Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA259B11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.167AlaAla: 4.167 ± 0.162
0.806AlaCys: 0.806 ± 0.075
3.371AlaAsp: 3.371 ± 0.136
5.884AlaGlu: 5.884 ± 0.211
2.482AlaPhe: 2.482 ± 0.112
5.395AlaGly: 5.395 ± 0.209
0.973AlaHis: 0.973 ± 0.061
4.245AlaIle: 4.245 ± 0.186
4.308AlaLys: 4.308 ± 0.142
5.843AlaLeu: 5.843 ± 0.221
1.514AlaMet: 1.514 ± 0.084
1.623AlaAsn: 1.623 ± 0.102
2.253AlaPro: 2.253 ± 0.109
1.436AlaGln: 1.436 ± 0.091
3.403AlaArg: 3.403 ± 0.142
3.616AlaSer: 3.616 ± 0.176
2.846AlaThr: 2.846 ± 0.129
4.698AlaVal: 4.698 ± 0.168
0.593AlaTrp: 0.593 ± 0.058
1.634AlaTyr: 1.634 ± 0.088
0.0AlaXaa: 0.0 ± 0.0
Cys
0.609CysAla: 0.609 ± 0.057
0.208CysCys: 0.208 ± 0.03
0.64CysAsp: 0.64 ± 0.056
0.9CysGlu: 0.9 ± 0.07
0.401CysPhe: 0.401 ± 0.05
1.264CysGly: 1.264 ± 0.086
0.177CysHis: 0.177 ± 0.034
0.583CysIle: 0.583 ± 0.053
0.583CysLys: 0.583 ± 0.058
0.791CysLeu: 0.791 ± 0.073
0.224CysMet: 0.224 ± 0.038
0.307CysAsn: 0.307 ± 0.044
0.77CysPro: 0.77 ± 0.063
0.265CysGln: 0.265 ± 0.033
0.567CysArg: 0.567 ± 0.059
0.78CysSer: 0.78 ± 0.069
0.421CysThr: 0.421 ± 0.052
0.619CysVal: 0.619 ± 0.064
0.078CysTrp: 0.078 ± 0.021
0.333CysTyr: 0.333 ± 0.045
0.0CysXaa: 0.0 ± 0.0
Asp
3.231AspAla: 3.231 ± 0.138
0.656AspCys: 0.656 ± 0.055
2.737AspAsp: 2.737 ± 0.128
5.822AspGlu: 5.822 ± 0.207
2.497AspPhe: 2.497 ± 0.126
3.751AspGly: 3.751 ± 0.159
0.931AspHis: 0.931 ± 0.078
4.329AspIle: 4.329 ± 0.152
3.668AspLys: 3.668 ± 0.15
6.191AspLeu: 6.191 ± 0.217
1.29AspMet: 1.29 ± 0.078
1.556AspAsn: 1.556 ± 0.101
2.934AspPro: 2.934 ± 0.124
1.155AspGln: 1.155 ± 0.069
3.548AspArg: 3.548 ± 0.139
3.319AspSer: 3.319 ± 0.126
2.57AspThr: 2.57 ± 0.145
4.193AspVal: 4.193 ± 0.159
0.827AspTrp: 0.827 ± 0.075
2.216AspTyr: 2.216 ± 0.13
0.0AspXaa: 0.0 ± 0.0
Glu
5.832GluAla: 5.832 ± 0.213
0.635GluCys: 0.635 ± 0.062
6.087GluAsp: 6.087 ± 0.201
12.809GluGlu: 12.809 ± 0.342
3.314GluPhe: 3.314 ± 0.152
7.05GluGly: 7.05 ± 0.192
1.373GluHis: 1.373 ± 0.093
8.173GluIle: 8.173 ± 0.235
10.978GluLys: 10.978 ± 0.28
8.277GluLeu: 8.277 ± 0.229
2.341GluMet: 2.341 ± 0.116
5.26GluAsn: 5.26 ± 0.198
2.939GluPro: 2.939 ± 0.136
1.649GluGln: 1.649 ± 0.097
6.045GluArg: 6.045 ± 0.196
4.844GluSer: 4.844 ± 0.17
4.859GluThr: 4.859 ± 0.178
6.737GluVal: 6.737 ± 0.194
1.056GluTrp: 1.056 ± 0.077
2.393GluTyr: 2.393 ± 0.111
0.0GluXaa: 0.0 ± 0.0
Phe
2.222PheAla: 2.222 ± 0.109
0.453PheCys: 0.453 ± 0.048
2.575PheAsp: 2.575 ± 0.136
3.559PheGlu: 3.559 ± 0.138
1.592PhePhe: 1.592 ± 0.104
3.2PheGly: 3.2 ± 0.119
0.77PheHis: 0.77 ± 0.055
2.008PheIle: 2.008 ± 0.103
2.362PheLys: 2.362 ± 0.126
4.068PheLeu: 4.068 ± 0.148
0.78PheMet: 0.78 ± 0.069
1.217PheAsn: 1.217 ± 0.084
1.909PhePro: 1.909 ± 0.108
0.983PheGln: 0.983 ± 0.076
1.977PheArg: 1.977 ± 0.092
3.007PheSer: 3.007 ± 0.135
1.837PheThr: 1.837 ± 0.104
2.591PheVal: 2.591 ± 0.125
0.484PheTrp: 0.484 ± 0.06
1.264PheTyr: 1.264 ± 0.084
0.0PheXaa: 0.0 ± 0.0
Gly
4.656GlyAla: 4.656 ± 0.184
0.822GlyCys: 0.822 ± 0.078
3.673GlyAsp: 3.673 ± 0.133
7.944GlyGlu: 7.944 ± 0.224
3.116GlyPhe: 3.116 ± 0.121
5.967GlyGly: 5.967 ± 0.25
1.129GlyHis: 1.129 ± 0.081
5.718GlyIle: 5.718 ± 0.2
5.962GlyLys: 5.962 ± 0.186
6.394GlyLeu: 6.394 ± 0.21
1.935GlyMet: 1.935 ± 0.106
2.581GlyAsn: 2.581 ± 0.115
2.404GlyPro: 2.404 ± 0.111
1.54GlyGln: 1.54 ± 0.099
4.401GlyArg: 4.401 ± 0.161
4.594GlySer: 4.594 ± 0.16
3.6GlyThr: 3.6 ± 0.142
5.723GlyVal: 5.723 ± 0.202
1.009GlyTrp: 1.009 ± 0.089
2.466GlyTyr: 2.466 ± 0.113
0.0GlyXaa: 0.0 ± 0.0
His
1.03HisAla: 1.03 ± 0.071
0.234HisCys: 0.234 ± 0.038
1.015HisAsp: 1.015 ± 0.075
1.29HisGlu: 1.29 ± 0.089
0.671HisPhe: 0.671 ± 0.072
1.217HisGly: 1.217 ± 0.075
0.312HisHis: 0.312 ± 0.044
1.03HisIle: 1.03 ± 0.075
0.817HisLys: 0.817 ± 0.069
1.608HisLeu: 1.608 ± 0.096
0.333HisMet: 0.333 ± 0.046
0.536HisAsn: 0.536 ± 0.058
1.16HisPro: 1.16 ± 0.087
0.38HisGln: 0.38 ± 0.045
0.895HisArg: 0.895 ± 0.071
0.973HisSer: 0.973 ± 0.074
0.812HisThr: 0.812 ± 0.056
1.041HisVal: 1.041 ± 0.076
0.25HisTrp: 0.25 ± 0.036
0.63HisTyr: 0.63 ± 0.067
0.0HisXaa: 0.0 ± 0.0
Ile
4.859IleAla: 4.859 ± 0.171
0.723IleCys: 0.723 ± 0.056
4.61IleAsp: 4.61 ± 0.158
7.05IleGlu: 7.05 ± 0.221
2.768IlePhe: 2.768 ± 0.138
5.51IleGly: 5.51 ± 0.218
1.176IleHis: 1.176 ± 0.077
4.641IleIle: 4.641 ± 0.194
4.516IleLys: 4.516 ± 0.155
6.389IleLeu: 6.389 ± 0.241
1.483IleMet: 1.483 ± 0.088
2.612IleAsn: 2.612 ± 0.128
3.215IlePro: 3.215 ± 0.125
1.644IleGln: 1.644 ± 0.094
3.715IleArg: 3.715 ± 0.135
5.099IleSer: 5.099 ± 0.199
3.231IleThr: 3.231 ± 0.141
4.916IleVal: 4.916 ± 0.181
0.614IleTrp: 0.614 ± 0.054
1.909IleTyr: 1.909 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
4.641LysAla: 4.641 ± 0.158
0.64LysCys: 0.64 ± 0.063
3.98LysAsp: 3.98 ± 0.151
7.658LysGlu: 7.658 ± 0.232
2.679LysPhe: 2.679 ± 0.125
5.005LysGly: 5.005 ± 0.177
1.108LysHis: 1.108 ± 0.095
6.597LysIle: 6.597 ± 0.21
6.894LysLys: 6.894 ± 0.233
6.118LysLeu: 6.118 ± 0.182
1.644LysMet: 1.644 ± 0.094
3.72LysAsn: 3.72 ± 0.155
2.409LysPro: 2.409 ± 0.134
1.53LysGln: 1.53 ± 0.092
4.24LysArg: 4.24 ± 0.166
4.162LysSer: 4.162 ± 0.169
3.881LysThr: 3.881 ± 0.18
5.0LysVal: 5.0 ± 0.171
0.858LysTrp: 0.858 ± 0.081
2.263LysTyr: 2.263 ± 0.115
0.0LysXaa: 0.0 ± 0.0
Leu
6.113LeuAla: 6.113 ± 0.219
0.744LeuCys: 0.744 ± 0.064
5.494LeuAsp: 5.494 ± 0.191
9.297LeuGlu: 9.297 ± 0.272
3.366LeuPhe: 3.366 ± 0.15
6.415LeuGly: 6.415 ± 0.215
1.457LeuHis: 1.457 ± 0.09
5.723LeuIle: 5.723 ± 0.208
6.524LeuLys: 6.524 ± 0.194
7.736LeuLeu: 7.736 ± 0.304
2.06LeuMet: 2.06 ± 0.104
3.569LeuAsn: 3.569 ± 0.162
3.845LeuPro: 3.845 ± 0.171
2.196LeuGln: 2.196 ± 0.112
5.151LeuArg: 5.151 ± 0.16
6.519LeuSer: 6.519 ± 0.172
4.688LeuThr: 4.688 ± 0.159
5.53LeuVal: 5.53 ± 0.219
0.931LeuTrp: 0.931 ± 0.069
2.242LeuTyr: 2.242 ± 0.117
0.0LeuXaa: 0.0 ± 0.0
Met
1.368MetAla: 1.368 ± 0.097
0.182MetCys: 0.182 ± 0.028
1.524MetAsp: 1.524 ± 0.084
2.196MetGlu: 2.196 ± 0.111
0.723MetPhe: 0.723 ± 0.055
1.665MetGly: 1.665 ± 0.084
0.276MetHis: 0.276 ± 0.038
1.504MetIle: 1.504 ± 0.081
1.951MetLys: 1.951 ± 0.086
1.66MetLeu: 1.66 ± 0.098
0.458MetMet: 0.458 ± 0.05
1.119MetAsn: 1.119 ± 0.098
0.89MetPro: 0.89 ± 0.066
0.432MetGln: 0.432 ± 0.045
1.295MetArg: 1.295 ± 0.071
1.545MetSer: 1.545 ± 0.082
1.197MetThr: 1.197 ± 0.086
1.498MetVal: 1.498 ± 0.091
0.156MetTrp: 0.156 ± 0.03
0.401MetTyr: 0.401 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
1.987AsnAla: 1.987 ± 0.095
0.52AsnCys: 0.52 ± 0.05
1.722AsnAsp: 1.722 ± 0.101
2.898AsnGlu: 2.898 ± 0.136
1.571AsnPhe: 1.571 ± 0.117
2.419AsnGly: 2.419 ± 0.121
0.734AsnHis: 0.734 ± 0.075
2.955AsnIle: 2.955 ± 0.139
2.294AsnLys: 2.294 ± 0.12
4.5AsnLeu: 4.5 ± 0.165
0.749AsnMet: 0.749 ± 0.062
1.275AsnAsn: 1.275 ± 0.078
2.502AsnPro: 2.502 ± 0.105
0.942AsnGln: 0.942 ± 0.085
2.289AsnArg: 2.289 ± 0.114
2.461AsnSer: 2.461 ± 0.124
1.66AsnThr: 1.66 ± 0.093
2.742AsnVal: 2.742 ± 0.122
0.567AsnTrp: 0.567 ± 0.061
1.457AsnTyr: 1.457 ± 0.101
0.0AsnXaa: 0.0 ± 0.0
Pro
2.43ProAla: 2.43 ± 0.103
0.401ProCys: 0.401 ± 0.042
2.742ProAsp: 2.742 ± 0.134
4.885ProGlu: 4.885 ± 0.155
1.597ProPhe: 1.597 ± 0.105
3.142ProGly: 3.142 ± 0.118
0.895ProHis: 0.895 ± 0.061
2.679ProIle: 2.679 ± 0.119
2.341ProLys: 2.341 ± 0.104
3.324ProLeu: 3.324 ± 0.138
0.812ProMet: 0.812 ± 0.073
1.649ProAsn: 1.649 ± 0.082
2.133ProPro: 2.133 ± 0.109
1.046ProGln: 1.046 ± 0.079
1.8ProArg: 1.8 ± 0.102
3.158ProSer: 3.158 ± 0.157
2.081ProThr: 2.081 ± 0.092
2.971ProVal: 2.971 ± 0.155
0.421ProTrp: 0.421 ± 0.048
1.514ProTyr: 1.514 ± 0.1
0.0ProXaa: 0.0 ± 0.0
Gln
1.462GlnAla: 1.462 ± 0.093
0.177GlnCys: 0.177 ± 0.029
1.264GlnAsp: 1.264 ± 0.084
2.055GlnGlu: 2.055 ± 0.102
0.78GlnPhe: 0.78 ± 0.068
1.566GlnGly: 1.566 ± 0.096
0.333GlnHis: 0.333 ± 0.046
1.883GlnIle: 1.883 ± 0.105
2.143GlnLys: 2.143 ± 0.102
1.805GlnLeu: 1.805 ± 0.105
0.52GlnMet: 0.52 ± 0.052
1.113GlnAsn: 1.113 ± 0.082
0.77GlnPro: 0.77 ± 0.067
0.614GlnGln: 0.614 ± 0.069
1.238GlnArg: 1.238 ± 0.09
1.264GlnSer: 1.264 ± 0.085
1.16GlnThr: 1.16 ± 0.09
1.379GlnVal: 1.379 ± 0.078
0.198GlnTrp: 0.198 ± 0.036
0.557GlnTyr: 0.557 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
3.371ArgAla: 3.371 ± 0.136
0.598ArgCys: 0.598 ± 0.055
3.101ArgAsp: 3.101 ± 0.153
6.722ArgGlu: 6.722 ± 0.178
2.227ArgPhe: 2.227 ± 0.113
4.173ArgGly: 4.173 ± 0.162
0.786ArgHis: 0.786 ± 0.063
3.98ArgIle: 3.98 ± 0.128
5.192ArgLys: 5.192 ± 0.173
4.537ArgLeu: 4.537 ± 0.178
1.42ArgMet: 1.42 ± 0.08
2.461ArgAsn: 2.461 ± 0.11
1.982ArgPro: 1.982 ± 0.113
1.259ArgGln: 1.259 ± 0.085
3.574ArgArg: 3.574 ± 0.157
2.992ArgSer: 2.992 ± 0.132
2.414ArgThr: 2.414 ± 0.104
3.845ArgVal: 3.845 ± 0.164
0.619ArgTrp: 0.619 ± 0.07
1.618ArgTyr: 1.618 ± 0.105
0.0ArgXaa: 0.0 ± 0.0
Ser
3.647SerAla: 3.647 ± 0.126
0.656SerCys: 0.656 ± 0.06
3.683SerAsp: 3.683 ± 0.184
6.581SerGlu: 6.581 ± 0.198
2.825SerPhe: 2.825 ± 0.137
5.135SerGly: 5.135 ± 0.19
1.025SerHis: 1.025 ± 0.081
4.381SerIle: 4.381 ± 0.154
4.381SerLys: 4.381 ± 0.176
5.686SerLeu: 5.686 ± 0.183
1.327SerMet: 1.327 ± 0.083
1.935SerAsn: 1.935 ± 0.11
2.882SerPro: 2.882 ± 0.112
1.634SerGln: 1.634 ± 0.102
3.574SerArg: 3.574 ± 0.132
3.996SerSer: 3.996 ± 0.189
2.908SerThr: 2.908 ± 0.135
4.157SerVal: 4.157 ± 0.161
0.843SerTrp: 0.843 ± 0.073
1.904SerTyr: 1.904 ± 0.108
0.0SerXaa: 0.0 ± 0.0
Thr
3.288ThrAla: 3.288 ± 0.154
0.661ThrCys: 0.661 ± 0.064
2.549ThrAsp: 2.549 ± 0.115
3.923ThrGlu: 3.923 ± 0.136
1.717ThrPhe: 1.717 ± 0.093
4.313ThrGly: 4.313 ± 0.152
0.78ThrHis: 0.78 ± 0.062
3.413ThrIle: 3.413 ± 0.15
2.57ThrLys: 2.57 ± 0.116
4.386ThrLeu: 4.386 ± 0.152
0.942ThrMet: 0.942 ± 0.06
1.691ThrAsn: 1.691 ± 0.1
2.518ThrPro: 2.518 ± 0.107
1.035ThrGln: 1.035 ± 0.078
2.471ThrArg: 2.471 ± 0.115
3.012ThrSer: 3.012 ± 0.13
2.372ThrThr: 2.372 ± 0.12
4.173ThrVal: 4.173 ± 0.174
0.453ThrTrp: 0.453 ± 0.055
1.613ThrTyr: 1.613 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
3.975ValAla: 3.975 ± 0.163
0.91ValCys: 0.91 ± 0.074
4.391ValAsp: 4.391 ± 0.176
7.346ValGlu: 7.346 ± 0.214
2.705ValPhe: 2.705 ± 0.143
5.213ValGly: 5.213 ± 0.19
1.139ValHis: 1.139 ± 0.063
4.537ValIle: 4.537 ± 0.158
5.0ValLys: 5.0 ± 0.18
6.285ValLeu: 6.285 ± 0.174
1.415ValMet: 1.415 ± 0.091
2.409ValAsn: 2.409 ± 0.096
2.731ValPro: 2.731 ± 0.134
1.405ValGln: 1.405 ± 0.083
3.829ValArg: 3.829 ± 0.133
4.932ValSer: 4.932 ± 0.199
3.382ValThr: 3.382 ± 0.151
4.76ValVal: 4.76 ± 0.161
0.682ValTrp: 0.682 ± 0.06
1.883ValTyr: 1.883 ± 0.097
0.0ValXaa: 0.0 ± 0.0
Trp
0.567TrpAla: 0.567 ± 0.055
0.146TrpCys: 0.146 ± 0.031
0.604TrpAsp: 0.604 ± 0.059
0.968TrpGlu: 0.968 ± 0.078
0.51TrpPhe: 0.51 ± 0.068
0.869TrpGly: 0.869 ± 0.077
0.239TrpHis: 0.239 ± 0.039
0.671TrpIle: 0.671 ± 0.062
0.952TrpLys: 0.952 ± 0.072
0.91TrpLeu: 0.91 ± 0.081
0.291TrpMet: 0.291 ± 0.045
0.525TrpAsn: 0.525 ± 0.064
0.317TrpPro: 0.317 ± 0.038
0.208TrpGln: 0.208 ± 0.031
1.046TrpArg: 1.046 ± 0.084
0.734TrpSer: 0.734 ± 0.065
0.572TrpThr: 0.572 ± 0.06
0.708TrpVal: 0.708 ± 0.066
0.166TrpTrp: 0.166 ± 0.028
0.265TrpTyr: 0.265 ± 0.048
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.634TyrAla: 1.634 ± 0.078
0.349TyrCys: 0.349 ± 0.041
1.66TyrAsp: 1.66 ± 0.087
2.867TyrGlu: 2.867 ± 0.12
1.316TyrPhe: 1.316 ± 0.083
2.367TyrGly: 2.367 ± 0.102
0.619TyrHis: 0.619 ± 0.051
1.628TyrIle: 1.628 ± 0.087
1.592TyrLys: 1.592 ± 0.094
3.09TyrLeu: 3.09 ± 0.128
0.494TyrMet: 0.494 ± 0.05
1.087TyrAsn: 1.087 ± 0.083
1.457TyrPro: 1.457 ± 0.095
0.936TyrGln: 0.936 ± 0.062
1.811TyrArg: 1.811 ± 0.096
2.154TyrSer: 2.154 ± 0.103
1.389TyrThr: 1.389 ± 0.087
1.649TyrVal: 1.649 ± 0.087
0.463TyrTrp: 0.463 ± 0.051
1.025TyrTyr: 1.025 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 852 proteins (192211 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski