Amino acid dipepetide frequency for Vibrio phage Saratov-12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.633AlaAla: 6.633 ± 1.404
0.971AlaCys: 0.971 ± 0.398
4.691AlaAsp: 4.691 ± 0.629
5.662AlaGlu: 5.662 ± 0.872
2.427AlaPhe: 2.427 ± 0.442
7.28AlaGly: 7.28 ± 1.218
1.213AlaHis: 1.213 ± 0.261
3.316AlaIle: 3.316 ± 0.395
4.611AlaLys: 4.611 ± 0.728
5.986AlaLeu: 5.986 ± 0.769
2.75AlaMet: 2.75 ± 0.546
4.287AlaAsn: 4.287 ± 0.588
3.074AlaPro: 3.074 ± 0.634
3.963AlaGln: 3.963 ± 0.792
4.53AlaArg: 4.53 ± 0.594
4.206AlaSer: 4.206 ± 0.619
6.714AlaThr: 6.714 ± 0.801
5.986AlaVal: 5.986 ± 0.738
0.971AlaTrp: 0.971 ± 0.26
2.993AlaTyr: 2.993 ± 0.516
0.0AlaXaa: 0.0 ± 0.0
Cys
0.647CysAla: 0.647 ± 0.306
0.162CysCys: 0.162 ± 0.107
0.404CysAsp: 0.404 ± 0.26
0.971CysGlu: 0.971 ± 0.381
0.162CysPhe: 0.162 ± 0.11
0.971CysGly: 0.971 ± 0.37
0.404CysHis: 0.404 ± 0.231
0.647CysIle: 0.647 ± 0.254
0.89CysLys: 0.89 ± 0.298
0.647CysLeu: 0.647 ± 0.304
0.324CysMet: 0.324 ± 0.202
0.243CysAsn: 0.243 ± 0.172
0.243CysPro: 0.243 ± 0.15
0.243CysGln: 0.243 ± 0.135
0.404CysArg: 0.404 ± 0.194
0.324CysSer: 0.324 ± 0.165
0.485CysThr: 0.485 ± 0.19
0.404CysVal: 0.404 ± 0.198
0.243CysTrp: 0.243 ± 0.153
0.404CysTyr: 0.404 ± 0.174
0.0CysXaa: 0.0 ± 0.0
Asp
5.419AspAla: 5.419 ± 0.982
1.052AspCys: 1.052 ± 0.287
3.883AspAsp: 3.883 ± 0.512
3.802AspGlu: 3.802 ± 0.651
2.184AspPhe: 2.184 ± 0.45
5.258AspGly: 5.258 ± 0.884
0.971AspHis: 0.971 ± 0.318
4.206AspIle: 4.206 ± 0.689
4.691AspLys: 4.691 ± 0.741
4.287AspLeu: 4.287 ± 0.613
1.941AspMet: 1.941 ± 0.409
3.074AspAsn: 3.074 ± 0.654
2.75AspPro: 2.75 ± 0.437
1.294AspGln: 1.294 ± 0.24
2.184AspArg: 2.184 ± 0.593
4.368AspSer: 4.368 ± 0.596
4.125AspThr: 4.125 ± 0.629
4.611AspVal: 4.611 ± 0.524
0.566AspTrp: 0.566 ± 0.222
3.316AspTyr: 3.316 ± 0.48
0.0AspXaa: 0.0 ± 0.0
Glu
4.772GluAla: 4.772 ± 0.748
0.728GluCys: 0.728 ± 0.282
4.044GluAsp: 4.044 ± 0.61
5.177GluGlu: 5.177 ± 0.828
3.559GluPhe: 3.559 ± 0.429
5.743GluGly: 5.743 ± 0.893
0.728GluHis: 0.728 ± 0.228
4.449GluIle: 4.449 ± 0.782
4.206GluLys: 4.206 ± 0.703
5.5GluLeu: 5.5 ± 0.497
1.941GluMet: 1.941 ± 0.417
3.074GluAsn: 3.074 ± 0.465
1.699GluPro: 1.699 ± 0.423
3.074GluGln: 3.074 ± 0.566
3.559GluArg: 3.559 ± 0.667
3.559GluSer: 3.559 ± 0.585
2.831GluThr: 2.831 ± 0.515
5.015GluVal: 5.015 ± 0.636
1.375GluTrp: 1.375 ± 0.331
2.184GluTyr: 2.184 ± 0.457
0.0GluXaa: 0.0 ± 0.0
Phe
3.64PheAla: 3.64 ± 0.541
0.404PheCys: 0.404 ± 0.194
2.912PheAsp: 2.912 ± 0.434
2.184PheGlu: 2.184 ± 0.41
1.294PhePhe: 1.294 ± 0.301
2.75PheGly: 2.75 ± 0.61
0.485PheHis: 0.485 ± 0.167
2.103PheIle: 2.103 ± 0.544
2.75PheLys: 2.75 ± 0.402
1.941PheLeu: 1.941 ± 0.394
0.971PheMet: 0.971 ± 0.333
1.294PheAsn: 1.294 ± 0.232
1.456PhePro: 1.456 ± 0.434
2.022PheGln: 2.022 ± 0.519
2.022PheArg: 2.022 ± 0.34
2.265PheSer: 2.265 ± 0.542
2.265PheThr: 2.265 ± 0.424
1.86PheVal: 1.86 ± 0.443
0.324PheTrp: 0.324 ± 0.137
1.699PheTyr: 1.699 ± 0.33
0.0PheXaa: 0.0 ± 0.0
Gly
6.228GlyAla: 6.228 ± 0.959
0.728GlyCys: 0.728 ± 0.381
5.015GlyAsp: 5.015 ± 0.798
4.53GlyGlu: 4.53 ± 0.63
3.397GlyPhe: 3.397 ± 0.566
6.956GlyGly: 6.956 ± 1.727
0.971GlyHis: 0.971 ± 0.322
5.258GlyIle: 5.258 ± 0.659
4.368GlyLys: 4.368 ± 0.663
5.258GlyLeu: 5.258 ± 0.789
1.941GlyMet: 1.941 ± 0.433
4.044GlyAsn: 4.044 ± 0.793
4.611GlyPro: 4.611 ± 3.348
2.912GlyGln: 2.912 ± 0.489
3.235GlyArg: 3.235 ± 0.567
5.258GlySer: 5.258 ± 0.824
5.5GlyThr: 5.5 ± 0.95
5.905GlyVal: 5.905 ± 0.869
0.971GlyTrp: 0.971 ± 0.297
3.235GlyTyr: 3.235 ± 0.644
0.0GlyXaa: 0.0 ± 0.0
His
0.647HisAla: 0.647 ± 0.293
0.566HisCys: 0.566 ± 0.251
0.89HisAsp: 0.89 ± 0.343
0.809HisGlu: 0.809 ± 0.251
0.89HisPhe: 0.89 ± 0.211
0.809HisGly: 0.809 ± 0.286
0.243HisHis: 0.243 ± 0.138
0.647HisIle: 0.647 ± 0.306
1.132HisLys: 1.132 ± 0.369
0.89HisLeu: 0.89 ± 0.279
0.566HisMet: 0.566 ± 0.208
0.728HisAsn: 0.728 ± 0.26
1.052HisPro: 1.052 ± 0.51
0.324HisGln: 0.324 ± 0.144
0.485HisArg: 0.485 ± 0.209
1.132HisSer: 1.132 ± 0.3
1.052HisThr: 1.052 ± 0.275
1.132HisVal: 1.132 ± 0.298
0.081HisTrp: 0.081 ± 0.099
0.243HisTyr: 0.243 ± 0.127
0.0HisXaa: 0.0 ± 0.0
Ile
4.044IleAla: 4.044 ± 0.811
0.162IleCys: 0.162 ± 0.137
4.206IleAsp: 4.206 ± 0.558
3.559IleGlu: 3.559 ± 0.458
1.699IlePhe: 1.699 ± 0.421
4.53IleGly: 4.53 ± 0.548
0.89IleHis: 0.89 ± 0.33
3.155IleIle: 3.155 ± 0.398
4.044IleLys: 4.044 ± 0.66
2.588IleLeu: 2.588 ± 0.438
1.213IleMet: 1.213 ± 0.309
4.368IleAsn: 4.368 ± 0.696
1.941IlePro: 1.941 ± 0.318
3.316IleGln: 3.316 ± 0.615
3.478IleArg: 3.478 ± 0.581
4.125IleSer: 4.125 ± 0.554
3.559IleThr: 3.559 ± 0.79
3.963IleVal: 3.963 ± 0.639
0.485IleTrp: 0.485 ± 0.177
1.86IleTyr: 1.86 ± 0.351
0.0IleXaa: 0.0 ± 0.0
Lys
6.714LysAla: 6.714 ± 1.068
0.324LysCys: 0.324 ± 0.218
3.721LysAsp: 3.721 ± 0.583
5.339LysGlu: 5.339 ± 0.711
2.669LysPhe: 2.669 ± 0.456
5.096LysGly: 5.096 ± 0.69
0.728LysHis: 0.728 ± 0.261
3.963LysIle: 3.963 ± 0.561
2.427LysLys: 2.427 ± 0.76
4.611LysLeu: 4.611 ± 0.579
1.294LysMet: 1.294 ± 0.407
1.294LysAsn: 1.294 ± 0.319
1.78LysPro: 1.78 ± 0.472
2.427LysGln: 2.427 ± 0.52
3.316LysArg: 3.316 ± 0.484
2.993LysSer: 2.993 ± 0.366
3.074LysThr: 3.074 ± 0.429
5.5LysVal: 5.5 ± 0.653
0.971LysTrp: 0.971 ± 0.283
2.588LysTyr: 2.588 ± 0.549
0.0LysXaa: 0.0 ± 0.0
Leu
6.875LeuAla: 6.875 ± 0.808
0.647LeuCys: 0.647 ± 0.273
4.934LeuAsp: 4.934 ± 0.704
5.581LeuGlu: 5.581 ± 0.622
1.86LeuPhe: 1.86 ± 0.387
4.449LeuGly: 4.449 ± 0.631
1.052LeuHis: 1.052 ± 0.348
4.206LeuIle: 4.206 ± 0.642
4.044LeuLys: 4.044 ± 0.672
5.5LeuLeu: 5.5 ± 0.707
2.346LeuMet: 2.346 ± 0.388
3.64LeuAsn: 3.64 ± 0.514
2.265LeuPro: 2.265 ± 0.49
3.235LeuGln: 3.235 ± 0.408
4.287LeuArg: 4.287 ± 0.635
4.449LeuSer: 4.449 ± 0.632
4.691LeuThr: 4.691 ± 0.724
3.802LeuVal: 3.802 ± 0.565
1.294LeuTrp: 1.294 ± 0.351
2.346LeuTyr: 2.346 ± 0.377
0.0LeuXaa: 0.0 ± 0.0
Met
2.912MetAla: 2.912 ± 0.537
0.404MetCys: 0.404 ± 0.195
1.699MetAsp: 1.699 ± 0.398
2.265MetGlu: 2.265 ± 0.517
0.971MetPhe: 0.971 ± 0.286
2.103MetGly: 2.103 ± 0.43
0.162MetHis: 0.162 ± 0.119
0.89MetIle: 0.89 ± 0.27
1.699MetLys: 1.699 ± 0.457
2.427MetLeu: 2.427 ± 0.444
1.132MetMet: 1.132 ± 0.326
1.052MetAsn: 1.052 ± 0.387
0.971MetPro: 0.971 ± 0.343
0.809MetGln: 0.809 ± 0.246
0.971MetArg: 0.971 ± 0.283
2.346MetSer: 2.346 ± 0.523
2.184MetThr: 2.184 ± 0.412
1.537MetVal: 1.537 ± 0.335
0.404MetTrp: 0.404 ± 0.175
0.971MetTyr: 0.971 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
3.721AsnAla: 3.721 ± 0.563
0.809AsnCys: 0.809 ± 0.422
2.831AsnAsp: 2.831 ± 0.541
2.022AsnGlu: 2.022 ± 0.364
1.456AsnPhe: 1.456 ± 0.304
3.721AsnGly: 3.721 ± 0.844
0.647AsnHis: 0.647 ± 0.25
2.507AsnIle: 2.507 ± 0.444
2.912AsnLys: 2.912 ± 0.431
5.177AsnLeu: 5.177 ± 0.768
1.699AsnMet: 1.699 ± 0.414
2.103AsnAsn: 2.103 ± 0.425
2.831AsnPro: 2.831 ± 0.418
2.427AsnGln: 2.427 ± 0.387
2.022AsnArg: 2.022 ± 0.365
3.397AsnSer: 3.397 ± 0.583
2.427AsnThr: 2.427 ± 0.411
4.044AsnVal: 4.044 ± 0.583
0.728AsnTrp: 0.728 ± 0.24
1.78AsnTyr: 1.78 ± 0.321
0.0AsnXaa: 0.0 ± 0.0
Pro
2.993ProAla: 2.993 ± 0.535
0.0ProCys: 0.0 ± 0.0
2.507ProAsp: 2.507 ± 0.364
4.206ProGlu: 4.206 ± 0.485
1.537ProPhe: 1.537 ± 0.408
0.404ProGly: 0.404 ± 0.15
0.809ProHis: 0.809 ± 0.262
2.507ProIle: 2.507 ± 0.499
2.184ProLys: 2.184 ± 0.344
2.346ProLeu: 2.346 ± 0.373
1.213ProMet: 1.213 ± 0.244
2.831ProAsn: 2.831 ± 0.548
0.647ProPro: 0.647 ± 0.194
3.397ProGln: 3.397 ± 1.601
1.86ProArg: 1.86 ± 0.392
2.022ProSer: 2.022 ± 0.534
3.559ProThr: 3.559 ± 0.85
2.669ProVal: 2.669 ± 0.496
0.485ProTrp: 0.485 ± 0.189
0.971ProTyr: 0.971 ± 0.28
0.0ProXaa: 0.0 ± 0.0
Gln
4.611GlnAla: 4.611 ± 0.866
0.324GlnCys: 0.324 ± 0.159
2.75GlnAsp: 2.75 ± 0.498
2.265GlnGlu: 2.265 ± 0.432
2.265GlnPhe: 2.265 ± 0.435
5.581GlnGly: 5.581 ± 2.761
0.566GlnHis: 0.566 ± 0.164
2.265GlnIle: 2.265 ± 0.526
1.699GlnLys: 1.699 ± 0.351
3.397GlnLeu: 3.397 ± 0.697
1.537GlnMet: 1.537 ± 0.269
1.86GlnAsn: 1.86 ± 0.455
1.132GlnPro: 1.132 ± 0.393
2.184GlnGln: 2.184 ± 0.595
2.022GlnArg: 2.022 ± 0.433
2.75GlnSer: 2.75 ± 0.592
2.346GlnThr: 2.346 ± 0.568
2.669GlnVal: 2.669 ± 0.382
0.243GlnTrp: 0.243 ± 0.15
1.941GlnTyr: 1.941 ± 0.398
0.0GlnXaa: 0.0 ± 0.0
Arg
3.235ArgAla: 3.235 ± 0.596
0.243ArgCys: 0.243 ± 0.166
3.478ArgAsp: 3.478 ± 0.462
4.206ArgGlu: 4.206 ± 0.739
1.375ArgPhe: 1.375 ± 0.4
4.044ArgGly: 4.044 ± 0.612
0.728ArgHis: 0.728 ± 0.189
3.963ArgIle: 3.963 ± 0.701
3.155ArgLys: 3.155 ± 0.599
2.993ArgLeu: 2.993 ± 0.51
1.537ArgMet: 1.537 ± 0.382
2.75ArgAsn: 2.75 ± 0.398
1.537ArgPro: 1.537 ± 0.396
2.669ArgGln: 2.669 ± 0.49
2.993ArgArg: 2.993 ± 0.512
2.346ArgSer: 2.346 ± 0.366
2.588ArgThr: 2.588 ± 0.47
2.912ArgVal: 2.912 ± 0.531
1.052ArgTrp: 1.052 ± 0.216
1.78ArgTyr: 1.78 ± 0.439
0.0ArgXaa: 0.0 ± 0.0
Ser
5.419SerAla: 5.419 ± 0.723
0.243SerCys: 0.243 ± 0.123
4.691SerAsp: 4.691 ± 0.873
3.64SerGlu: 3.64 ± 0.476
2.346SerPhe: 2.346 ± 0.518
5.015SerGly: 5.015 ± 0.869
0.728SerHis: 0.728 ± 0.227
2.912SerIle: 2.912 ± 0.4
4.368SerLys: 4.368 ± 0.664
3.721SerLeu: 3.721 ± 0.614
1.294SerMet: 1.294 ± 0.32
3.155SerAsn: 3.155 ± 0.44
3.397SerPro: 3.397 ± 0.483
3.559SerGln: 3.559 ± 0.522
3.235SerArg: 3.235 ± 0.483
4.449SerSer: 4.449 ± 0.654
3.963SerThr: 3.963 ± 0.665
4.368SerVal: 4.368 ± 0.65
0.971SerTrp: 0.971 ± 0.236
1.699SerTyr: 1.699 ± 0.465
0.0SerXaa: 0.0 ± 0.0
Thr
5.177ThrAla: 5.177 ± 0.637
0.162ThrCys: 0.162 ± 0.116
2.993ThrAsp: 2.993 ± 0.592
3.721ThrGlu: 3.721 ± 0.502
2.265ThrPhe: 2.265 ± 0.536
6.552ThrGly: 6.552 ± 1.178
0.728ThrHis: 0.728 ± 0.267
4.206ThrIle: 4.206 ± 0.708
3.478ThrLys: 3.478 ± 0.458
4.287ThrLeu: 4.287 ± 0.476
1.294ThrMet: 1.294 ± 0.352
3.559ThrAsn: 3.559 ± 0.675
3.721ThrPro: 3.721 ± 0.468
1.78ThrGln: 1.78 ± 0.349
2.669ThrArg: 2.669 ± 0.457
4.611ThrSer: 4.611 ± 0.513
4.934ThrThr: 4.934 ± 0.744
3.802ThrVal: 3.802 ± 0.547
0.89ThrTrp: 0.89 ± 0.316
2.265ThrTyr: 2.265 ± 0.477
0.0ThrXaa: 0.0 ± 0.0
Val
5.339ValAla: 5.339 ± 0.892
0.728ValCys: 0.728 ± 0.297
4.853ValAsp: 4.853 ± 0.863
4.044ValGlu: 4.044 ± 0.521
2.265ValPhe: 2.265 ± 0.458
5.258ValGly: 5.258 ± 1.081
1.213ValHis: 1.213 ± 0.394
3.883ValIle: 3.883 ± 0.491
4.611ValLys: 4.611 ± 0.553
5.824ValLeu: 5.824 ± 0.807
1.618ValMet: 1.618 ± 0.295
3.235ValAsn: 3.235 ± 0.505
2.103ValPro: 2.103 ± 0.416
2.912ValGln: 2.912 ± 0.445
3.64ValArg: 3.64 ± 0.611
4.611ValSer: 4.611 ± 0.658
4.53ValThr: 4.53 ± 0.515
5.177ValVal: 5.177 ± 0.627
1.294ValTrp: 1.294 ± 0.297
2.427ValTyr: 2.427 ± 0.412
0.0ValXaa: 0.0 ± 0.0
Trp
1.132TrpAla: 1.132 ± 0.321
0.0TrpCys: 0.0 ± 0.0
0.89TrpAsp: 0.89 ± 0.267
0.89TrpGlu: 0.89 ± 0.261
0.728TrpPhe: 0.728 ± 0.265
0.971TrpGly: 0.971 ± 0.255
0.324TrpHis: 0.324 ± 0.198
0.324TrpIle: 0.324 ± 0.157
1.213TrpLys: 1.213 ± 0.308
1.213TrpLeu: 1.213 ± 0.343
0.485TrpMet: 0.485 ± 0.19
0.404TrpAsn: 0.404 ± 0.188
0.485TrpPro: 0.485 ± 0.25
1.213TrpGln: 1.213 ± 0.294
0.162TrpArg: 0.162 ± 0.102
1.052TrpSer: 1.052 ± 0.28
0.89TrpThr: 0.89 ± 0.288
0.728TrpVal: 0.728 ± 0.238
0.485TrpTrp: 0.485 ± 0.234
0.485TrpTyr: 0.485 ± 0.211
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.103TyrAla: 2.103 ± 0.369
0.566TyrCys: 0.566 ± 0.288
2.588TyrAsp: 2.588 ± 0.503
2.427TyrGlu: 2.427 ± 0.377
1.294TyrPhe: 1.294 ± 0.368
2.831TyrGly: 2.831 ± 0.41
0.728TyrHis: 0.728 ± 0.189
1.78TyrIle: 1.78 ± 0.5
2.346TyrLys: 2.346 ± 0.61
2.912TyrLeu: 2.912 ± 0.617
0.728TyrMet: 0.728 ± 0.23
2.265TyrAsn: 2.265 ± 0.448
1.456TyrPro: 1.456 ± 0.383
0.647TyrGln: 0.647 ± 0.243
2.507TyrArg: 2.507 ± 0.321
2.912TyrSer: 2.912 ± 0.394
1.375TyrThr: 1.375 ± 0.341
3.478TyrVal: 3.478 ± 0.491
0.243TyrTrp: 0.243 ± 0.178
1.132TyrTyr: 1.132 ± 0.305
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 41 proteins (12364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski