Amino acid dipepetide frequency for Streptococcus satellite phage Javan723

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.29AlaAla: 0.29 ± 0.28
0.0AlaCys: 0.0 ± 0.0
4.058AlaAsp: 4.058 ± 1.32
5.797AlaGlu: 5.797 ± 1.952
3.188AlaPhe: 3.188 ± 0.848
2.029AlaGly: 2.029 ± 0.61
0.87AlaHis: 0.87 ± 0.682
4.928AlaIle: 4.928 ± 1.42
4.348AlaLys: 4.348 ± 1.24
4.638AlaLeu: 4.638 ± 1.033
2.609AlaMet: 2.609 ± 1.146
2.319AlaAsn: 2.319 ± 0.853
0.87AlaPro: 0.87 ± 0.506
2.319AlaGln: 2.319 ± 0.661
3.768AlaArg: 3.768 ± 0.956
2.899AlaSer: 2.899 ± 0.967
3.188AlaThr: 3.188 ± 1.043
3.768AlaVal: 3.768 ± 0.958
0.0AlaTrp: 0.0 ± 0.0
2.029AlaTyr: 2.029 ± 0.902
0.0AlaXaa: 0.0 ± 0.0
Cys
0.29CysAla: 0.29 ± 0.256
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.29CysGlu: 0.29 ± 0.256
0.58CysPhe: 0.58 ± 0.331
0.29CysGly: 0.29 ± 0.244
0.29CysHis: 0.29 ± 0.256
0.87CysIle: 0.87 ± 0.673
0.29CysLys: 0.29 ± 0.234
0.87CysLeu: 0.87 ± 0.494
0.0CysMet: 0.0 ± 0.0
0.58CysAsn: 0.58 ± 0.335
0.29CysPro: 0.29 ± 0.256
0.29CysGln: 0.29 ± 0.407
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.319AspAla: 2.319 ± 0.632
0.58AspCys: 0.58 ± 0.433
4.638AspAsp: 4.638 ± 1.055
5.217AspGlu: 5.217 ± 1.495
2.609AspPhe: 2.609 ± 0.661
2.029AspGly: 2.029 ± 0.694
0.0AspHis: 0.0 ± 0.0
5.217AspIle: 5.217 ± 1.018
4.638AspLys: 4.638 ± 0.881
7.536AspLeu: 7.536 ± 1.369
2.319AspMet: 2.319 ± 0.996
3.478AspAsn: 3.478 ± 0.835
1.159AspPro: 1.159 ± 0.53
0.87AspGln: 0.87 ± 0.518
2.609AspArg: 2.609 ± 0.778
1.449AspSer: 1.449 ± 0.563
2.899AspThr: 2.899 ± 0.921
1.449AspVal: 1.449 ± 0.754
0.0AspTrp: 0.0 ± 0.0
3.478AspTyr: 3.478 ± 1.034
0.0AspXaa: 0.0 ± 0.0
Glu
5.797GluAla: 5.797 ± 1.594
0.87GluCys: 0.87 ± 0.449
4.348GluAsp: 4.348 ± 1.503
8.116GluGlu: 8.116 ± 2.302
2.899GluPhe: 2.899 ± 1.012
2.609GluGly: 2.609 ± 0.705
1.159GluHis: 1.159 ± 0.578
9.275GluIle: 9.275 ± 1.758
9.275GluLys: 9.275 ± 1.793
10.145GluLeu: 10.145 ± 1.681
3.478GluMet: 3.478 ± 1.051
6.957GluAsn: 6.957 ± 1.503
2.029GluPro: 2.029 ± 0.727
4.638GluGln: 4.638 ± 1.235
4.928GluArg: 4.928 ± 1.293
4.638GluSer: 4.638 ± 1.226
3.478GluThr: 3.478 ± 0.915
7.246GluVal: 7.246 ± 1.745
0.29GluTrp: 0.29 ± 0.268
4.058GluTyr: 4.058 ± 1.053
0.0GluXaa: 0.0 ± 0.0
Phe
1.159PheAla: 1.159 ± 0.542
0.0PheCys: 0.0 ± 0.0
2.609PheAsp: 2.609 ± 0.97
3.768PheGlu: 3.768 ± 1.246
1.449PhePhe: 1.449 ± 0.932
1.449PheGly: 1.449 ± 0.769
1.159PheHis: 1.159 ± 0.404
5.217PheIle: 5.217 ± 1.689
3.478PheLys: 3.478 ± 1.035
4.058PheLeu: 4.058 ± 1.086
0.87PheMet: 0.87 ± 0.605
2.319PheAsn: 2.319 ± 0.638
0.58PhePro: 0.58 ± 0.395
1.739PheGln: 1.739 ± 0.604
1.739PheArg: 1.739 ± 0.654
3.478PheSer: 3.478 ± 0.727
0.87PheThr: 0.87 ± 0.543
1.739PheVal: 1.739 ± 0.777
0.58PheTrp: 0.58 ± 0.329
3.478PheTyr: 3.478 ± 0.81
0.0PheXaa: 0.0 ± 0.0
Gly
1.159GlyAla: 1.159 ± 0.657
0.0GlyCys: 0.0 ± 0.0
2.899GlyAsp: 2.899 ± 0.752
3.478GlyGlu: 3.478 ± 0.873
2.319GlyPhe: 2.319 ± 0.901
1.159GlyGly: 1.159 ± 0.415
0.58GlyHis: 0.58 ± 0.366
6.667GlyIle: 6.667 ± 1.117
4.348GlyLys: 4.348 ± 1.168
5.507GlyLeu: 5.507 ± 1.202
0.58GlyMet: 0.58 ± 0.297
2.029GlyAsn: 2.029 ± 0.737
0.0GlyPro: 0.0 ± 0.0
2.029GlyGln: 2.029 ± 0.613
2.609GlyArg: 2.609 ± 0.883
1.159GlySer: 1.159 ± 0.585
2.319GlyThr: 2.319 ± 0.757
4.348GlyVal: 4.348 ± 1.017
1.739GlyTrp: 1.739 ± 0.66
3.478GlyTyr: 3.478 ± 1.052
0.0GlyXaa: 0.0 ± 0.0
His
0.87HisAla: 0.87 ± 0.566
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
2.319HisGlu: 2.319 ± 0.922
1.159HisPhe: 1.159 ± 0.734
0.58HisGly: 0.58 ± 0.403
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.87HisLys: 0.87 ± 0.463
1.449HisLeu: 1.449 ± 0.634
0.29HisMet: 0.29 ± 0.302
0.87HisAsn: 0.87 ± 0.511
0.58HisPro: 0.58 ± 0.468
0.0HisGln: 0.0 ± 0.0
1.739HisArg: 1.739 ± 0.545
0.58HisSer: 0.58 ± 0.312
0.58HisThr: 0.58 ± 0.512
0.58HisVal: 0.58 ± 0.299
0.0HisTrp: 0.0 ± 0.0
0.58HisTyr: 0.58 ± 0.537
0.0HisXaa: 0.0 ± 0.0
Ile
4.058IleAla: 4.058 ± 1.23
0.58IleCys: 0.58 ± 0.479
4.348IleAsp: 4.348 ± 0.939
7.536IleGlu: 7.536 ± 1.576
4.638IlePhe: 4.638 ± 1.061
3.768IleGly: 3.768 ± 0.951
1.159IleHis: 1.159 ± 0.631
4.928IleIle: 4.928 ± 1.201
9.565IleLys: 9.565 ± 1.524
4.638IleLeu: 4.638 ± 1.228
0.87IleMet: 0.87 ± 0.477
2.899IleAsn: 2.899 ± 1.071
2.319IlePro: 2.319 ± 0.721
3.478IleGln: 3.478 ± 1.21
2.609IleArg: 2.609 ± 0.835
6.087IleSer: 6.087 ± 1.279
3.478IleThr: 3.478 ± 0.788
3.768IleVal: 3.768 ± 0.773
0.58IleTrp: 0.58 ± 0.403
3.768IleTyr: 3.768 ± 1.026
0.0IleXaa: 0.0 ± 0.0
Lys
8.696LysAla: 8.696 ± 1.701
0.29LysCys: 0.29 ± 0.256
4.928LysAsp: 4.928 ± 1.031
10.145LysGlu: 10.145 ± 1.206
2.029LysPhe: 2.029 ± 0.775
5.507LysGly: 5.507 ± 1.215
1.159LysHis: 1.159 ± 0.634
5.217LysIle: 5.217 ± 0.93
6.377LysLys: 6.377 ± 1.493
7.826LysLeu: 7.826 ± 1.589
3.478LysMet: 3.478 ± 0.999
6.667LysAsn: 6.667 ± 1.399
2.899LysPro: 2.899 ± 0.994
3.478LysGln: 3.478 ± 0.871
5.507LysArg: 5.507 ± 1.501
6.377LysSer: 6.377 ± 1.045
5.797LysThr: 5.797 ± 1.372
4.348LysVal: 4.348 ± 0.993
1.159LysTrp: 1.159 ± 0.486
2.609LysTyr: 2.609 ± 1.067
0.0LysXaa: 0.0 ± 0.0
Leu
6.667LeuAla: 6.667 ± 0.793
0.58LeuCys: 0.58 ± 0.537
5.507LeuAsp: 5.507 ± 1.511
12.464LeuGlu: 12.464 ± 2.362
4.638LeuPhe: 4.638 ± 1.503
5.217LeuGly: 5.217 ± 1.094
0.87LeuHis: 0.87 ± 0.702
5.217LeuIle: 5.217 ± 1.236
8.116LeuLys: 8.116 ± 1.642
7.826LeuLeu: 7.826 ± 1.025
1.159LeuMet: 1.159 ± 0.64
6.667LeuAsn: 6.667 ± 1.53
4.348LeuPro: 4.348 ± 0.93
4.348LeuGln: 4.348 ± 1.01
4.638LeuArg: 4.638 ± 0.966
5.797LeuSer: 5.797 ± 1.263
7.536LeuThr: 7.536 ± 1.571
2.609LeuVal: 2.609 ± 0.808
0.87LeuTrp: 0.87 ± 0.469
4.348LeuTyr: 4.348 ± 1.086
0.0LeuXaa: 0.0 ± 0.0
Met
2.319MetAla: 2.319 ± 1.027
0.0MetCys: 0.0 ± 0.0
2.029MetAsp: 2.029 ± 0.844
2.899MetGlu: 2.899 ± 0.835
0.87MetPhe: 0.87 ± 0.424
2.029MetGly: 2.029 ± 0.657
0.29MetHis: 0.29 ± 0.303
0.29MetIle: 0.29 ± 0.312
1.739MetLys: 1.739 ± 0.703
1.159MetLeu: 1.159 ± 0.504
0.0MetMet: 0.0 ± 0.0
2.029MetAsn: 2.029 ± 0.904
1.159MetPro: 1.159 ± 0.672
0.58MetGln: 0.58 ± 0.606
1.449MetArg: 1.449 ± 0.523
0.58MetSer: 0.58 ± 0.363
2.899MetThr: 2.899 ± 1.07
0.87MetVal: 0.87 ± 0.583
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.609AsnAla: 2.609 ± 0.895
0.58AsnCys: 0.58 ± 0.512
3.768AsnAsp: 3.768 ± 1.01
2.319AsnGlu: 2.319 ± 0.658
1.159AsnPhe: 1.159 ± 0.625
5.797AsnGly: 5.797 ± 1.143
0.87AsnHis: 0.87 ± 0.617
2.319AsnIle: 2.319 ± 0.734
7.246AsnLys: 7.246 ± 1.979
4.348AsnLeu: 4.348 ± 0.741
1.739AsnMet: 1.739 ± 0.594
1.449AsnAsn: 1.449 ± 0.653
2.609AsnPro: 2.609 ± 0.671
2.029AsnGln: 2.029 ± 0.676
2.609AsnArg: 2.609 ± 0.572
3.188AsnSer: 3.188 ± 1.069
3.768AsnThr: 3.768 ± 1.032
2.319AsnVal: 2.319 ± 0.907
0.87AsnTrp: 0.87 ± 0.369
2.609AsnTyr: 2.609 ± 1.053
0.0AsnXaa: 0.0 ± 0.0
Pro
1.449ProAla: 1.449 ± 0.796
0.0ProCys: 0.0 ± 0.0
2.319ProAsp: 2.319 ± 0.656
4.348ProGlu: 4.348 ± 1.015
1.449ProPhe: 1.449 ± 0.558
0.29ProGly: 0.29 ± 0.303
0.29ProHis: 0.29 ± 0.234
1.159ProIle: 1.159 ± 0.457
2.319ProLys: 2.319 ± 1.004
2.029ProLeu: 2.029 ± 0.863
0.29ProMet: 0.29 ± 0.268
1.449ProAsn: 1.449 ± 0.538
1.159ProPro: 1.159 ± 0.709
0.87ProGln: 0.87 ± 0.438
2.609ProArg: 2.609 ± 0.835
2.029ProSer: 2.029 ± 0.956
2.609ProThr: 2.609 ± 0.879
2.029ProVal: 2.029 ± 0.638
0.0ProTrp: 0.0 ± 0.0
2.609ProTyr: 2.609 ± 0.628
0.0ProXaa: 0.0 ± 0.0
Gln
3.768GlnAla: 3.768 ± 1.143
0.0GlnCys: 0.0 ± 0.0
2.899GlnAsp: 2.899 ± 0.903
4.928GlnGlu: 4.928 ± 1.361
0.58GlnPhe: 0.58 ± 0.363
2.609GlnGly: 2.609 ± 0.782
0.58GlnHis: 0.58 ± 0.37
1.739GlnIle: 1.739 ± 0.604
3.478GlnLys: 3.478 ± 0.709
5.507GlnLeu: 5.507 ± 1.021
1.449GlnMet: 1.449 ± 0.806
1.159GlnAsn: 1.159 ± 0.457
0.87GlnPro: 0.87 ± 0.424
2.319GlnGln: 2.319 ± 0.761
2.319GlnArg: 2.319 ± 0.876
0.87GlnSer: 0.87 ± 0.658
1.449GlnThr: 1.449 ± 0.516
3.768GlnVal: 3.768 ± 0.983
0.29GlnTrp: 0.29 ± 0.256
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.319ArgAla: 2.319 ± 0.845
0.29ArgCys: 0.29 ± 0.244
1.449ArgAsp: 1.449 ± 0.705
4.348ArgGlu: 4.348 ± 0.943
2.899ArgPhe: 2.899 ± 0.847
0.87ArgGly: 0.87 ± 0.464
1.739ArgHis: 1.739 ± 0.84
5.507ArgIle: 5.507 ± 1.362
4.638ArgLys: 4.638 ± 1.161
7.536ArgLeu: 7.536 ± 1.359
1.159ArgMet: 1.159 ± 0.597
2.319ArgAsn: 2.319 ± 1.006
1.159ArgPro: 1.159 ± 0.549
4.348ArgGln: 4.348 ± 1.124
3.188ArgArg: 3.188 ± 0.725
2.609ArgSer: 2.609 ± 0.84
2.609ArgThr: 2.609 ± 0.681
3.188ArgVal: 3.188 ± 0.825
0.0ArgTrp: 0.0 ± 0.0
2.609ArgTyr: 2.609 ± 0.841
0.0ArgXaa: 0.0 ± 0.0
Ser
3.188SerAla: 3.188 ± 1.061
0.29SerCys: 0.29 ± 0.303
2.319SerAsp: 2.319 ± 0.77
6.087SerGlu: 6.087 ± 1.633
1.449SerPhe: 1.449 ± 0.52
2.609SerGly: 2.609 ± 0.97
0.87SerHis: 0.87 ± 0.416
4.058SerIle: 4.058 ± 1.019
5.507SerLys: 5.507 ± 1.081
4.928SerLeu: 4.928 ± 1.196
0.58SerMet: 0.58 ± 0.334
4.638SerAsn: 4.638 ± 1.13
2.029SerPro: 2.029 ± 0.634
1.449SerGln: 1.449 ± 0.59
3.478SerArg: 3.478 ± 1.028
2.609SerSer: 2.609 ± 0.885
2.609SerThr: 2.609 ± 0.657
3.188SerVal: 3.188 ± 0.875
0.29SerTrp: 0.29 ± 0.234
1.159SerTyr: 1.159 ± 0.511
0.0SerXaa: 0.0 ± 0.0
Thr
1.739ThrAla: 1.739 ± 0.87
0.0ThrCys: 0.0 ± 0.0
2.029ThrAsp: 2.029 ± 0.796
2.899ThrGlu: 2.899 ± 0.912
1.739ThrPhe: 1.739 ± 0.705
3.768ThrGly: 3.768 ± 0.728
0.29ThrHis: 0.29 ± 0.256
4.348ThrIle: 4.348 ± 1.122
5.217ThrLys: 5.217 ± 1.088
6.667ThrLeu: 6.667 ± 1.098
0.58ThrMet: 0.58 ± 0.391
0.29ThrAsn: 0.29 ± 0.28
3.768ThrPro: 3.768 ± 0.844
2.609ThrGln: 2.609 ± 0.895
2.609ThrArg: 2.609 ± 0.845
2.899ThrSer: 2.899 ± 0.659
3.478ThrThr: 3.478 ± 0.87
6.087ThrVal: 6.087 ± 1.274
0.58ThrTrp: 0.58 ± 0.519
2.609ThrTyr: 2.609 ± 1.524
0.0ThrXaa: 0.0 ± 0.0
Val
2.899ValAla: 2.899 ± 1.272
0.58ValCys: 0.58 ± 0.299
2.609ValAsp: 2.609 ± 0.988
6.377ValGlu: 6.377 ± 1.477
2.899ValPhe: 2.899 ± 0.911
3.478ValGly: 3.478 ± 1.112
0.0ValHis: 0.0 ± 0.0
4.348ValIle: 4.348 ± 1.049
5.507ValLys: 5.507 ± 1.273
4.928ValLeu: 4.928 ± 1.099
1.159ValMet: 1.159 ± 0.539
4.058ValAsn: 4.058 ± 0.859
2.319ValPro: 2.319 ± 0.942
1.449ValGln: 1.449 ± 0.583
2.899ValArg: 2.899 ± 0.852
4.058ValSer: 4.058 ± 1.032
2.029ValThr: 2.029 ± 0.723
2.319ValVal: 2.319 ± 0.981
0.87ValTrp: 0.87 ± 0.462
1.739ValTyr: 1.739 ± 0.812
0.0ValXaa: 0.0 ± 0.0
Trp
0.29TrpAla: 0.29 ± 0.256
0.0TrpCys: 0.0 ± 0.0
0.58TrpAsp: 0.58 ± 0.431
0.58TrpGlu: 0.58 ± 0.409
0.0TrpPhe: 0.0 ± 0.0
0.58TrpGly: 0.58 ± 0.393
0.29TrpHis: 0.29 ± 0.268
1.159TrpIle: 1.159 ± 0.595
1.449TrpLys: 1.449 ± 0.618
1.159TrpLeu: 1.159 ± 0.595
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.29TrpArg: 0.29 ± 0.283
0.58TrpSer: 0.58 ± 0.343
0.0TrpThr: 0.0 ± 0.0
0.87TrpVal: 0.87 ± 0.544
0.0TrpTrp: 0.0 ± 0.0
0.29TrpTyr: 0.29 ± 0.268
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.029TyrAla: 2.029 ± 0.864
0.29TyrCys: 0.29 ± 0.256
1.159TyrAsp: 1.159 ± 0.455
2.319TyrGlu: 2.319 ± 0.643
3.188TyrPhe: 3.188 ± 1.146
1.739TyrGly: 1.739 ± 0.667
0.58TyrHis: 0.58 ± 0.468
2.609TyrIle: 2.609 ± 0.8
6.087TyrLys: 6.087 ± 1.741
6.957TyrLeu: 6.957 ± 1.498
0.29TyrMet: 0.29 ± 0.32
2.029TyrAsn: 2.029 ± 0.577
1.159TyrPro: 1.159 ± 0.439
1.739TyrGln: 1.739 ± 0.721
3.188TyrArg: 3.188 ± 0.893
1.449TyrSer: 1.449 ± 0.629
2.609TyrThr: 2.609 ± 0.643
2.029TyrVal: 2.029 ± 0.909
0.0TyrTrp: 0.0 ± 0.0
0.58TyrTyr: 0.58 ± 0.403
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 26 proteins (3451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski