Amino acid dipepetide frequency for Paracoccus aestuariivivens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.354AlaAla: 16.354 ± 0.154	0.965AlaCys: 0.965 ± 0.029	6.685AlaAsp: 6.685 ± 0.08	8.043AlaGlu: 8.043 ± 0.093	4.006AlaPhe: 4.006 ± 0.061	10.528AlaGly: 10.528 ± 0.098	2.243AlaHis: 2.243 ± 0.039	6.52AlaIle: 6.52 ± 0.082	3.879AlaLys: 3.879 ± 0.059	13.628AlaLeu: 13.628 ± 0.13	4.014AlaMet: 4.014 ± 0.059	2.903AlaAsn: 2.903 ± 0.05	5.619AlaPro: 5.619 ± 0.077	4.405AlaGln: 4.405 ± 0.065	8.771AlaArg: 8.771 ± 0.109	6.14AlaSer: 6.14 ± 0.076	6.105AlaThr: 6.105 ± 0.076	8.172AlaVal: 8.172 ± 0.081	1.421AlaTrp: 1.421 ± 0.036	2.387AlaTyr: 2.387 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.927CysAla: 0.927 ± 0.028	0.111CysCys: 0.111 ± 0.009	0.554CysAsp: 0.554 ± 0.023	0.381CysGlu: 0.381 ± 0.018	0.312CysPhe: 0.312 ± 0.016	0.905CysGly: 0.905 ± 0.027	0.269CysHis: 0.269 ± 0.016	0.405CysIle: 0.405 ± 0.017	0.18CysLys: 0.18 ± 0.011	0.798CysLeu: 0.798 ± 0.026	0.174CysMet: 0.174 ± 0.011	0.198CysAsn: 0.198 ± 0.012	0.453CysPro: 0.453 ± 0.019	0.241CysGln: 0.241 ± 0.013	0.561CysArg: 0.561 ± 0.021	0.459CysSer: 0.459 ± 0.019	0.383CysThr: 0.383 ± 0.018	0.542CysVal: 0.542 ± 0.021	0.12CysTrp: 0.12 ± 0.009	0.181CysTyr: 0.181 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.847AspAla: 6.847 ± 0.084	0.499AspCys: 0.499 ± 0.02	3.134AspAsp: 3.134 ± 0.06	3.542AspGlu: 3.542 ± 0.055	2.273AspPhe: 2.273 ± 0.045	5.103AspGly: 5.103 ± 0.069	1.341AspHis: 1.341 ± 0.033	2.846AspIle: 2.846 ± 0.05	1.582AspLys: 1.582 ± 0.036	6.649AspLeu: 6.649 ± 0.083	1.51AspMet: 1.51 ± 0.033	1.247AspAsn: 1.247 ± 0.034	3.671AspPro: 3.671 ± 0.055	2.045AspGln: 2.045 ± 0.043	4.498AspArg: 4.498 ± 0.068	2.384AspSer: 2.384 ± 0.045	2.475AspThr: 2.475 ± 0.054	3.698AspVal: 3.698 ± 0.058	1.189AspTrp: 1.189 ± 0.029	1.569AspTyr: 1.569 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.562GluAla: 7.562 ± 0.096	0.349GluCys: 0.349 ± 0.016	2.774GluAsp: 2.774 ± 0.042	2.685GluGlu: 2.685 ± 0.053	1.939GluPhe: 1.939 ± 0.041	4.433GluGly: 4.433 ± 0.061	1.138GluHis: 1.138 ± 0.027	3.691GluIle: 3.691 ± 0.058	2.061GluLys: 2.061 ± 0.048	5.47GluLeu: 5.47 ± 0.075	1.73GluMet: 1.73 ± 0.034	1.756GluAsn: 1.756 ± 0.038	2.608GluPro: 2.608 ± 0.049	1.972GluGln: 1.972 ± 0.038	4.169GluArg: 4.169 ± 0.061	2.408GluSer: 2.408 ± 0.043	3.429GluThr: 3.429 ± 0.047	3.982GluVal: 3.982 ± 0.059	0.817GluTrp: 0.817 ± 0.024	1.079GluTyr: 1.079 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.408PheAla: 4.408 ± 0.066	0.365PheCys: 0.365 ± 0.016	2.739PheAsp: 2.739 ± 0.051	1.911PheGlu: 1.911 ± 0.034	1.357PhePhe: 1.357 ± 0.035	3.726PheGly: 3.726 ± 0.061	0.799PheHis: 0.799 ± 0.024	1.724PheIle: 1.724 ± 0.041	0.803PheLys: 0.803 ± 0.026	3.485PheLeu: 3.485 ± 0.056	0.858PheMet: 0.858 ± 0.026	0.966PheAsn: 0.966 ± 0.026	1.614PhePro: 1.614 ± 0.034	0.998PheGln: 0.998 ± 0.024	2.334PheArg: 2.334 ± 0.041	2.225PheSer: 2.225 ± 0.046	1.903PheThr: 1.903 ± 0.041	2.639PheVal: 2.639 ± 0.047	0.605PheTrp: 0.605 ± 0.024	0.844PheTyr: 0.844 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.397GlyAla: 9.397 ± 0.095	0.824GlyCys: 0.824 ± 0.029	4.382GlyAsp: 4.382 ± 0.074	4.492GlyGlu: 4.492 ± 0.057	3.669GlyPhe: 3.669 ± 0.05	7.17GlyGly: 7.17 ± 0.101	1.96GlyHis: 1.96 ± 0.042	4.991GlyIle: 4.991 ± 0.062	3.232GlyLys: 3.232 ± 0.055	9.387GlyLeu: 9.387 ± 0.091	2.609GlyMet: 2.609 ± 0.042	2.375GlyAsn: 2.375 ± 0.063	3.8GlyPro: 3.8 ± 0.06	3.364GlyGln: 3.364 ± 0.061	6.027GlyArg: 6.027 ± 0.068	4.529GlySer: 4.529 ± 0.062	4.518GlyThr: 4.518 ± 0.065	6.088GlyVal: 6.088 ± 0.08	1.537GlyTrp: 1.537 ± 0.034	2.319GlyTyr: 2.319 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.356HisAla: 2.356 ± 0.048	0.214HisCys: 0.214 ± 0.011	1.383HisAsp: 1.383 ± 0.038	1.127HisGlu: 1.127 ± 0.032	0.814HisPhe: 0.814 ± 0.024	1.972HisGly: 1.972 ± 0.042	0.548HisHis: 0.548 ± 0.024	1.022HisIle: 1.022 ± 0.032	0.474HisLys: 0.474 ± 0.02	2.196HisLeu: 2.196 ± 0.039	0.532HisMet: 0.532 ± 0.02	0.468HisAsn: 0.468 ± 0.022	1.382HisPro: 1.382 ± 0.038	0.618HisGln: 0.618 ± 0.023	1.455HisArg: 1.455 ± 0.035	1.011HisSer: 1.011 ± 0.03	0.738HisThr: 0.738 ± 0.028	1.489HisVal: 1.489 ± 0.031	0.344HisTrp: 0.344 ± 0.016	0.524HisTyr: 0.524 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.645IleAla: 7.645 ± 0.08	0.611IleCys: 0.611 ± 0.022	3.502IleAsp: 3.502 ± 0.052	3.531IleGlu: 3.531 ± 0.057	1.869IlePhe: 1.869 ± 0.037	5.346IleGly: 5.346 ± 0.074	1.022IleHis: 1.022 ± 0.029	2.366IleIle: 2.366 ± 0.045	1.323IleLys: 1.323 ± 0.034	5.131IleLeu: 5.131 ± 0.071	1.238IleMet: 1.238 ± 0.03	1.369IleAsn: 1.369 ± 0.034	2.672IlePro: 2.672 ± 0.049	1.242IleGln: 1.242 ± 0.028	3.785IleArg: 3.785 ± 0.053	3.465IleSer: 3.465 ± 0.059	2.839IleThr: 2.839 ± 0.047	3.954IleVal: 3.954 ± 0.067	0.828IleTrp: 0.828 ± 0.026	1.201IleTyr: 1.201 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.801LysAla: 3.801 ± 0.07	0.154LysCys: 0.154 ± 0.011	1.616LysAsp: 1.616 ± 0.039	1.371LysGlu: 1.371 ± 0.033	0.874LysPhe: 0.874 ± 0.028	2.734LysGly: 2.734 ± 0.045	0.557LysHis: 0.557 ± 0.021	1.597LysIle: 1.597 ± 0.038	0.988LysLys: 0.988 ± 0.037	3.18LysLeu: 3.18 ± 0.057	0.801LysMet: 0.801 ± 0.026	0.783LysAsn: 0.783 ± 0.024	1.826LysPro: 1.826 ± 0.042	0.933LysGln: 0.933 ± 0.023	2.024LysArg: 2.024 ± 0.042	1.814LysSer: 1.814 ± 0.038	1.724LysThr: 1.724 ± 0.036	2.174LysVal: 2.174 ± 0.049	0.364LysTrp: 0.364 ± 0.016	0.597LysTyr: 0.597 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.747LeuAla: 13.747 ± 0.134	0.899LeuCys: 0.899 ± 0.028	6.091LeuAsp: 6.091 ± 0.067	4.915LeuGlu: 4.915 ± 0.065	3.427LeuPhe: 3.427 ± 0.055	8.789LeuGly: 8.789 ± 0.094	1.989LeuHis: 1.989 ± 0.044	5.821LeuIle: 5.821 ± 0.082	2.942LeuLys: 2.942 ± 0.05	9.364LeuLeu: 9.364 ± 0.119	2.683LeuMet: 2.683 ± 0.048	2.758LeuAsn: 2.758 ± 0.051	6.079LeuPro: 6.079 ± 0.079	2.864LeuGln: 2.864 ± 0.044	7.502LeuArg: 7.502 ± 0.085	6.814LeuSer: 6.814 ± 0.082	6.256LeuThr: 6.256 ± 0.074	7.129LeuVal: 7.129 ± 0.082	1.32LeuTrp: 1.32 ± 0.028	1.917LeuTyr: 1.917 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.545MetAla: 3.545 ± 0.055	0.171MetCys: 0.171 ± 0.011	1.364MetAsp: 1.364 ± 0.031	1.108MetGlu: 1.108 ± 0.029	0.821MetPhe: 0.821 ± 0.022	2.229MetGly: 2.229 ± 0.039	0.473MetHis: 0.473 ± 0.02	1.713MetIle: 1.713 ± 0.035	1.008MetLys: 1.008 ± 0.029	2.791MetLeu: 2.791 ± 0.045	0.764MetMet: 0.764 ± 0.022	0.866MetAsn: 0.866 ± 0.024	1.619MetPro: 1.619 ± 0.032	1.041MetGln: 1.041 ± 0.025	2.047MetArg: 2.047 ± 0.044	1.752MetSer: 1.752 ± 0.035	2.084MetThr: 2.084 ± 0.033	1.901MetVal: 1.901 ± 0.041	0.237MetTrp: 0.237 ± 0.012	0.321MetTyr: 0.321 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.163AsnAla: 3.163 ± 0.049	0.246AsnCys: 0.246 ± 0.014	1.546AsnAsp: 1.546 ± 0.057	1.183AsnGlu: 1.183 ± 0.029	0.996AsnPhe: 0.996 ± 0.027	2.393AsnGly: 2.393 ± 0.05	0.554AsnHis: 0.554 ± 0.021	1.431AsnIle: 1.431 ± 0.037	0.638AsnLys: 0.638 ± 0.024	2.664AsnLeu: 2.664 ± 0.047	0.699AsnMet: 0.699 ± 0.022	0.606AsnAsn: 0.606 ± 0.023	1.946AsnPro: 1.946 ± 0.039	0.798AsnGln: 0.798 ± 0.024	1.87AsnArg: 1.87 ± 0.035	1.349AsnSer: 1.349 ± 0.034	1.193AsnThr: 1.193 ± 0.032	1.837AsnVal: 1.837 ± 0.039	0.482AsnTrp: 0.482 ± 0.017	0.648AsnTyr: 0.648 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.303ProAla: 6.303 ± 0.069	0.327ProCys: 0.327 ± 0.018	3.956ProAsp: 3.956 ± 0.062	4.351ProGlu: 4.351 ± 0.061	1.929ProPhe: 1.929 ± 0.038	4.083ProGly: 4.083 ± 0.062	1.102ProHis: 1.102 ± 0.031	2.395ProIle: 2.395 ± 0.039	1.586ProLys: 1.586 ± 0.039	4.857ProLeu: 4.857 ± 0.071	1.371ProMet: 1.371 ± 0.031	1.377ProAsn: 1.377 ± 0.033	2.274ProPro: 2.274 ± 0.049	1.858ProGln: 1.858 ± 0.041	3.058ProArg: 3.058 ± 0.045	2.702ProSer: 2.702 ± 0.044	2.478ProThr: 2.478 ± 0.04	4.491ProVal: 4.491 ± 0.06	0.678ProTrp: 0.678 ± 0.022	1.11ProTyr: 1.11 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.932GlnAla: 3.932 ± 0.056	0.2GlnCys: 0.2 ± 0.013	1.773GlnAsp: 1.773 ± 0.039	1.42GlnGlu: 1.42 ± 0.034	1.101GlnPhe: 1.101 ± 0.028	2.954GlnGly: 2.954 ± 0.049	0.674GlnHis: 0.674 ± 0.024	2.366GlnIle: 2.366 ± 0.043	1.115GlnLys: 1.115 ± 0.03	3.02GlnLeu: 3.02 ± 0.051	1.089GlnMet: 1.089 ± 0.029	1.011GlnAsn: 1.011 ± 0.027	1.785GlnPro: 1.785 ± 0.038	1.205GlnGln: 1.205 ± 0.038	2.353GlnArg: 2.353 ± 0.049	1.937GlnSer: 1.937 ± 0.039	1.8GlnThr: 1.8 ± 0.035	2.359GlnVal: 2.359 ± 0.042	0.378GlnTrp: 0.378 ± 0.017	0.565GlnTyr: 0.565 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.962ArgAla: 7.962 ± 0.093	0.445ArgCys: 0.445 ± 0.019	4.394ArgAsp: 4.394 ± 0.062	4.107ArgGlu: 4.107 ± 0.071	2.679ArgPhe: 2.679 ± 0.044	4.746ArgGly: 4.746 ± 0.066	1.682ArgHis: 1.682 ± 0.04	4.478ArgIle: 4.478 ± 0.056	2.268ArgLys: 2.268 ± 0.044	7.926ArgLeu: 7.926 ± 0.099	2.113ArgMet: 2.113 ± 0.041	1.927ArgAsn: 1.927 ± 0.036	3.5ArgPro: 3.5 ± 0.049	2.622ArgGln: 2.622 ± 0.046	5.232ArgArg: 5.232 ± 0.087	3.626ArgSer: 3.626 ± 0.056	2.967ArgThr: 2.967 ± 0.044	4.748ArgVal: 4.748 ± 0.064	0.975ArgTrp: 0.975 ± 0.031	1.523ArgTyr: 1.523 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.167SerAla: 6.167 ± 0.066	0.425SerCys: 0.425 ± 0.017	3.269SerAsp: 3.269 ± 0.053	2.927SerGlu: 2.927 ± 0.045	2.348SerPhe: 2.348 ± 0.045	5.939SerGly: 5.939 ± 0.078	1.158SerHis: 1.158 ± 0.03	2.744SerIle: 2.744 ± 0.05	1.454SerLys: 1.454 ± 0.033	5.317SerLeu: 5.317 ± 0.056	1.35SerMet: 1.35 ± 0.029	1.333SerAsn: 1.333 ± 0.032	2.785SerPro: 2.785 ± 0.046	1.77SerGln: 1.77 ± 0.041	3.839SerArg: 3.839 ± 0.055	2.72SerSer: 2.72 ± 0.051	2.648SerThr: 2.648 ± 0.045	3.978SerVal: 3.978 ± 0.062	0.794SerTrp: 0.794 ± 0.028	1.316SerTyr: 1.316 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.032ThrAla: 6.032 ± 0.067	0.45ThrCys: 0.45 ± 0.021	3.026ThrAsp: 3.026 ± 0.045	3.027ThrGlu: 3.027 ± 0.047	1.841ThrPhe: 1.841 ± 0.035	5.245ThrGly: 5.245 ± 0.067	1.066ThrHis: 1.066 ± 0.033	2.78ThrIle: 2.78 ± 0.045	1.384ThrLys: 1.384 ± 0.035	5.682ThrLeu: 5.682 ± 0.064	1.252ThrMet: 1.252 ± 0.028	1.29ThrAsn: 1.29 ± 0.03	3.28ThrPro: 3.28 ± 0.049	1.52ThrGln: 1.52 ± 0.032	3.536ThrArg: 3.536 ± 0.052	2.702ThrSer: 2.702 ± 0.05	2.828ThrThr: 2.828 ± 0.056	4.088ThrVal: 4.088 ± 0.052	0.634ThrTrp: 0.634 ± 0.024	1.157ThrTyr: 1.157 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.855ValAla: 8.855 ± 0.083	0.571ValCys: 0.571 ± 0.021	3.673ValAsp: 3.673 ± 0.052	4.21ValGlu: 4.21 ± 0.06	2.631ValPhe: 2.631 ± 0.046	5.247ValGly: 5.247 ± 0.073	1.262ValHis: 1.262 ± 0.03	4.424ValIle: 4.424 ± 0.066	1.995ValLys: 1.995 ± 0.042	7.612ValLeu: 7.612 ± 0.086	2.194ValMet: 2.194 ± 0.044	1.983ValAsn: 1.983 ± 0.041	3.557ValPro: 3.557 ± 0.052	2.111ValGln: 2.111 ± 0.04	4.094ValArg: 4.094 ± 0.061	4.181ValSer: 4.181 ± 0.061	4.695ValThr: 4.695 ± 0.067	5.381ValVal: 5.381 ± 0.076	0.988ValTrp: 0.988 ± 0.028	1.303ValTyr: 1.303 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.382TrpAla: 1.382 ± 0.036	0.127TrpCys: 0.127 ± 0.01	0.77TrpAsp: 0.77 ± 0.025	0.577TrpGlu: 0.577 ± 0.024	0.579TrpPhe: 0.579 ± 0.019	1.044TrpGly: 1.044 ± 0.029	0.369TrpHis: 0.369 ± 0.016	0.75TrpIle: 0.75 ± 0.025	0.445TrpLys: 0.445 ± 0.019	1.824TrpLeu: 1.824 ± 0.04	0.404TrpMet: 0.404 ± 0.017	0.45TrpAsn: 0.45 ± 0.017	0.731TrpPro: 0.731 ± 0.024	0.73TrpGln: 0.73 ± 0.025	1.146TrpArg: 1.146 ± 0.03	0.86TrpSer: 0.86 ± 0.026	0.763TrpThr: 0.763 ± 0.025	0.867TrpVal: 0.867 ± 0.03	0.237TrpTrp: 0.237 ± 0.013	0.257TrpTyr: 0.257 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.402TyrAla: 2.402 ± 0.041	0.2TyrCys: 0.2 ± 0.012	1.475TyrAsp: 1.475 ± 0.035	1.142TyrGlu: 1.142 ± 0.035	0.835TyrPhe: 0.835 ± 0.025	2.084TyrGly: 2.084 ± 0.04	0.464TyrHis: 0.464 ± 0.018	0.876TyrIle: 0.876 ± 0.029	0.554TyrLys: 0.554 ± 0.022	2.33TyrLeu: 2.33 ± 0.047	0.472TyrMet: 0.472 ± 0.019	0.576TyrAsn: 0.576 ± 0.023	1.083TyrPro: 1.083 ± 0.03	0.699TyrGln: 0.699 ± 0.023	1.621TyrArg: 1.621 ± 0.032	1.203TyrSer: 1.203 ± 0.031	0.991TyrThr: 0.991 ± 0.027	1.45TyrVal: 1.45 ± 0.033	0.362TyrTrp: 0.362 ± 0.017	0.562TyrTyr: 0.562 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4256 proteins (1347648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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