Amino acid dipepetide frequency for Gibbsiella quercinecans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.792AlaAla: 12.792 ± 0.131	1.216AlaCys: 1.216 ± 0.03	5.266AlaAsp: 5.266 ± 0.072	6.17AlaGlu: 6.17 ± 0.085	3.825AlaPhe: 3.825 ± 0.052	8.607AlaGly: 8.607 ± 0.088	2.055AlaHis: 2.055 ± 0.042	6.205AlaIle: 6.205 ± 0.07	3.722AlaLys: 3.722 ± 0.06	13.487AlaLeu: 13.487 ± 0.113	2.987AlaMet: 2.987 ± 0.051	3.294AlaAsn: 3.294 ± 0.052	4.36AlaPro: 4.36 ± 0.07	5.42AlaGln: 5.42 ± 0.077	6.098AlaArg: 6.098 ± 0.071	5.449AlaSer: 5.449 ± 0.059	4.927AlaThr: 4.927 ± 0.061	7.305AlaVal: 7.305 ± 0.077	1.537AlaTrp: 1.537 ± 0.039	2.48AlaTyr: 2.48 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.039CysAla: 1.039 ± 0.027	0.185CysCys: 0.185 ± 0.011	0.563CysAsp: 0.563 ± 0.021	0.509CysGlu: 0.509 ± 0.02	0.416CysPhe: 0.416 ± 0.013	1.129CysGly: 1.129 ± 0.027	0.318CysHis: 0.318 ± 0.015	0.529CysIle: 0.529 ± 0.018	0.289CysLys: 0.289 ± 0.013	1.057CysLeu: 1.057 ± 0.027	0.253CysMet: 0.253 ± 0.012	0.295CysAsn: 0.295 ± 0.014	0.488CysPro: 0.488 ± 0.02	0.452CysGln: 0.452 ± 0.018	0.669CysArg: 0.669 ± 0.021	0.661CysSer: 0.661 ± 0.022	0.468CysThr: 0.468 ± 0.018	0.736CysVal: 0.736 ± 0.021	0.175CysTrp: 0.175 ± 0.01	0.35CysTyr: 0.35 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.195AspAla: 5.195 ± 0.061	0.507AspCys: 0.507 ± 0.017	2.713AspAsp: 2.713 ± 0.051	3.198AspGlu: 3.198 ± 0.045	2.067AspPhe: 2.067 ± 0.038	3.789AspGly: 3.789 ± 0.052	0.953AspHis: 0.953 ± 0.025	3.36AspIle: 3.36 ± 0.046	2.141AspLys: 2.141 ± 0.043	4.672AspLeu: 4.672 ± 0.058	1.29AspMet: 1.29 ± 0.027	2.022AspAsn: 2.022 ± 0.036	2.154AspPro: 2.154 ± 0.036	1.571AspGln: 1.571 ± 0.032	2.81AspArg: 2.81 ± 0.045	2.734AspSer: 2.734 ± 0.044	2.358AspThr: 2.358 ± 0.04	3.66AspVal: 3.66 ± 0.054	0.833AspTrp: 0.833 ± 0.022	1.844AspTyr: 1.844 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.105GluAla: 5.105 ± 0.069	0.404GluCys: 0.404 ± 0.017	2.249GluAsp: 2.249 ± 0.041	2.775GluGlu: 2.775 ± 0.051	1.707GluPhe: 1.707 ± 0.034	3.258GluGly: 3.258 ± 0.045	1.402GluHis: 1.402 ± 0.032	3.083GluIle: 3.083 ± 0.043	2.759GluLys: 2.759 ± 0.041	5.716GluLeu: 5.716 ± 0.074	1.544GluMet: 1.544 ± 0.034	2.161GluAsn: 2.161 ± 0.038	2.124GluPro: 2.124 ± 0.038	3.702GluGln: 3.702 ± 0.058	3.747GluArg: 3.747 ± 0.053	2.581GluSer: 2.581 ± 0.045	2.628GluThr: 2.628 ± 0.041	3.357GluVal: 3.357 ± 0.054	0.666GluTrp: 0.666 ± 0.021	1.34GluTyr: 1.34 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.808PheAla: 3.808 ± 0.047	0.527PheCys: 0.527 ± 0.019	2.39PheAsp: 2.39 ± 0.045	1.659PheGlu: 1.659 ± 0.037	1.598PhePhe: 1.598 ± 0.04	3.324PheGly: 3.324 ± 0.06	0.803PheHis: 0.803 ± 0.025	2.463PheIle: 2.463 ± 0.048	1.181PheLys: 1.181 ± 0.031	3.378PheLeu: 3.378 ± 0.06	0.945PheMet: 0.945 ± 0.023	1.714PheAsn: 1.714 ± 0.039	1.497PhePro: 1.497 ± 0.029	1.198PheGln: 1.198 ± 0.026	1.839PheArg: 1.839 ± 0.039	3.085PheSer: 3.085 ± 0.049	2.272PheThr: 2.272 ± 0.045	2.43PheVal: 2.43 ± 0.043	0.571PheTrp: 0.571 ± 0.021	1.239PheTyr: 1.239 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.027GlyAla: 7.027 ± 0.08	0.996GlyCys: 0.996 ± 0.027	3.586GlyAsp: 3.586 ± 0.046	4.504GlyGlu: 4.504 ± 0.059	3.314GlyPhe: 3.314 ± 0.051	5.72GlyGly: 5.72 ± 0.079	1.663GlyHis: 1.663 ± 0.034	5.159GlyIle: 5.159 ± 0.062	3.851GlyLys: 3.851 ± 0.06	7.977GlyLeu: 7.977 ± 0.081	2.367GlyMet: 2.367 ± 0.044	2.716GlyAsn: 2.716 ± 0.048	2.286GlyPro: 2.286 ± 0.043	3.283GlyGln: 3.283 ± 0.057	3.999GlyArg: 3.999 ± 0.051	4.382GlySer: 4.382 ± 0.067	3.677GlyThr: 3.677 ± 0.058	5.931GlyVal: 5.931 ± 0.063	1.304GlyTrp: 1.304 ± 0.029	2.686GlyTyr: 2.686 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.112HisAla: 2.112 ± 0.036	0.34HisCys: 0.34 ± 0.013	1.152HisAsp: 1.152 ± 0.031	1.05HisGlu: 1.05 ± 0.029	1.005HisPhe: 1.005 ± 0.029	1.918HisGly: 1.918 ± 0.032	0.713HisHis: 0.713 ± 0.024	1.316HisIle: 1.316 ± 0.03	0.66HisLys: 0.66 ± 0.022	2.265HisLeu: 2.265 ± 0.038	0.538HisMet: 0.538 ± 0.018	0.792HisAsn: 0.792 ± 0.024	1.365HisPro: 1.365 ± 0.029	1.282HisGln: 1.282 ± 0.03	1.297HisArg: 1.297 ± 0.033	1.29HisSer: 1.29 ± 0.03	1.111HisThr: 1.111 ± 0.026	1.233HisVal: 1.233 ± 0.026	0.466HisTrp: 0.466 ± 0.017	0.914HisTyr: 0.914 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.925IleAla: 6.925 ± 0.071	0.622IleCys: 0.622 ± 0.019	3.48IleAsp: 3.48 ± 0.046	3.12IleGlu: 3.12 ± 0.046	1.937IlePhe: 1.937 ± 0.035	5.019IleGly: 5.019 ± 0.057	1.204IleHis: 1.204 ± 0.029	3.253IleIle: 3.253 ± 0.058	2.198IleLys: 2.198 ± 0.04	4.856IleLeu: 4.856 ± 0.061	1.227IleMet: 1.227 ± 0.029	2.574IleAsn: 2.574 ± 0.043	2.76IlePro: 2.76 ± 0.043	1.818IleGln: 1.818 ± 0.033	2.892IleArg: 2.892 ± 0.041	3.775IleSer: 3.775 ± 0.049	3.476IleThr: 3.476 ± 0.05	3.901IleVal: 3.901 ± 0.061	0.634IleTrp: 0.634 ± 0.02	1.517IleTyr: 1.517 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.884LysAla: 3.884 ± 0.054	0.218LysCys: 0.218 ± 0.012	1.803LysAsp: 1.803 ± 0.038	1.889LysGlu: 1.889 ± 0.042	1.005LysPhe: 1.005 ± 0.023	2.59LysGly: 2.59 ± 0.048	0.808LysHis: 0.808 ± 0.025	2.159LysIle: 2.159 ± 0.04	1.837LysLys: 1.837 ± 0.044	3.969LysLeu: 3.969 ± 0.063	1.103LysMet: 1.103 ± 0.029	1.558LysAsn: 1.558 ± 0.04	2.023LysPro: 2.023 ± 0.044	1.979LysGln: 1.979 ± 0.04	2.43LysArg: 2.43 ± 0.04	2.025LysSer: 2.025 ± 0.038	2.324LysThr: 2.324 ± 0.037	2.703LysVal: 2.703 ± 0.044	0.414LysTrp: 0.414 ± 0.017	1.036LysTyr: 1.036 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.786LeuAla: 13.786 ± 0.118	1.345LeuCys: 1.345 ± 0.034	5.426LeuAsp: 5.426 ± 0.066	5.188LeuGlu: 5.188 ± 0.062	4.404LeuPhe: 4.404 ± 0.064	7.989LeuGly: 7.989 ± 0.096	2.438LeuHis: 2.438 ± 0.04	5.884LeuIle: 5.884 ± 0.072	4.147LeuLys: 4.147 ± 0.059	13.085LeuLeu: 13.085 ± 0.152	2.857LeuMet: 2.857 ± 0.047	4.056LeuAsn: 4.056 ± 0.052	6.205LeuPro: 6.205 ± 0.072	4.901LeuGln: 4.901 ± 0.069	6.461LeuArg: 6.461 ± 0.074	7.092LeuSer: 7.092 ± 0.069	5.739LeuThr: 5.739 ± 0.066	7.233LeuVal: 7.233 ± 0.084	1.379LeuTrp: 1.379 ± 0.032	2.675LeuTyr: 2.675 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.024MetAla: 3.024 ± 0.042	0.192MetCys: 0.192 ± 0.01	1.086MetAsp: 1.086 ± 0.026	1.072MetGlu: 1.072 ± 0.023	0.822MetPhe: 0.822 ± 0.025	1.814MetGly: 1.814 ± 0.034	0.511MetHis: 0.511 ± 0.019	1.369MetIle: 1.369 ± 0.029	1.237MetLys: 1.237 ± 0.029	3.164MetLeu: 3.164 ± 0.055	0.785MetMet: 0.785 ± 0.024	0.983MetAsn: 0.983 ± 0.026	1.351MetPro: 1.351 ± 0.029	1.174MetGln: 1.174 ± 0.031	1.474MetArg: 1.474 ± 0.033	1.67MetSer: 1.67 ± 0.037	1.497MetThr: 1.497 ± 0.027	1.88MetVal: 1.88 ± 0.038	0.217MetTrp: 0.217 ± 0.012	0.516MetTyr: 0.516 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.63AsnAla: 3.63 ± 0.057	0.301AsnCys: 0.301 ± 0.013	1.826AsnAsp: 1.826 ± 0.039	1.676AsnGlu: 1.676 ± 0.031	1.268AsnPhe: 1.268 ± 0.032	3.007AsnGly: 3.007 ± 0.05	0.831AsnHis: 0.831 ± 0.023	2.227AsnIle: 2.227 ± 0.045	1.381AsnLys: 1.381 ± 0.033	3.509AsnLeu: 3.509 ± 0.046	0.827AsnMet: 0.827 ± 0.021	1.507AsnAsn: 1.507 ± 0.036	2.102AsnPro: 2.102 ± 0.035	1.614AsnGln: 1.614 ± 0.037	1.957AsnArg: 1.957 ± 0.035	1.923AsnSer: 1.923 ± 0.04	1.897AsnThr: 1.897 ± 0.036	2.442AsnVal: 2.442 ± 0.043	0.525AsnTrp: 0.525 ± 0.02	1.151AsnTyr: 1.151 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.544ProAla: 5.544 ± 0.074	0.384ProCys: 0.384 ± 0.018	2.544ProAsp: 2.544 ± 0.046	3.134ProGlu: 3.134 ± 0.045	1.864ProPhe: 1.864 ± 0.04	3.706ProGly: 3.706 ± 0.054	1.107ProHis: 1.107 ± 0.027	2.1ProIle: 2.1 ± 0.041	1.473ProLys: 1.473 ± 0.03	5.629ProLeu: 5.629 ± 0.071	1.054ProMet: 1.054 ± 0.028	1.419ProAsn: 1.419 ± 0.026	1.9ProPro: 1.9 ± 0.044	2.642ProGln: 2.642 ± 0.045	2.157ProArg: 2.157 ± 0.044	2.22ProSer: 2.22 ± 0.037	2.138ProThr: 2.138 ± 0.04	3.691ProVal: 3.691 ± 0.05	0.715ProTrp: 0.715 ± 0.023	1.377ProTyr: 1.377 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	5.773GlnAla: 5.773 ± 0.08	0.418GlnCys: 0.418 ± 0.018	2.025GlnAsp: 2.025 ± 0.041	2.245GlnGlu: 2.245 ± 0.04	1.495GlnPhe: 1.495 ± 0.035	3.527GlnGly: 3.527 ± 0.055	1.4GlnHis: 1.4 ± 0.034	2.453GlnIle: 2.453 ± 0.043	1.555GlnLys: 1.555 ± 0.034	5.541GlnLeu: 5.541 ± 0.077	1.21GlnMet: 1.21 ± 0.033	1.329GlnAsn: 1.329 ± 0.032	2.555GlnPro: 2.555 ± 0.046	4.171GlnGln: 4.171 ± 0.083	3.759GlnArg: 3.759 ± 0.054	2.201GlnSer: 2.201 ± 0.041	2.116GlnThr: 2.116 ± 0.042	3.297GlnVal: 3.297 ± 0.057	0.747GlnTrp: 0.747 ± 0.024	1.246GlnTyr: 1.246 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.234ArgAla: 5.234 ± 0.059	0.626ArgCys: 0.626 ± 0.024	2.881ArgAsp: 2.881 ± 0.045	3.432ArgGlu: 3.432 ± 0.046	2.597ArgPhe: 2.597 ± 0.04	3.418ArgGly: 3.418 ± 0.056	1.606ArgHis: 1.606 ± 0.034	3.457ArgIle: 3.457 ± 0.047	2.177ArgLys: 2.177 ± 0.035	6.961ArgLeu: 6.961 ± 0.084	1.515ArgMet: 1.515 ± 0.032	1.915ArgAsn: 1.915 ± 0.035	2.467ArgPro: 2.467 ± 0.038	3.55ArgGln: 3.55 ± 0.059	3.768ArgArg: 3.768 ± 0.068	2.854ArgSer: 2.854 ± 0.043	2.412ArgThr: 2.412 ± 0.039	3.967ArgVal: 3.967 ± 0.055	1.004ArgTrp: 1.004 ± 0.031	2.32ArgTyr: 2.32 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.866SerAla: 5.866 ± 0.068	0.542SerCys: 0.542 ± 0.018	2.764SerAsp: 2.764 ± 0.05	2.907SerGlu: 2.907 ± 0.045	2.242SerPhe: 2.242 ± 0.036	5.369SerGly: 5.369 ± 0.066	1.359SerHis: 1.359 ± 0.03	2.981SerIle: 2.981 ± 0.046	1.846SerLys: 1.846 ± 0.035	6.528SerLeu: 6.528 ± 0.075	1.368SerMet: 1.368 ± 0.028	1.796SerAsn: 1.796 ± 0.037	2.646SerPro: 2.646 ± 0.042	2.573SerGln: 2.573 ± 0.051	3.213SerArg: 3.213 ± 0.047	3.507SerSer: 3.507 ± 0.054	2.836SerThr: 2.836 ± 0.051	4.041SerVal: 4.041 ± 0.055	0.891SerTrp: 0.891 ± 0.025	1.743SerTyr: 1.743 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.08ThrAla: 5.08 ± 0.066	0.419ThrCys: 0.419 ± 0.016	2.443ThrAsp: 2.443 ± 0.051	2.372ThrGlu: 2.372 ± 0.042	1.853ThrPhe: 1.853 ± 0.04	4.094ThrGly: 4.094 ± 0.058	1.207ThrHis: 1.207 ± 0.026	2.681ThrIle: 2.681 ± 0.045	1.288ThrLys: 1.288 ± 0.031	7.292ThrLeu: 7.292 ± 0.071	1.021ThrMet: 1.021 ± 0.025	1.424ThrAsn: 1.424 ± 0.038	3.194ThrPro: 3.194 ± 0.051	2.072ThrGln: 2.072 ± 0.038	2.847ThrArg: 2.847 ± 0.045	2.655ThrSer: 2.655 ± 0.049	2.665ThrThr: 2.665 ± 0.05	3.777ThrVal: 3.777 ± 0.053	0.686ThrTrp: 0.686 ± 0.022	1.238ThrTyr: 1.238 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.552ValAla: 7.552 ± 0.074	0.779ValCys: 0.779 ± 0.024	3.585ValAsp: 3.585 ± 0.056	3.758ValGlu: 3.758 ± 0.059	2.637ValPhe: 2.637 ± 0.041	4.913ValGly: 4.913 ± 0.063	1.194ValHis: 1.194 ± 0.028	4.493ValIle: 4.493 ± 0.058	2.768ValLys: 2.768 ± 0.046	7.574ValLeu: 7.574 ± 0.081	2.01ValMet: 2.01 ± 0.035	2.594ValAsn: 2.594 ± 0.049	3.141ValPro: 3.141 ± 0.052	2.544ValGln: 2.544 ± 0.042	3.681ValArg: 3.681 ± 0.049	4.44ValSer: 4.44 ± 0.062	3.92ValThr: 3.92 ± 0.053	5.525ValVal: 5.525 ± 0.064	0.89ValTrp: 0.89 ± 0.025	1.749ValTyr: 1.749 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.164TrpAla: 1.164 ± 0.033	0.186TrpCys: 0.186 ± 0.012	0.595TrpAsp: 0.595 ± 0.023	0.521TrpGlu: 0.521 ± 0.019	0.623TrpPhe: 0.623 ± 0.02	0.915TrpGly: 0.915 ± 0.029	0.443TrpHis: 0.443 ± 0.015	0.653TrpIle: 0.653 ± 0.022	0.423TrpLys: 0.423 ± 0.018	2.301TrpLeu: 2.301 ± 0.047	0.363TrpMet: 0.363 ± 0.015	0.465TrpAsn: 0.465 ± 0.018	0.644TrpPro: 0.644 ± 0.023	1.254TrpGln: 1.254 ± 0.031	1.1TrpArg: 1.1 ± 0.03	0.748TrpSer: 0.748 ± 0.023	0.433TrpThr: 0.433 ± 0.017	0.915TrpVal: 0.915 ± 0.026	0.24TrpTrp: 0.24 ± 0.013	0.371TrpTyr: 0.371 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.662TyrAla: 2.662 ± 0.044	0.376TyrCys: 0.376 ± 0.017	1.494TyrAsp: 1.494 ± 0.032	1.13TyrGlu: 1.13 ± 0.028	1.241TyrPhe: 1.241 ± 0.03	2.324TyrGly: 2.324 ± 0.042	0.804TyrHis: 0.804 ± 0.025	1.365TyrIle: 1.365 ± 0.033	0.826TyrLys: 0.826 ± 0.022	3.329TyrLeu: 3.329 ± 0.046	0.575TyrMet: 0.575 ± 0.021	0.987TyrAsn: 0.987 ± 0.029	1.535TyrPro: 1.535 ± 0.034	1.862TyrGln: 1.862 ± 0.038	1.961TyrArg: 1.961 ± 0.038	1.727TyrSer: 1.727 ± 0.034	1.415TyrThr: 1.415 ± 0.036	1.721TyrVal: 1.721 ± 0.033	0.46TyrTrp: 0.46 ± 0.017	0.94TyrTyr: 0.94 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4735 proteins (1558740 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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