Amino acid dipepetide frequency for Mycobacterium virus Pacc40

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.141AlaAla: 13.141 ± 1.498
0.851AlaCys: 0.851 ± 0.238
7.023AlaAsp: 7.023 ± 0.607
7.236AlaGlu: 7.236 ± 0.683
2.767AlaPhe: 2.767 ± 0.41
9.896AlaGly: 9.896 ± 1.195
2.447AlaHis: 2.447 ± 0.417
4.416AlaIle: 4.416 ± 0.526
4.309AlaLys: 4.309 ± 0.446
7.768AlaLeu: 7.768 ± 0.729
2.128AlaMet: 2.128 ± 0.317
2.82AlaAsn: 2.82 ± 0.37
4.629AlaPro: 4.629 ± 0.463
3.618AlaGln: 3.618 ± 0.431
7.129AlaArg: 7.129 ± 0.758
5.161AlaSer: 5.161 ± 0.535
5.799AlaThr: 5.799 ± 0.535
6.331AlaVal: 6.331 ± 0.605
2.235AlaTrp: 2.235 ± 0.385
2.075AlaTyr: 2.075 ± 0.352
0.0AlaXaa: 0.0 ± 0.0
Cys
0.904CysAla: 0.904 ± 0.285
0.053CysCys: 0.053 ± 0.053
1.117CysAsp: 1.117 ± 0.308
1.064CysGlu: 1.064 ± 0.241
0.106CysPhe: 0.106 ± 0.067
1.436CysGly: 1.436 ± 0.323
0.372CysHis: 0.372 ± 0.15
0.16CysIle: 0.16 ± 0.089
0.585CysLys: 0.585 ± 0.197
0.745CysLeu: 0.745 ± 0.238
0.266CysMet: 0.266 ± 0.101
0.532CysAsn: 0.532 ± 0.172
1.17CysPro: 1.17 ± 0.281
0.372CysGln: 0.372 ± 0.128
0.638CysArg: 0.638 ± 0.179
0.692CysSer: 0.692 ± 0.223
0.745CysThr: 0.745 ± 0.242
0.798CysVal: 0.798 ± 0.198
0.266CysTrp: 0.266 ± 0.113
0.106CysTyr: 0.106 ± 0.07
0.0CysXaa: 0.0 ± 0.0
Asp
6.81AspAla: 6.81 ± 0.56
0.692AspCys: 0.692 ± 0.184
4.682AspAsp: 4.682 ± 0.527
3.352AspGlu: 3.352 ± 0.486
1.436AspPhe: 1.436 ± 0.24
6.384AspGly: 6.384 ± 0.585
1.277AspHis: 1.277 ± 0.231
2.394AspIle: 2.394 ± 0.307
1.756AspLys: 1.756 ± 0.277
5.746AspLeu: 5.746 ± 0.425
1.383AspMet: 1.383 ± 0.28
1.862AspAsn: 1.862 ± 0.419
4.629AspPro: 4.629 ± 0.55
2.713AspGln: 2.713 ± 0.34
5.214AspArg: 5.214 ± 0.676
3.565AspSer: 3.565 ± 0.513
4.363AspThr: 4.363 ± 0.573
4.682AspVal: 4.682 ± 0.572
1.436AspTrp: 1.436 ± 0.275
2.022AspTyr: 2.022 ± 0.263
0.0AspXaa: 0.0 ± 0.0
Glu
5.906GluAla: 5.906 ± 0.669
0.745GluCys: 0.745 ± 0.213
3.245GluAsp: 3.245 ± 0.397
2.607GluGlu: 2.607 ± 0.401
2.341GluPhe: 2.341 ± 0.366
3.352GluGly: 3.352 ± 0.395
1.862GluHis: 1.862 ± 0.417
2.235GluIle: 2.235 ± 0.337
2.022GluLys: 2.022 ± 0.321
6.065GluLeu: 6.065 ± 0.731
1.49GluMet: 1.49 ± 0.344
1.702GluAsn: 1.702 ± 0.297
2.607GluPro: 2.607 ± 0.398
2.82GluGln: 2.82 ± 0.376
5.267GluArg: 5.267 ± 0.664
3.511GluSer: 3.511 ± 0.502
4.469GluThr: 4.469 ± 0.548
4.203GluVal: 4.203 ± 0.447
1.383GluTrp: 1.383 ± 0.257
1.756GluTyr: 1.756 ± 0.283
0.0GluXaa: 0.0 ± 0.0
Phe
3.086PheAla: 3.086 ± 0.342
0.266PheCys: 0.266 ± 0.108
2.607PheAsp: 2.607 ± 0.536
1.543PheGlu: 1.543 ± 0.291
0.958PhePhe: 0.958 ± 0.264
3.352PheGly: 3.352 ± 0.763
0.745PheHis: 0.745 ± 0.218
1.33PheIle: 1.33 ± 0.358
0.958PheLys: 0.958 ± 0.244
1.436PheLeu: 1.436 ± 0.236
0.745PheMet: 0.745 ± 0.196
1.17PheAsn: 1.17 ± 0.28
1.383PhePro: 1.383 ± 0.281
1.17PheGln: 1.17 ± 0.294
1.49PheArg: 1.49 ± 0.314
1.649PheSer: 1.649 ± 0.295
2.022PheThr: 2.022 ± 0.391
2.022PheVal: 2.022 ± 0.268
0.692PheTrp: 0.692 ± 0.162
0.851PheTyr: 0.851 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
9.044GlyAla: 9.044 ± 1.087
1.224GlyCys: 1.224 ± 0.289
5.746GlyAsp: 5.746 ± 0.604
4.895GlyGlu: 4.895 ± 0.561
2.501GlyPhe: 2.501 ± 0.53
10.747GlyGly: 10.747 ± 2.088
2.128GlyHis: 2.128 ± 0.357
3.831GlyIle: 3.831 ± 0.589
2.607GlyLys: 2.607 ± 0.336
6.384GlyLeu: 6.384 ± 0.573
2.128GlyMet: 2.128 ± 0.438
3.724GlyAsn: 3.724 ± 0.488
4.363GlyPro: 4.363 ± 0.585
2.767GlyGln: 2.767 ± 0.7
5.639GlyArg: 5.639 ± 0.842
6.012GlySer: 6.012 ± 0.854
6.012GlyThr: 6.012 ± 0.872
6.012GlyVal: 6.012 ± 0.548
2.394GlyTrp: 2.394 ± 0.369
2.181GlyTyr: 2.181 ± 0.48
0.0GlyXaa: 0.0 ± 0.0
His
2.022HisAla: 2.022 ± 0.362
0.319HisCys: 0.319 ± 0.133
1.33HisAsp: 1.33 ± 0.231
1.011HisGlu: 1.011 ± 0.24
0.426HisPhe: 0.426 ± 0.132
1.649HisGly: 1.649 ± 0.324
0.851HisHis: 0.851 ± 0.256
1.543HisIle: 1.543 ± 0.302
0.958HisLys: 0.958 ± 0.242
1.596HisLeu: 1.596 ± 0.267
0.532HisMet: 0.532 ± 0.15
0.958HisAsn: 0.958 ± 0.208
1.33HisPro: 1.33 ± 0.267
0.851HisGln: 0.851 ± 0.178
2.022HisArg: 2.022 ± 0.35
1.117HisSer: 1.117 ± 0.19
1.383HisThr: 1.383 ± 0.284
1.702HisVal: 1.702 ± 0.365
0.372HisTrp: 0.372 ± 0.157
1.064HisTyr: 1.064 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
4.629IleAla: 4.629 ± 0.506
0.532IleCys: 0.532 ± 0.17
3.884IleAsp: 3.884 ± 0.454
3.352IleGlu: 3.352 ± 0.315
0.638IlePhe: 0.638 ± 0.219
3.99IleGly: 3.99 ± 0.466
1.596IleHis: 1.596 ± 0.322
1.49IleIle: 1.49 ± 0.245
1.011IleLys: 1.011 ± 0.242
2.341IleLeu: 2.341 ± 0.441
0.319IleMet: 0.319 ± 0.107
1.702IleAsn: 1.702 ± 0.319
2.926IlePro: 2.926 ± 0.367
1.702IleGln: 1.702 ± 0.235
2.075IleArg: 2.075 ± 0.39
2.288IleSer: 2.288 ± 0.465
3.618IleThr: 3.618 ± 0.385
3.245IleVal: 3.245 ± 0.31
0.958IleTrp: 0.958 ± 0.22
0.851IleTyr: 0.851 ± 0.174
0.0IleXaa: 0.0 ± 0.0
Lys
3.724LysAla: 3.724 ± 0.5
0.585LysCys: 0.585 ± 0.178
1.862LysAsp: 1.862 ± 0.321
1.702LysGlu: 1.702 ± 0.299
1.383LysPhe: 1.383 ± 0.215
2.341LysGly: 2.341 ± 0.359
1.224LysHis: 1.224 ± 0.286
0.904LysIle: 0.904 ± 0.247
1.277LysLys: 1.277 ± 0.371
2.607LysLeu: 2.607 ± 0.351
0.692LysMet: 0.692 ± 0.168
1.011LysAsn: 1.011 ± 0.213
2.394LysPro: 2.394 ± 0.403
1.862LysGln: 1.862 ± 0.342
2.235LysArg: 2.235 ± 0.374
2.235LysSer: 2.235 ± 0.334
2.022LysThr: 2.022 ± 0.299
2.288LysVal: 2.288 ± 0.369
0.904LysTrp: 0.904 ± 0.218
0.585LysTyr: 0.585 ± 0.193
0.0LysXaa: 0.0 ± 0.0
Leu
7.448LeuAla: 7.448 ± 0.789
0.745LeuCys: 0.745 ± 0.201
4.575LeuAsp: 4.575 ± 0.488
4.629LeuGlu: 4.629 ± 0.506
2.82LeuPhe: 2.82 ± 0.309
5.32LeuGly: 5.32 ± 0.583
0.904LeuHis: 0.904 ± 0.193
3.352LeuIle: 3.352 ± 0.381
2.394LeuLys: 2.394 ± 0.385
4.895LeuLeu: 4.895 ± 0.534
1.543LeuMet: 1.543 ± 0.253
2.394LeuAsn: 2.394 ± 0.333
5.214LeuPro: 5.214 ± 0.629
3.192LeuGln: 3.192 ± 0.426
5.001LeuArg: 5.001 ± 0.633
5.161LeuSer: 5.161 ± 0.487
5.48LeuThr: 5.48 ± 0.555
5.214LeuVal: 5.214 ± 0.507
1.383LeuTrp: 1.383 ± 0.259
2.128LeuTyr: 2.128 ± 0.393
0.0LeuXaa: 0.0 ± 0.0
Met
1.969MetAla: 1.969 ± 0.322
0.266MetCys: 0.266 ± 0.176
1.277MetAsp: 1.277 ± 0.236
0.851MetGlu: 0.851 ± 0.187
0.426MetPhe: 0.426 ± 0.162
1.809MetGly: 1.809 ± 0.371
0.213MetHis: 0.213 ± 0.104
0.798MetIle: 0.798 ± 0.202
0.638MetLys: 0.638 ± 0.169
1.862MetLeu: 1.862 ± 0.308
0.372MetMet: 0.372 ± 0.192
0.798MetAsn: 0.798 ± 0.169
1.436MetPro: 1.436 ± 0.263
0.479MetGln: 0.479 ± 0.165
1.649MetArg: 1.649 ± 0.312
2.82MetSer: 2.82 ± 0.469
2.394MetThr: 2.394 ± 0.342
1.117MetVal: 1.117 ± 0.325
0.319MetTrp: 0.319 ± 0.13
0.319MetTyr: 0.319 ± 0.143
0.0MetXaa: 0.0 ± 0.0
Asn
3.405AsnAla: 3.405 ± 0.347
0.426AsnCys: 0.426 ± 0.16
1.862AsnAsp: 1.862 ± 0.352
1.756AsnGlu: 1.756 ± 0.356
0.745AsnPhe: 0.745 ± 0.26
4.522AsnGly: 4.522 ± 0.603
0.851AsnHis: 0.851 ± 0.168
1.383AsnIle: 1.383 ± 0.424
1.224AsnLys: 1.224 ± 0.322
2.713AsnLeu: 2.713 ± 0.395
0.585AsnMet: 0.585 ± 0.168
1.862AsnAsn: 1.862 ± 0.286
2.66AsnPro: 2.66 ± 0.404
1.224AsnGln: 1.224 ± 0.316
1.969AsnArg: 1.969 ± 0.381
1.596AsnSer: 1.596 ± 0.307
2.288AsnThr: 2.288 ± 0.352
1.969AsnVal: 1.969 ± 0.228
0.851AsnTrp: 0.851 ± 0.221
0.692AsnTyr: 0.692 ± 0.144
0.0AsnXaa: 0.0 ± 0.0
Pro
4.948ProAla: 4.948 ± 0.519
0.692ProCys: 0.692 ± 0.181
4.363ProAsp: 4.363 ± 0.572
4.203ProGlu: 4.203 ± 0.414
1.756ProPhe: 1.756 ± 0.324
6.704ProGly: 6.704 ± 0.664
1.436ProHis: 1.436 ± 0.264
1.969ProIle: 1.969 ± 0.276
1.915ProLys: 1.915 ± 0.308
3.937ProLeu: 3.937 ± 0.522
1.702ProMet: 1.702 ± 0.408
2.181ProAsn: 2.181 ± 0.357
4.309ProPro: 4.309 ± 0.523
2.66ProGln: 2.66 ± 0.392
3.245ProArg: 3.245 ± 0.539
3.458ProSer: 3.458 ± 0.428
3.086ProThr: 3.086 ± 0.396
4.788ProVal: 4.788 ± 0.505
1.436ProTrp: 1.436 ± 0.34
1.649ProTyr: 1.649 ± 0.288
0.0ProXaa: 0.0 ± 0.0
Gln
4.097GlnAla: 4.097 ± 0.618
0.638GlnCys: 0.638 ± 0.227
1.596GlnAsp: 1.596 ± 0.257
1.702GlnGlu: 1.702 ± 0.315
1.224GlnPhe: 1.224 ± 0.243
2.447GlnGly: 2.447 ± 0.403
1.064GlnHis: 1.064 ± 0.221
1.969GlnIle: 1.969 ± 0.31
1.064GlnLys: 1.064 ± 0.208
2.926GlnLeu: 2.926 ± 0.431
0.798GlnMet: 0.798 ± 0.189
0.904GlnAsn: 0.904 ± 0.226
2.82GlnPro: 2.82 ± 0.45
1.224GlnGln: 1.224 ± 0.256
3.192GlnArg: 3.192 ± 0.512
2.341GlnSer: 2.341 ± 0.316
2.022GlnThr: 2.022 ± 0.345
2.447GlnVal: 2.447 ± 0.321
0.585GlnTrp: 0.585 ± 0.216
0.904GlnTyr: 0.904 ± 0.244
0.0GlnXaa: 0.0 ± 0.0
Arg
6.916ArgAla: 6.916 ± 0.701
1.17ArgCys: 1.17 ± 0.281
4.841ArgAsp: 4.841 ± 0.659
5.054ArgGlu: 5.054 ± 0.682
1.969ArgPhe: 1.969 ± 0.4
4.043ArgGly: 4.043 ± 0.423
1.117ArgHis: 1.117 ± 0.264
4.203ArgIle: 4.203 ± 0.586
2.341ArgLys: 2.341 ± 0.426
5.427ArgLeu: 5.427 ± 0.622
2.128ArgMet: 2.128 ± 0.41
2.394ArgAsn: 2.394 ± 0.375
3.831ArgPro: 3.831 ± 0.435
1.543ArgGln: 1.543 ± 0.344
5.32ArgArg: 5.32 ± 0.788
3.937ArgSer: 3.937 ± 0.444
3.245ArgThr: 3.245 ± 0.517
5.054ArgVal: 5.054 ± 0.706
2.022ArgTrp: 2.022 ± 0.416
1.915ArgTyr: 1.915 ± 0.299
0.0ArgXaa: 0.0 ± 0.0
Ser
5.533SerAla: 5.533 ± 0.761
0.532SerCys: 0.532 ± 0.231
3.777SerAsp: 3.777 ± 0.53
3.086SerGlu: 3.086 ± 0.4
2.181SerPhe: 2.181 ± 0.407
6.384SerGly: 6.384 ± 0.88
1.17SerHis: 1.17 ± 0.221
2.979SerIle: 2.979 ± 0.401
2.341SerLys: 2.341 ± 0.37
4.097SerLeu: 4.097 ± 0.482
1.277SerMet: 1.277 ± 0.248
2.554SerAsn: 2.554 ± 0.503
3.405SerPro: 3.405 ± 0.423
1.543SerGln: 1.543 ± 0.206
3.299SerArg: 3.299 ± 0.47
4.043SerSer: 4.043 ± 0.701
3.565SerThr: 3.565 ± 0.476
4.948SerVal: 4.948 ± 0.675
1.224SerTrp: 1.224 ± 0.23
1.49SerTyr: 1.49 ± 0.23
0.0SerXaa: 0.0 ± 0.0
Thr
6.597ThrAla: 6.597 ± 0.572
0.798ThrCys: 0.798 ± 0.209
3.777ThrAsp: 3.777 ± 0.569
3.618ThrGlu: 3.618 ± 0.385
2.181ThrPhe: 2.181 ± 0.35
6.65ThrGly: 6.65 ± 0.678
1.543ThrHis: 1.543 ± 0.316
2.873ThrIle: 2.873 ± 0.429
2.501ThrLys: 2.501 ± 0.395
4.309ThrLeu: 4.309 ± 0.527
1.117ThrMet: 1.117 ± 0.221
2.022ThrAsn: 2.022 ± 0.379
4.469ThrPro: 4.469 ± 0.457
1.809ThrGln: 1.809 ± 0.344
4.256ThrArg: 4.256 ± 0.442
3.458ThrSer: 3.458 ± 0.451
4.363ThrThr: 4.363 ± 0.607
5.852ThrVal: 5.852 ± 0.585
1.117ThrTrp: 1.117 ± 0.237
1.756ThrTyr: 1.756 ± 0.267
0.0ThrXaa: 0.0 ± 0.0
Val
7.023ValAla: 7.023 ± 0.507
1.117ValCys: 1.117 ± 0.225
5.533ValAsp: 5.533 ± 0.568
4.788ValGlu: 4.788 ± 0.599
2.288ValPhe: 2.288 ± 0.381
5.959ValGly: 5.959 ± 0.635
1.436ValHis: 1.436 ± 0.259
2.926ValIle: 2.926 ± 0.382
2.447ValLys: 2.447 ± 0.33
5.214ValLeu: 5.214 ± 0.595
1.543ValMet: 1.543 ± 0.251
2.394ValAsn: 2.394 ± 0.355
4.097ValPro: 4.097 ± 0.406
2.66ValGln: 2.66 ± 0.297
4.841ValArg: 4.841 ± 0.712
4.469ValSer: 4.469 ± 0.688
4.948ValThr: 4.948 ± 0.547
6.544ValVal: 6.544 ± 0.58
1.702ValTrp: 1.702 ± 0.351
1.33ValTyr: 1.33 ± 0.327
0.0ValXaa: 0.0 ± 0.0
Trp
2.288TrpAla: 2.288 ± 0.329
0.266TrpCys: 0.266 ± 0.104
1.33TrpAsp: 1.33 ± 0.249
1.224TrpGlu: 1.224 ± 0.34
0.638TrpPhe: 0.638 ± 0.152
1.011TrpGly: 1.011 ± 0.305
0.532TrpHis: 0.532 ± 0.171
1.224TrpIle: 1.224 ± 0.235
0.851TrpLys: 0.851 ± 0.173
1.756TrpLeu: 1.756 ± 0.305
0.798TrpMet: 0.798 ± 0.219
0.745TrpAsn: 0.745 ± 0.236
1.224TrpPro: 1.224 ± 0.323
0.904TrpGln: 0.904 ± 0.24
2.181TrpArg: 2.181 ± 0.393
1.064TrpSer: 1.064 ± 0.222
1.543TrpThr: 1.543 ± 0.253
1.809TrpVal: 1.809 ± 0.332
1.117TrpTrp: 1.117 ± 0.234
0.372TrpTyr: 0.372 ± 0.148
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.288TyrAla: 2.288 ± 0.314
0.213TyrCys: 0.213 ± 0.117
2.022TyrAsp: 2.022 ± 0.394
1.915TyrGlu: 1.915 ± 0.3
0.692TyrPhe: 0.692 ± 0.176
2.341TyrGly: 2.341 ± 0.417
0.266TyrHis: 0.266 ± 0.131
1.17TyrIle: 1.17 ± 0.188
0.638TyrLys: 0.638 ± 0.193
1.969TyrLeu: 1.969 ± 0.426
0.213TyrMet: 0.213 ± 0.094
0.851TyrAsn: 0.851 ± 0.204
1.543TyrPro: 1.543 ± 0.271
0.851TyrGln: 0.851 ± 0.209
1.809TyrArg: 1.809 ± 0.338
0.851TyrSer: 0.851 ± 0.222
1.702TyrThr: 1.702 ± 0.335
2.235TyrVal: 2.235 ± 0.299
0.479TyrTrp: 0.479 ± 0.139
0.532TyrTyr: 0.532 ± 0.161
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 101 proteins (18797 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski