Amino acid dipepetide frequency for Acetanaerobacterium elongatum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.982AlaAla: 9.982 ± 0.178	1.33AlaCys: 1.33 ± 0.046	4.6AlaAsp: 4.6 ± 0.089	5.648AlaGlu: 5.648 ± 0.086	3.544AlaPhe: 3.544 ± 0.075	6.576AlaGly: 6.576 ± 0.103	1.25AlaHis: 1.25 ± 0.045	5.541AlaIle: 5.541 ± 0.096	5.316AlaLys: 5.316 ± 0.1	8.702AlaLeu: 8.702 ± 0.121	2.296AlaMet: 2.296 ± 0.049	2.928AlaAsn: 2.928 ± 0.063	2.907AlaPro: 2.907 ± 0.084	3.404AlaGln: 3.404 ± 0.075	3.605AlaArg: 3.605 ± 0.072	4.917AlaSer: 4.917 ± 0.086	4.005AlaThr: 4.005 ± 0.097	7.714AlaVal: 7.714 ± 0.119	0.601AlaTrp: 0.601 ± 0.029	2.919AlaTyr: 2.919 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	1.267CysAla: 1.267 ± 0.038	0.313CysCys: 0.313 ± 0.022	0.894CysAsp: 0.894 ± 0.036	1.026CysGlu: 1.026 ± 0.041	0.614CysPhe: 0.614 ± 0.029	1.651CysGly: 1.651 ± 0.052	0.284CysHis: 0.284 ± 0.019	1.075CysIle: 1.075 ± 0.042	0.757CysLys: 0.757 ± 0.032	1.109CysLeu: 1.109 ± 0.039	0.327CysMet: 0.327 ± 0.022	0.507CysAsn: 0.507 ± 0.026	0.675CysPro: 0.675 ± 0.034	0.315CysGln: 0.315 ± 0.018	0.762CysArg: 0.762 ± 0.038	0.99CysSer: 0.99 ± 0.041	0.856CysThr: 0.856 ± 0.031	0.997CysVal: 0.997 ± 0.036	0.117CysTrp: 0.117 ± 0.012	0.52CysTyr: 0.52 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.178AspAla: 4.178 ± 0.066	0.745AspCys: 0.745 ± 0.033	2.645AspAsp: 2.645 ± 0.066	4.002AspGlu: 4.002 ± 0.08	2.401AspPhe: 2.401 ± 0.053	3.999AspGly: 3.999 ± 0.084	0.655AspHis: 0.655 ± 0.032	4.742AspIle: 4.742 ± 0.083	3.424AspLys: 3.424 ± 0.074	3.827AspLeu: 3.827 ± 0.074	1.413AspMet: 1.413 ± 0.036	2.283AspAsn: 2.283 ± 0.05	1.544AspPro: 1.544 ± 0.041	0.953AspGln: 0.953 ± 0.032	2.038AspArg: 2.038 ± 0.054	3.011AspSer: 3.011 ± 0.072	3.277AspThr: 3.277 ± 0.055	3.51AspVal: 3.51 ± 0.071	0.459AspTrp: 0.459 ± 0.023	2.458AspTyr: 2.458 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.242GluAla: 5.242 ± 0.073	0.714GluCys: 0.714 ± 0.032	3.068GluAsp: 3.068 ± 0.062	4.35GluGlu: 4.35 ± 0.088	2.146GluPhe: 2.146 ± 0.053	3.897GluGly: 3.897 ± 0.078	1.211GluHis: 1.211 ± 0.044	4.489GluIle: 4.489 ± 0.083	4.629GluLys: 4.629 ± 0.079	6.707GluLeu: 6.707 ± 0.093	1.754GluMet: 1.754 ± 0.051	3.306GluAsn: 3.306 ± 0.069	1.96GluPro: 1.96 ± 0.05	3.168GluGln: 3.168 ± 0.072	3.298GluArg: 3.298 ± 0.068	3.185GluSer: 3.185 ± 0.063	3.2GluThr: 3.2 ± 0.061	4.127GluVal: 4.127 ± 0.078	0.452GluTrp: 0.452 ± 0.024	2.605GluTyr: 2.605 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.481PheAla: 3.481 ± 0.068	0.758PheCys: 0.758 ± 0.031	2.454PheAsp: 2.454 ± 0.053	2.696PheGlu: 2.696 ± 0.06	1.847PhePhe: 1.847 ± 0.052	3.207PheGly: 3.207 ± 0.075	0.586PheHis: 0.586 ± 0.026	3.057PheIle: 3.057 ± 0.069	2.316PheLys: 2.316 ± 0.053	3.481PheLeu: 3.481 ± 0.086	0.981PheMet: 0.981 ± 0.039	1.753PheAsn: 1.753 ± 0.047	1.319PhePro: 1.319 ± 0.045	0.988PheGln: 0.988 ± 0.031	1.385PheArg: 1.385 ± 0.04	3.089PheSer: 3.089 ± 0.063	2.964PheThr: 2.964 ± 0.067	2.688PheVal: 2.688 ± 0.058	0.366PheTrp: 0.366 ± 0.021	1.648PheTyr: 1.648 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	5.835GlyAla: 5.835 ± 0.1	1.296GlyCys: 1.296 ± 0.048	3.528GlyAsp: 3.528 ± 0.063	4.504GlyGlu: 4.504 ± 0.072	3.396GlyPhe: 3.396 ± 0.065	5.363GlyGly: 5.363 ± 0.111	1.132GlyHis: 1.132 ± 0.038	5.892GlyIle: 5.892 ± 0.087	4.897GlyLys: 4.897 ± 0.093	6.586GlyLeu: 6.586 ± 0.093	2.171GlyMet: 2.171 ± 0.056	2.716GlyAsn: 2.716 ± 0.063	1.513GlyPro: 1.513 ± 0.128	1.948GlyGln: 1.948 ± 0.048	3.347GlyArg: 3.347 ± 0.064	4.585GlySer: 4.585 ± 0.096	4.325GlyThr: 4.325 ± 0.108	5.364GlyVal: 5.364 ± 0.079	0.627GlyTrp: 0.627 ± 0.03	3.111GlyTyr: 3.111 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.127HisAla: 1.127 ± 0.039	0.327HisCys: 0.327 ± 0.022	0.738HisAsp: 0.738 ± 0.032	0.904HisGlu: 0.904 ± 0.04	0.763HisPhe: 0.763 ± 0.034	1.148HisGly: 1.148 ± 0.039	0.365HisHis: 0.365 ± 0.021	1.243HisIle: 1.243 ± 0.048	0.865HisLys: 0.865 ± 0.032	1.471HisLeu: 1.471 ± 0.043	0.41HisMet: 0.41 ± 0.021	0.788HisAsn: 0.788 ± 0.029	0.867HisPro: 0.867 ± 0.031	0.485HisGln: 0.485 ± 0.023	0.77HisArg: 0.77 ± 0.027	0.982HisSer: 0.982 ± 0.037	0.997HisThr: 0.997 ± 0.034	0.862HisVal: 0.862 ± 0.03	0.136HisTrp: 0.136 ± 0.013	0.723HisTyr: 0.723 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.226IleAla: 6.226 ± 0.089	1.096IleCys: 1.096 ± 0.039	3.997IleAsp: 3.997 ± 0.078	4.412IleGlu: 4.412 ± 0.076	2.626IlePhe: 2.626 ± 0.073	4.909IleGly: 4.909 ± 0.086	1.079IleHis: 1.079 ± 0.036	5.241IleIle: 5.241 ± 0.095	4.36IleLys: 4.36 ± 0.082	6.72IleLeu: 6.72 ± 0.111	1.61IleMet: 1.61 ± 0.051	3.185IleAsn: 3.185 ± 0.067	3.063IlePro: 3.063 ± 0.062	1.868IleGln: 1.868 ± 0.048	3.111IleArg: 3.111 ± 0.069	4.937IleSer: 4.937 ± 0.086	4.961IleThr: 4.961 ± 0.104	4.753IleVal: 4.753 ± 0.069	0.52IleTrp: 0.52 ± 0.025	2.322IleTyr: 2.322 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.788LysAla: 5.788 ± 0.096	0.618LysCys: 0.618 ± 0.03	3.377LysAsp: 3.377 ± 0.071	4.453LysGlu: 4.453 ± 0.081	1.449LysPhe: 1.449 ± 0.038	4.283LysGly: 4.283 ± 0.074	0.98LysHis: 0.98 ± 0.036	3.838LysIle: 3.838 ± 0.076	4.314LysLys: 4.314 ± 0.087	5.985LysLeu: 5.985 ± 0.094	1.604LysMet: 1.604 ± 0.041	3.321LysAsn: 3.321 ± 0.063	2.501LysPro: 2.501 ± 0.056	2.507LysGln: 2.507 ± 0.054	3.314LysArg: 3.314 ± 0.078	3.581LysSer: 3.581 ± 0.071	3.917LysThr: 3.917 ± 0.074	3.914LysVal: 3.914 ± 0.089	0.447LysTrp: 0.447 ± 0.023	2.097LysTyr: 2.097 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	8.204LeuAla: 8.204 ± 0.132	1.806LeuCys: 1.806 ± 0.059	4.611LeuAsp: 4.611 ± 0.083	5.348LeuGlu: 5.348 ± 0.087	4.209LeuPhe: 4.209 ± 0.085	6.488LeuGly: 6.488 ± 0.089	1.516LeuHis: 1.516 ± 0.043	6.241LeuIle: 6.241 ± 0.118	6.316LeuLys: 6.316 ± 0.098	9.974LeuLeu: 9.974 ± 0.159	2.604LeuMet: 2.604 ± 0.067	4.232LeuAsn: 4.232 ± 0.073	4.296LeuPro: 4.296 ± 0.08	3.04LeuGln: 3.04 ± 0.067	4.191LeuArg: 4.191 ± 0.08	7.392LeuSer: 7.392 ± 0.091	6.13LeuThr: 6.13 ± 0.079	5.798LeuVal: 5.798 ± 0.093	0.81LeuTrp: 0.81 ± 0.034	3.405LeuTyr: 3.405 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.266MetAla: 2.266 ± 0.053	0.254MetCys: 0.254 ± 0.02	1.304MetAsp: 1.304 ± 0.042	1.524MetGlu: 1.524 ± 0.041	0.951MetPhe: 0.951 ± 0.037	1.907MetGly: 1.907 ± 0.058	0.401MetHis: 0.401 ± 0.021	1.644MetIle: 1.644 ± 0.047	1.901MetLys: 1.901 ± 0.05	2.913MetLeu: 2.913 ± 0.061	0.709MetMet: 0.709 ± 0.032	1.343MetAsn: 1.343 ± 0.038	1.252MetPro: 1.252 ± 0.042	1.011MetGln: 1.011 ± 0.035	1.252MetArg: 1.252 ± 0.044	1.634MetSer: 1.634 ± 0.05	1.348MetThr: 1.348 ± 0.044	1.825MetVal: 1.825 ± 0.044	0.139MetTrp: 0.139 ± 0.013	0.652MetTyr: 0.652 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.686AsnAla: 3.686 ± 0.077	0.583AsnCys: 0.583 ± 0.025	2.126AsnAsp: 2.126 ± 0.052	2.676AsnGlu: 2.676 ± 0.059	1.424AsnPhe: 1.424 ± 0.046	3.702AsnGly: 3.702 ± 0.076	0.738AsnHis: 0.738 ± 0.03	3.493AsnIle: 3.493 ± 0.071	2.42AsnLys: 2.42 ± 0.051	3.992AsnLeu: 3.992 ± 0.068	1.075AsnMet: 1.075 ± 0.04	2.076AsnAsn: 2.076 ± 0.054	2.262AsnPro: 2.262 ± 0.044	1.305AsnGln: 1.305 ± 0.04	2.16AsnArg: 2.16 ± 0.056	2.683AsnSer: 2.683 ± 0.062	2.614AsnThr: 2.614 ± 0.066	2.654AsnVal: 2.654 ± 0.063	0.37AsnTrp: 0.37 ± 0.021	1.567AsnTyr: 1.567 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	3.47ProAla: 3.47 ± 0.069	0.48ProCys: 0.48 ± 0.022	2.259ProAsp: 2.259 ± 0.054	2.919ProGlu: 2.919 ± 0.057	1.661ProPhe: 1.661 ± 0.047	2.173ProGly: 2.173 ± 0.054	0.67ProHis: 0.67 ± 0.029	2.29ProIle: 2.29 ± 0.052	2.255ProLys: 2.255 ± 0.053	3.449ProLeu: 3.449 ± 0.059	0.929ProMet: 0.929 ± 0.034	1.573ProAsn: 1.573 ± 0.044	1.298ProPro: 1.298 ± 0.05	1.502ProGln: 1.502 ± 0.047	1.222ProArg: 1.222 ± 0.039	2.294ProSer: 2.294 ± 0.056	1.968ProThr: 1.968 ± 0.101	3.289ProVal: 3.289 ± 0.068	0.328ProTrp: 0.328 ± 0.02	1.483ProTyr: 1.483 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.929GlnAla: 2.929 ± 0.057	0.359GlnCys: 0.359 ± 0.024	1.364GlnAsp: 1.364 ± 0.041	1.976GlnGlu: 1.976 ± 0.05	1.179GlnPhe: 1.179 ± 0.036	2.114GlnGly: 2.114 ± 0.064	0.52GlnHis: 0.52 ± 0.023	2.178GlnIle: 2.178 ± 0.055	2.44GlnLys: 2.44 ± 0.051	3.124GlnLeu: 3.124 ± 0.068	1.009GlnMet: 1.009 ± 0.035	1.878GlnAsn: 1.878 ± 0.044	1.258GlnPro: 1.258 ± 0.044	1.528GlnGln: 1.528 ± 0.05	1.619GlnArg: 1.619 ± 0.048	2.026GlnSer: 2.026 ± 0.054	1.966GlnThr: 1.966 ± 0.055	2.03GlnVal: 2.03 ± 0.054	0.292GlnTrp: 0.292 ± 0.017	1.263GlnTyr: 1.263 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.316ArgAla: 3.316 ± 0.069	0.728ArgCys: 0.728 ± 0.031	2.026ArgAsp: 2.026 ± 0.056	3.122ArgGlu: 3.122 ± 0.063	2.373ArgPhe: 2.373 ± 0.056	2.577ArgGly: 2.577 ± 0.063	0.829ArgHis: 0.829 ± 0.026	3.402ArgIle: 3.402 ± 0.07	2.617ArgLys: 2.617 ± 0.059	4.888ArgLeu: 4.888 ± 0.101	1.516ArgMet: 1.516 ± 0.042	1.724ArgAsn: 1.724 ± 0.049	1.486ArgPro: 1.486 ± 0.046	1.681ArgGln: 1.681 ± 0.042	2.511ArgArg: 2.511 ± 0.066	2.278ArgSer: 2.278 ± 0.055	2.111ArgThr: 2.111 ± 0.051	3.113ArgVal: 3.113 ± 0.064	0.456ArgTrp: 0.456 ± 0.028	1.998ArgTyr: 1.998 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.564SerAla: 5.564 ± 0.107	0.909SerCys: 0.909 ± 0.035	3.283SerAsp: 3.283 ± 0.064	3.766SerGlu: 3.766 ± 0.068	3.04SerPhe: 3.04 ± 0.058	5.507SerGly: 5.507 ± 0.098	0.949SerHis: 0.949 ± 0.035	4.18SerIle: 4.18 ± 0.084	3.527SerLys: 3.527 ± 0.079	6.182SerLeu: 6.182 ± 0.097	1.585SerMet: 1.585 ± 0.045	2.372SerAsn: 2.372 ± 0.066	2.252SerPro: 2.252 ± 0.058	1.977SerGln: 1.977 ± 0.057	2.751SerArg: 2.751 ± 0.062	4.721SerSer: 4.721 ± 0.154	3.203SerThr: 3.203 ± 0.08	4.726SerVal: 4.726 ± 0.09	0.459SerTrp: 0.459 ± 0.023	2.329SerTyr: 2.329 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	6.034ThrAla: 6.034 ± 0.126	0.659ThrCys: 0.659 ± 0.027	3.197ThrAsp: 3.197 ± 0.072	3.511ThrGlu: 3.511 ± 0.064	2.199ThrPhe: 2.199 ± 0.048	5.105ThrGly: 5.105 ± 0.154	0.905ThrHis: 0.905 ± 0.032	4.086ThrIle: 4.086 ± 0.087	2.871ThrLys: 2.871 ± 0.065	5.816ThrLeu: 5.816 ± 0.087	1.384ThrMet: 1.384 ± 0.045	2.115ThrAsn: 2.115 ± 0.06	2.707ThrPro: 2.707 ± 0.061	1.732ThrGln: 1.732 ± 0.05	2.231ThrArg: 2.231 ± 0.058	2.999ThrSer: 2.999 ± 0.07	3.076ThrThr: 3.076 ± 0.081	5.312ThrVal: 5.312 ± 0.12	0.445ThrTrp: 0.445 ± 0.026	1.915ThrTyr: 1.915 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	5.598ValAla: 5.598 ± 0.103	1.274ValCys: 1.274 ± 0.042	3.436ValAsp: 3.436 ± 0.075	3.913ValGlu: 3.913 ± 0.074	3.182ValPhe: 3.182 ± 0.07	4.193ValGly: 4.193 ± 0.079	1.076ValHis: 1.076 ± 0.039	5.084ValIle: 5.084 ± 0.086	4.525ValLys: 4.525 ± 0.087	7.467ValLeu: 7.467 ± 0.099	1.83ValMet: 1.83 ± 0.045	3.14ValAsn: 3.14 ± 0.072	2.739ValPro: 2.739 ± 0.063	2.054ValGln: 2.054 ± 0.052	2.881ValArg: 2.881 ± 0.068	5.132ValSer: 5.132 ± 0.074	4.643ValThr: 4.643 ± 0.134	5.106ValVal: 5.106 ± 0.101	0.577ValTrp: 0.577 ± 0.027	2.705ValTyr: 2.705 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.626TrpAla: 0.626 ± 0.029	0.157TrpCys: 0.157 ± 0.015	0.423TrpAsp: 0.423 ± 0.024	0.45TrpGlu: 0.45 ± 0.023	0.417TrpPhe: 0.417 ± 0.023	0.618TrpGly: 0.618 ± 0.03	0.177TrpHis: 0.177 ± 0.015	0.453TrpIle: 0.453 ± 0.026	0.43TrpLys: 0.43 ± 0.026	0.834TrpLeu: 0.834 ± 0.035	0.219TrpMet: 0.219 ± 0.019	0.411TrpAsn: 0.411 ± 0.02	0.188TrpPro: 0.188 ± 0.017	0.385TrpGln: 0.385 ± 0.024	0.394TrpArg: 0.394 ± 0.02	0.436TrpSer: 0.436 ± 0.029	0.339TrpThr: 0.339 ± 0.023	0.61TrpVal: 0.61 ± 0.031	0.104TrpTrp: 0.104 ± 0.012	0.331TrpTyr: 0.331 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.968TyrAla: 2.968 ± 0.058	0.65TyrCys: 0.65 ± 0.029	2.234TyrAsp: 2.234 ± 0.054	2.307TyrGlu: 2.307 ± 0.056	1.645TyrPhe: 1.645 ± 0.052	2.716TyrGly: 2.716 ± 0.053	0.646TyrHis: 0.646 ± 0.032	2.825TyrIle: 2.825 ± 0.058	2.109TyrLys: 2.109 ± 0.053	3.386TyrLeu: 3.386 ± 0.074	0.804TyrMet: 0.804 ± 0.031	1.958TyrAsn: 1.958 ± 0.057	1.426TyrPro: 1.426 ± 0.041	1.201TyrGln: 1.201 ± 0.04	1.911TyrArg: 1.911 ± 0.056	2.407TyrSer: 2.407 ± 0.056	2.399TyrThr: 2.399 ± 0.068	2.164TyrVal: 2.164 ± 0.043	0.298TyrTrp: 0.298 ± 0.02	1.677TyrTyr: 1.677 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2758 proteins (829626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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