Amino acid dipepetide frequency for Ephemeroptericola cinctiostellae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.657AlaAla: 11.657 ± 0.2	1.17AlaCys: 1.17 ± 0.037	5.448AlaAsp: 5.448 ± 0.101	5.326AlaGlu: 5.326 ± 0.112	3.912AlaPhe: 3.912 ± 0.075	7.518AlaGly: 7.518 ± 0.136	3.085AlaHis: 3.085 ± 0.068	5.862AlaIle: 5.862 ± 0.135	4.653AlaLys: 4.653 ± 0.107	11.822AlaLeu: 11.822 ± 0.137	3.166AlaMet: 3.166 ± 0.074	3.463AlaAsn: 3.463 ± 0.077	4.107AlaPro: 4.107 ± 0.097	5.737AlaGln: 5.737 ± 0.111	5.232AlaArg: 5.232 ± 0.104	5.687AlaSer: 5.687 ± 0.108	5.854AlaThr: 5.854 ± 0.358	7.847AlaVal: 7.847 ± 0.156	1.412AlaTrp: 1.412 ± 0.048	2.753AlaTyr: 2.753 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	1.139CysAla: 1.139 ± 0.044	0.149CysCys: 0.149 ± 0.015	0.589CysAsp: 0.589 ± 0.029	0.558CysGlu: 0.558 ± 0.029	0.365CysPhe: 0.365 ± 0.022	0.905CysGly: 0.905 ± 0.039	0.29CysHis: 0.29 ± 0.021	0.54CysIle: 0.54 ± 0.027	0.286CysLys: 0.286 ± 0.021	0.912CysLeu: 0.912 ± 0.034	0.231CysMet: 0.231 ± 0.018	0.3CysAsn: 0.3 ± 0.021	0.466CysPro: 0.466 ± 0.025	0.318CysGln: 0.318 ± 0.022	0.372CysArg: 0.372 ± 0.022	0.58CysSer: 0.58 ± 0.027	0.572CysThr: 0.572 ± 0.026	0.767CysVal: 0.767 ± 0.033	0.126CysTrp: 0.126 ± 0.014	0.259CysTyr: 0.259 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	6.718AspAla: 6.718 ± 0.149	0.506AspCys: 0.506 ± 0.025	3.302AspAsp: 3.302 ± 0.081	3.312AspGlu: 3.312 ± 0.076	2.286AspPhe: 2.286 ± 0.065	4.125AspGly: 4.125 ± 0.085	1.171AspHis: 1.171 ± 0.043	3.081AspIle: 3.081 ± 0.066	2.424AspLys: 2.424 ± 0.079	5.245AspLeu: 5.245 ± 0.092	1.564AspMet: 1.564 ± 0.047	2.957AspAsn: 2.957 ± 0.449	1.885AspPro: 1.885 ± 0.054	1.608AspGln: 1.608 ± 0.045	2.142AspArg: 2.142 ± 0.065	2.479AspSer: 2.479 ± 0.07	2.885AspThr: 2.885 ± 0.09	5.323AspVal: 5.323 ± 0.118	0.894AspTrp: 0.894 ± 0.037	1.648AspTyr: 1.648 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	6.35GluAla: 6.35 ± 0.345	0.46GluCys: 0.46 ± 0.025	2.142GluAsp: 2.142 ± 0.057	2.358GluGlu: 2.358 ± 0.076	1.999GluPhe: 1.999 ± 0.044	3.195GluGly: 3.195 ± 0.081	1.751GluHis: 1.751 ± 0.053	2.865GluIle: 2.865 ± 0.074	2.79GluLys: 2.79 ± 0.084	5.765GluLeu: 5.765 ± 0.186	1.46GluMet: 1.46 ± 0.046	1.896GluAsn: 1.896 ± 0.056	1.934GluPro: 1.934 ± 0.056	2.881GluGln: 2.881 ± 0.063	3.318GluArg: 3.318 ± 0.095	3.218GluSer: 3.218 ± 0.231	2.814GluThr: 2.814 ± 0.063	5.005GluVal: 5.005 ± 0.457	0.821GluTrp: 0.821 ± 0.029	1.367GluTyr: 1.367 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.885PheAla: 3.885 ± 0.073	0.464PheCys: 0.464 ± 0.025	2.713PheAsp: 2.713 ± 0.064	2.43PheGlu: 2.43 ± 0.068	1.741PhePhe: 1.741 ± 0.064	3.209PheGly: 3.209 ± 0.075	0.771PheHis: 0.771 ± 0.033	2.335PheIle: 2.335 ± 0.067	2.03PheLys: 2.03 ± 0.053	3.246PheLeu: 3.246 ± 0.082	1.099PheMet: 1.099 ± 0.046	1.866PheAsn: 1.866 ± 0.055	1.321PhePro: 1.321 ± 0.049	1.0PheGln: 1.0 ± 0.034	1.379PheArg: 1.379 ± 0.043	2.655PheSer: 2.655 ± 0.078	2.195PheThr: 2.195 ± 0.051	2.839PheVal: 2.839 ± 0.062	0.59PheTrp: 0.59 ± 0.031	1.24PheTyr: 1.24 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	6.848GlyAla: 6.848 ± 0.114	0.786GlyCys: 0.786 ± 0.034	3.794GlyAsp: 3.794 ± 0.104	3.839GlyGlu: 3.839 ± 0.076	3.331GlyPhe: 3.331 ± 0.075	5.608GlyGly: 5.608 ± 0.153	1.849GlyHis: 1.849 ± 0.049	4.049GlyIle: 4.049 ± 0.078	3.408GlyLys: 3.408 ± 0.073	7.544GlyLeu: 7.544 ± 0.128	2.294GlyMet: 2.294 ± 0.061	2.554GlyAsn: 2.554 ± 0.126	1.362GlyPro: 1.362 ± 0.049	3.1GlyGln: 3.1 ± 0.066	3.482GlyArg: 3.482 ± 0.085	3.952GlySer: 3.952 ± 0.081	3.714GlyThr: 3.714 ± 0.08	6.472GlyVal: 6.472 ± 0.106	1.058GlyTrp: 1.058 ± 0.042	2.125GlyTyr: 2.125 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.938HisAla: 2.938 ± 0.069	0.303HisCys: 0.303 ± 0.019	1.472HisAsp: 1.472 ± 0.05	1.269HisGlu: 1.269 ± 0.04	1.149HisPhe: 1.149 ± 0.034	1.876HisGly: 1.876 ± 0.049	0.916HisHis: 0.916 ± 0.042	1.701HisIle: 1.701 ± 0.051	0.903HisLys: 0.903 ± 0.032	2.519HisLeu: 2.519 ± 0.074	0.702HisMet: 0.702 ± 0.03	0.99HisAsn: 0.99 ± 0.039	1.476HisPro: 1.476 ± 0.039	0.972HisGln: 0.972 ± 0.038	1.201HisArg: 1.201 ± 0.044	1.456HisSer: 1.456 ± 0.047	1.526HisThr: 1.526 ± 0.05	2.05HisVal: 2.05 ± 0.051	0.432HisTrp: 0.432 ± 0.027	0.803HisTyr: 0.803 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.448IleAla: 6.448 ± 0.104	0.554IleCys: 0.554 ± 0.032	3.664IleAsp: 3.664 ± 0.079	4.112IleGlu: 4.112 ± 0.096	1.839IlePhe: 1.839 ± 0.056	4.503IleGly: 4.503 ± 0.088	1.347IleHis: 1.347 ± 0.042	2.876IleIle: 2.876 ± 0.073	2.919IleLys: 2.919 ± 0.084	4.588IleLeu: 4.588 ± 0.09	1.325IleMet: 1.325 ± 0.045	2.535IleAsn: 2.535 ± 0.075	2.287IlePro: 2.287 ± 0.058	1.943IleGln: 1.943 ± 0.051	2.483IleArg: 2.483 ± 0.064	3.24IleSer: 3.24 ± 0.07	3.17IleThr: 3.17 ± 0.071	4.008IleVal: 4.008 ± 0.084	0.571IleTrp: 0.571 ± 0.028	1.321IleTyr: 1.321 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.436LysAla: 4.436 ± 0.112	0.256LysCys: 0.256 ± 0.017	2.379LysAsp: 2.379 ± 0.067	2.235LysGlu: 2.235 ± 0.075	1.349LysPhe: 1.349 ± 0.043	3.082LysGly: 3.082 ± 0.075	1.289LysHis: 1.289 ± 0.04	2.789LysIle: 2.789 ± 0.073	2.62LysLys: 2.62 ± 0.071	3.968LysLeu: 3.968 ± 0.079	1.537LysMet: 1.537 ± 0.05	2.206LysAsn: 2.206 ± 0.068	2.893LysPro: 2.893 ± 0.285	1.964LysGln: 1.964 ± 0.055	2.339LysArg: 2.339 ± 0.069	2.671LysSer: 2.671 ± 0.059	3.104LysThr: 3.104 ± 0.067	3.25LysVal: 3.25 ± 0.075	0.501LysTrp: 0.501 ± 0.028	1.133LysTyr: 1.133 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	10.452LeuAla: 10.452 ± 0.14	1.098LeuCys: 1.098 ± 0.038	5.14LeuAsp: 5.14 ± 0.089	4.615LeuGlu: 4.615 ± 0.092	3.914LeuPhe: 3.914 ± 0.084	7.04LeuGly: 7.04 ± 0.116	2.378LeuHis: 2.378 ± 0.066	5.666LeuIle: 5.666 ± 0.103	5.792LeuLys: 5.792 ± 0.301	9.857LeuLeu: 9.857 ± 0.159	2.929LeuMet: 2.929 ± 0.067	4.731LeuAsn: 4.731 ± 0.092	5.283LeuPro: 5.283 ± 0.116	3.642LeuGln: 3.642 ± 0.087	4.912LeuArg: 4.912 ± 0.091	7.299LeuSer: 7.299 ± 0.101	6.068LeuThr: 6.068 ± 0.093	6.401LeuVal: 6.401 ± 0.107	1.21LeuTrp: 1.21 ± 0.045	2.421LeuTyr: 2.421 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	3.068MetAla: 3.068 ± 0.079	0.238MetCys: 0.238 ± 0.017	1.401MetAsp: 1.401 ± 0.05	1.004MetGlu: 1.004 ± 0.04	0.976MetPhe: 0.976 ± 0.042	2.249MetGly: 2.249 ± 0.061	0.726MetHis: 0.726 ± 0.03	1.272MetIle: 1.272 ± 0.046	1.299MetLys: 1.299 ± 0.045	2.896MetLeu: 2.896 ± 0.079	0.969MetMet: 0.969 ± 0.048	1.289MetAsn: 1.289 ± 0.039	1.477MetPro: 1.477 ± 0.05	1.281MetGln: 1.281 ± 0.04	1.677MetArg: 1.677 ± 0.051	2.082MetSer: 2.082 ± 0.054	1.848MetThr: 1.848 ± 0.054	1.995MetVal: 1.995 ± 0.058	0.316MetTrp: 0.316 ± 0.019	0.576MetTyr: 0.576 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	4.35AsnAla: 4.35 ± 0.101	0.344AsnCys: 0.344 ± 0.024	2.955AsnAsp: 2.955 ± 0.14	2.908AsnGlu: 2.908 ± 0.345	1.325AsnPhe: 1.325 ± 0.041	3.055AsnGly: 3.055 ± 0.069	1.006AsnHis: 1.006 ± 0.034	2.245AsnIle: 2.245 ± 0.063	1.67AsnLys: 1.67 ± 0.051	3.45AsnLeu: 3.45 ± 0.074	1.01AsnMet: 1.01 ± 0.035	1.682AsnAsn: 1.682 ± 0.064	2.228AsnPro: 2.228 ± 0.061	1.644AsnGln: 1.644 ± 0.05	1.705AsnArg: 1.705 ± 0.052	2.03AsnSer: 2.03 ± 0.056	2.317AsnThr: 2.317 ± 0.057	2.912AsnVal: 2.912 ± 0.096	0.571AsnTrp: 0.571 ± 0.031	1.009AsnTyr: 1.009 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.376ProAla: 4.376 ± 0.092	0.338ProCys: 0.338 ± 0.024	2.357ProAsp: 2.357 ± 0.06	2.796ProGlu: 2.796 ± 0.079	1.771ProPhe: 1.771 ± 0.047	1.58ProGly: 1.58 ± 0.046	1.226ProHis: 1.226 ± 0.041	2.492ProIle: 2.492 ± 0.064	1.955ProLys: 1.955 ± 0.058	4.184ProLeu: 4.184 ± 0.091	1.262ProMet: 1.262 ± 0.042	1.955ProAsn: 1.955 ± 0.06	1.427ProPro: 1.427 ± 0.047	1.593ProGln: 1.593 ± 0.053	1.794ProArg: 1.794 ± 0.059	2.64ProSer: 2.64 ± 0.061	2.567ProThr: 2.567 ± 0.072	4.165ProVal: 4.165 ± 0.323	0.53ProTrp: 0.53 ± 0.028	1.272ProTyr: 1.272 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	4.758GlnAla: 4.758 ± 0.098	0.357GlnCys: 0.357 ± 0.023	1.671GlnAsp: 1.671 ± 0.053	1.702GlnGlu: 1.702 ± 0.053	1.602GlnPhe: 1.602 ± 0.054	2.706GlnGly: 2.706 ± 0.059	1.34GlnHis: 1.34 ± 0.046	2.207GlnIle: 2.207 ± 0.061	1.854GlnLys: 1.854 ± 0.052	4.423GlnLeu: 4.423 ± 0.089	1.274GlnMet: 1.274 ± 0.04	1.577GlnAsn: 1.577 ± 0.047	1.696GlnPro: 1.696 ± 0.048	1.905GlnGln: 1.905 ± 0.053	2.352GlnArg: 2.352 ± 0.065	2.259GlnSer: 2.259 ± 0.059	2.535GlnThr: 2.535 ± 0.059	3.098GlnVal: 3.098 ± 0.071	0.591GlnTrp: 0.591 ± 0.029	1.151GlnTyr: 1.151 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	4.934ArgAla: 4.934 ± 0.097	0.423ArgCys: 0.423 ± 0.025	2.691ArgAsp: 2.691 ± 0.077	2.918ArgGlu: 2.918 ± 0.069	2.086ArgPhe: 2.086 ± 0.051	3.084ArgGly: 3.084 ± 0.079	1.361ArgHis: 1.361 ± 0.052	3.049ArgIle: 3.049 ± 0.069	1.87ArgLys: 1.87 ± 0.059	5.195ArgLeu: 5.195 ± 0.101	1.491ArgMet: 1.491 ± 0.042	1.742ArgAsn: 1.742 ± 0.059	1.844ArgPro: 1.844 ± 0.061	1.964ArgGln: 1.964 ± 0.054	2.564ArgArg: 2.564 ± 0.073	2.481ArgSer: 2.481 ± 0.066	2.619ArgThr: 2.619 ± 0.068	3.767ArgVal: 3.767 ± 0.077	0.728ArgTrp: 0.728 ± 0.032	1.575ArgTyr: 1.575 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.648SerAla: 5.648 ± 0.112	0.508SerCys: 0.508 ± 0.025	3.019SerAsp: 3.019 ± 0.067	2.933SerGlu: 2.933 ± 0.07	2.309SerPhe: 2.309 ± 0.066	4.82SerGly: 4.82 ± 0.084	1.588SerHis: 1.588 ± 0.039	3.46SerIle: 3.46 ± 0.076	2.537SerLys: 2.537 ± 0.061	5.55SerLeu: 5.55 ± 0.086	1.688SerMet: 1.688 ± 0.05	2.488SerAsn: 2.488 ± 0.068	2.629SerPro: 2.629 ± 0.059	2.146SerGln: 2.146 ± 0.055	2.723SerArg: 2.723 ± 0.061	3.762SerSer: 3.762 ± 0.091	4.196SerThr: 4.196 ± 0.226	4.14SerVal: 4.14 ± 0.078	0.733SerTrp: 0.733 ± 0.036	1.539SerTyr: 1.539 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	6.176ThrAla: 6.176 ± 0.15	0.518ThrCys: 0.518 ± 0.027	2.992ThrAsp: 2.992 ± 0.072	2.985ThrGlu: 2.985 ± 0.082	1.991ThrPhe: 1.991 ± 0.055	4.24ThrGly: 4.24 ± 0.096	1.741ThrHis: 1.741 ± 0.051	3.081ThrIle: 3.081 ± 0.075	1.965ThrLys: 1.965 ± 0.058	6.265ThrLeu: 6.265 ± 0.088	1.299ThrMet: 1.299 ± 0.041	1.79ThrAsn: 1.79 ± 0.051	3.282ThrPro: 3.282 ± 0.089	2.541ThrGln: 2.541 ± 0.06	2.637ThrArg: 2.637 ± 0.062	3.099ThrSer: 3.099 ± 0.069	3.175ThrThr: 3.175 ± 0.07	5.362ThrVal: 5.362 ± 0.47	0.733ThrTrp: 0.733 ± 0.03	1.415ThrTyr: 1.415 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	7.673ValAla: 7.673 ± 0.119	0.804ValCys: 0.804 ± 0.035	5.582ValAsp: 5.582 ± 0.574	5.334ValGlu: 5.334 ± 0.655	3.13ValPhe: 3.13 ± 0.074	5.356ValGly: 5.356 ± 0.115	1.722ValHis: 1.722 ± 0.051	4.21ValIle: 4.21 ± 0.085	3.499ValLys: 3.499 ± 0.078	8.93ValLeu: 8.93 ± 0.297	2.238ValMet: 2.238 ± 0.063	2.916ValAsn: 2.916 ± 0.079	2.997ValPro: 2.997 ± 0.074	2.897ValGln: 2.897 ± 0.074	3.644ValArg: 3.644 ± 0.08	4.629ValSer: 4.629 ± 0.083	4.054ValThr: 4.054 ± 0.089	6.3ValVal: 6.3 ± 0.127	1.009ValTrp: 1.009 ± 0.042	1.826ValTyr: 1.826 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.164TrpAla: 1.164 ± 0.042	0.149TrpCys: 0.149 ± 0.014	0.657TrpAsp: 0.657 ± 0.03	0.477TrpGlu: 0.477 ± 0.025	0.626TrpPhe: 0.626 ± 0.03	0.869TrpGly: 0.869 ± 0.039	0.437TrpHis: 0.437 ± 0.025	0.642TrpIle: 0.642 ± 0.032	0.398TrpLys: 0.398 ± 0.025	1.919TrpLeu: 1.919 ± 0.066	0.442TrpMet: 0.442 ± 0.025	0.45TrpAsn: 0.45 ± 0.026	0.463TrpPro: 0.463 ± 0.023	0.884TrpGln: 0.884 ± 0.034	0.914TrpArg: 0.914 ± 0.035	0.675TrpSer: 0.675 ± 0.027	0.58TrpThr: 0.58 ± 0.031	1.166TrpVal: 1.166 ± 0.039	0.22TrpTrp: 0.22 ± 0.018	0.334TrpTyr: 0.334 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.692TyrAla: 2.692 ± 0.069	0.299TyrCys: 0.299 ± 0.021	1.59TyrAsp: 1.59 ± 0.052	1.28TyrGlu: 1.28 ± 0.045	1.307TyrPhe: 1.307 ± 0.052	2.152TyrGly: 2.152 ± 0.059	0.662TyrHis: 0.662 ± 0.028	1.309TyrIle: 1.309 ± 0.043	1.128TyrLys: 1.128 ± 0.042	2.571TyrLeu: 2.571 ± 0.066	0.653TyrMet: 0.653 ± 0.032	1.031TyrAsn: 1.031 ± 0.037	1.22TyrPro: 1.22 ± 0.037	1.039TyrGln: 1.039 ± 0.037	1.514TyrArg: 1.514 ± 0.05	1.522TyrSer: 1.522 ± 0.047	1.495TyrThr: 1.495 ± 0.046	1.884TyrVal: 1.884 ± 0.056	0.418TyrTrp: 0.418 ± 0.024	0.745TyrTyr: 0.745 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2476 proteins (776007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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