Amino acid dipepetide frequency for Kaumoebavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.631AlaAla: 4.631 ± 0.294
0.763AlaCys: 0.763 ± 0.088
3.686AlaAsp: 3.686 ± 0.22
5.104AlaGlu: 5.104 ± 0.235
2.611AlaPhe: 2.611 ± 0.168
3.202AlaGly: 3.202 ± 0.258
1.171AlaHis: 1.171 ± 0.105
4.029AlaIle: 4.029 ± 0.191
5.211AlaLys: 5.211 ± 0.269
5.19AlaLeu: 5.19 ± 0.256
1.494AlaMet: 1.494 ± 0.118
2.708AlaAsn: 2.708 ± 0.208
2.493AlaPro: 2.493 ± 0.164
2.085AlaGln: 2.085 ± 0.179
3.105AlaArg: 3.105 ± 0.185
3.503AlaSer: 3.503 ± 0.207
3.299AlaThr: 3.299 ± 0.244
3.449AlaVal: 3.449 ± 0.187
0.72AlaTrp: 0.72 ± 0.076
2.611AlaTyr: 2.611 ± 0.152
0.0AlaXaa: 0.0 ± 0.0
Cys
0.817CysAla: 0.817 ± 0.088
0.226CysCys: 0.226 ± 0.05
1.214CysAsp: 1.214 ± 0.122
1.214CysGlu: 1.214 ± 0.105
0.645CysPhe: 0.645 ± 0.091
1.472CysGly: 1.472 ± 0.137
0.376CysHis: 0.376 ± 0.061
0.806CysIle: 0.806 ± 0.081
1.279CysLys: 1.279 ± 0.115
1.139CysLeu: 1.139 ± 0.105
0.236CysMet: 0.236 ± 0.056
0.677CysAsn: 0.677 ± 0.099
0.827CysPro: 0.827 ± 0.165
0.677CysGln: 0.677 ± 0.094
1.246CysArg: 1.246 ± 0.127
0.999CysSer: 0.999 ± 0.111
0.666CysThr: 0.666 ± 0.074
0.795CysVal: 0.795 ± 0.097
0.215CysTrp: 0.215 ± 0.049
0.677CysTyr: 0.677 ± 0.109
0.0CysXaa: 0.0 ± 0.0
Asp
3.772AspAla: 3.772 ± 0.233
0.989AspCys: 0.989 ± 0.097
3.965AspAsp: 3.965 ± 0.264
5.115AspGlu: 5.115 ± 0.269
2.912AspPhe: 2.912 ± 0.186
3.621AspGly: 3.621 ± 0.282
0.956AspHis: 0.956 ± 0.113
4.32AspIle: 4.32 ± 0.236
4.287AspLys: 4.287 ± 0.226
5.007AspLeu: 5.007 ± 0.239
1.257AspMet: 1.257 ± 0.138
2.697AspAsn: 2.697 ± 0.167
2.439AspPro: 2.439 ± 0.193
1.375AspGln: 1.375 ± 0.118
2.74AspArg: 2.74 ± 0.148
3.181AspSer: 3.181 ± 0.222
2.504AspThr: 2.504 ± 0.155
3.825AspVal: 3.825 ± 0.194
0.87AspTrp: 0.87 ± 0.138
2.955AspTyr: 2.955 ± 0.18
0.0AspXaa: 0.0 ± 0.0
Glu
4.599GluAla: 4.599 ± 0.268
0.956GluCys: 0.956 ± 0.107
4.642GluAsp: 4.642 ± 0.289
6.941GluGlu: 6.941 ± 0.334
3.589GluPhe: 3.589 ± 0.241
3.739GluGly: 3.739 ± 0.224
1.418GluHis: 1.418 ± 0.111
6.2GluIle: 6.2 ± 0.253
6.952GluLys: 6.952 ± 0.323
7.135GluLeu: 7.135 ± 0.305
2.278GluMet: 2.278 ± 0.154
3.61GluAsn: 3.61 ± 0.175
2.063GluPro: 2.063 ± 0.183
1.945GluGln: 1.945 ± 0.161
3.503GluArg: 3.503 ± 0.201
3.395GluSer: 3.395 ± 0.234
3.471GluThr: 3.471 ± 0.236
4.953GluVal: 4.953 ± 0.217
0.999GluTrp: 0.999 ± 0.116
3.847GluTyr: 3.847 ± 0.217
0.0GluXaa: 0.0 ± 0.0
Phe
2.794PheAla: 2.794 ± 0.164
0.698PheCys: 0.698 ± 0.091
2.923PheAsp: 2.923 ± 0.154
3.503PheGlu: 3.503 ± 0.218
1.87PhePhe: 1.87 ± 0.163
2.751PheGly: 2.751 ± 0.151
0.999PheHis: 0.999 ± 0.108
3.148PheIle: 3.148 ± 0.198
2.869PheLys: 2.869 ± 0.166
3.675PheLeu: 3.675 ± 0.21
1.085PheMet: 1.085 ± 0.117
2.181PheAsn: 2.181 ± 0.159
1.816PhePro: 1.816 ± 0.151
1.3PheGln: 1.3 ± 0.135
2.461PheArg: 2.461 ± 0.153
2.901PheSer: 2.901 ± 0.173
2.547PheThr: 2.547 ± 0.167
3.041PheVal: 3.041 ± 0.183
0.559PheTrp: 0.559 ± 0.07
1.891PheTyr: 1.891 ± 0.15
0.0PheXaa: 0.0 ± 0.0
Gly
3.632GlyAla: 3.632 ± 0.268
0.86GlyCys: 0.86 ± 0.084
3.729GlyAsp: 3.729 ± 0.193
4.266GlyGlu: 4.266 ± 0.215
2.471GlyPhe: 2.471 ± 0.164
3.847GlyGly: 3.847 ± 0.238
1.139GlyHis: 1.139 ± 0.121
3.664GlyIle: 3.664 ± 0.206
4.663GlyLys: 4.663 ± 0.253
3.997GlyLeu: 3.997 ± 0.213
1.236GlyMet: 1.236 ± 0.123
2.633GlyAsn: 2.633 ± 0.166
1.676GlyPro: 1.676 ± 0.162
1.644GlyGln: 1.644 ± 0.134
2.869GlyArg: 2.869 ± 0.2
3.675GlySer: 3.675 ± 0.33
2.88GlyThr: 2.88 ± 0.317
3.309GlyVal: 3.309 ± 0.225
0.698GlyTrp: 0.698 ± 0.083
2.622GlyTyr: 2.622 ± 0.184
0.0GlyXaa: 0.0 ± 0.0
His
0.956HisAla: 0.956 ± 0.101
0.473HisCys: 0.473 ± 0.071
1.032HisAsp: 1.032 ± 0.1
1.139HisGlu: 1.139 ± 0.102
1.214HisPhe: 1.214 ± 0.124
1.032HisGly: 1.032 ± 0.11
0.494HisHis: 0.494 ± 0.095
1.569HisIle: 1.569 ± 0.129
1.268HisLys: 1.268 ± 0.109
1.891HisLeu: 1.891 ± 0.127
0.505HisMet: 0.505 ± 0.072
1.042HisAsn: 1.042 ± 0.115
0.999HisPro: 0.999 ± 0.104
0.677HisGln: 0.677 ± 0.083
0.838HisArg: 0.838 ± 0.092
1.16HisSer: 1.16 ± 0.116
0.795HisThr: 0.795 ± 0.091
1.16HisVal: 1.16 ± 0.112
0.398HisTrp: 0.398 ± 0.072
0.989HisTyr: 0.989 ± 0.099
0.0HisXaa: 0.0 ± 0.0
Ile
4.137IleAla: 4.137 ± 0.25
1.203IleCys: 1.203 ± 0.126
3.793IleAsp: 3.793 ± 0.197
5.018IleGlu: 5.018 ± 0.258
3.277IlePhe: 3.277 ± 0.202
3.213IleGly: 3.213 ± 0.217
1.515IleHis: 1.515 ± 0.12
5.125IleIle: 5.125 ± 0.228
5.265IleLys: 5.265 ± 0.272
6.286IleLeu: 6.286 ± 0.247
1.73IleMet: 1.73 ± 0.136
3.686IleAsn: 3.686 ± 0.206
2.761IlePro: 2.761 ± 0.174
1.322IleGln: 1.322 ± 0.126
3.664IleArg: 3.664 ± 0.206
4.943IleSer: 4.943 ± 0.23
3.847IleThr: 3.847 ± 0.269
4.427IleVal: 4.427 ± 0.234
0.967IleTrp: 0.967 ± 0.094
3.385IleTyr: 3.385 ± 0.209
0.0IleXaa: 0.0 ± 0.0
Lys
4.191LysAla: 4.191 ± 0.211
1.289LysCys: 1.289 ± 0.15
4.352LysAsp: 4.352 ± 0.258
6.006LysGlu: 6.006 ± 0.274
3.514LysPhe: 3.514 ± 0.179
4.051LysGly: 4.051 ± 0.212
1.289LysHis: 1.289 ± 0.133
5.835LysIle: 5.835 ± 0.249
8.585LysLys: 8.585 ± 0.432
7.113LysLeu: 7.113 ± 0.296
2.289LysMet: 2.289 ± 0.173
4.534LysAsn: 4.534 ± 0.264
2.482LysPro: 2.482 ± 0.173
1.708LysGln: 1.708 ± 0.165
3.976LysArg: 3.976 ± 0.213
4.33LysSer: 4.33 ± 0.281
3.772LysThr: 3.772 ± 0.212
5.383LysVal: 5.383 ± 0.235
1.053LysTrp: 1.053 ± 0.122
4.212LysTyr: 4.212 ± 0.211
0.0LysXaa: 0.0 ± 0.0
Leu
5.233LeuAla: 5.233 ± 0.269
1.676LeuCys: 1.676 ± 0.125
5.007LeuAsp: 5.007 ± 0.247
6.662LeuGlu: 6.662 ± 0.238
3.653LeuPhe: 3.653 ± 0.201
4.244LeuGly: 4.244 ± 0.235
1.966LeuHis: 1.966 ± 0.17
5.77LeuIle: 5.77 ± 0.248
6.458LeuLys: 6.458 ± 0.24
6.888LeuLeu: 6.888 ± 0.366
2.396LeuMet: 2.396 ± 0.174
4.126LeuAsn: 4.126 ± 0.217
3.857LeuPro: 3.857 ± 0.221
2.686LeuGln: 2.686 ± 0.236
5.373LeuArg: 5.373 ± 0.253
6.017LeuSer: 6.017 ± 0.265
5.061LeuThr: 5.061 ± 0.242
4.642LeuVal: 4.642 ± 0.193
0.903LeuTrp: 0.903 ± 0.09
3.718LeuTyr: 3.718 ± 0.222
0.0LeuXaa: 0.0 ± 0.0
Met
1.44MetAla: 1.44 ± 0.132
0.365MetCys: 0.365 ± 0.059
1.483MetAsp: 1.483 ± 0.119
2.02MetGlu: 2.02 ± 0.15
1.021MetPhe: 1.021 ± 0.094
1.171MetGly: 1.171 ± 0.103
0.376MetHis: 0.376 ± 0.064
1.676MetIle: 1.676 ± 0.147
1.956MetLys: 1.956 ± 0.15
2.106MetLeu: 2.106 ± 0.156
0.86MetMet: 0.86 ± 0.094
1.515MetAsn: 1.515 ± 0.128
0.978MetPro: 0.978 ± 0.1
0.978MetGln: 0.978 ± 0.122
1.44MetArg: 1.44 ± 0.126
2.332MetSer: 2.332 ± 0.131
1.483MetThr: 1.483 ± 0.121
1.483MetVal: 1.483 ± 0.114
0.344MetTrp: 0.344 ± 0.056
1.096MetTyr: 1.096 ± 0.099
0.0MetXaa: 0.0 ± 0.0
Asn
3.062AsnAla: 3.062 ± 0.234
1.064AsnCys: 1.064 ± 0.13
2.461AsnAsp: 2.461 ± 0.173
3.03AsnGlu: 3.03 ± 0.175
2.708AsnPhe: 2.708 ± 0.2
3.127AsnGly: 3.127 ± 0.169
0.903AsnHis: 0.903 ± 0.101
3.782AsnIle: 3.782 ± 0.225
3.481AsnLys: 3.481 ± 0.212
4.513AsnLeu: 4.513 ± 0.215
1.44AsnMet: 1.44 ± 0.112
2.74AsnAsn: 2.74 ± 0.252
2.171AsnPro: 2.171 ± 0.179
1.526AsnGln: 1.526 ± 0.138
2.353AsnArg: 2.353 ± 0.156
3.019AsnSer: 3.019 ± 0.209
2.729AsnThr: 2.729 ± 0.246
2.912AsnVal: 2.912 ± 0.21
0.741AsnTrp: 0.741 ± 0.09
2.708AsnTyr: 2.708 ± 0.205
0.0AsnXaa: 0.0 ± 0.0
Pro
2.396ProAla: 2.396 ± 0.163
0.462ProCys: 0.462 ± 0.063
2.235ProAsp: 2.235 ± 0.154
3.589ProGlu: 3.589 ± 0.2
1.515ProPhe: 1.515 ± 0.157
2.031ProGly: 2.031 ± 0.144
0.709ProHis: 0.709 ± 0.098
2.482ProIle: 2.482 ± 0.141
3.148ProLys: 3.148 ± 0.211
2.847ProLeu: 2.847 ± 0.164
1.021ProMet: 1.021 ± 0.105
2.224ProAsn: 2.224 ± 0.151
1.547ProPro: 1.547 ± 0.172
1.096ProGln: 1.096 ± 0.133
1.623ProArg: 1.623 ± 0.129
2.385ProSer: 2.385 ± 0.165
2.461ProThr: 2.461 ± 0.188
2.428ProVal: 2.428 ± 0.164
0.451ProTrp: 0.451 ± 0.077
1.816ProTyr: 1.816 ± 0.132
0.0ProXaa: 0.0 ± 0.0
Gln
1.923GlnAla: 1.923 ± 0.185
0.441GlnCys: 0.441 ± 0.077
1.386GlnAsp: 1.386 ± 0.149
1.569GlnGlu: 1.569 ± 0.128
1.365GlnPhe: 1.365 ± 0.118
1.311GlnGly: 1.311 ± 0.105
0.548GlnHis: 0.548 ± 0.069
1.88GlnIle: 1.88 ± 0.177
2.439GlnLys: 2.439 ± 0.164
2.783GlnLeu: 2.783 ± 0.17
0.666GlnMet: 0.666 ± 0.087
1.644GlnAsn: 1.644 ± 0.131
1.182GlnPro: 1.182 ± 0.127
0.924GlnGln: 0.924 ± 0.099
1.526GlnArg: 1.526 ± 0.131
1.698GlnSer: 1.698 ± 0.13
1.612GlnThr: 1.612 ± 0.137
1.751GlnVal: 1.751 ± 0.179
0.419GlnTrp: 0.419 ± 0.064
1.655GlnTyr: 1.655 ± 0.146
0.0GlnXaa: 0.0 ± 0.0
Arg
3.041ArgAla: 3.041 ± 0.189
0.731ArgCys: 0.731 ± 0.1
3.159ArgAsp: 3.159 ± 0.184
4.663ArgGlu: 4.663 ± 0.286
2.063ArgPhe: 2.063 ± 0.133
2.976ArgGly: 2.976 ± 0.206
1.085ArgHis: 1.085 ± 0.108
3.814ArgIle: 3.814 ± 0.229
4.062ArgLys: 4.062 ± 0.205
4.459ArgLeu: 4.459 ± 0.23
1.665ArgMet: 1.665 ± 0.126
2.751ArgAsn: 2.751 ± 0.154
1.73ArgPro: 1.73 ± 0.148
1.633ArgGln: 1.633 ± 0.118
3.32ArgArg: 3.32 ± 0.191
2.514ArgSer: 2.514 ± 0.186
2.342ArgThr: 2.342 ± 0.186
3.277ArgVal: 3.277 ± 0.154
0.655ArgTrp: 0.655 ± 0.093
2.525ArgTyr: 2.525 ± 0.154
0.0ArgXaa: 0.0 ± 0.0
Ser
4.212SerAla: 4.212 ± 0.345
0.698SerCys: 0.698 ± 0.088
3.632SerAsp: 3.632 ± 0.242
4.405SerGlu: 4.405 ± 0.27
2.751SerPhe: 2.751 ± 0.164
3.986SerGly: 3.986 ± 0.301
1.15SerHis: 1.15 ± 0.111
3.664SerIle: 3.664 ± 0.218
4.803SerLys: 4.803 ± 0.238
5.276SerLeu: 5.276 ± 0.245
1.515SerMet: 1.515 ± 0.131
2.858SerAsn: 2.858 ± 0.211
2.665SerPro: 2.665 ± 0.166
1.805SerGln: 1.805 ± 0.126
2.976SerArg: 2.976 ± 0.198
4.169SerSer: 4.169 ± 0.277
3.342SerThr: 3.342 ± 0.236
3.385SerVal: 3.385 ± 0.195
0.881SerTrp: 0.881 ± 0.11
2.504SerTyr: 2.504 ± 0.147
0.0SerXaa: 0.0 ± 0.0
Thr
3.309ThrAla: 3.309 ± 0.275
0.817ThrCys: 0.817 ± 0.104
2.622ThrAsp: 2.622 ± 0.185
2.966ThrGlu: 2.966 ± 0.188
2.364ThrPhe: 2.364 ± 0.19
3.116ThrGly: 3.116 ± 0.23
0.956ThrHis: 0.956 ± 0.104
3.911ThrIle: 3.911 ± 0.236
3.675ThrLys: 3.675 ± 0.235
5.211ThrLeu: 5.211 ± 0.313
1.429ThrMet: 1.429 ± 0.126
2.471ThrAsn: 2.471 ± 0.196
2.278ThrPro: 2.278 ± 0.169
1.665ThrGln: 1.665 ± 0.163
2.289ThrArg: 2.289 ± 0.153
3.256ThrSer: 3.256 ± 0.268
3.428ThrThr: 3.428 ± 0.316
3.234ThrVal: 3.234 ± 0.19
0.602ThrTrp: 0.602 ± 0.092
2.686ThrTyr: 2.686 ± 0.179
0.0ThrXaa: 0.0 ± 0.0
Val
3.718ValAla: 3.718 ± 0.193
1.257ValCys: 1.257 ± 0.116
3.954ValAsp: 3.954 ± 0.182
4.76ValGlu: 4.76 ± 0.238
2.643ValPhe: 2.643 ± 0.162
3.46ValGly: 3.46 ± 0.205
1.268ValHis: 1.268 ± 0.121
4.244ValIle: 4.244 ± 0.229
4.792ValLys: 4.792 ± 0.246
5.05ValLeu: 5.05 ± 0.256
1.59ValMet: 1.59 ± 0.133
3.084ValAsn: 3.084 ± 0.195
2.676ValPro: 2.676 ± 0.154
1.612ValGln: 1.612 ± 0.137
3.46ValArg: 3.46 ± 0.177
3.793ValSer: 3.793 ± 0.228
2.804ValThr: 2.804 ± 0.178
4.663ValVal: 4.663 ± 0.243
0.881ValTrp: 0.881 ± 0.114
2.213ValTyr: 2.213 ± 0.16
0.0ValXaa: 0.0 ± 0.0
Trp
0.655TrpAla: 0.655 ± 0.078
0.279TrpCys: 0.279 ± 0.059
0.731TrpAsp: 0.731 ± 0.079
0.999TrpGlu: 0.999 ± 0.098
0.612TrpPhe: 0.612 ± 0.077
0.86TrpGly: 0.86 ± 0.11
0.183TrpHis: 0.183 ± 0.045
0.892TrpIle: 0.892 ± 0.112
1.171TrpLys: 1.171 ± 0.119
1.053TrpLeu: 1.053 ± 0.123
0.408TrpMet: 0.408 ± 0.074
0.752TrpAsn: 0.752 ± 0.102
0.344TrpPro: 0.344 ± 0.058
0.462TrpGln: 0.462 ± 0.065
0.87TrpArg: 0.87 ± 0.116
0.827TrpSer: 0.827 ± 0.106
0.774TrpThr: 0.774 ± 0.098
0.666TrpVal: 0.666 ± 0.076
0.161TrpTrp: 0.161 ± 0.04
0.484TrpTyr: 0.484 ± 0.095
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.547TyrAla: 2.547 ± 0.179
0.956TyrCys: 0.956 ± 0.114
2.783TyrAsp: 2.783 ± 0.181
3.266TyrGlu: 3.266 ± 0.198
2.213TyrPhe: 2.213 ± 0.129
2.299TyrGly: 2.299 ± 0.151
1.128TyrHis: 1.128 ± 0.112
2.751TyrIle: 2.751 ± 0.178
3.6TyrLys: 3.6 ± 0.23
4.717TyrLeu: 4.717 ± 0.236
1.021TyrMet: 1.021 ± 0.102
2.536TyrAsn: 2.536 ± 0.17
1.483TyrPro: 1.483 ± 0.156
1.601TyrGln: 1.601 ± 0.124
2.837TyrArg: 2.837 ± 0.172
2.579TyrSer: 2.579 ± 0.19
2.471TyrThr: 2.471 ± 0.159
3.138TyrVal: 3.138 ± 0.184
0.666TyrTrp: 0.666 ± 0.093
2.783TyrTyr: 2.783 ± 0.17
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 427 proteins (93067 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski