± 0.175
0.761GlnHis: 0.761 ± 0.091
1.857GlnIle: 1.857 ± 0.143
1.689GlnLys: 1.689 ± 0.178
3.804GlnLeu: 3.804 ± 0.219
1.225GlnMet: 1.225 ± 0.113
1.638GlnAsn: 1.638 ± 0.131
1.844GlnPro: 1.844 ± 0.144
1.947GlnGln: 1.947 ± 0.171
2.644GlnArg: 2.644 ± 0.229
2.089GlnSer: 2.089 ± 0.181
2.038GlnThr: 2.038 ± 0.191
2.476GlnVal: 2.476 ± 0.17
0.593GlnTrp: 0.593 ± 0.09
1.548GlnTyr: 1.548 ± 0.139
0.0GlnXaa: 0.0 ± 0.0
Arg
3.869ArgAla: 3.869 ± 0.217
0.671ArgCys: 0.671 ± 0.088
3.327ArgAsp: 3.327 ± 0.251
3.263ArgGlu: 3.263 ± 0.217
2.631ArgPhe: 2.631 ± 0.184
3.211ArgGly: 3.211 ± 0.21
1.251ArgHis: 1.251 ± 0.137
3.147ArgIle: 3.147 ± 0.203
3.185ArgLys: 3.185 ± 0.243
5.004ArgLeu: 5.004 ± 0.267
1.767ArgMet: 1.767 ± 0.151
2.863ArgAsn: 2.863 ± 0.191
1.986ArgPro: 1.986 ± 0.174
1.986ArgGln: 1.986 ± 0.174
3.263ArgArg: 3.263 ± 0.264
2.669ArgSer: 2.669 ± 0.205
2.786ArgThr: 2.786 ± 0.22
4.153ArgVal: 4.153 ± 0.241
1.122ArgTrp: 1.122 ± 0.144
2.257ArgTyr: 2.257 ± 0.167
0.0ArgXaa: 0.0 ± 0.0
Ser
4.346SerAla: 4.346 ± 0.336
0.464SerCys: 0.464 ± 0.103
3.417SerAsp: 3.417 ± 0.2
3.276SerGlu: 3.276 ± 0.241
2.321SerPhe: 2.321 ± 0.154
4.333SerGly: 4.333 ± 0.334
1.006SerHis: 1.006 ± 0.13
3.327SerIle: 3.327 ± 0.188
3.263SerLys: 3.263 ± 0.224
5.494SerLeu: 5.494 ± 0.235
1.457SerMet: 1.457 ± 0.128
2.682SerAsn: 2.682 ± 0.193
2.437SerPro: 2.437 ± 0.193
2.283SerGln: 2.283 ± 0.168
3.005SerArg: 3.005 ± 0.179
3.585SerSer: 3.585 ± 0.234
3.559SerThr: 3.559 ± 0.233
3.908SerVal: 3.908 ± 0.219
0.825SerTrp: 0.825 ± 0.098
1.793SerTyr: 1.793 ± 0.159
0.0SerXaa: 0.0 ± 0.0
Thr
4.952ThrAla: 4.952 ± 0.342
0.722ThrCys: 0.722 ± 0.113
4.127ThrAsp: 4.127 ± 0.236
3.546ThrGlu: 3.546 ± 0.219
2.695ThrPhe: 2.695 ± 0.206
4.733ThrGly: 4.733 ± 0.266
1.225ThrHis: 1.225 ± 0.132
3.379ThrIle: 3.379 ± 0.232
3.031ThrLys: 3.031 ± 0.204
6.409ThrLeu: 6.409 ± 0.321
1.444ThrMet: 1.444 ± 0.129
2.76ThrAsn: 2.76 ± 0.187
3.34ThrPro: 3.34 ± 0.224
2.424ThrGln: 2.424 ± 0.173
3.25ThrArg: 3.25 ± 0.218
3.224ThrSer: 3.224 ± 0.184
4.32ThrThr: 4.32 ± 0.35
5.223ThrVal: 5.223 ± 0.278
1.057ThrTrp: 1.057 ± 0.122
2.27ThrTyr: 2.27 ± 0.167
0.0ThrXaa: 0.0 ± 0.0
Val
6.332ValAla: 6.332 ± 0.326
0.619ValCys: 0.619 ± 0.095
4.823ValAsp: 4.823 ± 0.257
4.823ValGlu: 4.823 ± 0.291
2.682ValPhe: 2.682 ± 0.195
4.578ValGly: 4.578 ± 0.268
1.264ValHis: 1.264 ± 0.136
4.165ValIle: 4.165 ± 0.225
3.92ValLys: 3.92 ± 0.198
5.455ValLeu: 5.455 ± 0.227
1.676ValMet: 1.676 ± 0.165
3.534ValAsn: 3.534 ± 0.215
3.172ValPro: 3.172 ± 0.23
2.437ValGln: 2.437 ± 0.214
3.611ValArg: 3.611 ± 0.199
4.243ValSer: 4.243 ± 0.251
5.455ValThr: 5.455 ± 0.261
5.429ValVal: 5.429 ± 0.29
1.096ValTrp: 1.096 ± 0.134
2.682ValTyr: 2.682 ± 0.185
0.0ValXaa: 0.0 ± 0.0
Trp
0.993TrpAla: 0.993 ± 0.103
0.129TrpCys: 0.129 ± 0.044
1.109TrpAsp: 1.109 ± 0.105
0.954TrpGlu: 0.954 ± 0.099
0.645TrpPhe: 0.645 ± 0.1
0.825TrpGly: 0.825 ± 0.11
0.374TrpHis: 0.374 ± 0.071
0.812TrpIle: 0.812 ± 0.104
0.864TrpLys: 0.864 ± 0.089
1.676TrpLeu: 1.676 ± 0.164
0.4TrpMet: 0.4 ± 0.063
0.619TrpAsn: 0.619 ± 0.079
0.606TrpPro: 0.606 ± 0.098
0.606TrpGln: 0.606 ± 0.106
0.838TrpArg: 0.838 ± 0.11
0.89TrpSer: 0.89 ± 0.091
0.671TrpThr: 0.671 ± 0.091
1.199TrpVal: 1.199 ± 0.115
0.271TrpTrp: 0.271 ± 0.066
0.671TrpTyr: 0.671 ± 0.101
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.902TyrAla: 2.902 ± 0.195
0.464TyrCys: 0.464 ± 0.089
2.798TyrAsp: 2.798 ± 0.194
1.844TyrGlu: 1.844 ± 0.149
1.522TyrPhe: 1.522 ± 0.129
2.734TyrGly: 2.734 ± 0.196
1.135TyrHis: 1.135 ± 0.137
1.999TyrIle: 1.999 ± 0.175
1.689TyrLys: 1.689 ± 0.141
3.508TyrLeu: 3.508 ± 0.206
0.993TyrMet: 0.993 ± 0.118
2.05TyrAsn: 2.05 ± 0.163
1.754TyrPro: 1.754 ± 0.149
1.844TyrGln: 1.844 ± 0.161
2.321TyrArg: 2.321 ± 0.166
1.999TyrSer: 1.999 ± 0.169
2.347TyrThr: 2.347 ± 0.167
2.644TyrVal: 2.644 ± 0.217
0.542TyrTrp: 0.542 ± 0.071
1.767TyrTyr: 1.767 ± 0.173
0.013TyrXaa: 0.013 ± 0.012
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.013XaaSer: 0.013 ± 0.012
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 277 proteins (77544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski