Amino acid dipepetide frequency for Arthrobacter phage Oxynfrius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.053AlaAla: 11.053 ± 1.23
0.57AlaCys: 0.57 ± 0.181
5.134AlaAsp: 5.134 ± 0.633
7.131AlaGlu: 7.131 ± 0.801
2.496AlaPhe: 2.496 ± 0.432
9.057AlaGly: 9.057 ± 0.895
1.925AlaHis: 1.925 ± 0.294
5.277AlaIle: 5.277 ± 0.744
6.489AlaLys: 6.489 ± 0.985
8.771AlaLeu: 8.771 ± 1.014
2.924AlaMet: 2.924 ± 0.407
3.922AlaAsn: 3.922 ± 0.447
3.922AlaPro: 3.922 ± 0.616
4.564AlaGln: 4.564 ± 0.618
4.992AlaArg: 4.992 ± 0.61
5.776AlaSer: 5.776 ± 1.059
6.846AlaThr: 6.846 ± 0.764
6.917AlaVal: 6.917 ± 0.815
1.783AlaTrp: 1.783 ± 0.402
2.639AlaTyr: 2.639 ± 0.404
0.0AlaXaa: 0.0 ± 0.0
Cys
0.357CysAla: 0.357 ± 0.178
0.071CysCys: 0.071 ± 0.063
0.285CysAsp: 0.285 ± 0.134
0.357CysGlu: 0.357 ± 0.155
0.071CysPhe: 0.071 ± 0.079
1.284CysGly: 1.284 ± 0.363
0.071CysHis: 0.071 ± 0.07
0.499CysIle: 0.499 ± 0.163
0.357CysLys: 0.357 ± 0.162
0.428CysLeu: 0.428 ± 0.146
0.0CysMet: 0.0 ± 0.0
0.285CysAsn: 0.285 ± 0.149
0.357CysPro: 0.357 ± 0.145
0.57CysGln: 0.57 ± 0.219
0.57CysArg: 0.57 ± 0.229
0.428CysSer: 0.428 ± 0.202
0.499CysThr: 0.499 ± 0.199
0.285CysVal: 0.285 ± 0.131
0.214CysTrp: 0.214 ± 0.13
0.143CysTyr: 0.143 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
5.562AspAla: 5.562 ± 0.614
0.713AspCys: 0.713 ± 0.261
3.28AspAsp: 3.28 ± 0.639
4.421AspGlu: 4.421 ± 0.707
1.925AspPhe: 1.925 ± 0.371
5.134AspGly: 5.134 ± 0.593
1.141AspHis: 1.141 ± 0.359
2.639AspIle: 2.639 ± 0.355
1.997AspLys: 1.997 ± 0.34
5.705AspLeu: 5.705 ± 0.781
1.355AspMet: 1.355 ± 0.313
1.783AspAsn: 1.783 ± 0.442
3.78AspPro: 3.78 ± 0.526
2.211AspGln: 2.211 ± 0.373
3.851AspArg: 3.851 ± 0.615
2.995AspSer: 2.995 ± 0.461
2.567AspThr: 2.567 ± 0.398
2.068AspVal: 2.068 ± 0.374
1.569AspTrp: 1.569 ± 0.406
1.783AspTyr: 1.783 ± 0.365
0.0AspXaa: 0.0 ± 0.0
Glu
8.272GluAla: 8.272 ± 0.985
0.642GluCys: 0.642 ± 0.216
3.352GluAsp: 3.352 ± 0.691
5.063GluGlu: 5.063 ± 0.613
1.854GluPhe: 1.854 ± 0.434
4.992GluGly: 4.992 ± 0.637
1.212GluHis: 1.212 ± 0.311
3.28GluIle: 3.28 ± 0.479
2.995GluLys: 2.995 ± 0.668
6.275GluLeu: 6.275 ± 0.818
1.355GluMet: 1.355 ± 0.396
2.068GluAsn: 2.068 ± 0.284
2.995GluPro: 2.995 ± 0.405
3.423GluGln: 3.423 ± 0.605
3.922GluArg: 3.922 ± 0.605
2.353GluSer: 2.353 ± 0.474
3.352GluThr: 3.352 ± 0.529
4.635GluVal: 4.635 ± 0.559
1.284GluTrp: 1.284 ± 0.292
1.569GluTyr: 1.569 ± 0.367
0.0GluXaa: 0.0 ± 0.0
Phe
2.282PheAla: 2.282 ± 0.432
0.214PheCys: 0.214 ± 0.142
2.496PheAsp: 2.496 ± 0.4
1.925PheGlu: 1.925 ± 0.403
1.212PhePhe: 1.212 ± 0.469
3.352PheGly: 3.352 ± 0.706
0.784PheHis: 0.784 ± 0.262
0.784PheIle: 0.784 ± 0.211
1.498PheLys: 1.498 ± 0.316
2.068PheLeu: 2.068 ± 0.361
0.856PheMet: 0.856 ± 0.281
0.927PheAsn: 0.927 ± 0.26
0.784PhePro: 0.784 ± 0.214
1.284PheGln: 1.284 ± 0.334
1.997PheArg: 1.997 ± 0.369
2.425PheSer: 2.425 ± 0.687
2.353PheThr: 2.353 ± 0.544
1.711PheVal: 1.711 ± 0.361
0.214PheTrp: 0.214 ± 0.12
0.713PheTyr: 0.713 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
8.771GlyAla: 8.771 ± 1.021
0.927GlyCys: 0.927 ± 0.295
5.134GlyAsp: 5.134 ± 0.626
5.206GlyGlu: 5.206 ± 0.537
3.209GlyPhe: 3.209 ± 0.519
6.561GlyGly: 6.561 ± 0.57
1.569GlyHis: 1.569 ± 0.362
4.635GlyIle: 4.635 ± 0.541
3.78GlyLys: 3.78 ± 0.416
6.989GlyLeu: 6.989 ± 0.83
1.997GlyMet: 1.997 ± 0.432
2.995GlyAsn: 2.995 ± 0.446
4.207GlyPro: 4.207 ± 0.585
3.209GlyGln: 3.209 ± 0.496
4.635GlyArg: 4.635 ± 0.565
5.776GlySer: 5.776 ± 0.795
5.848GlyThr: 5.848 ± 0.733
6.775GlyVal: 6.775 ± 0.727
2.353GlyTrp: 2.353 ± 0.36
1.997GlyTyr: 1.997 ± 0.385
0.0GlyXaa: 0.0 ± 0.0
His
1.284HisAla: 1.284 ± 0.321
0.285HisCys: 0.285 ± 0.125
0.998HisAsp: 0.998 ± 0.252
0.998HisGlu: 0.998 ± 0.311
0.713HisPhe: 0.713 ± 0.242
1.925HisGly: 1.925 ± 0.334
0.642HisHis: 0.642 ± 0.191
0.784HisIle: 0.784 ± 0.245
1.07HisLys: 1.07 ± 0.262
1.711HisLeu: 1.711 ± 0.474
0.285HisMet: 0.285 ± 0.14
0.357HisAsn: 0.357 ± 0.146
0.713HisPro: 0.713 ± 0.208
0.57HisGln: 0.57 ± 0.257
0.856HisArg: 0.856 ± 0.241
1.498HisSer: 1.498 ± 0.287
1.141HisThr: 1.141 ± 0.324
1.498HisVal: 1.498 ± 0.317
0.499HisTrp: 0.499 ± 0.199
0.927HisTyr: 0.927 ± 0.348
0.0HisXaa: 0.0 ± 0.0
Ile
5.348IleAla: 5.348 ± 0.59
0.285IleCys: 0.285 ± 0.151
3.066IleAsp: 3.066 ± 0.563
3.708IleGlu: 3.708 ± 0.566
1.498IlePhe: 1.498 ± 0.362
4.35IleGly: 4.35 ± 0.682
0.642IleHis: 0.642 ± 0.203
2.353IleIle: 2.353 ± 0.518
2.353IleLys: 2.353 ± 0.402
3.78IleLeu: 3.78 ± 0.545
0.713IleMet: 0.713 ± 0.309
2.139IleAsn: 2.139 ± 0.417
2.211IlePro: 2.211 ± 0.372
2.282IleGln: 2.282 ± 0.401
3.566IleArg: 3.566 ± 0.388
3.209IleSer: 3.209 ± 0.593
3.637IleThr: 3.637 ± 0.61
4.065IleVal: 4.065 ± 0.586
0.57IleTrp: 0.57 ± 0.206
1.284IleTyr: 1.284 ± 0.35
0.0IleXaa: 0.0 ± 0.0
Lys
5.42LysAla: 5.42 ± 0.893
0.285LysCys: 0.285 ± 0.132
2.995LysAsp: 2.995 ± 0.57
2.496LysGlu: 2.496 ± 0.422
1.711LysPhe: 1.711 ± 0.36
4.493LysGly: 4.493 ± 0.383
1.284LysHis: 1.284 ± 0.35
3.066LysIle: 3.066 ± 0.498
2.282LysLys: 2.282 ± 0.52
4.207LysLeu: 4.207 ± 0.626
1.498LysMet: 1.498 ± 0.314
0.998LysAsn: 0.998 ± 0.255
2.924LysPro: 2.924 ± 0.518
1.569LysGln: 1.569 ± 0.304
2.995LysArg: 2.995 ± 0.499
3.066LysSer: 3.066 ± 0.505
3.494LysThr: 3.494 ± 0.6
3.922LysVal: 3.922 ± 0.622
0.642LysTrp: 0.642 ± 0.208
1.141LysTyr: 1.141 ± 0.23
0.0LysXaa: 0.0 ± 0.0
Leu
8.7LeuAla: 8.7 ± 0.744
0.57LeuCys: 0.57 ± 0.19
5.206LeuAsp: 5.206 ± 0.571
4.279LeuGlu: 4.279 ± 0.612
2.425LeuPhe: 2.425 ± 0.51
6.989LeuGly: 6.989 ± 0.957
1.498LeuHis: 1.498 ± 0.392
4.136LeuIle: 4.136 ± 0.584
3.28LeuLys: 3.28 ± 0.413
6.989LeuLeu: 6.989 ± 0.826
1.783LeuMet: 1.783 ± 0.421
4.207LeuAsn: 4.207 ± 0.5
5.848LeuPro: 5.848 ± 0.67
3.851LeuGln: 3.851 ± 0.398
4.849LeuArg: 4.849 ± 0.681
4.493LeuSer: 4.493 ± 0.631
5.562LeuThr: 5.562 ± 0.71
6.061LeuVal: 6.061 ± 0.86
1.426LeuTrp: 1.426 ± 0.356
1.783LeuTyr: 1.783 ± 0.394
0.0LeuXaa: 0.0 ± 0.0
Met
2.139MetAla: 2.139 ± 0.366
0.0MetCys: 0.0 ± 0.0
1.355MetAsp: 1.355 ± 0.368
1.711MetGlu: 1.711 ± 0.307
0.57MetPhe: 0.57 ± 0.2
1.212MetGly: 1.212 ± 0.303
0.357MetHis: 0.357 ± 0.161
1.783MetIle: 1.783 ± 0.349
0.927MetLys: 0.927 ± 0.214
1.355MetLeu: 1.355 ± 0.278
0.285MetMet: 0.285 ± 0.143
1.284MetAsn: 1.284 ± 0.282
1.711MetPro: 1.711 ± 0.351
1.07MetGln: 1.07 ± 0.36
0.57MetArg: 0.57 ± 0.186
1.711MetSer: 1.711 ± 0.295
2.068MetThr: 2.068 ± 0.369
1.854MetVal: 1.854 ± 0.295
0.499MetTrp: 0.499 ± 0.226
0.357MetTyr: 0.357 ± 0.148
0.0MetXaa: 0.0 ± 0.0
Asn
3.637AsnAla: 3.637 ± 0.626
0.071AsnCys: 0.071 ± 0.073
1.355AsnAsp: 1.355 ± 0.393
1.997AsnGlu: 1.997 ± 0.363
0.642AsnPhe: 0.642 ± 0.233
4.207AsnGly: 4.207 ± 0.415
0.428AsnHis: 0.428 ± 0.191
2.211AsnIle: 2.211 ± 0.49
1.64AsnLys: 1.64 ± 0.388
3.494AsnLeu: 3.494 ± 0.545
0.713AsnMet: 0.713 ± 0.223
1.284AsnAsn: 1.284 ± 0.335
2.139AsnPro: 2.139 ± 0.472
1.426AsnGln: 1.426 ± 0.356
1.498AsnArg: 1.498 ± 0.344
2.852AsnSer: 2.852 ± 0.545
2.425AsnThr: 2.425 ± 0.441
2.211AsnVal: 2.211 ± 0.396
0.856AsnTrp: 0.856 ± 0.231
0.784AsnTyr: 0.784 ± 0.248
0.0AsnXaa: 0.0 ± 0.0
Pro
5.277ProAla: 5.277 ± 0.643
0.428ProCys: 0.428 ± 0.194
2.852ProAsp: 2.852 ± 0.474
4.493ProGlu: 4.493 ± 0.609
0.927ProPhe: 0.927 ± 0.305
5.277ProGly: 5.277 ± 0.646
0.57ProHis: 0.57 ± 0.189
2.639ProIle: 2.639 ± 0.422
2.995ProLys: 2.995 ± 0.55
2.639ProLeu: 2.639 ± 0.367
0.998ProMet: 0.998 ± 0.261
1.925ProAsn: 1.925 ± 0.397
1.925ProPro: 1.925 ± 0.418
0.998ProGln: 0.998 ± 0.246
2.496ProArg: 2.496 ± 0.42
4.635ProSer: 4.635 ± 0.603
3.566ProThr: 3.566 ± 0.514
4.564ProVal: 4.564 ± 0.539
1.284ProTrp: 1.284 ± 0.28
0.927ProTyr: 0.927 ± 0.29
0.0ProXaa: 0.0 ± 0.0
Gln
4.065GlnAla: 4.065 ± 0.52
0.143GlnCys: 0.143 ± 0.153
2.139GlnAsp: 2.139 ± 0.387
2.068GlnGlu: 2.068 ± 0.436
1.426GlnPhe: 1.426 ± 0.311
2.995GlnGly: 2.995 ± 0.557
0.642GlnHis: 0.642 ± 0.24
2.496GlnIle: 2.496 ± 0.5
2.425GlnLys: 2.425 ± 0.361
5.206GlnLeu: 5.206 ± 0.696
0.57GlnMet: 0.57 ± 0.2
1.711GlnAsn: 1.711 ± 0.448
1.854GlnPro: 1.854 ± 0.384
1.426GlnGln: 1.426 ± 0.296
1.997GlnArg: 1.997 ± 0.417
1.783GlnSer: 1.783 ± 0.309
2.425GlnThr: 2.425 ± 0.408
2.995GlnVal: 2.995 ± 0.538
0.856GlnTrp: 0.856 ± 0.238
0.998GlnTyr: 0.998 ± 0.213
0.0GlnXaa: 0.0 ± 0.0
Arg
5.134ArgAla: 5.134 ± 0.51
0.357ArgCys: 0.357 ± 0.175
3.352ArgAsp: 3.352 ± 0.621
4.065ArgGlu: 4.065 ± 0.539
1.284ArgPhe: 1.284 ± 0.336
4.207ArgGly: 4.207 ± 0.552
1.07ArgHis: 1.07 ± 0.296
2.353ArgIle: 2.353 ± 0.337
4.065ArgLys: 4.065 ± 0.639
4.635ArgLeu: 4.635 ± 0.526
1.498ArgMet: 1.498 ± 0.283
2.496ArgAsn: 2.496 ± 0.437
2.71ArgPro: 2.71 ± 0.43
2.211ArgGln: 2.211 ± 0.473
3.851ArgArg: 3.851 ± 0.496
3.138ArgSer: 3.138 ± 0.453
3.209ArgThr: 3.209 ± 0.427
4.136ArgVal: 4.136 ± 0.659
0.713ArgTrp: 0.713 ± 0.298
1.426ArgTyr: 1.426 ± 0.351
0.0ArgXaa: 0.0 ± 0.0
Ser
5.848SerAla: 5.848 ± 1.891
0.357SerCys: 0.357 ± 0.185
3.066SerAsp: 3.066 ± 0.396
3.851SerGlu: 3.851 ± 0.519
2.496SerPhe: 2.496 ± 0.519
6.347SerGly: 6.347 ± 0.86
1.355SerHis: 1.355 ± 0.299
3.637SerIle: 3.637 ± 0.576
2.567SerLys: 2.567 ± 0.414
5.491SerLeu: 5.491 ± 0.831
1.498SerMet: 1.498 ± 0.338
1.783SerAsn: 1.783 ± 0.378
2.639SerPro: 2.639 ± 0.318
2.639SerGln: 2.639 ± 0.562
2.995SerArg: 2.995 ± 0.423
3.352SerSer: 3.352 ± 0.532
3.494SerThr: 3.494 ± 0.583
4.707SerVal: 4.707 ± 0.513
1.212SerTrp: 1.212 ± 0.285
2.068SerTyr: 2.068 ± 0.427
0.0SerXaa: 0.0 ± 0.0
Thr
7.202ThrAla: 7.202 ± 0.855
0.499ThrCys: 0.499 ± 0.17
3.352ThrAsp: 3.352 ± 0.453
3.993ThrGlu: 3.993 ± 0.577
2.139ThrPhe: 2.139 ± 0.399
4.992ThrGly: 4.992 ± 0.92
1.284ThrHis: 1.284 ± 0.327
2.71ThrIle: 2.71 ± 0.503
3.993ThrLys: 3.993 ± 0.569
5.634ThrLeu: 5.634 ± 0.63
0.998ThrMet: 0.998 ± 0.226
1.925ThrAsn: 1.925 ± 0.33
4.421ThrPro: 4.421 ± 0.485
2.425ThrGln: 2.425 ± 0.484
3.066ThrArg: 3.066 ± 0.512
4.207ThrSer: 4.207 ± 0.636
4.92ThrThr: 4.92 ± 0.814
4.849ThrVal: 4.849 ± 0.634
0.713ThrTrp: 0.713 ± 0.243
1.498ThrTyr: 1.498 ± 0.368
0.0ThrXaa: 0.0 ± 0.0
Val
7.488ValAla: 7.488 ± 0.807
0.285ValCys: 0.285 ± 0.135
3.494ValAsp: 3.494 ± 0.484
4.778ValGlu: 4.778 ± 0.639
1.854ValPhe: 1.854 ± 0.424
5.206ValGly: 5.206 ± 0.701
1.426ValHis: 1.426 ± 0.348
3.993ValIle: 3.993 ± 0.82
3.494ValLys: 3.494 ± 0.578
5.705ValLeu: 5.705 ± 0.598
2.639ValMet: 2.639 ± 0.402
2.567ValAsn: 2.567 ± 0.532
3.851ValPro: 3.851 ± 0.469
3.138ValGln: 3.138 ± 0.432
3.993ValArg: 3.993 ± 0.561
5.206ValSer: 5.206 ± 0.55
4.493ValThr: 4.493 ± 0.486
4.635ValVal: 4.635 ± 0.456
1.783ValTrp: 1.783 ± 0.355
1.498ValTyr: 1.498 ± 0.294
0.0ValXaa: 0.0 ± 0.0
Trp
2.211TrpAla: 2.211 ± 0.426
0.071TrpCys: 0.071 ± 0.068
1.925TrpAsp: 1.925 ± 0.402
0.856TrpGlu: 0.856 ± 0.266
0.57TrpPhe: 0.57 ± 0.198
1.64TrpGly: 1.64 ± 0.34
0.499TrpHis: 0.499 ± 0.198
0.927TrpIle: 0.927 ± 0.235
0.784TrpLys: 0.784 ± 0.234
0.998TrpLeu: 0.998 ± 0.246
0.642TrpMet: 0.642 ± 0.189
0.642TrpAsn: 0.642 ± 0.2
1.07TrpPro: 1.07 ± 0.38
0.499TrpGln: 0.499 ± 0.188
0.998TrpArg: 0.998 ± 0.268
1.355TrpSer: 1.355 ± 0.32
0.998TrpThr: 0.998 ± 0.198
2.068TrpVal: 2.068 ± 0.382
0.713TrpTrp: 0.713 ± 0.241
0.428TrpTyr: 0.428 ± 0.193
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.139TyrAla: 2.139 ± 0.504
0.357TyrCys: 0.357 ± 0.157
1.64TyrAsp: 1.64 ± 0.343
1.498TyrGlu: 1.498 ± 0.369
0.856TyrPhe: 0.856 ± 0.215
2.353TyrGly: 2.353 ± 0.389
0.357TyrHis: 0.357 ± 0.163
0.856TyrIle: 0.856 ± 0.262
1.569TyrLys: 1.569 ± 0.31
1.854TyrLeu: 1.854 ± 0.334
0.143TyrMet: 0.143 ± 0.084
0.57TyrAsn: 0.57 ± 0.226
1.355TyrPro: 1.355 ± 0.265
0.856TyrGln: 0.856 ± 0.208
2.211TyrArg: 2.211 ± 0.349
1.141TyrSer: 1.141 ± 0.352
1.925TyrThr: 1.925 ± 0.434
1.569TyrVal: 1.569 ± 0.337
0.713TyrTrp: 0.713 ± 0.221
0.784TyrTyr: 0.784 ± 0.282
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (14024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski