Amino acid dipepetide frequency for Salmonella phage SETP7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.39AlaAla: 10.39 ± 1.545
1.054AlaCys: 1.054 ± 0.318
6.475AlaAsp: 6.475 ± 0.704
7.002AlaGlu: 7.002 ± 0.967
3.99AlaPhe: 3.99 ± 0.496
7.83AlaGly: 7.83 ± 0.936
1.732AlaHis: 1.732 ± 0.43
3.84AlaIle: 3.84 ± 0.598
5.722AlaLys: 5.722 ± 0.861
7.077AlaLeu: 7.077 ± 0.748
2.334AlaMet: 2.334 ± 0.507
3.012AlaAsn: 3.012 ± 0.437
3.313AlaPro: 3.313 ± 0.482
3.463AlaGln: 3.463 ± 0.63
4.442AlaArg: 4.442 ± 0.615
5.571AlaSer: 5.571 ± 0.762
5.647AlaThr: 5.647 ± 0.844
6.927AlaVal: 6.927 ± 0.91
1.205AlaTrp: 1.205 ± 0.24
3.463AlaTyr: 3.463 ± 0.492
0.0AlaXaa: 0.0 ± 0.0
Cys
0.602CysAla: 0.602 ± 0.19
0.151CysCys: 0.151 ± 0.128
0.678CysAsp: 0.678 ± 0.247
0.903CysGlu: 0.903 ± 0.293
0.301CysPhe: 0.301 ± 0.133
0.678CysGly: 0.678 ± 0.225
0.226CysHis: 0.226 ± 0.128
0.226CysIle: 0.226 ± 0.121
0.527CysLys: 0.527 ± 0.198
0.753CysLeu: 0.753 ± 0.319
0.226CysMet: 0.226 ± 0.125
0.678CysAsn: 0.678 ± 0.276
0.301CysPro: 0.301 ± 0.163
0.376CysGln: 0.376 ± 0.238
0.753CysArg: 0.753 ± 0.205
0.226CysSer: 0.226 ± 0.181
0.678CysThr: 0.678 ± 0.179
0.602CysVal: 0.602 ± 0.214
0.301CysTrp: 0.301 ± 0.146
0.301CysTyr: 0.301 ± 0.141
0.0CysXaa: 0.0 ± 0.0
Asp
7.077AspAla: 7.077 ± 0.866
0.452AspCys: 0.452 ± 0.173
3.99AspAsp: 3.99 ± 0.586
4.066AspGlu: 4.066 ± 0.605
3.463AspPhe: 3.463 ± 0.397
6.023AspGly: 6.023 ± 0.747
0.903AspHis: 0.903 ± 0.311
3.614AspIle: 3.614 ± 0.396
3.313AspLys: 3.313 ± 0.479
4.517AspLeu: 4.517 ± 0.621
1.506AspMet: 1.506 ± 0.26
2.861AspAsn: 2.861 ± 0.573
1.807AspPro: 1.807 ± 0.441
0.753AspGln: 0.753 ± 0.273
2.635AspArg: 2.635 ± 0.417
4.141AspSer: 4.141 ± 0.542
4.367AspThr: 4.367 ± 0.565
4.367AspVal: 4.367 ± 0.486
0.903AspTrp: 0.903 ± 0.333
1.882AspTyr: 1.882 ± 0.376
0.0AspXaa: 0.0 ± 0.0
Glu
6.098GluAla: 6.098 ± 0.803
0.452GluCys: 0.452 ± 0.184
3.463GluAsp: 3.463 ± 0.485
4.593GluGlu: 4.593 ± 1.029
3.313GluPhe: 3.313 ± 0.734
5.12GluGly: 5.12 ± 0.825
0.828GluHis: 0.828 ± 0.243
3.764GluIle: 3.764 ± 0.403
4.141GluLys: 4.141 ± 0.59
6.174GluLeu: 6.174 ± 0.825
2.635GluMet: 2.635 ± 0.402
2.334GluAsn: 2.334 ± 0.393
2.033GluPro: 2.033 ± 0.601
3.012GluGln: 3.012 ± 0.515
3.99GluArg: 3.99 ± 0.599
4.141GluSer: 4.141 ± 0.702
3.388GluThr: 3.388 ± 0.556
4.894GluVal: 4.894 ± 0.578
1.129GluTrp: 1.129 ± 0.345
1.431GluTyr: 1.431 ± 0.318
0.0GluXaa: 0.0 ± 0.0
Phe
3.012PheAla: 3.012 ± 0.471
0.678PheCys: 0.678 ± 0.217
3.313PheAsp: 3.313 ± 0.511
2.861PheGlu: 2.861 ± 0.65
0.602PhePhe: 0.602 ± 0.198
2.71PheGly: 2.71 ± 0.394
0.753PheHis: 0.753 ± 0.263
2.409PheIle: 2.409 ± 0.398
1.958PheLys: 1.958 ± 0.456
1.882PheLeu: 1.882 ± 0.361
0.301PheMet: 0.301 ± 0.138
1.205PheAsn: 1.205 ± 0.41
1.732PhePro: 1.732 ± 0.402
1.431PheGln: 1.431 ± 0.356
2.259PheArg: 2.259 ± 0.341
2.183PheSer: 2.183 ± 0.602
3.162PheThr: 3.162 ± 0.58
2.861PheVal: 2.861 ± 0.539
0.753PheTrp: 0.753 ± 0.246
1.054PheTyr: 1.054 ± 0.271
0.0PheXaa: 0.0 ± 0.0
Gly
7.228GlyAla: 7.228 ± 0.69
0.828GlyCys: 0.828 ± 0.208
4.292GlyAsp: 4.292 ± 0.738
5.647GlyGlu: 5.647 ± 0.97
2.786GlyPhe: 2.786 ± 0.435
5.797GlyGly: 5.797 ± 0.949
1.355GlyHis: 1.355 ± 0.467
3.614GlyIle: 3.614 ± 0.414
4.894GlyLys: 4.894 ± 0.556
5.346GlyLeu: 5.346 ± 0.58
2.409GlyMet: 2.409 ± 0.668
3.614GlyAsn: 3.614 ± 0.57
1.958GlyPro: 1.958 ± 0.439
2.936GlyGln: 2.936 ± 0.427
4.668GlyArg: 4.668 ± 0.516
5.044GlySer: 5.044 ± 0.739
4.066GlyThr: 4.066 ± 0.655
6.475GlyVal: 6.475 ± 0.78
1.431GlyTrp: 1.431 ± 0.321
2.861GlyTyr: 2.861 ± 0.519
0.0GlyXaa: 0.0 ± 0.0
His
1.355HisAla: 1.355 ± 0.368
0.226HisCys: 0.226 ± 0.122
0.979HisAsp: 0.979 ± 0.231
0.979HisGlu: 0.979 ± 0.295
0.602HisPhe: 0.602 ± 0.234
1.129HisGly: 1.129 ± 0.418
0.903HisHis: 0.903 ± 0.301
1.205HisIle: 1.205 ± 0.307
1.506HisLys: 1.506 ± 0.339
1.28HisLeu: 1.28 ± 0.347
0.527HisMet: 0.527 ± 0.19
0.602HisAsn: 0.602 ± 0.214
0.979HisPro: 0.979 ± 0.282
0.903HisGln: 0.903 ± 0.234
0.979HisArg: 0.979 ± 0.266
0.903HisSer: 0.903 ± 0.332
0.753HisThr: 0.753 ± 0.318
0.828HisVal: 0.828 ± 0.273
0.075HisTrp: 0.075 ± 0.069
0.979HisTyr: 0.979 ± 0.276
0.0HisXaa: 0.0 ± 0.0
Ile
4.292IleAla: 4.292 ± 0.682
0.602IleCys: 0.602 ± 0.199
4.216IleAsp: 4.216 ± 0.68
2.861IleGlu: 2.861 ± 0.509
1.129IlePhe: 1.129 ± 0.33
3.087IleGly: 3.087 ± 0.401
0.903IleHis: 0.903 ± 0.299
2.183IleIle: 2.183 ± 0.49
3.162IleLys: 3.162 ± 0.668
3.237IleLeu: 3.237 ± 0.557
0.903IleMet: 0.903 ± 0.274
2.334IleAsn: 2.334 ± 0.407
2.56IlePro: 2.56 ± 0.333
1.732IleGln: 1.732 ± 0.432
2.786IleArg: 2.786 ± 0.33
2.635IleSer: 2.635 ± 0.465
4.668IleThr: 4.668 ± 0.628
3.463IleVal: 3.463 ± 0.476
0.979IleTrp: 0.979 ± 0.281
1.431IleTyr: 1.431 ± 0.396
0.0IleXaa: 0.0 ± 0.0
Lys
5.797LysAla: 5.797 ± 0.675
0.678LysCys: 0.678 ± 0.268
3.99LysAsp: 3.99 ± 0.551
4.216LysGlu: 4.216 ± 0.577
1.958LysPhe: 1.958 ± 0.374
4.066LysGly: 4.066 ± 0.488
1.355LysHis: 1.355 ± 0.312
1.882LysIle: 1.882 ± 0.515
3.237LysLys: 3.237 ± 0.637
5.647LysLeu: 5.647 ± 0.645
2.786LysMet: 2.786 ± 0.588
2.259LysAsn: 2.259 ± 0.473
2.334LysPro: 2.334 ± 0.519
2.409LysGln: 2.409 ± 0.413
3.614LysArg: 3.614 ± 0.583
2.635LysSer: 2.635 ± 0.501
3.689LysThr: 3.689 ± 0.466
3.689LysVal: 3.689 ± 0.554
0.753LysTrp: 0.753 ± 0.263
2.71LysTyr: 2.71 ± 0.413
0.0LysXaa: 0.0 ± 0.0
Leu
6.701LeuAla: 6.701 ± 0.568
0.828LeuCys: 0.828 ± 0.256
4.066LeuAsp: 4.066 ± 0.508
4.743LeuGlu: 4.743 ± 0.761
1.656LeuPhe: 1.656 ± 0.372
5.195LeuGly: 5.195 ± 0.561
1.205LeuHis: 1.205 ± 0.298
4.216LeuIle: 4.216 ± 0.487
5.571LeuLys: 5.571 ± 0.692
6.023LeuLeu: 6.023 ± 0.795
1.958LeuMet: 1.958 ± 0.369
4.819LeuAsn: 4.819 ± 0.677
3.539LeuPro: 3.539 ± 0.57
3.012LeuGln: 3.012 ± 0.399
5.421LeuArg: 5.421 ± 0.674
4.593LeuSer: 4.593 ± 0.604
5.12LeuThr: 5.12 ± 0.492
5.948LeuVal: 5.948 ± 0.621
1.054LeuTrp: 1.054 ± 0.352
2.409LeuTyr: 2.409 ± 0.376
0.0LeuXaa: 0.0 ± 0.0
Met
2.71MetAla: 2.71 ± 0.337
0.226MetCys: 0.226 ± 0.113
1.431MetAsp: 1.431 ± 0.407
1.205MetGlu: 1.205 ± 0.287
1.054MetPhe: 1.054 ± 0.293
1.732MetGly: 1.732 ± 0.335
0.301MetHis: 0.301 ± 0.138
1.129MetIle: 1.129 ± 0.327
1.506MetLys: 1.506 ± 0.386
2.108MetLeu: 2.108 ± 0.444
0.602MetMet: 0.602 ± 0.217
0.979MetAsn: 0.979 ± 0.259
1.129MetPro: 1.129 ± 0.355
0.903MetGln: 0.903 ± 0.208
1.581MetArg: 1.581 ± 0.328
1.958MetSer: 1.958 ± 0.356
1.958MetThr: 1.958 ± 0.474
2.108MetVal: 2.108 ± 0.434
0.452MetTrp: 0.452 ± 0.16
0.602MetTyr: 0.602 ± 0.24
0.0MetXaa: 0.0 ± 0.0
Asn
3.764AsnAla: 3.764 ± 0.548
0.301AsnCys: 0.301 ± 0.15
2.71AsnAsp: 2.71 ± 0.353
2.56AsnGlu: 2.56 ± 0.413
1.807AsnPhe: 1.807 ± 0.292
4.141AsnGly: 4.141 ± 0.528
0.678AsnHis: 0.678 ± 0.231
2.71AsnIle: 2.71 ± 0.378
1.958AsnLys: 1.958 ± 0.416
3.99AsnLeu: 3.99 ± 0.431
0.903AsnMet: 0.903 ± 0.32
2.56AsnAsn: 2.56 ± 0.548
1.732AsnPro: 1.732 ± 0.41
1.129AsnGln: 1.129 ± 0.259
2.334AsnArg: 2.334 ± 0.409
2.259AsnSer: 2.259 ± 0.444
2.334AsnThr: 2.334 ± 0.48
3.463AsnVal: 3.463 ± 0.498
0.828AsnTrp: 0.828 ± 0.213
1.506AsnTyr: 1.506 ± 0.341
0.0AsnXaa: 0.0 ± 0.0
Pro
2.635ProAla: 2.635 ± 0.537
0.301ProCys: 0.301 ± 0.142
3.237ProAsp: 3.237 ± 0.531
3.162ProGlu: 3.162 ± 0.52
1.732ProPhe: 1.732 ± 0.303
3.012ProGly: 3.012 ± 0.482
0.527ProHis: 0.527 ± 0.174
1.431ProIle: 1.431 ± 0.322
2.485ProLys: 2.485 ± 0.457
3.313ProLeu: 3.313 ± 0.463
0.602ProMet: 0.602 ± 0.196
1.506ProAsn: 1.506 ± 0.54
1.506ProPro: 1.506 ± 0.344
1.205ProGln: 1.205 ± 0.247
1.958ProArg: 1.958 ± 0.363
2.108ProSer: 2.108 ± 0.329
1.656ProThr: 1.656 ± 0.298
3.764ProVal: 3.764 ± 0.489
0.452ProTrp: 0.452 ± 0.228
1.656ProTyr: 1.656 ± 0.405
0.0ProXaa: 0.0 ± 0.0
Gln
4.066GlnAla: 4.066 ± 0.592
0.075GlnCys: 0.075 ± 0.072
1.581GlnAsp: 1.581 ± 0.317
2.183GlnGlu: 2.183 ± 0.475
1.28GlnPhe: 1.28 ± 0.325
2.259GlnGly: 2.259 ± 0.45
0.602GlnHis: 0.602 ± 0.218
1.656GlnIle: 1.656 ± 0.37
1.882GlnLys: 1.882 ± 0.408
3.012GlnLeu: 3.012 ± 0.504
1.129GlnMet: 1.129 ± 0.303
2.033GlnAsn: 2.033 ± 0.327
1.807GlnPro: 1.807 ± 0.386
2.183GlnGln: 2.183 ± 0.573
1.882GlnArg: 1.882 ± 0.351
1.882GlnSer: 1.882 ± 0.36
1.732GlnThr: 1.732 ± 0.329
2.71GlnVal: 2.71 ± 0.49
0.527GlnTrp: 0.527 ± 0.215
1.581GlnTyr: 1.581 ± 0.283
0.0GlnXaa: 0.0 ± 0.0
Arg
4.593ArgAla: 4.593 ± 0.532
0.376ArgCys: 0.376 ± 0.177
3.388ArgAsp: 3.388 ± 0.433
3.689ArgGlu: 3.689 ± 0.564
1.958ArgPhe: 1.958 ± 0.425
4.292ArgGly: 4.292 ± 0.463
1.355ArgHis: 1.355 ± 0.342
2.71ArgIle: 2.71 ± 0.377
3.84ArgLys: 3.84 ± 0.556
4.593ArgLeu: 4.593 ± 0.636
2.183ArgMet: 2.183 ± 0.381
3.237ArgAsn: 3.237 ± 0.459
2.033ArgPro: 2.033 ± 0.345
3.012ArgGln: 3.012 ± 0.524
4.216ArgArg: 4.216 ± 0.689
2.183ArgSer: 2.183 ± 0.376
2.485ArgThr: 2.485 ± 0.412
4.593ArgVal: 4.593 ± 0.571
1.129ArgTrp: 1.129 ± 0.268
1.431ArgTyr: 1.431 ± 0.362
0.0ArgXaa: 0.0 ± 0.0
Ser
6.475SerAla: 6.475 ± 0.937
0.226SerCys: 0.226 ± 0.128
3.313SerAsp: 3.313 ± 0.477
3.237SerGlu: 3.237 ± 0.492
2.259SerPhe: 2.259 ± 0.466
6.324SerGly: 6.324 ± 0.736
1.054SerHis: 1.054 ± 0.252
3.162SerIle: 3.162 ± 0.517
3.087SerLys: 3.087 ± 0.462
5.27SerLeu: 5.27 ± 0.635
1.129SerMet: 1.129 ± 0.299
2.334SerAsn: 2.334 ± 0.353
1.732SerPro: 1.732 ± 0.427
1.958SerGln: 1.958 ± 0.351
2.786SerArg: 2.786 ± 0.511
3.237SerSer: 3.237 ± 0.435
3.99SerThr: 3.99 ± 0.575
4.819SerVal: 4.819 ± 0.689
0.678SerTrp: 0.678 ± 0.179
2.259SerTyr: 2.259 ± 0.397
0.0SerXaa: 0.0 ± 0.0
Thr
6.098ThrAla: 6.098 ± 0.718
0.678ThrCys: 0.678 ± 0.221
4.292ThrAsp: 4.292 ± 0.547
3.539ThrGlu: 3.539 ± 0.469
2.936ThrPhe: 2.936 ± 0.544
5.948ThrGly: 5.948 ± 0.775
0.979ThrHis: 0.979 ± 0.264
2.71ThrIle: 2.71 ± 0.499
3.012ThrLys: 3.012 ± 0.47
5.044ThrLeu: 5.044 ± 0.544
0.753ThrMet: 0.753 ± 0.271
2.259ThrAsn: 2.259 ± 0.374
3.84ThrPro: 3.84 ± 0.487
1.355ThrGln: 1.355 ± 0.29
3.313ThrArg: 3.313 ± 0.481
4.969ThrSer: 4.969 ± 0.594
3.614ThrThr: 3.614 ± 0.369
4.894ThrVal: 4.894 ± 0.654
0.828ThrTrp: 0.828 ± 0.221
2.334ThrTyr: 2.334 ± 0.491
0.0ThrXaa: 0.0 ± 0.0
Val
7.228ValAla: 7.228 ± 0.751
0.602ValCys: 0.602 ± 0.204
4.292ValAsp: 4.292 ± 0.559
6.249ValGlu: 6.249 ± 0.659
2.108ValPhe: 2.108 ± 0.466
3.99ValGly: 3.99 ± 0.484
1.054ValHis: 1.054 ± 0.241
4.141ValIle: 4.141 ± 0.542
5.346ValLys: 5.346 ± 0.783
4.743ValLeu: 4.743 ± 0.721
1.581ValMet: 1.581 ± 0.39
3.162ValAsn: 3.162 ± 0.539
2.259ValPro: 2.259 ± 0.636
2.259ValGln: 2.259 ± 0.366
4.066ValArg: 4.066 ± 0.482
6.023ValSer: 6.023 ± 0.82
6.701ValThr: 6.701 ± 0.838
5.27ValVal: 5.27 ± 0.748
0.979ValTrp: 0.979 ± 0.222
2.635ValTyr: 2.635 ± 0.466
0.0ValXaa: 0.0 ± 0.0
Trp
1.28TrpAla: 1.28 ± 0.458
0.226TrpCys: 0.226 ± 0.145
1.054TrpAsp: 1.054 ± 0.277
0.527TrpGlu: 0.527 ± 0.209
0.678TrpPhe: 0.678 ± 0.292
1.054TrpGly: 1.054 ± 0.289
0.376TrpHis: 0.376 ± 0.212
0.753TrpIle: 0.753 ± 0.226
0.226TrpLys: 0.226 ± 0.122
1.581TrpLeu: 1.581 ± 0.415
0.376TrpMet: 0.376 ± 0.165
0.678TrpAsn: 0.678 ± 0.275
0.527TrpPro: 0.527 ± 0.253
0.753TrpGln: 0.753 ± 0.234
1.205TrpArg: 1.205 ± 0.349
0.678TrpSer: 0.678 ± 0.212
0.828TrpThr: 0.828 ± 0.245
1.28TrpVal: 1.28 ± 0.273
0.301TrpTrp: 0.301 ± 0.203
0.376TrpTyr: 0.376 ± 0.197
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.087TyrAla: 3.087 ± 0.542
0.527TyrCys: 0.527 ± 0.218
1.882TyrAsp: 1.882 ± 0.533
2.71TyrGlu: 2.71 ± 0.498
1.506TyrPhe: 1.506 ± 0.375
2.861TyrGly: 2.861 ± 0.434
0.602TyrHis: 0.602 ± 0.222
1.807TyrIle: 1.807 ± 0.386
2.334TyrLys: 2.334 ± 0.441
2.56TyrLeu: 2.56 ± 0.519
0.753TyrMet: 0.753 ± 0.186
1.205TyrAsn: 1.205 ± 0.218
1.129TyrPro: 1.129 ± 0.303
1.28TyrGln: 1.28 ± 0.261
2.409TyrArg: 2.409 ± 0.53
1.958TyrSer: 1.958 ± 0.378
2.56TyrThr: 2.56 ± 0.377
1.732TyrVal: 1.732 ± 0.404
0.0TyrTrp: 0.0 ± 0.0
1.431TyrTyr: 1.431 ± 0.268
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (13283 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski